Ishii Seiji 石井聖二

Researcher Number	50468493
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 群馬大学, 大学院医学系研究科, 講師 2021 – 2022: 慶應義塾大学, 医学部(信濃町), 助教 2018 – 2020: 慶應義塾大学, 医学部(信濃町), 特任講師 2017: 慶應義塾大学, 医学部, 特任講師 (非常勤)
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Basic Section 51030:Pathophysiologic neuroscience-related / Neurophysiology / General neuroscience
Keywords	Principal Investigator アルコール / 環境ストレス / アルコール曝露 / 樹状突起 / 大脳皮質 / 環境ストレス / 細胞外小胞 / 麻酔薬 / 一次繊毛 / アルコール投与 / ゴルジ体 / 環境ストレス応答

環境ストレスに起因する非細胞死型カスパーゼによるシナプス形成障害機構の解明Principal Investigator
- Principal Investigator
  
  石井聖二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Gunma University
Significance and molecular mechanisms of primary cilia controlling the stress critical period of cortical development.Principal Investigator
- Principal Investigator
  
  ISHII Seiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Keio University
Analysis of environmental stress response downstream cascade in cerebral cortex formationPrincipal Investigator
- Principal Investigator
  
  Ishii Seiji
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Keio University

All 2023 2022 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Caspase-3 inhibition toward perinatal protection of the developing brain from environmental stress2023
- Author(s)
  Kaji Anna Arjun、Torii Masaaki、Ishii Seiji
- Journal Title
  
  Developmental Neuroscience
  
  Volume: - Issue: 2 Pages: 66-75
- DOI
  10.1159/000529125
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] The elucidation of environmental stress-resistant mechanism generated by primary cilia in the cerebral cortex2022
- Author(s)
  石井聖二
- Journal Title
  
  生化学
  
  Volume: 94 Issue: 1 Pages: 118-121
- DOI
  10.14952/SEIKAGAKU.2022.940118
- ISSN
  0037-1017
- Year and Date
  2022-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer2022
- Author(s)
  Shimada Hiroko、Sato Yuta、Sasaki Takashi、Shimozawa Aki、Imaizumi Kent、Shindo Tomoko、Miyao Sachiyo、Kiyama Kosuke、Kondo Takahiro、Shibata Shinsuke、Ishii Seiji、Kuromitsu Junro、Aoyagi Hirofumi、Ito Daisuke、Okano Hideyuki
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 9 Pages: 100289-100289
- DOI
  10.1016/j.crmeth.2022.100289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07829, KAKENHI-PUBLICLY-21H00438, KAKENHI-PROJECT-23K21397
[Journal Article] Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders2020
- Author(s)
  Mohammad Shahid、Page Stephen J.、Wang Li、Ishii Seiji、Li Peijun、Sasaki Toru、Basha Aiesha、Salzberg Anna、Quezado Zenaide、Imamura Fumiaki、Nishi Hirotaka、Isaka Keiichi、Corbin Joshua G.、Liu Judy S.、Kawasawa Yuka Imamura、Torii Masaaki、Hashimoto-Torii Kazue
- Journal Title
  
  Nature Neuroscience
  
  Volume: 23 Issue: 4 Pages: 533-543
- DOI
  10.1038/s41593-020-0592-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration2020
- Author(s)
  Ishii Seiji、Sasaki Toru、Mohammad Shahid、Hwang Hye、Tomy Edwin、Somaa Fahad、Ishibashi Nobuyuki、Okano Hideyuki、Rakic Pasko、Hashimoto-Torii Kazue、Torii Masaaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 1 Pages: 1-10
- DOI
  10.1073/pnas.2012482118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development2020
- Author(s)
  Son Alexander I、Mohammad Shahid、Sasaki Toru、Ishii Seiji、Yamashita Satoshi、Hashimoto-Torii Kazue、Torii Masaaki
- Journal Title
  
  Cerebral Cortex
  
  Volume: 30 Issue: 12 Pages: 6444-6457
- DOI
  10.1093/cercor/bhaa206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] Environmental stress impacts the developing brain2019
- Author(s)
  Ishii Seiji
- Journal Title
  
  Impact
  
  Volume: 2019 Issue: 7 Pages: 23-25
- DOI
  10.21820/23987073.2019.7.23
- Open Access
- Data Source
  KAKENHI-PROJECT-19K07829
[Journal Article] Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling2018
- Author(s)
  Imaizumi Kent、Fujimori Koki、Ishii Seiji、Otomo Asako、Hosoi Yasushi、Miyajima Hiroaki、Warita Hitoshi、Aoki Masashi、Hadano Shinji、Akamatsu Wado、Okano Hideyuki
- Journal Title
  
  eNeuro
  
  Volume: 5 Issue: 2 Pages: 0368-17
- DOI
  10.1523/eneuro.0368-17.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06563, KAKENHI-PROJECT-16J06437, KAKENHI-PUBLICLY-17H05706, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-16K09677
[Journal Article] Detection of vulnerable neurons damaged by environmental insults in utero2017
- Author(s)
  Torii Masaaki、Sasaki Masanori、Chang Yu-Wen、Ishii Seiji、Waxman Stephen G.、Kocsis Jeffery D.、Rakic Pasko、Hashimoto-Torii Kazue
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Issue: 9 Pages: 2367-2372
- DOI
  10.1073/pnas.1620641114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06563
[Journal Article] An Implantable Micro-Caged Device for Direct Local Delivery of Agents2017
- Author(s)
  Son Alexander I.、Opfermann Justin D.、McCue Caroline、Ziobro Julie、Abrahams John H.、Jones Katherine、Morton Paul D.、Ishii Seiji、Oluigbo Chima、Krieger Axel、Liu Judy S.、Hashimoto-Torii Kazue、Torii Masaaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-17912-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06563
[Journal Article] Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling2017
- Author(s)
  Ishii Seiji、Torii Masaaki、Son Alexander I.、Rajendraprasad Meenu、Morozov Yury M.、Kawasawa Yuka Imamura、Salzberg Anna C.、Fujimoto Mitsuaki、Brennand Kristen、Nakai Akira、Mezger Valerie、Gage Fred H.、Rakic Pasko、Hashimoto-Torii Kazue
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15157-15157
- DOI
  10.1038/ncomms15157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07256, KAKENHI-PROJECT-15H04706, KAKENHI-PROJECT-17H06563
[Patent] Porous implantable devices2018
- Inventor(s)
  Son A.I., Ishii S., 他6名
- Industrial Property Rights Holder
  Son A.I., Ishii S., 他6名
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H06563
[Presentation] 大脳皮質の一次繊毛が生み出す環境ストレス耐性機構2022
- Author(s)
  石井聖二
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07829
[Presentation] IGFR-Akt signaling through primary cilia protects degeneration of developing neurons in exposure to environmental stress2017
- Author(s)
  Seiji Ishii, Mohammad Shahid, Toru Sasaki, Masaaki Torii and Kazue Hashimoto-Torii
- Organizer
  第47回北米神経科学学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06563

1. 藤本充章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishii Seiji 石井 聖二

Research Projects

Research Products

Co-Researchers

環境ストレスに起因する非細胞死型カスパーゼによるシナプス形成障害機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance and molecular mechanisms of primary cilia controlling the stress critical period of cortical development.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of environmental stress response downstream cascade in cerebral cortex formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Caspase-3 inhibition toward perinatal protection of the developing brain from environmental stress2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The elucidation of environmental stress-resistant mechanism generated by primary cilia in the cerebral cortex2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental stress impacts the developing brain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of vulnerable neurons damaged by environmental insults in utero2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Implantable Micro-Caged Device for Direct Local Delivery of Agents2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling2017

Author(s)

Journal Title

DOI

Data Source

Ishii Seiji 石井聖二