Akutsu Noriyuki 阿久津典之

Researcher Number	50531191
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2023: 札幌医科大学, 医学部, 講師 2018 – 2019: 札幌医科大学, 医学部, 助教 2017: 札幌医科大学, 医学部消化器内科, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 肝細胞癌 / 時計遺伝子 / 分子標的治療 / 癌 / 薬剤耐性 Except Principal Investigator 肝発癌 / 概日時計 / 非アルコール性脂肪性肝炎 / 肝癌 / 時計遺伝子 / 肝がん / 概日リズム / 脂肪肝

Correlation between molecularly targeted therapy and circadian clock in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  akutsu noriyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
Effect of circadian clock on liver carcinogenesis based on non-alcoholic steatohepatitis
- Principal Investigator
  
  SASAKI SHIGERU
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
The role of HIF1 alfa in sorafenib resistant hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Akutsu Noriyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Genomic analysis of an aggressive hepatic leiomyosarcoma case following treatment for hepatocellular carcinoma2024
- Author(s)
  Numata Yuto、Akutsu Noriyuki、Idogawa Masashi、Wagatsuma Kohei、Numata Yasunao、Ishigami Keisuike、Nakamura Tomoya、Hirano Takehiro、Kawakami Yujiro、Masaki Yoshiharu、Murota Ayako、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Hepatology Research
  
  Volume: Online ahead of print. Issue: 9 Pages: 859-865
- DOI
  10.1111/hepr.14034
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Generalized crystal-storing histiocytosis with noncirrhotic portal hypertension: an autopsy case report2023
- Author(s)
  Numata Yasunao、Sasaki Shigeru、Magara Kazufumi、Takasawa Akira、Sugawara Taro、Ohara Naruki、Akutsu Noriyuki、Hasegawa Tadashi、Osanai Makoto、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 16 Issue: 3 Pages: 450-456
- DOI
  10.1007/s12328-023-01782-1
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Serum Soluble Fas Levels and Incidence of Liver Cancer in Nested Case?Control Study2022
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Kubo Toshiyuki、Akutsu Noriyuki、Sasaki Yasushi、Nakase Hiroshi、Lin Yingsong、Kurozawa Youichi、Wakai Kenji、Tamakoshi Akiko、for the Japan Collaborative Cohort Study
- Journal Title
  
  Cancer Epidemiology, Biomarkers & Prevention
  
  Volume: 32 Issue: 2 Pages: 260-265
- DOI
  10.1158/1055-9965.epi-22-0902
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-21K08801, KAKENHI-PROJECT-20K08335, KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-22H04923
[Journal Article] Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma2022
- Author(s)
  Sae Ohwada 1 , Noriyuki Akutsu 1 , Yoshiharu Masaki 1 , Shigeru Sasaki 1 , Minoru Nagayama 2 , Yasutoshi Kimura 2 , Ichiro Takemasa 2 , Hiroki Takahashi 3 , Hiroshi Nakase 1
- Journal Title
  
  JMA Journal
  
  Volume: 5 Issue: 3 Pages: 393-397
- DOI
  10.31662/jmaj.2022-0066
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2022-07-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cholangiocarcinoma.2022
- Author(s)
  Yoshiharu Masaki
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: 15 Issue: 4 Pages: 809-817
- DOI
  10.1007/s12328-022-01649-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09179, KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-20K08390, KAKENHI-PROJECT-22H04925
[Journal Article] Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History2022
- Author(s)
  Masayuki Tsujisaki 1 , Shigeru Sasaki 2 , Noriyuki Akutsu 2 , Takenori Takamura 1 , Tetsuyuki Igarashi 3 , Mitsuru Yoshimoto 1 , Hideto Itoh 1 , Yoshio Kurihara 4 , Hiroshi Nakase 2
- Journal Title
  
  JMA Journal
  
  Volume: 5 Issue: 2 Pages: 230-239
- DOI
  10.31662/jmaj.2021-0199
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2022-04-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Calibrating Hepatitis E Virus Serological Assays Using Asymptomatic Specimens Obtained in Japan2022
- Author(s)
  Terahara Kazutaka、Li Tian-Cheng、Matsubayashi Keiji、Sakata Hidekatsu、Kato Takanobu、Naganuma Atsushi、Ogawa Koji、Honda Koichi、Itakura Jun、Akutsu Noriyuki、Tobita Hiroshi、Korenaga Masaaki、Kanto Tatsuya、Sugiyama Ryuichi、Suzuki Ryosuke、Hamaguchi Isao、Isogawa Masanori、Takahashi Yoshimasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 10 Issue: 5
- DOI
  10.1128/spectrum.02146-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Synergistic effect of IFN-γ and IL-1β on PD-L1 expression in hepatocellular carcinoma2022
- Author(s)
  Numata Yasunao、Akutsu Noriyuki、Ishigami Keisuke、Koide Hideyuki、Wagatsuma Kohei、Motoya Masayo、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101270-101270
- DOI
  10.1016/j.bbrep.2022.101270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] A case of hepatocellular carcinoma with long-term survival by multidisciplinary treatment for cranial and skeletal muscle metastases2022
- Author(s)
  Akutsu Noriyuki、Kawakami Yujiro、Numata Yasunao、Hirano Takehiro、Wagatsuma Kohei、Ishigami Keisuke、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 15 Issue: 5 Pages: 960-967
- DOI
  10.1007/s12328-022-01669-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Pharmacological Treatments Available for Immune-Checkpoint-Inhibitor-Induced Colitis2022
- Author(s)
  Ohwada Sae、Ishigami Keisuke、Akutsu Noriyuki、Nakase Hiroshi
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 6 Pages: 1334-1334
- DOI
  10.3390/biomedicines10061334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Insulin-Like Growth Factor 2 and Incidence of Liver Cancer in a Nested Case?Control Study2021
- Author(s)
  Adachi Yasushi、Nojima Masanori、Mori Mitsuru、Himori Ryogo、Kubo Toshiyuki、Akutsu Noriyuki、Lin Yingsong、Kurozawa Youichi、Wakai Kenji、Tamakoshi Akiko
- Journal Title
  
  Cancer Epidemiology, Biomarkers & Prevention
  
  Volume: 30 Issue: 11 Pages: 2130-2135
- DOI
  10.1158/1055-9965.epi-21-0481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-20K08335
[Journal Article] Immunoglobulin G4-related autoimmune hepatitis simultaneously concomitant with autoimmune pancreatitis: a case report2021
- Author(s)
  Yokoyama Yoshihiro、Akutsu Noriyuki、Numata Yasunao、Okuda Keiko、Morita Rena、Masaki Yoshiharu、Sasaki Hajime、Suzuki Ryo、Yabana Takashi、Arimura Yoshiaki、Kondo Yoshihiro、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1740-1745
- DOI
  10.1007/s12328-021-01509-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312, KAKENHI-PROJECT-21K15556
[Journal Article] Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment2021
- Author(s)
  Akutsu Noriyuki、Sasaki Shigeru、Matsui Takeshi、Akashi Hirofumi、Yonezawa Kazuhiko、Ishigami Keisuke、Tsujisaki Masayuki、Isshiki Hiroyuki、Yawata Atsushi、Yamaoka Satoshi、Ban Toshihiro、Adachi Takeya、Nakahara Seiya、Takagi Hideyasu、Nakachi Kohei、Tanaka Katsunori、Hirano Takehiro、Nakase Hiroshi
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 21 Pages: 3369-3376
- DOI
  10.2169/internalmedicine.7098-21
- NAID
  130008110304
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-11-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Sustained hyperbilirubinemia following clarithromycin administration2021
- Author(s)
  Yamamoto Tomoka、Ishigami Keisuke、Ueno Akari、Akutsu Noriyuki、Numata Yasunao、Wagatsuma Kohei、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Medicine: Case Reports and Study Protocols
  
  Volume: 2 Issue: 2 Pages: e0057-e0057
- DOI
  10.1097/md9.0000000000000057
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Mixed neuroendocrine non-neuroendocrine neoplasm of the gallbladder complicated by a pancreaticobiliary maljunction of a non-dilated biliary duct2021
- Author(s)
  Wagatsuma Kohei、Akita Kotaro、Motoya Masayo、Kimura Yasutoshi、Sugita Shintaro、Hirano Takehiro、Kawakami Yujiro、Numata Yasunao、Ishigami Keisuke、Masaki Yoshiharu、Murota Ayako、Shitani Masahiro、Akutsu Noriyuki、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Medicine
  
  Volume: 100 Issue: 39 Pages: e27336-e27336
- DOI
  10.1097/md.0000000000027336
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] A case of hepatitis B virus and hepatitis C virus co-infection that achieved sustained virological response 12 following treatment with glecaprevir hydrate/pibrentasvir for 3 days2021
- Author(s)
  Numata Yasunao、Sasaki Shigeru、Akutsu Noriyuki、Hirano Takehiro、Wagatsuma Kohei、Kawakami Yujiro、Ishigami Keisuke、Nakase Hiroshi
- Journal Title
  
  Kanzo
  
  Volume: 62 Issue: 9 Pages: 578-584
- DOI
  10.2957/kanzo.62.578
- NAID
  130008086356
- ISSN
  0451-4203, 1881-3593
- Year and Date
  2021-09-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Development of anti-centromere antibody-positive autoimmune hepatitis after childbirth2020
- Author(s)
  Saito Mitsunobu、Akutsu Noriyuki、Numata Yasunao、Ishigami Keisuke、Sasaki Shigeru、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 13 Issue: 5 Pages: 855-859
- DOI
  10.1007/s12328-020-01092-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Journal Article] Author’s reply: acute serologic autoimmune hepatitis in the post-partum period2020
- Author(s)
  Akutsu Noriyuki、Ishigami Keisuke、Nakase Hiroshi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 13 Issue: 4 Pages: 634-634
- DOI
  10.1007/s12328-020-01120-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 当科の核酸アナログ治療20年の検討2023
- Author(s)
  阿久津典之, 佐々木茂, 沼田泰尚, 平野雄大, 我妻康平, 石上敬介, 川上裕次郎, 柾木喜晴, 室田文子, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 高齢者肝細胞癌に対する経皮的ラジオ波焼灼療法の検討2023
- Author(s)
  沼田泰尚, 阿久津典之, 我妻康平, 平野雄大, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 佐々木茂, 仲瀬裕志
- Organizer
  日本高齢消化器病学
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 肝硬変の成因と病態の推移　2018年以降に当科で加療した肝硬変症例の検討2023
- Author(s)
  阿久津典之, 沼田泰尚, 石上敬介, 我妻康平, 平野雄大, 川上裕次郎, 佐々木茂, 仲瀬裕志
- Organizer
  日本肝臓学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 当科における原発性硬化性胆管炎(PSC)症例の検討2023
- Author(s)
  沼田泰尚, 阿久津典之, 世戸凌太, 中村隼人, 浪岡万由子, 廣部洋輔, 三浦克与志, 平野雄大, 我妻康平, 川上裕次郎, 石上敬介, 柾木喜晴, 室田文子, 佐々木茂, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 切除不能肝細胞癌に対する分子標的治療症例の複数レジメン治療の有用性2023
- Author(s)
  阿久津典之, 沼田泰尚, 平野雄大, 我妻康平, 川上裕次郎, 柾木喜晴, 石上敬介, 室田文子, 佐々木茂, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 胆道鏡下生検検体で遺伝パネル検査を施行しえた切除不能胆嚢管癌の1例2022
- Author(s)
  越前栄次朗, 川上裕次郎, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 本谷雅代, 佐々木茂, 杉田真太郎, 櫻井晃洋, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] FDG-PETを契機に診断に至ったIgG4関連消化管病変の1例2022
- Author(s)
  沼田有斗, 川上裕次郎, 越前栄次郎, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 本谷雅代, 佐々木茂, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 胆膵癌におけるEUS-FNA検体を用いたMSI検査2022
- Author(s)
  川上裕次郎, 本谷雅代, 仲瀬裕志, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之
- Organizer
  日本消化器内視鏡学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 転移性肺腫瘍に対するEUS-FNAにて診断した後腹膜原発の絨毛癌の1例2022
- Author(s)
  廣部洋輔, 川上裕次郎, 越前栄次朗, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 本谷雅代, 佐々木茂, 辻脇光洋, 舛森直哉, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 難治性腹水を呈した全身性結晶蓄積性組織球症の1例2022
- Author(s)
  大原成喜, 沼田泰尚, 沼田有斗, 谷口正浩, 越前栄次朗, 平野雄大, 我妻康平, 川上裕次郎, 柾木喜晴, 石上敬介, 室田文子, 阿久津典之, 本谷雅代, 佐々木茂, 真柄和史, 菅原太郎, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 5年の経過で消失した多発肝炎症性偽腫瘍の1例2022
- Author(s)
  浪岡万由子, 阿久津典之, 石上敬介, 三浦克予志, 平野雄大, 我妻康平, 沼田泰尚, 佐々木茂, 永山稔, 菅原太郎, 長谷川匡, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 当院における悪性肝門部胆管狭窄に対するドレナージの成績2022
- Author(s)
  室田文子, 我妻康平, 川上裕次郎, 沼田泰尚, 石上敬介, 柾木喜晴, 阿久津典之, 本谷雅代, 佐々木茂, 仲瀬裕志
- Organizer
  日本胆道学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 陰茎転移をきたした膵尾部癌の1例2022
- Author(s)
  井澤朋, 川上裕次郎, 世戸凌太, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 本谷雅代, 舛森直哉, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 術前に肝細胞癌との鑑別が困難であった肝血管筋脂肪腫の2切除例2022
- Author(s)
  加藤透, 永山稔, 木村康利, 今村将史, 久木田和晴, 村上武志, 水口徹, 阿久津典之, 佐々木茂, 仲瀬裕志, 竹政伊知朗
- Organizer
  日本臨床外科学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 高齢者切除不能膵癌患者に対するGEM+nabPTX療法の有効性と安全性2022
- Author(s)
  大和田紗恵, 室田文子, 本谷雅代, 我妻康平, 沼田泰尚, 川上裕次郎, 石上敬介, 柾木喜晴, 阿久津典之, 佐々木茂, 仲瀬裕志
- Organizer
  日本高齢消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 小腸原発Gastrointestinal stromal tumor(GIST)に対するイマチニブ投与中に肝転移破裂、腹腔内出血をきたした1例2022
- Author(s)
  山本智香, 室田文子, 沼田泰尚, 川上裕次郎, 石上敬介, 柾木喜晴, 阿久津典之, 本谷雅代, 佐々木茂, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312
[Presentation] 治療困難肝内結石に対するSpyGlass DSを用いた胆道鏡下治療の検討2022
- Author(s)
  越前栄次朗, 川上裕次郎, 我妻康平, 沼田泰尚, 石上敬介, 柾木喜晴, 室田文子, 阿久津典之, 本谷雅代, 佐々木茂, 仲瀬裕志
- Organizer
  日本消化器病学会
- Data Source
  KAKENHI-PROJECT-20K08312

1. SASAKI SHIGERU (10305229)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
2. 仲瀬裕志 (60362498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. 佐々木泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akutsu Noriyuki 阿久津 典之

Research Projects

Research Products

Co-Researchers

Correlation between molecularly targeted therapy and circadian clock in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Effect of circadian clock on liver carcinogenesis based on non-alcoholic steatohepatitis

Principal Investigator

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Review Section

Research Institution

The role of HIF1 alfa in sorafenib resistant hepatocellular carcinomaPrincipal Investigator

Principal Investigator

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Research Category

Research Field

Research Institution

[Journal Article] Genomic analysis of an aggressive hepatic leiomyosarcoma case following treatment for hepatocellular carcinoma2024

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[Journal Article] Generalized crystal-storing histiocytosis with noncirrhotic portal hypertension: an autopsy case report2023

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[Journal Article] Serum Soluble Fas Levels and Incidence of Liver Cancer in Nested Case?Control Study2022

Author(s)

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Data Source

[Journal Article] Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome Precedes the Development of Hepatocellular Carcinoma2022

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[Journal Article] Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cholangiocarcinoma.2022

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[Journal Article] Positive Pattern Recognition System Using Alanine Aminotransferase, Type IV Collagen 7s, and E Value (Liver Stiffness) for the Diagnosis of Nonalcoholic Steatohepatitis Based on Natural History2022

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[Journal Article] Calibrating Hepatitis E Virus Serological Assays Using Asymptomatic Specimens Obtained in Japan2022

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[Journal Article] Synergistic effect of IFN-γ and IL-1β on PD-L1 expression in hepatocellular carcinoma2022

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[Journal Article] A case of hepatocellular carcinoma with long-term survival by multidisciplinary treatment for cranial and skeletal muscle metastases2022

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[Journal Article] Pharmacological Treatments Available for Immune-Checkpoint-Inhibitor-Induced Colitis2022

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[Journal Article] Insulin-Like Growth Factor 2 and Incidence of Liver Cancer in a Nested Case?Control Study2021

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Akutsu Noriyuki 阿久津典之

[Presentation] 肝硬変の成因と病態の推移　2018年以降に当科で加療した肝硬変症例の検討2023