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Yokoyama Takeshi  横山 武司

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YOKOYAMA Takeshi  横山 武司

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Researcher Number 50524162
Other IDs
Affiliation (Current) 2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help 2019 – 2024: 富山大学, 学術研究部薬学・和漢系, 助教
2016 – 2018: 富山大学, 大学院医学薬学研究部(薬学), 助教
2014 – 2015: 富山大学, 医学薬学研究部(薬学), 助教
2013: 富山大学, 大学院医学薬学研究部(薬学), 助教
2011: 富山大学, 医学薬学研究部(薬学), 助教 … More
2011: 富山大学, 大学院・医学薬学研究部(薬学), 助教
2010: 茨城大学, フロンティア応用原子科学研究センター, 産学官連携研究員
2009: Ibaraki University, フロンティア応用原子科学研究センター, 産学管連携研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy / Biophysics
Except Principal Investigator
Basic Section 43020:Structural biochemistry-related
Keywords
Principal Investigator
中性子結晶構造解析 / アミロイドーシス / 構造生物学 / X線結晶構造解析 / 医薬品化学 / 標的選択性 / ダサチニブ / 創薬 / 等温滴定カロリメトリ / brd4 … More / 阻害剤 / ブロモドメイン / 水分子クラスター / 水素結合 / エンタルピー / イソリキリチゲニン / 等温滴定カロリメトリー / BRD4 / 蛋白質 / アントラキノン / PPI創薬 / ジアセレイン / ATTR-FAP / トランスサイレチン / BIODIFF / 大型結晶化 / リセドロネート / 生物物理学 / 蛋白質科学 / イソペンテニル二リン酸 / ファルネシル二リン酸合成酵素 / ビスホスホネート / リン酸基 / pH / プロトン化状態 / 構造活性相関 … More
Except Principal Investigator
プロトン移動 / Sirtuin5 / SIRT5 / 中性子構造解析 Less
  • Research Projects

    (6 results)
  • Research Products

    (73 results)
  • Co-Researchers

    (9 People)
  •  中性子解析に基づく分子標的薬の選択性向上と治療薬開発Principal Investigator

    • Principal Investigator
      横山 武司
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      University of Toyama
  •  中性子回折を用いたSIRT5の脱スクシニル反応におけるプロトン移動経路解明

    • Principal Investigator
      日下 勝弘
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Comprehensive Research Organization for Science and Society
      Ibaraki University
  •  Development of a selective BRD4 inhibitor by neutron protein crystallographic analysisPrincipal Investigator

    • Principal Investigator
      Yokoyama Takeshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      University of Toyama
  •  Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomersPrincipal Investigator

    • Principal Investigator
      Takeshi Yokoyama
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Toyama
  •  Neutron Diffraction Analysis of Human Farnesyl Pyrophosphate Synthase in Complex with BisphosphonatePrincipal Investigator

    • Principal Investigator
      Yokoyama Takeshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Toyama
  •  Neutron crystallographic analysis of human transthyretinPrincipal Investigator

    • Principal Investigator
      YOKOYAMA Takeshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biophysics
    • Research Institution
      University of Toyama
      Ibaraki University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins2021

    • Author(s)
      Segawa Ryosuke、Takeda Hiroyuki、Yokoyama Takeshi、Ishida Momoha、Miyata Chihiro、Saito Taiji、Ishihara Ryosuke、Nakagita Tomoya、Sasano Yusuke、Kanoh Naoki、Iwabuchi Yoshiharu、Mizuguchi Mineyuki、Hiratsuka Masahiro、Hirasawa Noriyasu
    • Journal Title

      Biochemical Pharmacology

      Volume: 194 Pages: 114819-114819

    • DOI

      10.1016/j.bcp.2021.114819

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012, KAKENHI-PROJECT-21H00854, KAKENHI-PROJECT-17K09887, KAKENHI-PROJECT-20K05709, KAKENHI-PROJECT-20K08867
  • [Journal Article] Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol2021

    • Author(s)
      Yokoyama Takeshi、Suzuki Ryoya、Mizuguchi Mineyuki
    • Journal Title

      IUCrJ

      Volume: 8 Issue: 1 Pages: 131-138

    • DOI

      10.1107/s2052252520015614

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis2021

    • Author(s)
      Kitakami Ryota、Inui Kishin、Nakagawa Yusuke、Sawai Yurika、Katayama Wakana、Yokoyama Takeshi、Okada Takuya、Kanamitsu Kayoko、Nakagawa Shinsaku、Toyooka Naoki、Mizuguchi Mineyuki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 44 Pages: 116292-116292

    • DOI

      10.1016/j.bmc.2021.116292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors2021

    • Author(s)
      Yokoyama Takeshi、Kashihara Mirai、Mizuguchi Mineyuki
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 19 Pages: 14344-14357

    • DOI

      10.1021/acs.jmedchem.1c00823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Neutron diffraction experiment with the Y116S variant of transthyretin using iBIX at J-PARC: application of a new integration method2020

    • Author(s)
      Kusaka Katsuhiro、Yokoyama Takeshi、Yamada Taro、Yano Naomine、Tanaka Ichiro、Mizuguchi Mineyuki
    • Journal Title

      Acta Crystallographica Section D Structural Biology

      Volume: 76 Issue: 11 Pages: 1050-1056

    • DOI

      10.1107/s2059798320012498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments2020

    • Author(s)
      Yokoyama Takeshi、Mizuguchi Mineyuki
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 63 Issue: 23 Pages: 14228-14242

    • DOI

      10.1021/acs.jmedchem.0c00934

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Structural and thermodynamic analyses of interactions between death-associated protein kinase 1 and anthraquinones2020

    • Author(s)
      Yokoyama Takeshi、Wijaya Peter、Kosaka Yuto、Mizuguchi Mineyuki
    • Journal Title

      Acta Crystallographica Section D Structural Biology

      Volume: 76 Issue: 5 Pages: 438-446

    • DOI

      10.1107/s2059798320003940

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. var. cordiformis (Makino) Kitam.2019

    • Author(s)
      Chaudhary N., Sasaki, R., Shuto, T., Watanabe, M., Kawahara, T., Suico, M.A., Yokoyama, T., Mizuguchi, M., Kai, H., Devkota, H.
    • Journal Title

      Molecules

      Volume: 24 Issue: 3 Pages: 500-500

    • DOI

      10.3390/molecules24030500

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08309, KAKENHI-PROJECT-16K08193
  • [Journal Article] Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening2019

    • Author(s)
      Yokoyama Takeshi、Kitakami Ryota、Mizuguchi Mineyuki
    • Journal Title

      European Journal of Medicinal Chemistry

      Volume: 167 Pages: 153-160

    • DOI

      10.1016/j.ejmech.2019.02.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Journal Article] Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD42019

    • Author(s)
      Yokoyama Takeshi、Matsumoto Kazunori、Ostermann Andreas、Schrader Tobias E.、Nabeshima Yuko、Mizuguchi Mineyuki
    • Journal Title

      The FEBS Journal

      Volume: 286 Issue: 9 Pages: 1656-1667

    • DOI

      10.1111/febs.14736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Journal Article] Crown Ethers as Transthyretin Amyloidogenesis Inhibitors2019

    • Author(s)
      Yokoyama Takeshi、Mizuguchi Mineyuki
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 62 Issue: 4 Pages: 2076-2082

    • DOI

      10.1021/acs.jmedchem.8b01700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Journal Article] Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds2018

    • Author(s)
      Yokoyama Takeshi、Mizuguchi Mineyuki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 7 Pages: 979-984

    • DOI

      10.1248/bpb.b18-00166

    • NAID

      130007387203

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2018-07-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Journal Article] Stability and crystal structures of His88 mutant human transthyretins2017

    • Author(s)
      Yokoyama Takeshi、Hanawa Yuma、Obita Takayuki、Mizuguchi Mineyuki
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 13 Pages: 1862-1871

    • DOI

      10.1002/1873-3468.12704

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Journal Article] Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP2017

    • Author(s)
      Yokoyama Takeshi、Ostermann Andreas、Schrader Tobias E.、Mizuguchi Mineyuki
    • Journal Title

      Acta Crystallographica Section F Structural Biology Communications

      Volume: 73 Issue: 10 Pages: 555-559

    • DOI

      10.1107/s2053230x1701264x

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Journal Article] Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione2015

    • Author(s)
      Yokoyama T, Takaki S, Chosa K, Sato T, Suico MA, Teranishi Y, Shuto T, Mizuguchi M, Kai H
    • Journal Title

      J Pharmacol Sci.

      Volume: 129 Issue: 4 Pages: 240-243

    • DOI

      10.1016/j.jphs.2015.09.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25253012, KAKENHI-PROJECT-25860022
  • [Journal Article] Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor.2015

    • Author(s)
      Yokoyama T, Ueda M, Ando Y, Mizuguchi M.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13570-13570

    • DOI

      10.1038/srep13570

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09318, KAKENHI-PROJECT-15K15195, KAKENHI-PROJECT-15H04841, KAKENHI-PROJECT-25860022
  • [Journal Article] Crystal structures of human transthyretin complexed with glabridin.2014

    • Author(s)
      Yokoyama T, Kosaka Y, Mizuguchi M.
    • Journal Title

      J Med Chem.

      Volume: 57 Issue: 3 Pages: 1090-1096

    • DOI

      10.1021/jm401832j

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21113003, KAKENHI-PROJECT-25860022
  • [Journal Article] Inhibitory Activities of Propolis and its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin2014

    • Author(s)
      Yokoyama, T.; Kosaka, Y.; Mizuguchi, M
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 57 Issue: 21 Pages: 8928-8935

    • DOI

      10.1021/jm500997m

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Journal Article] Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate.2014

    • Author(s)
      Yokoyama T, Ostermann A, Mizuguchi M, Niimura N, Schrader TE, Tanaka I.
    • Journal Title

      Acta Crystallogr F Struct Biol Commun.

      Volume: 70 Issue: 4 Pages: 470-472

    • DOI

      10.1107/s2053230x14004087

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21113003, KAKENHI-PROJECT-25860022, KAKENHI-PLANNED-23108003
  • [Journal Article] Hydrogen-bond network and pH sensitivity in human transthyretin2013

    • Author(s)
      T. Yokoyama, M. Mizuguchi, Y. Nabeshima, K. Kusaka, T. Yamada, T. Hosoya, T. Ohhara, K. Kurihara, I. Tanaka, N. Niimura
    • Journal Title

      J. Synchrotron Radiat.

      Volume: 2013 Issue: 6 Pages: 834-837

    • DOI

      10.1107/s090904951302075x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24681016, KAKENHI-PROJECT-25860022
  • [Journal Article] Hydrogen-bond network and pH sensitivity in transthyretin : neutron crystal structure of human transthyretin2012

    • Author(s)
      Yokoyama, T., Mizuguchi, M., 他9名
    • Journal Title

      Journal of Structural Biology

      Volume: 177 Issue: 2 Pages: 283-290

    • DOI

      10.1016/j.jsb.2011.12.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21113003, KAKENHI-PROJECT-21750007, KAKENHI-PROJECT-21770159
  • [Journal Article] Hydrogen-bond network and pH sensitivity in transthyretin : Neutron crystal structure of human transthyretin2012

    • Author(s)
      Yokoyama T., Mizuguchi M., Nabeshima Y., Kusaka K., Yamada T., Hosoya T., Ohhara T., Kurihara K., Tomoyori K., Tanaka I., Niimura N.
    • Journal Title

      J. Struct. Biol

      Volume: 177-2 Pages: 283-290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Journal Article] Neutron structure analysis using the IBARAKI biological crystal diffractometer(iBIX) at J-PARC2010

    • Author(s)
      Tanaka I., Kusaka K., Hosoya T., Niimura N., Ohhara T., Kurihara K., Yamada T., Ohnishi Y., Tomoyori K., Yokoyama T.
    • Journal Title

      Acta Crystallogr D Biol Crystallogr

      Volume: 66-11 Pages: 1194-1197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Journal Article] Structure of a sigma28-regulated nonflagellar virulence protein from Campylobacter jejuni2009

    • Author(s)
      Kirkpatrick AS., Yokoyama T., Choi KJ., Yeo HJ.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 6 ; 380(2) Pages: 407-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Journal Article] Structure and function of a Campylobacter jejuni thioesterase Cj0915, a hexameric hot dog fold enzyme2009

    • Author(s)
      Yokoyama T., Choi KJ., Bosch AM., Yeo HJ.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1974-7 Pages: 1073-1081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] Hsp72-NBD-ADP複合体の中性子結晶構造解析2021

    • Author(s)
      横山 武司、藤井 志帆、Andreas Ostermann、Tobias E Schrader、鍋島 裕子、水口峰之
    • Organizer
      日本結晶学会
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] X 線結晶解析スクリーニングによる分子標的薬の探索2019

    • Author(s)
      横山武司,松本知憲,北上龍太,鍋島裕子,アンドレアス オスターマン,トビアス シュレイダー,水口 峰之
    • Organizer
      日本結晶学会 令和元年(2019年)度年会
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] クラウンエーテルによるトランスサイレチンアミロイド形成のアロステリック阻害2019

    • Author(s)
      横山武司,水口峰之
    • Organizer
      第19回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] Neutron diffraction experiment of transthyretin variant by using iBIX at J-PARC2019

    • Author(s)
      Kusaska K, Yokoyama T, Yamada T, Yano N, Tanaka I, Mizuguchi M
    • Organizer
      Internatinal Symposium on Diffraction Structural Bioloty 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] Discovery of Molecular-Targeted Drugs by X-ray Crystallographic Screening2019

    • Author(s)
      Yokoyama T
    • Organizer
      Internatinal Symposium on Diffraction Structural Bioloty 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] 創薬標的タンパク質の中性子結晶構造解析2019

    • Author(s)
      横山武司
    • Organizer
      第57回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] 茨城県生命構造解析装置iBIXによるトランスサイレチン変異体の中性子回折実験2019

    • Author(s)
      日下勝弘,横山武司,山田太郎,矢野直峰,田中伊知朗,水口峰之
    • Organizer
      第19回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-19K07012
  • [Presentation] Characterization of diacerein as a transthyretin amyloidogenesis inhibitor2018

    • Author(s)
      6) Ryota Kitakami, Takeshi Yokoyama, Kishin Inui, Takuya Okada, Naoki Toyooka, and Mineyuki Mizuguchi
    • Organizer
      The 3rd Toyama-Asia-Africa-Pharm Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] The effect of amino acid substitution at position 88 on the structure and stability of transthyretin2018

    • Author(s)
      4) Takeshi Yokoyama, Yuma Hanawa, Takayuki Obita, Mineyuki Mizguchi
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] γ-mangostinを基盤としたアミロイド病治療薬の開発研究2018

    • Author(s)
      12) 乾貴信,岡田卓哉,北上龍太,横山武司,水口峰之,豊岡尚樹
    • Organizer
      平成30年度有機合成化学北陸セミナー
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] iBIXによるトランスサイレチン変異体の中性子回折実験2018

    • Author(s)
      14) 日下勝弘,横山武司,山田太郎,矢野直峰,田中伊知朗,水口峰之
    • Organizer
      日本中性子科学学会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] トランスサイレチンのアミロイド線維形成を阻害する天然化合物の探索2018

    • Author(s)
      水口峰之,横山武司
    • Organizer
      第6回日本アミロイドーシス研究会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] DAPK1阻害剤としての天然アントラキノンの同定と構造活性相関研究2018

    • Author(s)
      横山武司,Peter Wijaya,水口峰之
    • Organizer
      第18回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] Virtual and high-throughput screenings identify novel TTR stabilizers for hereditary ATTR amyloidosis2018

    • Author(s)
      5) Keisuke Chosa, Yukiko Teranishi, Ryoko Sasaki, Shun Takaki, Takeshi Yokoyama, Yoshiki Imai, Yuriko Wakita, Takashi Sato, Tsuyoshi Shuto, Mary Ann Suico, Mineyuki Mizuguchi, Hirofumi Kai
    • Organizer
      The XVIth International Symposium on Amyloidosis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] 中性子結晶解析によるHSP70内部の水和構造の可視化2017

    • Author(s)
      横山武司,Andreas Ostermann,Tobias Schrader,水口峰之
    • Organizer
      日本薬学会北陸支部第129回例会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] クラウンエーテルと創薬標的タンパク質複合体のX線結晶構造解析2017

    • Author(s)
      横山武司、小坂友人、松本知憲、北上龍太、水口峰之
    • Organizer
      第17回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] X線結晶解析スクリーニングによるBRD4阻害剤の探索とBRD4-阻害剤複合体の中性子結晶構造解析2017

    • Author(s)
      横山武司,松本知憲,鍋島裕子,水口峰之
    • Organizer
      第55回日本生物物理学会年会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] Identification of Purpurin as DAPK1 Inhibitor and X-ray Structural Analysis of DAPK1-Purpurin Complex2017

    • Author(s)
      Wijaya P, Yokoyama T, Mizuguchi M.
    • Organizer
      日本薬学会北陸支部第129回例会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] アントラキノン誘導体のプルプリンによるトランスサイレチンアミロイド線維形成の阻害機構2017

    • Author(s)
      北上龍太、横山武司、水口峰之
    • Organizer
      第17回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] トランスサイレチンのアミロイド線維形成におけるアントラキノン類の阻害機構2016

    • Author(s)
      北上龍太、横山武司、水口峰之
    • Organizer
      日本薬学会北陸支部第128回例会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] Novel BRD4 bromodomain binders with different binding modes revealed by crystallographic limited screening.2016

    • Author(s)
      Matsumoto, K., Yokoyama, T., and Mizuguchi, M.
    • Organizer
      The first international symposium on Toyama-Asia-Africa Pharmaceutical Network
    • Place of Presentation
      Toyama
    • Year and Date
      2016-09-12
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] トランスサイレチン型アミロイドーシスの治療を目指した構造生物学的研究2016

    • Author(s)
      横山武司
    • Organizer
      第1051回金曜セミナーおよび第4回neutrons in biology研究会
    • Place of Presentation
      東海
    • Year and Date
      2016-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] FPPS-ビスホスホネート複合体におけるプロトン化状態の変化と水和構造2016

    • Author(s)
      横山武司
    • Organizer
      平成28 年度J-PARC/MLF 産業利用報告会
    • Place of Presentation
      秋葉原コンベンションホール
    • Year and Date
      2016-07-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] 抗アミロイドーシス薬としてのクラウンエーテルの有用性:クラウンエーテル-トランスサイレチン複合体の安定性と結晶構造2016

    • Author(s)
      横山武司、水口峰之
    • Organizer
      第16回日本蛋白質科学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-06-07
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] Analysis of the stability of transthyretins from different primates.2016

    • Author(s)
      Inose, M., Obita, T., Yokoyama, T., and Mizuguchi, M.
    • Organizer
      The first international symposium on Toyama-Asia-Africa Pharmaceutical Network
    • Place of Presentation
      Toyama
    • Year and Date
      2016-09-12
    • Data Source
      KAKENHI-PROJECT-16K08193
  • [Presentation] プロポリスとその有効成分CAPE のトランスサイレチンアミロイド線維形成阻害効果2015

    • Author(s)
      小坂友人,横山武司,水口峰之
    • Organizer
      第15回日本蛋白質科学会
    • Place of Presentation
      徳島
    • Year and Date
      2015-06-24
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] 創薬標的タンパク質の中性子結晶構造解析および天然物阻害剤との相互作用解析2015

    • Author(s)
      横山武司
    • Organizer
      2015年度第一回水和ナノ構造研究会
    • Place of Presentation
      塩原
    • Year and Date
      2015-09-01
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] γ-マンゴスチンはトランスサイレチンのアミロイド線形成を阻害する2015

    • Author(s)
      横山武司,水口峰之
    • Organizer
      第15回日本蛋白質科学会
    • Place of Presentation
      徳島
    • Year and Date
      2015-06-24
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] Structural insight into the interaction between Death-associated protein kinase 1 and natural flavonoids2015

    • Author(s)
      小坂友人,水口峰之,横山武司
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-13
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] FPPS-ビスホスホネート複合体におけるプロトン化状態の変化と水和構造2015

    • Author(s)
      横山武司
    • Organizer
      第8回iBIX研究会
    • Place of Presentation
      東海村
    • Year and Date
      2015-01-28
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] 天然物の結合によるヒトトランスサイレチンの構造変化2015

    • Author(s)
      横山武司
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-13
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] FPPS-ビスホスホネート複合体におけるプロトン化状態の変化と水和構造2015

    • Author(s)
      横山武司
    • Organizer
      第15回日本蛋白質科学会
    • Place of Presentation
      徳島
    • Year and Date
      2015-06-24
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] トランスサイレチンの結晶構造解析2012

    • Author(s)
      横山武司
    • Organizer
      第三回MLFシンポジウム
    • Place of Presentation
      東海村
    • Year and Date
      2012-01-19
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] トランスサイレチンの結晶構造解析2012

    • Author(s)
      横山武司
    • Organizer
      第3回MLFシンポジウム
    • Place of Presentation
      東海(口頭発表)
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] トランスサイレチンの中性子結晶構造解析2011

    • Author(s)
      横山武司
    • Organizer
      第12回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      富山(口頭発表)
    • Year and Date
      2011-06-18
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] トランスサイレチンの中性子結晶構造解析2011

    • Author(s)
      横山武司
    • Organizer
      第12回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2011-06-18
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] Preliminary neutron crystallographic study of mutant transthyretin2011

    • Author(s)
      Takeshi Yokoyama
    • Organizer
      XXII Congress and General Assembly International Union of Crystallography
    • Place of Presentation
      マドリッド(スペイン)
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] トランスサイレチンの結晶構造解析2011

    • Author(s)
      横山武司
    • Organizer
      平成22年度茨城県中性子ビームライン成果報告会
    • Place of Presentation
      東京(口頭発表)
    • Year and Date
      2011-09-26
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] XXII Congress and General Assembly International Union of Crystallography(IUCr2011)2011

    • Author(s)
      Yokoyama T., Nabeshima Y., Hosoya T., Ohhara T., Kurihara K., Kusaka K., Mizuguchi M., Tanaka I., Niimura N.
    • Place of Presentation
      マドリッド(ポスター発表)
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] トランスサイレチンの結晶構造解析2011

    • Author(s)
      横山武司
    • Organizer
      平成22年度茨城県中性子ビームライン成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-26
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] 変異体トランスサイレチンの中性子回折測定及びX線結晶構造解析2010

    • Author(s)
      Yokoyama T., Nabeshima Y., Hosoya T., Ohhara T., Kurihara K., Kusaka K., Mizuguchi M., Tanaka I., Niimura N.
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台(ポスター発表)
    • Year and Date
      2010-09-20
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] Preliminary neutron crystallographic study and X-ray structural analysis of mutant Transthyretin2010

    • Author(s)
      Takeshi Yokoyama
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      東北大学・川内北キャンパス
    • Year and Date
      2010-09-21
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] 変異体トランスサイレチンの中性子回折実験2010

    • Author(s)
      横山武司
    • Organizer
      水和ナノ構造研究会
    • Place of Presentation
      伊豆(口頭発表)
    • Year and Date
      2010-09-06
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] Towards the neutron crystallographic analysis of amyloid protein, TTR.2009

    • Author(s)
      Yokoyama T., Nabeshima Y., Mizuguchi M., Tanaka I., Niimura N.
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      徳島(ポスター発表)
    • Year and Date
      2009-10-30
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] アミロイドーシス原因タンパク質トランスサイレチンの中性子結晶構造解析に向けて2009

    • Author(s)
      横山武司
    • Organizer
      日本生物物理学会 第47回
    • Place of Presentation
      徳島・アスティとくしま
    • Data Source
      KAKENHI-PROJECT-21770159
  • [Presentation] ファルネシル二リン酸合成酵素の中性子結晶構造解析

    • Author(s)
      横山武司、オスターマン アンドレアス、水口峰之、新村信雄、シュレイダー トビアス、田中伊知朗
    • Organizer
      第14回日本蛋白質科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] トランスサイレチンとグラブリジンの複合体結晶構造解析

    • Author(s)
      小坂友人、横山武司、水口峰之
    • Organizer
      第14回日本蛋白質科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-25860022
  • [Presentation] Neutron crystal structure of human FPPS complexed with risedronate

    • Author(s)
      Takeshi Yokoyama, Andreas Ostermann, Mineyuki Mizuguchi, Nobuo Niimura, Tobias Schrader, Ichiro Tanaka
    • Organizer
      XXIII Congress and General Assembly International Union of Crystallography
    • Place of Presentation
      カナダ
    • Year and Date
      2014-08-01 – 2014-08-08
    • Data Source
      KAKENHI-PROJECT-25860022
  • 1.  日下 勝弘 (10414591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  岡田 卓哉 (70848613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  OHHARA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  UEDA Mitsuharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  メリー・アン スイコ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  水口 峰之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 7.  首藤 剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  甲斐 広文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  安東 由喜雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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