TAKEI NORIO 武井則雄

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Takei Norio 武井則雄

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Researcher Number	50523461
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 北海道大学, 医学研究院, 助教 2016 – 2017: 北海道大学, 産学・地域協働推進機構, 特任助教 2014 – 2015: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 49030:Experimental pathology-related / Experimental pathology / Pediatrics Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 癌 / GPCR / 嗅受容体 / cancer / 糖代謝 / CRISPR/Cas9 / OR7C1 / KOマウス / 嗅覚受容体 / KIマウス … More / ゲノム編集 / 精巣 / warburg effect / olfactory receptor / GCPR / Warburg effect / CRISPR./Cas9 / ワールブルグ効果 / 癌幹細胞 / 嗅神経細胞 / 移植片対宿主病 / ケモカイン / ZFN / CCL8 / ＧＶＨＤ … More Except Principal Investigator 炎症性腸疾患 / 治療標的分子 / ゲノム編集 / 悪性化 / ノックアウトマウス / 分子病態 / PBK / 多発性骨髄腫 / HBx蛋白 / HBc抗原 / HBs抗原 / B型肝炎ウイルス / 宿主制限因子 / HBx / 宿主因子 / HBV / 創薬 / セルベースアッセイ / ゲノム異常 / 薬剤スクリーニング / 細胞生物学 / 羊膜MSC由来エクソソーム / エクソソーム / HSPB6 / 羊膜MSC / 受容体修飾因子 / 腸オルガノイド / CRISPR/Cas9 / 複数同時ゲノム編集 / 多遺伝子同時改変 / 大腸オルガノイド / 受容体活性調節タンパク質 / RAMP / アドレノメデュリン / マウス / 治療 / トランスレーショナルリサーチ / 治療薬 / 造腫瘍性 / キナーゼ / 分子標的薬 Less

癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用Principal Investigator
- Principal Investigator
  
  武井則雄
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hokkaido University
Examination of the therapeutic effect on inflammatory bowel disease using HSPB6-positive exosomes derived from amnion-derived MSCs
- Principal Investigator
  
  Katsurada Takehiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Establishment of the platform for a drug discovery of multiple myeloma by targeting PBK-related signaling pathway
- Principal Investigator
  
  Ota Akinobu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kinjo Gakuin University
  Aichi Medical University
Development of novel antiviral therapy targeting hepatitis B virus host restriction factor
- Principal Investigator
  
  Morikawa Kenichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Analyses of functional differentiation and interaction of RAMP1,2 and 3 applying the maternal Cas9-based multiple genome editing
- Principal Investigator
  
  SAKURAI TAKAYUKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Shinshu University
Elucidation of the mechanism of action of the olfactory receptor involved in cancer-specific metabolismPrincipal Investigator
- Principal Investigator
  
  Takei Norio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hokkaido University
Investigation of molecular mechanism by which PBK contributes to tumorigenesis in myeloma cells
- Principal Investigator
  
  Ota Akinobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Aichi Medical University
Uncovering the molecular mechanisms of OR7C1 in cancer biology.Principal Investigator
- Principal Investigator
  
  Takei Norio
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
CCL8 KOマウスにおけるGVHD消失の分子機構解明に向けた基礎的研究Principal Investigator
- Principal Investigator
  
  武井則雄
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Sapporo Medical University

All 2023 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020
- Author(s)
  Ota Akinobu、Hanamura Ichiro、Karnan Sivasundaram、Inaguma Shingo、Takei Norio、Lam Vu Quang、Mizuno Shohei、Kanasugi Jo、Wahiduzzaman Md、Rahman Md Lutfur、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Ikeda Hiroshi、Takami Akiyoshi、Hosokawa Yoshitaka
- Journal Title
  
  Journal of Interferon & Cytokine Research
  
  Volume: 40 Issue: 8 Pages: 389-405
- DOI
  10.1089/jir.2020.0111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07060, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-20K06613, KAKENHI-PROJECT-17K07263
[Journal Article] ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines2019
- Author(s)
  Takei Norio、Yoneda Akihiro、Kosaka Marina、Sakai-Sawada Kaori、Tamura Yasuaki
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 510-510
- DOI
  10.1186/s12885-019-5727-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07060
[Journal Article] Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase2019
- Author(s)
  Sakurai Takayuki、Kamiyoshi Akiko、Takei Norio、Watanabe Satoshi、Sato Masahiro、Shindo Takayuki
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9923-9923
- DOI
  10.1038/s41598-019-46357-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07060, KAKENHI-PROJECT-19K06372, KAKENHI-PROJECT-19K07477, KAKENHI-PROJECT-18H02602
[Journal Article] Endoplasmic reticulum oxidase 1α is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells2017
- Author(s)
  Fujii M, Yoneda A, Takei N, Sakai-Sawada K, Kosaka M, Minomi K, Yokoyama A, Tamura Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 38 Pages: 15649-15660
- DOI
  10.1074/jbc.m117.783126
- NAID
  120006522663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18435, KAKENHI-PROJECT-16K20874
[Journal Article] Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells.2017
- Author(s)
  Takei N, Yoneda A, Sakai-Sawada K, Kosaka M, Minomi K, Tamura Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 9389-9389
- DOI
  10.1038/s41598-017-09976-7
- NAID
  120006352230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20874
[Journal Article] Spatiotemporal Regulation of Hsp90-Ligand Complex Leads to Immune Activation.2016
- Author(s)
  Tamura Y, Yoneda A, Takei N, Sawada K.
- Journal Title
  
  Front Immunol.
  
  Volume: 7
- DOI
  10.3389/fimmu.2016.00201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20874
[Journal Article] Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage2015
- Author(s)
  Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 2 Pages: 987-995
- DOI
  10.1074/jbc.m114.599852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26870464, KAKENHI-PROJECT-15K18854, KAKENHI-PROJECT-25460059
[Journal Article] Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.2014
- Author(s)
  Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 34(1) Issue: 1 Pages: 110-119
- DOI
  10.1161/atvbaha.113.302107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790198, KAKENHI-PROJECT-24790308, KAKENHI-PROJECT-26870464, KAKENHI-PROJECT-24500445, KAKENHI-PUBLICLY-25116521
[Presentation] Generation and analysis of Olfactory receptor Knock-out and Knock-in mice.2023
- Author(s)
  武井則雄, 太田明伸, 桜井敬之
- Organizer
  第8回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-23K07801
[Presentation] Deletion of Pbk Locus by using CRISPR/Cas9-based gene editing without apparent phenotype in C57BL/6 Mice2020
- Author(s)
  武井則雄, 太田明伸, シバスンダランカルナン, 稲熊真悟, 細川好孝
- Organizer
  日本動物学会第91回大会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] HSP47はトリプルネガティブ乳癌の転移能を増強する2018
- Author(s)
  米田明弘, 武井則雄, 澤田香織, 小坂まりな, 田村保明
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] HSP47によるトリプルネガティブ乳癌の転移能獲得機序の解明2018
- Author(s)
  米田明弘, 武井則雄, 澤田香織, 小坂まりな, 田村保明
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] トリプルネガティブ乳癌の転移能におけるHSP47の作用機序の解明2018
- Author(s)
  米田明弘, 武井則雄, 澤田香織, 小坂まりな, 田村保明
- Organizer
  第13回　臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] 癌におけるERO1αの新規内在性低酸素マーカーとしての有効性の検証2018
- Author(s)
  武井則雄, 米田明弘, 澤田香織, 小坂まりな, 田村保明
- Organizer
  第13回　臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] ERO1αは癌における新規内在性低酸素マーカーと成り得る2018
- Author(s)
  武井則雄, 米田明弘, 澤田香織, 小坂まりな, 田村保明
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07060
[Presentation] 低酸素誘導性ERO1αは大腸がん細胞株においてがん増殖に寄与する2017
- Author(s)
  武井則雄、米田明弘、澤田香織、田村保明
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] HSP47はERストレスセンサーIRE1αの活性抑制を介して癌細胞増殖を調節する2017
- Author(s)
  米田明弘、武井則雄、澤田香織、小坂まりな、味呑憲二郎、田村保明
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] Heat shock protein 47 maintain cancer cell survival through its inhibitory effect on ER stress sensor IRE1α activity2017
- Author(s)
  Akihiro Yoneda, Norio Takei, Kori Sakai-Sawada, Marina Kosaka, Kenjiro Minomi, Yasuaki Tamura.
- Organizer
  American Association for Cancer Research
- Place of Presentation
  WASHINGTON, DC, USA
- Year and Date
  2017-04-01
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] 癌細胞における HSP47 の IRE1α活性調節機構2017
- Author(s)
  米田明弘、武井則雄、澤田香織、小坂まりな、味呑憲二郎、田村保明
- Organizer
  第12回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] ERO1α は低酸素環境下において integrin-β1 の立体構造形成に関与し癌細胞増殖に寄与する2017
- Author(s)
  武井則雄、米田明弘、澤田香織、小坂まりな、味呑憲二郎、田村保明
- Organizer
  第12回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] 癌細胞におけるHSP47のERストレスセンサーIRE1αの活性調節機構2017
- Author(s)
  米田明弘、武井則雄、澤田香織、小坂まりな、味呑憲二郎、田村保明
- Organizer
  2017年度生命科学会合同年次大会（ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] 肝星細胞における小胞体酸化還元酵素ERO1αの機能解析2016
- Author(s)
  米田明弘、藤井瑞希、武井則雄、澤田香織、横山敦郎、田村保明
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K20874
[Presentation] CCL8 Deficiency in Host Abolishes Early Mortality in Murine Graft-Versus-Host Disease Model
- Author(s)
  Igarashi K, Takei N, Hori T, Yamamoto M, Kokai Y.
- Organizer
  56th ASH Annual Meeting and Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26870464

1. Ota Akinobu (30438048)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. SAKURAI TAKAYUKI (80317825)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 花村一朗 (70440740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Katsurada Takehiko (90507592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Morikawa Kenichi (60384377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 新藤隆行 (90345215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山本幸司 (70608322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大西俊介 (10443475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. シバスンダランカルナン (30557096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 坂本直哉 (10334418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 須田剛生 (20447460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YONEDA Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TARU Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 芝大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKEI NORIO 武井 則雄

Takei Norio 武井 則雄

Research Projects

Research Products

Co-Researchers

癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examination of the therapeutic effect on inflammatory bowel disease using HSPB6-positive exosomes derived from amnion-derived MSCs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of the platform for a drug discovery of multiple myeloma by targeting PBK-related signaling pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel antiviral therapy targeting hepatitis B virus host restriction factor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of functional differentiation and interaction of RAMP1,2 and 3 applying the maternal Cas9-based multiple genome editing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of action of the olfactory receptor involved in cancer-specific metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of molecular mechanism by which PBK contributes to tumorigenesis in myeloma cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Uncovering the molecular mechanisms of OR7C1 in cancer biology.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CCL8 KOマウスにおけるGVHD消失の分子機構解明に向けた基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum oxidase 1α is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells2017

Author(s)

Journal Title

DOI

NAID

Data Source

TAKEI NORIO 武井則雄

Takei Norio 武井則雄

[Presentation] ERO1α は低酸素環境下において integrin-β1 の立体構造形成に関与し癌細胞増殖に寄与する2017