MURAI Hiroki 村井宏生

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MURAI HIROKI 村井宏生

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Researcher Number	50464566
Other IDs
Affiliation (Current)	2025: 福井大学, 学術研究院医学系部門, 特別研究員 2025: 独立行政法人国立病院機構三重病院(臨床研究部), 臨床研究部, 研究員(移行)
Affiliation (based on the past Project Information) *help	2019 – 2022: 福井大学, 学術研究院医学系部門, 特別研究員 2016 – 2017: 福井大学, 学術研究院医学系部門, 助教 2014 – 2015: 福井大学, 医学部, 助教 2013 – 2014: 福井大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 気道上皮細胞 / アレルギー / オートファジー / 気管支喘息 / 気道上皮 / 気道リモデリング / 選択的オートファジー / βディフェンシン / ウイルス感染症 / 自然免疫応答 … More / 小胞体ストレス応答 / ER ストレス / 小児 / 喘息 Less

The role of selective autophagy in the pathogenesis of asthma.Principal Investigator
- Principal Investigator
  
  MURAI HIROKI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Fukui
The effect of ER stress against atopic asthma in airway epithelial cellsPrincipal Investigator
- Principal Investigator
  
  MURAI HIROKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Fukui
Autophagy evoked in airway epithelial cell play an important role in steroid resistant asthma.Principal Investigator
- Principal Investigator
  
  MURAI HIROKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Fukui

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Ovomucoid‐specific IgD increases in children who naturally outgrow egg allergy in a cross‐sectional study2021
- Author(s)
  Itoh Naohiro、Yasutomi Motoko、Kawasaki Akiko、Murai Hiroki、Nomura Eishi、Hagihara Yuuki、Ogura Kazumasa、Ohshima Yusei
- Journal Title
  
  Allergy
  
  Volume: 76 Issue: 8 Pages: 2607-2609
- DOI
  10.1111/all.14841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08272, KAKENHI-PROJECT-19K08340, KAKENHI-PROJECT-21K07769
[Journal Article] Acute food protein‐induced enterocolitis syndrome due to short‐neck clams2021
- Author(s)
  Murai Hiroki、Yoshikawa Toshihide、Itoh Naohiro、Miyanaga Miki、Ohshima Yusei
- Journal Title
  
  Pediatrics International
  
  Volume: 64 Issue: 1
- DOI
  10.1111/ped.14859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08272, KAKENHI-PROJECT-19K08340
[Journal Article] Eosinophilic gastroenteritis developed after remission of cow's milk allergy.2020
- Author(s)
  Itoh N, Murai H, Kawasaki A, Suzuki K, Ohshima Y.
- Journal Title
  
  Pediatr Int
  
  Volume: 62 Issue: 2 Pages: 233-234
- DOI
  10.1111/ped.14078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08272, KAKENHI-PROJECT-19K08340, KAKENHI-PROJECT-16K19633
[Journal Article] Learning Effects of a Pediatric Allergy Skill-up Course Using Active Learning Methods2019
- Author(s)
  伊藤靖典, 長尾みづほ, 村井宏生, 福家辰樹, 手塚純一郎, 佐藤さくら, 藤澤隆夫, 足立雄一
- Journal Title
  
  Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
  
  Volume: 33 Issue: 2 Pages: 180-188
- DOI
  10.3388/jspaci.33.180
- NAID
  130007670354
- ISSN
  0914-2649, 1882-2738
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19K08340
[Journal Article] The effectiveness of repeated attendance at a lecture on food allergies and the downside of the lecture’s content.2018
- Author(s)
  村井宏生、伊藤尚弘、川﨑亜希子、安冨素子、大嶋勇成
- Journal Title
  
  Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
  
  Volume: 32 Issue: 1 Pages: 127-135
- DOI
  10.3388/jspaci.32.127
- NAID
  130006594429
- ISSN
  0914-2649, 1882-2738
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] CQ4　Is the addition of leukotriene receptor antagonist to inhaled corticosteroids in children with persistent asthma effective?2017
- Author(s)
  真部哲治, 村井宏生, 高岡有理, 荒川浩一
- Journal Title
  
  Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
  
  Volume: 31 Issue: 2 Pages: 224-230
- DOI
  10.3388/jspaci.31.224
- NAID
  130006832523
- ISSN
  0914-2649, 1882-2738
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] YKL-402017
- Author(s)
  村井　宏生
- Journal Title
  
  Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
  
  Volume: 31 Issue: 5 Pages: 751-752
- DOI
  10.3388/jspaci.31.751
- NAID
  130006300552
- ISSN
  0914-2649, 1882-2738
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] 初発時に急性腎障害を合併し、マルチターゲット療法と二重膜濾過血漿交換を行ったループス腎炎の1女児例2017
- Author(s)
  伊藤尚弘、村井宏生、清水達人、前田夢吉、林泰平、津田雅世、安冨素子、玉村宗一、森夕起子、石原靖紀、糟野健司、大嶋勇成
- Journal Title
  
  小児リウマチ
  
  Volume: 8 Pages: 29-33
- NAID
  130007969818
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] The Biomarker Salivary SP-D May Indicate Small Airway Inflammation and Asthma Exacerbation2017
- Author(s)
  Okazaki S、Murai H、Kidoguchi S、Nomura E、Itoh N、Hashimoto N、Hamada T、Kawakita A、Yasutomi M、Ohshima Y
- Journal Title
  
  Journal of Investigational Allergology and Clinical Immunology
  
  Volume: 27 Issue: 5 Pages: 305-312
- DOI
  10.18176/jiaci.0174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10018, KAKENHI-PROJECT-16K19633, KAKENHI-PROJECT-15K19606
[Journal Article] 教育現場で学校生活管理指導表(アレルギー疾患用)が活用されるための提案2016
- Author(s)
  安冨素子, 村井宏生, 岡崎新太郎, 河北亜希子, 林仁幸子, 眞弓光文, 大嶋勇成
- Journal Title
  
  小児科臨床
  
  Volume: 69 Pages: 1692-1698
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] 児童館職員の食物アレルギーに対する認識とその問題点2016
- Author(s)
  村井宏生, 林仁幸子, 河北亜希子, 安冨素子, 大嶋勇成
- Journal Title
  
  日本小児アレルギー学会誌
  
  Volume: 30 Pages: 553-561
- NAID
  130005268398
- Data Source
  KAKENHI-PROJECT-15K19606
[Journal Article] Alternaria extract activates autophagy that induces IL-18 release from airway epithelial cells.2015
- Author(s)
  Murai H, Okazaki S, Hayashi H, Kawakita A, Hosoki K, Yasutomi M, Sur S, Ohshima Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 464 Issue: 4 Pages: 969-74
- DOI
  10.1016/j.bbrc.2015.05.076
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19606, KAKENHI-PROJECT-26860787, KAKENHI-PROJECT-25461583, KAKENHI-PROJECT-25461584, KAKENHI-PROJECT-25860851
[Presentation] miRNAs in breast milk may correlate with early onset of allergy.2018
- Author(s)
  Hiroki Murai, Naohiro Itoh, Motoko Yasutomi, Akiko Kawasaki, Yusei Ohshima
- Organizer
  2018 AAAAI/WAO JOINT CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 教職員に食物アレルギー講習会を反復受講することの有用性と問題点2018
- Author(s)
  村井宏生,　野村詠史,　伊藤尚弘, 　川﨑亜希子,　安冨素子,　大嶋勇成
- Organizer
  日本小児アレルギー学会第54回学術集会
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] Salivary SP-D is a novel biomarker reflecting the resistance of peripheral airways.2018
- Author(s)
  Hiroki Murai, Shintaro Okazaki, Shuhei Kidoguchi, Naohiro Itoh, Akiko K. Kawasaki, Motoko Yasutomi, Toshihiko Hamada, Yusei Ohshima
- Organizer
  30 th anniversary congress of Korean Academy of Pediatric Allergy and Respiratory Diseases 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 呼吸リアクタンスとスパイロメトリーとの関連性2017
- Author(s)
  木戸口周平、浜田敏彦、橋本儀一、津田裕美子、村井宏生、石塚　全、石崎武志、木村秀樹
- Organizer
  第67回日本医学検査学会
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] Salivary YKL-40 could reflect peripheral airflow limitation in asthmatic children2017
- Author(s)
  Murai H, Nomura E, Itoh N, Kawasaki A, Yasutomi M, Ohshima Y
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 食物アレルギー発症後の皮膚症状への介入が誘発症状に与える影響2016
- Author(s)
  河北亜希子, 野村詠史, 伊藤尚弘, 林仁幸子, 村井宏生, 安冨素子, 大嶋勇成
- Organizer
  第53回日本小児アレルギー学会
- Place of Presentation
  前橋　ベイシア文化ホール
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] Public Elementary School Teachers’ Comprehension of the Usage of an Epinephrine-auto-injector (EAI) in Japan2016
- Author(s)
  Murai H, Itoh N, Kawasaki A, Yasutomi M, Ohshima Y
- Organizer
  American College of Allergy, Asthma and Immunology 2016 Annual Scientific Meeting
- Place of Presentation
  sanfrancisco, CA, USA
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 完全母乳栄養児におけるアレルギー疾患発症と母乳中miRNAプロファイルとの関係2016
- Author(s)
  村井宏生, 岡崎新太郎, 伊藤尚弘, 河北亜希子, 安冨素子, 大嶋勇成
- Organizer
  第53回日本小児アレルギー学会
- Place of Presentation
  前橋　ベイシア文化ホール
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 唾液中YKL-40は気管支喘息患者の末梢気道狭窄を反映する2016
- Author(s)
  村井宏生, 伊藤尚弘, 川崎亜希子, 安冨素子, 大嶋勇成
- Organizer
  第49回日本小児呼吸器学会
- Place of Presentation
  富山　富山国際会議場
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] ミニシンポジウム27 動物モデル　病態形成食物アレルギー発症後の皮膚症状が誘発症状の推移に与える影響2016
- Author(s)
  河北亜希子, 林仁幸子, 村井宏生, 安冨素子, 眞弓光文, 大嶋勇成
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京　東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] 汎下垂体機能低下症に合併した食物依存性運動誘発アナフィラキシーの1例2016
- Author(s)
  安冨素子, 畑郁江, 野村詠史, 伊藤尚弘, 岡崎新太郎, 河北亜希子, 林仁幸子, 村井宏生, 眞弓光文, 大嶋勇成
- Organizer
  第53回日本小児アレルギー学会
- Place of Presentation
  前橋　ベイシア文化ホール
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] Saliva SP-D may be a biomarker of peripheral airwy inflammation2016
- Author(s)
  Murai H, Okazaki S, Hayashi H, Kawakita A, Yasutomi M, Mayumi M, Ohshima Y
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京　東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] The mechanism of suppressive effects on a food allergy mouse model by 3-methyladenine2016
- Author(s)
  Yastumomi M, Kawakita A, Okazaki S,Hayashi H, Murai H, Mayumi M, Ohshima Y
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京　東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K19606
[Presentation] Airway epithelial cells exposed to Alternaria release IL-18 independent of NALP3/caspase-1 pathway by inducing autophagy and NF-kB activation2014
- Author(s)
  H. Murai, S. Okazaki, H. Hayashi, A. Kawakita, M. Yasutomi, S. Sur, Y. Ohshima
- Organizer
  the 2014 AAAAI Annual Meeting
- Place of Presentation
  San diego, USA
- Data Source
  KAKENHI-PROJECT-25860850
[Presentation] Autophagy is involved in IL-18 release from epithelial cells induced by Alternaria exposure.2013
- Author(s)
  Hiroki Murai, Shintaro Okazaki, Hisako Hayashi, Akiko Kawakita, Motoko Yasutomi, Mitsufumi Mayumi, Sanjiv Sur , and Yusei Ohshima
- Organizer
  第23回国際喘息学会日本・北アジア部会
- Place of Presentation
  東京都千代田区　都市センターホテル
- Data Source
  KAKENHI-PROJECT-25860850
[Presentation] オートファジーを介して気道上皮より分泌されるIL-18はCaspase 1 非依存性である2013
- Author(s)
  村井　宏生, 岡崎　新太郎, 林　仁幸子, 河北　亜希子, 安冨　素子, 眞弓　光文, Sur S, 大嶋　勇成
- Organizer
  第63回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京都千代田区ホテルニューオータニ
- Data Source
  KAKENHI-PROJECT-25860850
[Presentation] アルテルナリアは気道上皮のオートファジーを誘導し、IL-18を分泌する2013
- Author(s)
  村井　宏生, 岡崎　新太郎, 林　仁幸子, 河北　亜希子, 安冨　素子, Sur Sanjiv, 眞弓　光文, 大嶋　勇成
- Organizer
  第50回日本小児アレルギー学会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860850
[Presentation] Airway Epithelial Cells Exposed To Alternaria Release IL-18 through secretory autophagy.
- Author(s)
  Hiroki Murai, Shintaro Okazaki, Hisako Hayashi, Akiko Kawakita, Motoko Yasutomi, Mitsufumi Mayumi, Sanjiv Sur, Yusei Ohshima
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪　国際館パミール（東京）
- Year and Date
  2015-05-26 – 2015-05-28
- Data Source
  KAKENHI-PROJECT-25860850
[Presentation] アルテルナリア刺激を受けた気道上皮細胞はオートファジーを介してIL-18を分泌する。
- Author(s)
  村井　宏生
- Organizer
  ロイコトリエンフォーラム　2013
- Place of Presentation
  東京都千代田区北の丸スクエア
- Invited
- Data Source
  KAKENHI-PROJECT-25860850

1. 大嶋勇成 (40303391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

MURAI Hiroki 村井 宏生

MURAI HIROKI 村井 宏生

Research Projects

Research Products

Co-Researchers

The role of selective autophagy in the pathogenesis of asthma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of ER stress against atopic asthma in airway epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autophagy evoked in airway epithelial cell play an important role in steroid resistant asthma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ovomucoid‐specific IgD increases in children who naturally outgrow egg allergy in a cross‐sectional study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute food protein‐induced enterocolitis syndrome due to short‐neck clams2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eosinophilic gastroenteritis developed after remission of cow's milk allergy.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Learning Effects of a Pediatric Allergy Skill-up Course Using Active Learning Methods2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] The effectiveness of repeated attendance at a lecture on food allergies and the downside of the lecture’s content.2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] CQ4 Is the addition of leukotriene receptor antagonist to inhaled corticosteroids in children with persistent asthma effective?2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] YKL-402017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 初発時に急性腎障害を合併し、マルチターゲット療法と二重膜濾過血漿交換を行ったループス腎炎の1女児例2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The Biomarker Salivary SP-D May Indicate Small Airway Inflammation and Asthma Exacerbation2017

Author(s)

Journal Title

DOI

Data Source

MURAI Hiroki 村井宏生

MURAI HIROKI 村井宏生

[Journal Article] CQ4　Is the addition of leukotriene receptor antagonist to inhaled corticosteroids in children with persistent asthma effective?2017

[Presentation] 教職員に食物アレルギー講習会を反復受講することの有用性と問題点2018

[Presentation] ミニシンポジウム27 動物モデル　病態形成食物アレルギー発症後の皮膚症状が誘発症状の推移に与える影響2016