IMOTO HITOMI 井本ひとみ (山本ひとみ)

… Alternative Names

山本ひとみ

IMOTO Hitomi 井本ひとみ

YAMAMOTO Hitomi 山本ひとみ

井本ひとみ(山本ひとみ) イモトヒトミ

Less

Researcher Number	50532230
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院医学系研究科, 特任助教(常勤) 2012 – 2013: 独立行政法人国立循環器病研究センター, 研究所, 非常勤研究員 2011: 独立行政法人国立循環器病研究センター, 分子病態部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Functional biochemistry Except Principal Investigator Functional biochemistry / Hematology
Keywords	Principal Investigator 肝がん / 加齢 / オートファジー / ナトリウム/カリウム-ATPase / 心臓 / 脳 / ナトリウム/カリウムATPase / 神経細胞 / NDRG4 Except Principal Investigator 虚血 … More / BDNF / NDRG4 / NDRG1 / 神経細胞 / 心機能 / 脳機能 / タンパク質 / フォンビルランド因子 / 遺伝子多型 / 血小板血栓 / マウスモデル / 遺伝子 / 血小板 / 凝固 / 血栓症 / 脳梗塞 / プロテインS / フォンビルブランド因子 / 血栓性血小板減少性紫斑病 / ADAMTS13 / 凝固制御因子 / 静脈血栓症 Less

加齢依存的オートファジー活性低下による肝発がん機構の解明Principal Investigator
- Principal Investigator
  
  井本ひとみ (山本ひとみ)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
Cytoplasmic interactions of NDRG4Principal Investigator
- Principal Investigator
  
  IMOTO Hitomi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Molecular and physiological functions of NDRG1 and NDRG4
- Principal Investigator
  
  KOKAME Koichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute

All 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Journal Title
  
  Thromb. Haemost.
  
  Volume: 108 Issue: 12 Pages: 1236-1238
- DOI
  10.1160/th12-09-0674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-24592744
[Journal Article] 虚血に対して保護的作用を示す細胞内タンパク質NDRG42012
- Author(s)
  山本ひとみ
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: vol.23 Pages: 399-406
- Data Source
  KAKENHI-PROJECT-24770139
[Journal Article] NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia2011
- Author(s)
  Hitomi Yamamoto, 他5名
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 29 Pages: 26158-26165
- DOI
  10.1074/jbc.m111.256446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.2011
- Author(s)
  Hitomi Yamamoto, Koichi Kokame, Tomohiko Okuda, Yukako Nakajo, Hiroji Yanamoto, and Toshiyuki Miyata.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 26158-26165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion2010
- Author(s)
  M. Fujioka, K. Hayakawa, K. Mishima, A. Kunizawa, K. Irie, S. Higuchi, T. Nakano, C. Muroi, H. Fukushima, M. Sugimoto, F. Banno, K. Kokame, T. Miyata, M. Fujiwara, K. Okuchi, K. Nishio
- Journal Title
  
  Blood
  
  Volume: 15 Issue: 8 Pages: 1650-1653
- DOI
  10.1182/blood-2009-06-230110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-22790923
[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.2010
- Author(s)
  M.Fujioka, K.Hayakawa, K.Mishima, A.Kunizawa, K.Irie, S.Higuchi, T.Nakano, C.Muroi, H.Fukushima, M.Sugimoto, F.Banno, K.Kokame, T.Miyata, M.Fujiwara, K.Okuchi, K.Nishio
- Journal Title
  
  Blood 115
  
  Pages: 1650-1653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Upregulation of eNOS, SIRT1, and autophagy-related genes by repeated treatment with resveratrol in human umbilical vein endothelial cells.
- Author(s)
  Yoshie Takizawa, Yukiko Kosuge, Hiroyo Awaji, Emi Tamura, Ayako Takai, Takaaki Yanai, Reiko Yamamoto, Koichi Kokame, Toshiyuki Miyata, Rieko Nakata, and Hiroyasu Inoue.
- Journal Title
  
  Brit. J. Nutr.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Temporary cerebral ischemia induced by three-vessel occlusion in mice2013
- Author(s)
  Hitomi Yamamoto
- Organizer
  59th Annual Scientific and Standardization Committee Meeting and 24th Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam
- Invited
- Data Source
  KAKENHI-PROJECT-24770139
[Presentation] Temporary cerebral ischemia induced by three-vessel occlusion in mice2013
- Author(s)
  Hitomi Yamamoto
- Organizer
  59th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Amsterdam
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-24770139
[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa+/K+-ATPase α3サブユニットに結合する2012
- Author(s)
  井本(山本)ひとみ
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa+/K+-ATPase α3サブユニットに結合する2012
- Author(s)
  井本（山本）ひとみ
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24770139
[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa^+/K^+-ATPase α3サブユニットに結合する2012
- Author(s)
  井本(山本)ひとみ・宮田敏行・小亀浩市
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Protective Role of ADAMTS13 for Myocardium in Mouse Model of Experimental Myocardial Infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Organizer
  2012 ASH Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa+/K+-ATPaseα3サブユニットに結合する2012
- Author(s)
  井本(山本)ひとみ、宮田敏行、小亀浩市
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24770139
[Presentation] NDRG4欠損マウスは,大脳皮質BDNF量の低下とともに,記憶学習能力の低下と局所脳虚血による梗塞巣の増大を示す2011
- Author(s)
  井本(山本)ひとみ・小亀浩市・奥田智彦・中城有香子・柳本広二・宮田敏行
- Organizer
  第9回血液・血管オルビス
- Place of Presentation
  東京
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4欠損マウスは、大脳皮質BDNF量の低下とともに、記憶学習能力の低下と局所脳虚血による梗塞巣の増大を示す2011
- Author(s)
  井本(山本)ひとみ, 他5名
- Organizer
  第9回血液・血管オルビス
- Place of Presentation
  東京都
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4は大脳皮質中のBDNF量を正常に保ち、記憶学習能力の維持作用と虚血性脳卒中に対する脳保護作用を示す2011
- Author(s)
  井本(山本)ひとみ, 他5名
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia with the decreased level of BDNF in the cortex.2011
- Author(s)
  Hitomi Yamamoto, Koichi Kokame, Tomohiko Okuda, Yukako Nakajo, Hiroji Yanamoto, and Toshiyuki Miyata
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4は大脳皮質中のBDNF量を正常に保ち,記憶学習能力の維持作用と虚血性脳卒中に対する脳保護作用を示す2011
- Author(s)
  井本(山本)ひとみ・小亀浩市・奥田智彦・中城有香子・柳本広二・宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia with the decreased level of BDNF in the cortex2011
- Author(s)
  Hitomi Yamamoto, 他5名
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  京都市
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22570151

1. KOKAME Koichi (40270730)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. MIYATA Toshiyuki (90183970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. BANNO Fumiaki (00373514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. AKIYAMA Masashi (30298179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKADA Hiromi (00426503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATSUMOTO Sachiko (80463272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KITA Toshiyuki (70589986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKATA Toshiyuki (80531029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKAMOTO Akira (10531030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FAN Xinping

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMOTO HITOMI 井本 ひとみ (山本 ひとみ)

山本ひとみ

IMOTO Hitomi 井本 ひとみ

YAMAMOTO Hitomi 山本 ひとみ

井本 ひとみ(山本ひとみ) イモト ヒトミ

Research Projects

Research Products

Co-Researchers

加齢依存的オートファジー活性低下による肝発がん機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cytoplasmic interactions of NDRG4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and physiological functions of NDRG1 and NDRG4

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 虚血に対して保護的作用を示す細胞内タンパク質NDRG42012

Author(s)

Journal Title

Data Source

[Journal Article] NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.2011

Author(s)

Journal Title

Data Source

[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.2010

Author(s)

Journal Title

Data Source

[Journal Article] Upregulation of eNOS, SIRT1, and autophagy-related genes by repeated treatment with resveratrol in human umbilical vein endothelial cells.

Author(s)

Journal Title

Data Source

[Presentation] Temporary cerebral ischemia induced by three-vessel occlusion in mice2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Temporary cerebral ischemia induced by three-vessel occlusion in mice2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa+/K+-ATPase α3サブユニットに結合する2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa+/K+-ATPase α3サブユニットに結合する2012

IMOTO HITOMI 井本ひとみ (山本ひとみ)

IMOTO Hitomi 井本ひとみ

YAMAMOTO Hitomi 山本ひとみ

井本ひとみ(山本ひとみ) イモトヒトミ