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Okuda Suguru  奥田 傑

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… Alternative Names

OKUDA Suguru  奥田 傑

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Researcher Number 50511846
Other IDs
Affiliation (Current) 2025: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
Affiliation (based on the past Project Information) *help 2024: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
2021 – 2022: 東京大学, 大学院農学生命科学研究科(農学部), 准教授
2016 – 2021: 大阪大学, 医学系研究科, 助教
2017: 大阪大学, 大学院医学系研究科, 助教
2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教
2014: 大阪大学, 医学系研究科, 助教
Review Section/Research Field
Principal Investigator
General pharmacology / Basic Section 38020:Applied microbiology-related / Basic Section 48040:Medical biochemistry-related
Except Principal Investigator
General pharmacology / General medical chemistry / Basic Section 48030:Pharmacology-related / Medium-sized Section 48:Biomedical structure and function and related fields / Kidney internal medicine
Keywords
Principal Investigator
トランスポーター / シグナル伝達 / アミノ酸 / mTOR / タンパク質複合体 / 分子輸送 / セルロース / がん / 蛋白質 / 機能解析 / 情報伝達 / 細胞増殖 / シグナル情報伝達 … More
Except Principal Investigator
… More トランスポーター / アミノ酸 / 受容体 / 抗腫瘍薬 / 細胞代謝制御 / シグナル情報伝達系 / 輸送系 / チャネル / 輸送体 / 細胞内代謝制御 / シグナル情報伝達 / 寿命 / 細胞内シグナル伝達 / シグナル伝達 / mTORC1 / 代謝制御・細胞機能制御 / 輸送体介在シグナル / 腫瘍血管新生 / リン酸化プロテオミクス / アミノ酸トランスポーター / がん / シグナル伝達系 / リピドミクス / リパーゼ / 角質細胞間脂質ラメラ / 表皮バリア / 糖 / 腎近位尿細管 / マルチオミクス / 腎臓 / メタボロミクス / プロテオミクス / 膜輸送複合体 / 腎生理 / 腎生理学 / 腎臓学 Less
  • Research Projects

    (12 results)
  • Research Products

    (152 results)
  • Co-Researchers

    (9 People)
  •  細菌セルロース分泌システムにおけるセルロース輸送の観察法確立および分子機構解析Principal Investigator

    • Principal Investigator
      奥田 傑
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38020:Applied microbiology-related
    • Research Institution
      The University of Tokyo
  •  Identification and mechanistic analysis of intracellular amino acid sensors and their potential as drug targetsPrincipal Investigator

    • Principal Investigator
      Okuda Suguru
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      The University of Tokyo
      Osaka University
  •  Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism

    • Principal Investigator
      Kanai Yoshikatsu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Osaka University
  •  Study on the effects of amino acid availability on life span and the underlying molecular mechanisms

    • Principal Investigator
      Kanai Yoshikatsu
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Osaka University
  •  Identification of factors involved in the amino acid signaling to mTOR in lysosome and clarification of its functional significancePrincipal Investigator

    • Principal Investigator
      Okuda Suguru
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  The function of a novel membrane protein in renal proximal tubules

    • Principal Investigator
      Nagamori Shushi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Nara Medical University
      Osaka University
  •  Investigation of a novel lipase-like transmembrane protein for the discovery of drugs to regulate the epidermal barrier function

    • Principal Investigator
      Kanai Yoshikatsu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  Regulation of cellular metabolism and functions mediated by amino acid transporters and the mechanisms of action of their inhibitors

    • Principal Investigator
      KANAI Yoshikatsu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  Molecular identification of amino acid sensor and its function in mTORC1 signaling pathway

    • Principal Investigator
      Ohgaki Ryuichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  Identification of a Vesicle specific D-serine transporter in the brain.

    • Principal Investigator
      YOSHIKATSU Kanai
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  Analysis of amino acid-dependent signal transduction from transporters to mTOR by cell-free assay systemPrincipal Investigator

    • Principal Investigator
      OKUDA Suguru
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  Identification and characterization of a membrane protein TRAP involved in Fanconi syndrome like symptoms.

    • Principal Investigator
      Kanai Yoshikatsu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells2022

    • Author(s)
      Nishikubo Kou、Ohgaki Ryuichi、Okanishi Hiroki、Okuda Suguru、Xu Minhui、Endou Hitoshi、Kanai Yoshikatsu
    • Journal Title

      Journal of Cellular and Molecular Medicine

      Volume: 26 Issue: 20 Pages: 5246-5256

    • DOI

      10.1111/jcmm.17553

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06856, KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-22KJ2171, KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-23K24071
  • [Journal Article] Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT22022

    • Author(s)
      Kato Takafumi、Kusakizako Tsukasa、Jin Chunhuan、Zhou Xinyu、Ohgaki Ryuichi、Quan LiLi、Xu Minhui、Okuda Suguru、Kobayashi Kan、Yamashita Keitaro、Nishizawa Tomohiro、Kanai Yoshikatsu、Nureki Osamu
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4714-4714

    • DOI

      10.1038/s41467-022-32442-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19404, KAKENHI-PROJECT-22K15072, KAKENHI-PROJECT-21K20742, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037, KAKENHI-PROJECT-23K24071
  • [Journal Article] Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes2020

    • Author(s)
      Jin Chunhuan、Wei Ling、Ohgaki Ryuichi、Tominaga Hideyuki、Xu Minhui、Okuda Suguru、Okanishi Hiroki、Kawamoto Yasuharu、He Xin、Nagamori Shushi、Kanai Yoshikatsu
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 375 Issue: 3 Pages: 451-462

    • DOI

      10.1124/jpet.120.000235

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19H05648
  • [Journal Article] Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor2020

    • Author(s)
      Okanishi Hiroki、Ohgaki Ryuichi、Okuda Suguru、Endou Hitoshi、Kanai Yoshikatsu
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 2 Pages: 871-883

    • DOI

      10.1111/cas.14756

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19K16743
  • [Journal Article] Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation2020

    • Author(s)
      Quan Lili、Ohgaki Ryuichi、Hara Saori、Okuda Suguru、Wei Ling、Okanishi Hiroki、Nagamori Shushi、Endou Hitoshi、Kanai Yoshikatsu
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 39 Issue: 1 Pages: 266-266

    • DOI

      10.1186/s13046-020-01762-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07327, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19H05648
  • [Journal Article] Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter2019

    • Author(s)
      Miyabe Junji、Ohgaki Ryuichi、Saito Keijiro、Wei Ling、Quan Lili、Jin Chunhuan、Liu Xingming、Okuda Suguru、Nagamori Shushi、Ohki Hiroshi、Yoshino Kazuo、Inohara Hidenori、Kanai Yoshikatsu
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 139 Issue: 3 Pages: 215-222

    • DOI

      10.1016/j.jphs.2019.01.012

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19429, KAKENHI-PROJECT-16K19018
  • [Journal Article] Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc2019

    • Author(s)
      Lee Yongchan、Wiriyasermkul Pattama、Jin Chunhuan、Quan Lili、Ohgaki Ryuichi、Okuda Suguru、Kusakizako Tsukasa、Nishizawa Tomohiro、Oda Kazumasa、Ishitani Ryuichiro、Yokoyama Takeshi、Nakane Takanori、Shirouzu Mikako、Endou Hitoshi、Nagamori Shushi、Kanai Yoshikatsu、Nureki Osamu
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 26 Issue: 6 Pages: 510-517

    • DOI

      10.1038/s41594-019-0237-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06931, KAKENHI-PROJECT-19K07373, KAKENHI-PLANNED-16H06574, KAKENHI-PROJECT-17H03640, KAKENHI-PROJECT-19H03407, KAKENHI-PROJECT-18K19429, KAKENHI-PROJECT-16H06294
  • [Journal Article] Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1).2017

    • Author(s)
      Kongpracha P, Nagamori S, Wiriyasermkul P, Tanaka Y, Kaneda K, Okuda S, Ohgaki R, Kanai Y.
    • Journal Title

      J Pharmacol Sci.

      Volume: 133 Issue: 2 Pages: 96-102

    • DOI

      10.1016/j.jphs.2017.01.006

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15K21133, KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-16K19018
  • [Journal Article] Essential roles of L-type amino acid transporter 1 in syncytiotrophoblast development by presenting fusogenic 4F2hc.2017

    • Author(s)
      Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y.
    • Journal Title

      Mol Cell Biol.

      Volume: 印刷中 Issue: 11

    • DOI

      10.1128/mcb.00427-16

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04282, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-16K19018, KAKENHI-PROJECT-16K15214, KAKENHI-PROJECT-15K08273
  • [Journal Article] Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate2017

    • Author(s)
      Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Suguru Okuda, Shushi Nagamori, Madoka Taka and Yoshikatsu Kanai
    • Journal Title

      Sci Res

      Volume: 7 Issue: 1 Pages: 17484-17484

    • DOI

      10.1038/s41598-017-17459-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K20085, KAKENHI-PROJECT-16K19018, KAKENHI-PROJECT-15KK0230, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-17H04190, KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-26702017
  • [Journal Article] Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuda S, Kojima N, Hari Y, Kiyonaka S, Mori Y, Tominaga H, Ohgaki R, Kanai Y.
    • Journal Title

      Amino Acids.

      Volume: 48 Issue: 4 Pages: 279-286

    • DOI

      10.1007/s00726-015-2158-z

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-25460159, KAKENHI-PROJECT-26461895, KAKENHI-PROJECT-26860171, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15K15053
  • [Journal Article] Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography.2016

    • Author(s)
      Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Kato Y, Oriuchi N, Nagamori S, Kanai Y.
    • Journal Title

      J Pharmacol Sci.

      Volume: 130 Issue: 2 Pages: 101-109

    • DOI

      10.1016/j.jphs.2016.01.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-26461895, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-25461801, KAKENHI-PROJECT-26860171, KAKENHI-PROJECT-16H05393
  • [Journal Article] Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M, Kanai Y.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Issue: 3 Pages: 775-780

    • DOI

      10.1073/pnas.1519959113

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15H04684, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-26860171
  • [Journal Article] Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition kinetics, sidedness of action, and transporter-associated incorporation accounting for its pharmacodynamic and pharmacokinetic features.2016

    • Author(s)
      Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Shiotani M, Nagamori S, Kanai Y.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 358 Issue: 1 Pages: 94-102

    • DOI

      10.1124/jpet.116.232025

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-16H06942, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274
  • [Journal Article] Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging.2016

    • Author(s)
      Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Oriuchi N, Nagamori S, Kanai Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 3 Pages: 347-352

    • DOI

      10.1111/cas.12878

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08273, KAKENHI-PROJECT-15K08274, KAKENHI-PROJECT-26461895, KAKENHI-PROJECT-15K15053, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-25461801, KAKENHI-PROJECT-26860171, KAKENHI-PROJECT-16H05393
  • [Presentation] アミノ酸トランスポーターLAT1阻害薬が腫瘍細胞の大型中性アミノ酸輸送とタンパク質合成に与える影響2022

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、徐 旻恵、遠藤 仁、金井 好克
    • Organizer
      第141回日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Inhibition of amino acid transporter LAT1 drastically suppresses the transport of large neutral amino acids and induces the downregulation of global translation in cancer cells2022

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、徐 旻恵、遠藤 仁、金井 好克
    • Organizer
      第96回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] がん細胞におけるLAT1のアミノ酸の取込みへの寄与とLAT1阻害薬によるタンパク質合成抑制効果2022

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、徐 旻恵、遠藤 仁、金井 好克
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析2021

    • Author(s)
      岡西 広樹、大垣 隆一、奥田 傑、遠藤 仁、金井 好克
    • Organizer
      第94回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞増殖抑制機構に関わるプロテオミクスおよびリン酸化プロテオミクス解析2021

    • Author(s)
      岡西 広樹、大垣 隆一、奥田 傑、遠藤 仁、金井 好克
    • Organizer
      第94回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Suppression of proliferation of cholangiocarcinoma cells by miRNAs targeting L-type amino acid transporter 1 downregulated in cholangiocarcinomas2021

    • Author(s)
      劉 星明、大垣 隆一、岡西 広樹、奥田 傑、徐 旻恵、金井 好克
    • Organizer
      第139回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Suppression of proliferation of cholangiocarcinoma cells by miRNAs targeting L type amino acid transporter 1 downregulated in cholangiocarcinomas2021

    • Author(s)
      劉 星明、大垣 隆一、岡西 広樹、奥田 傑、徐 旻ケイ、金井 好克
    • Organizer
      第139回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] 胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討2021

    • Author(s)
      岡西 広樹、大垣 隆一、奥田 傑、遠藤 仁、金井 好克
    • Organizer
      第140回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Amino acid transporter LAT1 is upregulated in tumor-associated vascular endothelial cells and plays essential roles in tumor angiogenesis by promoting proliferation and regulating VEGF-A-dependent pro-angiogenic mTORC1 activation2021

    • Author(s)
      Ryuichi Ohgaki、Lili Quan、Suguru Okuda、Hiroki Okanishi、Shushi Nagamori、Hitoshi Endou、Yoshikatsu Kanai
    • Organizer
      第94回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] がん細胞におけるLAT1のアミノ酸の取込みへの寄与とLAT1阻害薬によるタンパク質合成抑制効果2021

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、徐 旻ケイ、遠藤 仁、金井 好克
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] 胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討2021

    • Author(s)
      岡西 広樹、大垣 隆一、奥田 傑、遠藤 仁、金井 好克
    • Organizer
      第140回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] 腫瘍間質の血管内皮細胞に高発現するアミノ酸トランスポーターLAT1は細胞増殖の促進と血管新生促進因子VEGF-AによるmTORC1活性化の制御を介して腫瘍血管新生に寄与する2021

    • Author(s)
      大垣隆一、全麗麗、奥田傑、岡西広樹、永森收志、遠藤仁、金井好克
    • Organizer
      第94回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Suppression of LAT1 in endothelial cells of tumor tissues exhibits an anti-angiogenesis effect2020

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] Development of tumor-specific compounds avoiding renal uptake for PET imaging and targeted a-therapy2020

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Suguru Okuda, Minhui Xu, Hiroki Okanishi, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第138回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Time-course analysis of the changes in intracellular amino acid concentrations and amino acid-related signaling pathways in cancer cells induced by the inhibition of cancer-type amino acid transporter LAT12020

    • Author(s)
      西窪 航, 大垣 隆一, 岡西 広樹, 奥田 傑, 金井 好克
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] 遊離アミノ酸量の定量的経時変化解析によるアミノ酸トランスポーター阻害効果の検討2020

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、金井 好克
    • Organizer
      第137回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] Development of tumor-specific compounds avoiding renal uptake for PET imaging and targeted α-therapy2020

    • Author(s)
      Chunhuan Jin、Ling Wei、Ryuichi Ohgaki、Suguru Okuda、Minhui Xu、Hiroki Okanishi、Shushi Nagamori、Yoshikatsu Kanai
    • Organizer
      第138回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] Critical moieties of aromatic amino acid probes causing renal accumulation in tumor imaging2020

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Time-course analysis of the changes in intracellular amino acid concentrations and amino acid-related signaling pathways in cancer cells induced by the inhibition of cancer-type amino acid transporter LAT12020

    • Author(s)
      西窪 航, 大垣 隆一, 岡西 広樹, 奥田 傑, 金井 好克
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] 遊離アミノ酸量の定量的経時変化解析によるアミノ酸トランスポーター阻害効果の検討2020

    • Author(s)
      西窪 航,大垣 隆一,岡西 広樹,奥田 傑,金井 好克
    • Organizer
      第137回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-20K07327
  • [Presentation] Suppression of LAT1 in endothelial cells of tumor tissues exhibits an anti-angiogenesis effect2020

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Critical moieties of aromatic amino acid probes causing renal accumulation in tumor imaging2020

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] Suppression of tumor angiogenesis by inhibition of LAT1 in stromal endothelial cells2019

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] メラノーマ同種同所移植マウスモデルにおけるLAT1阻害薬の抗腫瘍効果の検討2019

    • Author(s)
      石 梓童、大垣 隆一、兼田 加珠子、奥田 傑、永森 收志、遠藤 仁、金井 好克
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Identification of substrate recognition by leucine-specific binding protein2019

    • Author(s)
      Yu Ma, Pattama Wiriyasermkul, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Critical moieties of aromatic amino acids for the interaction with organic anion transporter OAT1: Implications for reducing the renal background in tumor imaging.2019

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Expression of amino acid transporter LAT1 in the endothelial cells of tumor tissues and its contribution to angiogenesis2019

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第135回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] PEPT1-targeted boron delivery for boron neutron capture therapy using BPA-containing dipeptide2019

    • Author(s)
      Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Comparative phosphoproteomics between non-competitive and competitive inhibitions of L-type amino acid transporter 1 in cancer cells.2019

    • Author(s)
      Kongpracha Pornparn、Wiriyasermkul Pattama、田中 容子、奥田 傑、大垣 隆一、金井 好克、永森 收志
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Expression of amino acid transporter LAT1 in the endothelial cells of tumor tissues and its contribution to angiogenesis2019

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第135回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] アミノ酸アベイラビリティが細胞内遊離アミノ酸濃度に与える影響2019

    • Author(s)
      西窪 航,大垣 隆一,岡西 広樹,奥田 傑,金井 好克
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] PEPT1-targeted boron delivery for boron neutron capture therapy using BPA-containing dipeptide2019

    • Author(s)
      Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Identification of miRNA regulating the expression of cancer-type amino acid transporter LAT1: its potential as an antionco-miRNA2019

    • Author(s)
      劉 星明, 大垣 隆一, 岡西 広樹, 奥田 傑, 金井 好克
    • Organizer
      第136回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] アミノ酸トランスポーター阻害薬の併用による大腸癌細胞株に対する増殖抑制効果2019

    • Author(s)
      へ ビーフィ、西窪 航、大垣 隆一 、岡西 広樹、奥田 傑、金井 好克
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] ヘテロ二量型アミノ酸トランスポーター複合体LAT1-4F2hcは胎盤の合胞体性栄養膜形成に必須の細胞融合因子である2019

    • Author(s)
      大垣 隆一, 大森 崇弘, 原 早織, 中込 咲綾, 金井 正美, 兼田(中島)加珠子, 奥田 傑, 永森 收志, 金井 好克
    • Organizer
      第66回 日本生化学会近畿支部例会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] ヘテロ二量型アミノ酸トランスポーター複合体LAT1-4F2hcは胎盤の合胞体性栄養膜形成に必須の細胞融合因子である2019

    • Author(s)
      大垣 隆一, 大森 崇弘, 原 早織, 中込 咲綾, 金井 正美, 兼田(中島)加珠子, 奥田 傑, 永森 收志, 金井 好克
    • Organizer
      第66回 日本生化学会近畿支部例会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Identification of miRNA regulating the expression of cancer-type amino acid transporter LAT1: its potential as an antionco-miRNA2019

    • Author(s)
      劉 星明, 大垣 隆一, 岡西 広樹, 奥田 傑, 金井 好克
    • Organizer
      第136回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19H03407
  • [Presentation] アミノ酸アベイラビリティが細胞内遊離アミノ酸濃度に与える影響2019

    • Author(s)
      西窪 航、大垣 隆一、岡西 広樹、奥田 傑、金井 好克
    • Organizer
      第92回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Essential roles of amino acid transporter LAT1 in cell fusion for the development of placental syncytiotrophoblast2019

    • Author(s)
      Ryuichi Ohgaki, Takahiro Ohmori, Saori Hara, Saya Nakagomi, Masami Kanai, Kazuko Kaneda-Nakashima, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      The 1st OIST-OU Joint Symposium - Cell Biology and Immunology-
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] ペプチドトランスポーターを標的としたホウ素中性子捕捉療法に用いる新規ペプチド型ホウ素化合物の検討2018

    • Author(s)
      宮部淳二、大垣隆一、齋藤桂似郎、Wei Ling、奥田傑、永森收志、大木寛、 吉野和夫、猪原秀典、金井好克
    • Organizer
      第133回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Effect of five amino acids stimulation on mTORC1 signaling pathway in HEK293T cells2018

    • Author(s)
      Xuhao Huang, Chunhuan Jin, Ryuichi Ohgaki, Suguru Okuda, Yoshikatsu Kanai
    • Organizer
      Campus Asia Program Faculty meeting, Symopsium and Workshop
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] 腫瘍血管新生に寄与する血管内皮細胞のアミノ酸トランスポーター2018

    • Author(s)
      大垣隆一、Quan Lili、奥田傑、永森收志、金井好克
    • Organizer
      第1回 がんと代謝研究会・若手の会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Combination of amino acids necessary and sufficient for the optimal activation of mTORC12018

    • Author(s)
      Ryuichi Ohgaki, Chunhuan Jin, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] L-type amino acid transporter 1 (LAT1) in endothelial cells of tumor vessels contributes to tumor angiogenesis2018

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      WCP2018 KYOTO 18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Effect of five amino acids stimulation on mTORC1 signaling pathway in HEK293T cells2018

    • Author(s)
      Xuhao Huang, Chunhuan Jin, Ryuichi Ohgaki, Suguru Okuda, Yoshikatsu Kanai
    • Organizer
      Campus Asia Program Faculty meeting, Symopsium and Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, are transported by oligopeptide transporter2018

    • Author(s)
      Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
    • Organizer
      WCP2018 KYOTO 18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Phosphoproteome analysis reveals novel cellular responses affect by inhibition of LAT1, a cancer type amino acid transporter.2018

    • Author(s)
      Pornparn Kongpracha, Shushi Nagamori, Pattama Wiriyasermkul, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai
    • Organizer
      18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Construction of Flp-in 3T3 cell line stably express mLAT1 fused with AcGFP2018

    • Author(s)
      Hanbing Liu, Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Yoshikatsu Kanai
    • Organizer
      Campus Asia Program Faculty meeting, Symopsium and Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Combination of amino acids necessary and sufficient for the optimal activation of mTORC12018

    • Author(s)
      Ryuichi Ohgaki, Chunhuan Jin, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      WCP2018 KYOTO 18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, targeting the oligopeptide transporters2018

    • Author(s)
      Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
    • Organizer
      大阪大学医学系研究フォーラム 第10回若手研究フォーラム
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] 腫瘍血管新生に寄与する血管内皮細胞のアミノ酸トランスポーター2018

    • Author(s)
      大垣隆一、Quan Lili、奥田傑、永森收志、金井好克
    • Organizer
      第1回 がんと代謝研究会・若手の会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, are transported by oligopeptide transporter2018

    • Author(s)
      Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
    • Organizer
      18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] L-type amino acid transporter 1 (LAT1) in endothelial cells of tumor vessels contributes to tumor angiogenesis2018

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      WCP2018 KYOTO 18th World congress of basic and clinical pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] ペプチドトランスポーターを標的としたホウ素中性子捕捉療法に用いる新規ペプチド型ホウ素化合物の検討2018

    • Author(s)
      宮部淳二、大垣隆一、齋藤桂似郎、Wei Ling、奥田傑、永森收志、大木寛、吉野和夫、猪原秀典、金井好克
    • Organizer
      第133回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-18K19429
  • [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT12017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第131回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] LAT1 in endothelial cells as a novel target of anti-angiogenic cancer therapy2017

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] SGLT2阻害薬カナグリフロジンによる腎刷子縁膜タンパク質の発現変動の網羅的定量プロテオミクスを用いた解析2017

    • Author(s)
      永森收志、齊藤隆太、五十棲規嘉、栗山千亜紀、塩谷正治、大垣隆一、奥田傑、 金井好克
    • Organizer
      第60回 日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1は膜融合関連因子4F2hcの細胞膜提示による胎盤合胞体性栄養膜の形成に必須である2017

    • Author(s)
      大垣隆一、大森崇弘、原早織、中込咲綾、金井正美、兼田(中島)加珠子、奥田傑、永森收志、金井好克
    • Organizer
      第12回 トランスポーター研究会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors2017

    • Author(s)
      Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] SGLT2阻害薬カナグリフロジンによる腎刷子縁膜タンパク質の発現変動の網羅的定量プロテオミクスを用いた解析2017

    • Author(s)
      永森收志、齊藤隆太、五十棲規嘉、栗山千亜紀、塩谷正治、大垣隆一、奥田傑、 金井好克
    • Organizer
      第60回 日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT12017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      日本プロテオーム学会2017年大会 JHUPO 第15回大会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] SGLT2阻害薬カナグリフロジンのヒトSGLT1およびSGLT2に対する作用キネティクスと阻害メカニズムの検討2017

    • Author(s)
      大垣隆一、Ling Wei、山田和徳、原大樹、栗山千亜紀、奥田傑、植田喜一郎、Laurent Leclercq、Rao N.V.S. Mamidi、塩谷正治、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] SGLT2阻害薬カナグリフロジンのヒトSGLT1およびSGLT2に対する作用キネティクスと阻害メカニズムの検討2017

    • Author(s)
      大垣隆一、Ling Wei、山田和徳、原大樹、栗山千亜紀、奥田傑、植田喜一郎、Laurent Leclercq、Rao N.V.S. Mamidi、塩谷正治、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity.2017

    • Author(s)
      Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Gordon Research Conference: Mechanisms of Membrane Transport
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] 有機アニオントランスポーターOAT1に対する芳香族アミノ酸誘導体の構造活性相関:イメージングプローブの腎臓におけるバックグラウンド集積を誘起する分子内構造の同定2017

    • Author(s)
      魏玲、大垣隆一、富永英之、兼田加珠子、奥田傑、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT1, a cancer type amino acid transporter2017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      日本プロテオーム学会2017年大会 JHUPO 第15回大会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1によるロイシン誘導体の認識とmTORC1シグナル活性化の関係2017

    • Author(s)
      Suguru Okuda, Pattama Wiriyasermkul, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第90回 日本薬理学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT12017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第131回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT1, a cancer type amino acid transporter2017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      日本プロテオーム学会2017年大会 JHUPO 第15回大会
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity.2017

    • Author(s)
      Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Gordon Research Conference: Mechanisms of Membrane Transport
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] Structure-activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes2017

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      大阪大学医学系研究フォーラム 第9回若手研究フォーラム
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] LAT1 in endothelial cells as a novel target of anti-angiogenic cancer therapy2017

    • Author(s)
      Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Structure-activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes2017

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      大阪大学医学系研究フォーラム 第10回若手研究フォーラム
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] アミノ酸トランスポーターLAT1は膜融合関連因子4F2hcの細胞膜提示による胎盤合胞体性栄養膜の形成に必須である2017

    • Author(s)
      大垣隆一、大森崇弘、原早織、中込咲綾、金井正美、兼田(中島)加珠子、奥田傑、永森收志、金井好克
    • Organizer
      第12回 トランスポーター研究会
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] アミノ酸トランスポーターLAT1によるロイシン誘導体の認識とmTORC1シグナル活性化の関係2017

    • Author(s)
      奥田傑、Pattama Wiriyasermkul、大垣隆一、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors2017

    • Author(s)
      Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1によるロイシン誘導体の認識とmTORC1シグナル活性化の関係2017

    • Author(s)
      奥田傑、Pattama Wiriyasermkul、大垣隆一、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors2017

    • Author(s)
      Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors2017

    • Author(s)
      Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] 有機アニオントランスポーターOAT1に対する芳香族アミノ酸誘導体の構造活性相関:イメージングプローブの腎臓におけるバックグラウンド集積を誘起する分子内構造の同定2017

    • Author(s)
      魏玲、大垣隆一、富永英之、兼田加珠子、奥田傑、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity.2017

    • Author(s)
      Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Gordon Research Conference: Mechanisms of Membrane Transport
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity2017

    • Author(s)
      Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y
    • Organizer
      Gordon Research Conference: Mechanisms of Membrane Transport
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] 有機アニオントランスポーターOAT1に対する芳香族アミノ酸誘導体の構造活性相関:イメージングプローブの腎臓におけるバックグラウンド集積を誘起する分子内構造の同定2017

    • Author(s)
      魏玲、大垣隆一、富永英之、兼田加珠子、奥田傑、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT12017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第131回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1によるロイシン誘導体の認識とmTORC1シグナル活性化の関係2017

    • Author(s)
      奥田傑、Pattama Wiriyasermkul、大垣隆一、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Critical moieties of aromatic amino acid for renal accumulation of tumor imaging probes2017

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Critical moieties of aromatic amino acid for renal accumulation of tumor imaging probes2017

    • Author(s)
      Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第132回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT12017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第131回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT1, a cancer type amino acid transporter”.2017

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul,, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      日本プロテオーム学会2017年大会 JHUPO 第15回大会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] SGLT2阻害薬カナグリフロジンのヒトSGLT1およびSGLT2に対する作用キネティクスと阻害メカニズムの検討2017

    • Author(s)
      大垣隆一、Ling Wei、山田和徳、原大樹、栗山千亜紀、奥田傑、植田喜一郎、Laurent Leclercq、Rao N.V.S. Mamidi、塩谷正治、永森收志、金井好克
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] アミノ酸トランスポーターLAT1は膜融合関連因子4F2hcの細胞膜提示による胎盤合胞体性栄養膜の形成に必須である2017

    • Author(s)
      大垣隆一、大森崇弘、原早織 、中込咲綾 、金井正美 、兼田(中島)加珠子、奥田傑、○永森收志、金井好克
    • Organizer
      第12回 トランスポーター研究会年会
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      The Kaback Symposium
    • Place of Presentation
      Bethesda, Maryland, US
    • Year and Date
      2016-06-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel cystine transporter in renal proximal tubule identified as a “missing partner” of cystinuria-related membrane protein rBAT/SLC3A12016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Espino Guarch M, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Palacin M, Kanai Y.
    • Organizer
      第25回日本尿路結石症学会
    • Place of Presentation
      千葉
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      3.Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego, CA, US
    • Year and Date
      2016-04-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] アミノ酸トランスポーターLAT1による基質認識とmTORC1シグナル活性化に必要なロイシンの構造部位の決定2016

    • Author(s)
      奥田 傑, Pattama Wiriyasermkul, 大垣 隆一, 永森 收志, 金井 好克
    • Organizer
      第130回 日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] アミノ酸トランスポーターLAT1による基質認識とmTORC1シグナル活性化に必要なロイシンの構造部位の決定2016

    • Author(s)
      奥田 傑, Pattama Wiriyasermkul, 大垣 隆一, 永森 收志, 金井 好克
    • Organizer
      第130回 日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel cystine transporter in renal proximal tubule identified as a “missing partner” of cystinuria-related membrane protein rBAT/SLC3A12016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Espino Guarch M, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Palacin M, Kanai Y.
    • Organizer
      第26 回日本尿路結石症学会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ling Wei, Ryuichi Ohgaki, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu shiotani, Shushi Nagamori and Yoshikatsu Kanai
    • Organizer
      International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research”
    • Place of Presentation
      東京
    • Year and Date
      2016-07-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ling Wei, Ryuichi Ohgaki, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu shiotani, Shushi Nagamori and Yoshikatsu Kanai
    • Organizer
      International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research”
    • Place of Presentation
      東京
    • Year and Date
      2016-07-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-04-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      米国・サンディエゴ
    • Year and Date
      2016-04-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] Novel cystine transporter in renal proximal tubule identified as a “missing partner” of cystinuria-related membrane protein rBAT/SLC3A12016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Espino Guarch M, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Palacin M, Kanai Y.
    • Organizer
      第25回 日本尿路結石症学会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Leclercq L, Mamidi RN, Shiotani M, Nagamori S, Kanai Y
    • Organizer
      76th American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, US
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ling Wei, Ryuichi Ohgaki, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu shiotani, Shushi Nagamori and Yoshikatsu Kanai
    • Organizer
      International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research”
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Interaction of halogenated aromatic amino acid probes for tumor imaging with renal organic anion transporter OAT1: the mechanisms of renal accumulation of the imaging probes2016

    • Author(s)
      Ling Wei、大垣 隆一、富永 英之、Quan Lili、兼田(中島)加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第129回 日本薬理学会近畿部会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] LAT1による認識とmTORC1シグナル活性化に必要なロイシンの構造部位の同定2016

    • Author(s)
      奥田 傑、Pattama Wiriyasermkul、大垣 隆一、永森 收志、金井 好克
    • Organizer
      第130回 日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-16K19018
  • [Presentation] Interaction of halogenated aromatic amino acid probes for tumor imaging with renal organic anion transporter OAT1: the mechanisms of renal accumulation of the imaging probes2016

    • Author(s)
      Ling Wei、大垣 隆一、富永 英之、Quan Lili、兼田(中島)加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第129回 日本薬理学会近畿部会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      The Kaback Symposium
    • Place of Presentation
      Bethesda, Maryland, US
    • Year and Date
      2016-06-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Interaction of halogenated aromatic amino acid probes for tumor imaging with renal organic anion transporter OAT1: the mechanisms of renal accumulation of the imaging probes2016

    • Author(s)
      Ling Wei、大垣 隆一、富永 英之、Quan Lili、兼田(中島)加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第129回 日本薬理学会近畿部会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Leclercq L, Mamidi RN, Shiotani M, Nagamori S, Kanai Y
    • Organizer
      76th American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, US
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1は胎盤合胞体性栄養膜の形成に必須である:膜融合関連因子4F2hcの細胞膜提示による細胞融合への寄与2016

    • Author(s)
      大垣 隆一、大森 崇弘、原 早織、中込 咲綾、金井 正美、兼田 加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2016-04-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      The Kaback Symposium
    • Place of Presentation
      米国・メリーランド州ベセスダ
    • Year and Date
      2016-06-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08274
  • [Presentation] アミノ酸トランスポーターLAT1は胎盤合胞体性栄養膜の形成に必須である:膜融合関連因子4F2hcの細胞膜提示による細胞融合への寄与2016

    • Author(s)
      大垣 隆一、大森 崇弘、原 早織、中込 咲綾、金井 正美、兼田 加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features2016

    • Author(s)
      Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Leclercq L, Mamidi RN, Shiotani M, Nagamori S, Kanai Y
    • Organizer
      76th American Diabetes Association Scientific Sessions
    • Place of Presentation
      New Orleans, Louisiana, US
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] アミノ酸トランスポーターLAT1は胎盤合胞体性栄養膜の形成に必須である:膜融合関連因子4F2hcの細胞膜提示による細胞融合への寄与2016

    • Author(s)
      大垣 隆一、大森 崇弘、原 早織、中込 咲綾、金井 正美、兼田 加珠子、奥田 傑、永森 收志、金井 好克
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1.2016

    • Author(s)
      Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
    • Organizer
      Experimental Biology 2016
    • Place of Presentation
      San Diego, CA, US
    • Year and Date
      2016-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] アミノ酸トランスポーターLAT1による基質認識とmTORC1シグナル活性化に必要なロイシンの構造部位の決定2016

    • Author(s)
      奥田 傑, Pattama Wiriyasermkul, 大垣 隆一, 永森 收志, 金井 好克
    • Organizer
      第130回 日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] 3-fluoro-L-alpha-methyltyrosine (FAMT) PETにおける18F-FAMTの腎臓集積の分子機序の解明2015

    • Author(s)
      Ling Wei, Hideyuki Tominaka, Pattama Wiriyasermkul, Ryuichi Ohgaki, Kohei Hagiwara, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第88回 日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18
    • Data Source
      KAKENHI-PROJECT-24390217
  • [Presentation] 1.Suppression of cancer-type amino acid transporter LAT1 affects multiple cellular events in pancreatic cancer cells2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      The 88th Annual Meeting of Japanese Pharmacological society
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-24390217
  • [Presentation] Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters: a possible cause of renal background in 18F-FAMT PET2015

    • Author(s)
      Wei Ling、富永 英之、Wiriyasermkul Pattama、大垣 隆一、萩原 浩平、奥田 傑、永森 收志、金井 好克
    • Organizer
      第127回 日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Inhibition of the LAT1-mediated leucine transport affects multiple cellular processes in pancreatic cancer cells2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第62回 日本生化学会近畿支部例会
    • Place of Presentation
      草津
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-26860171
  • [Presentation] Inhibition of the LAT1-mediated leucine transport affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第62回日本生化学会近畿支部例会
    • Place of Presentation
      滋賀
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Inhibition of the LAT1-mediated leucine transport affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第62回日本生化学会近畿支部例会
    • Place of Presentation
      滋賀
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Leucine transported by a cancer-type amino acid transporter LAT1 affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第38回 日本分子生物学会年会・第88回 日本生化学会大会 合同大会 (BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] Leucine transported by a cancer-type amino acid transporter LAT1 affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第38回分子生物学会年会・第88回生化学会大会合同大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Inhibition of the LAT1-mediated leucine transport affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第62回 日本生化学会近畿支部例会
    • Place of Presentation
      滋賀
    • Year and Date
      2015-05-16
    • Data Source
      KAKENHI-PROJECT-15K08273
  • [Presentation] ロイシンによるmTOR活性化機構解明のためのロイシン誘導体とロイシン結合タンパク質との相互作用解析2015

    • Author(s)
      奥田 傑
    • Organizer
      第88回 日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-26860171
  • [Presentation] Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters: a possible cause of renal background in 18F-FAMT PET2015

    • Author(s)
      Wei Ling、富永英之、Wiriyasermkul Pattama、大垣隆一、萩原浩平、奥田傑、永森收志、金井好克
    • Organizer
      第127回 日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-26860171
  • [Presentation] Leucine transported by a cancer-type amino acid transporter LAT1 affects multiple cellular processes in pancreatic cancer cells.2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      第38回分子生物学会年会・第88回生化学会大会合同大会(BMB2015)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters: a possible cause of renal background in 18F-FAMT PET2015

    • Author(s)
      Wei Ling、富永 英之、Wiriyasermkul Pattama、大垣 隆一、萩原浩平、奥田 傑、永森 收志、金井 好克
    • Organizer
      第127回日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-15K15053
  • [Presentation] Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters: a possible cause of renal background in 18F-FAMT PET2015

    • Author(s)
      Wei Ling、富永 英之、Wiriyasermkul Pattama、大垣 隆一、萩原浩平、奥田傑、永森 收志、金井 好克
    • Organizer
      第127回日本薬理学会近畿部会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-06-26
    • Data Source
      KAKENHI-PROJECT-15H04685
  • [Presentation] Leucine transported by a cancer-type amino acid transporter LAT1 affects multiple cellular processes in pancreatic cancer cells2015

    • Author(s)
      Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      BMB2015 (第38回 日本分子生物学会年会、第88回 日本生化学会大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26860171
  • [Presentation] ロイシン結合タンパク質との相互作用とmTOR活性化に必要なロイシンの構造部位の同定とその相関2014

    • Author(s)
      奥田 傑
    • Organizer
      第87回 日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Data Source
      KAKENHI-PROJECT-26860171
  • [Presentation] Study of a cellular signaling network stimulated with leucine transported by a cancer-type amino acid transporter LAT1.2014

    • Author(s)
      Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      The 61th Japanese Biochemical Society Kinki Branch
    • Place of Presentation
      京都
    • Year and Date
      2014-05-17
    • Data Source
      KAKENHI-PROJECT-24390217
  • [Presentation] Inhibition of cancer-type amino acid transporter LAT1 affects multiple cellular events in pancreatic cancer cells2014

    • Author(s)
      Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
    • Organizer
      The 87th Meeting of Japanese Pharmacological Society Kinki Branch
    • Place of Presentation
      和歌山
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-24390217
  • [Presentation] トランスポーターの網羅的比較定量プロテオミクス技術の確立とショ糖摂取による小腸上皮トランスポーター発現変動解析への適用

    • Author(s)
      西山 俊、○奥田 傑、高藤 和輝、ウォンタイ プリンティップ、五十棲 規嘉、永森 收志、金井 好克
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24390217
  • 1.  OHGAKI Ryuichi (20467525)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 112 results
  • 2.  Kanai Yoshikatsu (60204533)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 78 results
  • 3.  NAGAMORI Shushi (90467572)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 81 results
  • 4.  中込 咲綾 (60423894)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 5.  岡西 広樹 (70792589)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 24 results
  • 6.  ISHIKAWA Junko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TERAMURA Yuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  金井 正美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  徐 旻恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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