KAMISHINA Hiroaki 神志那弘明

Researcher Number	50506847
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2021: 岐阜大学, 応用生物科学部, 准教授 2009: 岩手大, 農学部, 助教 2008 – 2009: Iwate University, 農学部, 助教
Review Section/Research Field	Principal Investigator Clinical veterinary science / Basic Section 42020:Veterinary medical science-related / Veterinary medical science Except Principal Investigator Clinical veterinary science / Veterinary medical science / General internal medicine and related fields
Keywords	Principal Investigator ALS / ミスフォールド / 犬 / 神経変性 / ミクログリア / 変性性脊髄症 / 神経変性疾患 / 脊髄損傷 / 抗体治療 / 分子シャペロン … More / 低分子化合物 / SOD1 / 小胞体ストレス / 抗体療法 / 車イス / 椎間板ヘルニア / 歩行トレーニング / リハビリテーション / 治療 / 軸索損傷 / 再生医療 … More Except Principal Investigator 脳・神経 / トランスレーショナルリサーチ / 臨床 / 移植・再生医療 / 抗炎症作用 / 分離 / 幹細胞 / 再生医療 / 中枢神経再生 / 間葉系幹細胞 / エクソソーム / 脳・神経疾患 / 内科 / ヒト乳歯歯髄幹細胞培養上清 / 筋萎縮性側索硬化症 / 筋萎縮性側索硬化症（ALS) / iPS細胞 / 凝集体 / Cu/Zn SOD (SOD1） / ヒト乳歯歯髄幹細胞培養上清 (SHED-CM) / 筋萎縮性側索硬化症 (ALS) / SOD1 / L-カルニチン / 超音波検査 / 呼吸不全 / 横隔膜 / MUNE / 犬 / 臨床治験 / バイオマーカー / レボカルニチン / DMスコア / ウェルシュ・コーギー / ALS / 変性性脊髄症 / ケラチノサイト / アトピー性皮膚炎 / 獣医学 / アレルギー・ぜんそく Less

犬の変性性脊髄症を起こす変異SOD1蛋白質の立体構造解析と治療基盤の構築Principal Investigator
- Principal Investigator
  
  神志那弘明
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Gifu University
Novel therapeutic strategies for amyotrophic lateral sclerosis using human deciduous dental pulp stem cells and their active ingredients
- Principal Investigator
  
  Hozimi Isao
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Gifu Pharmaceutical University
Development of method for central nervous regeneration using stem cell-derived exosomes
- Principal Investigator
  
  Nishida Hidetaka
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
  Gifu University
Investigation on pathomechanism and treatment of canine degenerative myelopathy using disease-specific iPS cellPrincipal Investigator
- Principal Investigator
  
  Kamishina Hiroaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Gifu University
Study on pathomechanisms of canine degenerative myelopathy and preclinical trial for antibody therapyPrincipal Investigator
- Principal Investigator
  
  KAMISHINA Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Gifu University
The mechanism of activation of Langerhans cells mediated by keratinocytes
- Principal Investigator
  
  MAEDA SADATOSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Gifu University
Clinical and histopathological characteristics and efficacy of Levocarnitine treatment in canine degenerative myelopathy
- Principal Investigator
  
  Saito Miyoko
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Azabu University
Development of new therapy for spinal cord injury in dogs using locomotor trainingPrincipal Investigator
- Principal Investigator
  
  KAMISHINA Hiroaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Gifu University
  Iwate University
犬骨髄間質細胞と合成ペプチドAG73を用いた神経再生医療の検討Principal Investigator
- Principal Investigator
  
  神志那弘明
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Iwate University

All 2022 2021 2020 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] 図解　小動物神経病学2011
- Author(s)
  齋藤弥代子、神志那弘明　他、監訳　長谷川大輔
- Total Pages
  595
- Publisher
  interzoo
- Data Source
  KAKENHI-PROJECT-23580450
[Journal Article] Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases2022
- Author(s)
  Kimura Shintaro、Kamishina Hiroaki、Hirata Yoko、Furuta Kyoji、Furukawa Yoshiaki、Yamato Osamu、Maeda Sadatoshi、Kamatari Yuji O.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1866 Issue: 5 Pages: 130114-130114
- DOI
  10.1016/j.bbagen.2022.130114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06410, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-20H04285
[Journal Article] Activation of the unfolded protein response in canine degenerative myelopathy.2018
- Author(s)
  Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamishina H.
- Journal Title
  
  Neurosci Lett
  
  Volume: 687 Pages: 216-222
- DOI
  10.1016/j.neulet.2018.09.040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03927, KAKENHI-PROJECT-16K08049
[Journal Article] Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy2016
- Author(s)
  Oyake K1, Kobatake Y, Shibata S, Sakai H, Saito M, Yamato O, Kushida K Maeda S, Kamishina H.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 78 Issue: 8 Pages: 1323-1327
- DOI
  10.1292/jvms.15-0521
- NAID
  130005261542
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23580450
[Journal Article] Genotyping Assays for the Canine Degenerative Myelopathy-Associated c.118G>A (p.E40K) Mutation of the <i>SOD1</i> Gene Using Conventional and Real-Time PCR Methods: A High Prevalence in the Pembroke Welsh Corgi Breed in Japan2013
- Author(s)
  Chang H.S., Kamishina H., Mizukami K., Momoi Y., Katayama M., Rahman M.M., Uddin M.M., Yabuki A., Kohyama M., Yamato O.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 75 Issue: 6 Pages: 795-798
- DOI
  10.1292/jvms.12-0451
- NAID
  130003362125
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580450, KAKENHI-PROJECT-25292181
[Journal Article] Genotyping Assays for the Canine Degenerative Myelopathy-Associated c,118G>A (p.E40K) Mutation of the SOD1 Gene Using Conventional and Real-Time PCR Methods : A High Prevalence in the Pembroke Welsh Corgi Breed in Japan.2013
- Author(s)
  Chang H.S., Kamishina H., Mizukami K., Momoi Y., Katayama M., Rahman M.M., Uddin M.M., Yabuki A., Kohyama M., Yamato O.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: (in press)
- NAID
  120006342278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24380169
[Journal Article] Involvement of nuclear factor of activated T cells in granulocyte-macrophage colony-stimulating factor production in canine keratinocytes stimulated with a cysteine protease2013
- Author(s)
  Kimura, T., Sekido, M., Iio, A., Chimura, N., Shibata, S., Kamishina H., Maeda, S
- Journal Title
  
  Vet Dermatol
  
  Volume: 24(3) Issue: 3 Pages: 310-314
- DOI
  10.1111/vde.12017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380184
[Journal Article] Genotyping Assays for the Canine Degenerative Myelopathy-Associated c.118G>A (p.E40K) Mutation of the SOD1 Gene Using Conventional and Real-Time PCR Methods: A High Prevalence in the Pembroke Welsh Corgi Breed in Japan. (in press)2013
- Author(s)
  Chang H.S., Kamishina H., Mizukami K., Momoi Y., Katayama M., Rahman M.M., Uddin M.M., Yabuki A., Kohyama M., Yamato O.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580450
[Journal Article] Production of GM-CSF Mediated by Cysteine Protease of Der f in Canine Keratinocytes2012
- Author(s)
  Kimura, T., Sekido, M., Chimura, N., Shibata, S., Kondo, N., Kamishina, H., Maeda, S
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 74 Issue: 8 Pages: 1033-1036
- DOI
  10.1292/jvms.11-0522
- NAID
  130001879794
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380184
[Patent] タンパク質凝集抑制剤2021
- Inventor(s)
  鎌足雄司、森田洋子、神志那弘明、木村慎太郎、古田享史
- Industrial Property Rights Holder
  鎌足雄司、森田洋子、神志那弘明、木村慎太郎、古田享史
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K06410
[Presentation] Molecular mechanism of protein aggregation of mutant SOD1 in canine ALS-like disease.2020
- Author(s)
  S.Kimura, R.Honda, Y.O.Kamatari, Z.Kato, H.Hara, S.Maeda, H.Kamishina.
- Organizer
  61th Annual Meeting of the Japanese Society of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06410
[Presentation] Structure-Based-Drug-Design of Small Molecule Inhibitors for Canine Superoxide Dismutase 1 Aggregation.2020
- Author(s)
  S.Kimura, Y.O.Kamatari, R.Honda, Z.Kato, S.Maeda, H.Kamishina.
- Organizer
  Sapporo Summer Symposium for One Health
- Data Source
  KAKENHI-PROJECT-20K06410
[Presentation] Molecular insights into protein aggregation of mutant Superoxide dismutase 1 in Degenerative Myelopathy.2020
- Author(s)
  S.Kimura, R.Honda, Y.O.Kamatari, Z.Kato, H.Hara, S.Maeda, H.Kamishina.
- Organizer
  American College of Veterinary Internal Medicine Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06410
[Presentation] 犬の頚部椎間板ヘルニアに対するMRI伸延撮像法の検討2018
- Author(s)
  西田英高、中田浩平、山﨑緑、中野有希子、田中宏、中山正成、秋吉秀保、前田貞俊、神志那弘明
- Organizer
  第 44 回獣医神経病学会
- Data Source
  KAKENHI-PROJECT-17K15378
[Presentation] qRT-PCRを用いた犬の血漿エクソソームmiRNA定量法の確立2017
- Author(s)
  成田桃子、西田英高、朝比奈良太、中田浩平、矢野大仁、前田貞俊、神志那弘明
- Organizer
  第４回日本細胞外小胞学会/第９回日本RNAi研究会
- Data Source
  KAKENHI-PROJECT-17K15378
[Presentation] Clinical, histopathological, and biochemical characterization of the canine model of SOD1-mediated amyotrophic lateral sclerosis2014
- Author(s)
  Kobatake Yui, Oyake Kanae, Tsukui Toshihiro, Sakai Hiroki, Yamato Osamu, Saito Miyoko, Urushitani Makoto, Kato Shinsuke, Sasaki Jun, Shibata Sanae, Maeda Sadatoshi, Kamishina Hiroaki
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] イヌ変性性脊髄症に認められる変異型SOD1蛋白（E40K）に対するモノクローナル抗体の作製と特異性の解析2013
- Author(s)
  小畠結, 漆谷真, 加藤信介, 酒井洋樹, 大和修, 津久井利広, 鈴木理恵子, 前田貞俊, 神志那弘明
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] イヌの変性性脊髄症に認められる変異型SOD1蛋白の生化学的解析2012
- Author(s)
  並木まり子, 漆谷真, 大和修, 津久井利広, 鈴木理恵子, 加藤信介, Janice Robertson, Kate Banks, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] 変性性脊髄症とその類似疾患との鑑別法2012
- Author(s)
  神志那弘明
- Organizer
  日本獣医臨床学フォーラム　第8回京都地区大会(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] イヌの変性性脊髄症における変異型SOD1蛋白凝集体の証明2012
- Author(s)
  中前早百合, 漆谷真, 加藤信介, 酒井洋樹, 大和修, 内田和幸, 小川瑞恵, 津久井利広, 鈴木理恵子, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] イヌの変性性脊髄症におけるミクロクリアの組織学的解析と細胞傷害因子の定量2012
- Author(s)
  山田修平, 酒井洋樹, 千村直輝, 漆谷真, 大和修, 加藤信介, 内田和幸, 小川瑞恵, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] リハビリへつなげる「正しい」診断2011
- Author(s)
  神志那弘明
- Organizer
  第32回動物臨床医学会年次大会
- Place of Presentation
  大阪国際会議場(グランキューブ大阪)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-21780284
[Presentation] イヌの変性性脊髄症に認められる変異型SOD1蛋白の生化学的解析
- Author(s)
  並木まり子,　漆谷真,　大和修,　津久井利広, 鈴木理恵子,　加藤信介,　 Janice Robertson,　Kate Banks, 前田貞俊,　神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学（盛岡市）
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] Investigation of biomarker for disease progression in dogs with degenerative myelopathy
- Author(s)
  G. Togawa, M. Saito, H. Kamishina, R. Watanabe, E. Takeda, O. Yamato
- Organizer
  Asian Society of Veterinary Surgery (AiSvS)
- Place of Presentation
  Osaka,Japan
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] イヌの変性性脊髄症における変異型SOD1蛋白凝集体の証明
- Author(s)
  中前早百合,　漆谷真,　加藤信介,　酒井洋樹,　大和修,　内田和幸,　小川瑞恵, 津久井利広,　鈴木理恵子,　前田貞俊,　神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学（盛岡市）
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] イヌの変性性脊髄症におけるミクログリアの組織学的解析と細胞傷害因子の定量
- Author(s)
  山田修平,　酒井洋樹,　千村直輝,　漆谷真,　大和修,　加藤信介,　内田和幸,　小川瑞恵,　前田貞俊,　神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学（盛岡市）
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] ウェルシュ・コーギーの変性性脊髄症における症状進行度の客観的指標の開発と治療評価法の検討
- Author(s)
  竹田絵美, 齋藤弥代子, 渡邊亮太, 大和修, 神志那弘明
- Organizer
  第20回獣医神経病学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] イヌ変性性脊髄症に認められる変異型SOD1蛋白 (E40K) に対するモノクローナル抗体の作製と特異性の解析
- Author(s)
  小畠結,　漆谷真,　加藤信介,　酒井洋樹,　大和修,　津久井利広,　鈴木理恵子,　前田貞俊,　神志那弘明
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜大学（岐阜市）
- Data Source
  KAKENHI-PROJECT-23580450
[Presentation] 犬の変性性脊髄症における呼吸機能の経時的変化
- Author(s)
  小宅　香苗、小畠　結、柴田　早苗、大和　修、前田　貞俊、神志那　弘明
- Organizer
  H26年度中部地区獣医師大会　獣医学術中部地区学会
- Place of Presentation
  静岡市
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-23580450

1. MAEDA SADATOSHI (50377694)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. KATO Shinsuke (60194817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. Hozimi Isao (20242430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 柴田敏之 (50226172)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 位田雅俊 (70512424)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NISHIFUJI Koji (20365422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIZUNO Takuya (90398826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Saito Miyoko (80367242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. YAMATO Osamu (80261337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. UCHIDA Kazuyuki (10223554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. URUSHITANI Makoto (60332326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. Nishida Hidetaka (00622804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. AKIYOSHI Hideo (50420740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. HATOYA Shingo (40453138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 栗田尚佳 (00746315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山本朗仁 (50244083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小畠結 (00805442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 本田諒 (00820143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. 原英彰 (20381717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 鎌足雄司 (70342772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. 加藤善一郎 (90303502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. Prockop Darwin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAMISHINA Hiroaki 神志那 弘明

Research Projects

Research Products

Co-Researchers

犬の変性性脊髄症を起こす変異SOD1蛋白質の立体構造解析と治療基盤の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic strategies for amyotrophic lateral sclerosis using human deciduous dental pulp stem cells and their active ingredients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of method for central nervous regeneration using stem cell-derived exosomes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on pathomechanism and treatment of canine degenerative myelopathy using disease-specific iPS cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on pathomechanisms of canine degenerative myelopathy and preclinical trial for antibody therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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The mechanism of activation of Langerhans cells mediated by keratinocytes

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Clinical and histopathological characteristics and efficacy of Levocarnitine treatment in canine degenerative myelopathy

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Development of new therapy for spinal cord injury in dogs using locomotor trainingPrincipal Investigator

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犬骨髄間質細胞と合成ペプチドAG73を用いた神経再生医療の検討Principal Investigator

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[Book] 図解 小動物神経病学2011

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[Journal Article] Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases2022

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[Journal Article] Activation of the unfolded protein response in canine degenerative myelopathy.2018

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[Journal Article] Changes in respiratory function in Pembroke Welsh Corgi dogs with degenerative myelopathy2016

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KAMISHINA Hiroaki 神志那弘明

[Book] 図解　小動物神経病学2011

[Presentation] イヌ変性性脊髄症に認められる変異型SOD1蛋白（E40K）に対するモノクローナル抗体の作製と特異性の解析2013