KUNIMASA Kazuhiro 國政和宏

Researcher Number	50534020
Other IDs
Affiliation (based on the past Project Information) *help	2022: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 2018 – 2020: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 2014 – 2015: 公益財団法人がん研究会, その他部局等, 研究員 2013: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 特任研究員 2012: がん研究会, がん化学療法センター, 特任研究員 … More 2012: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 2012: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 2011: 武庫川女子大学, 国際健康開発研究所, 博士研究員 2009 – 2010: Mukogawa Women's University, 国際健康開発研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology / Eating habits, studies on eating habits Except Principal Investigator Eating habits, studies on eating habits
Keywords	Principal Investigator ミトコンドリア / 小胞体ストレス応答 / がん微小環境 / マイクロアレイ / がん代謝 / 薬剤感受性 / がん微笑環境 / 小胞体ストレス抵抗性 / 小胞体ストレス / 活性化変異 … More / がん遺伝子 / UPR / オートファジー / グルコース飢餓 / オリゴマー / 癌 / 細胞遊走 / 腫瘍 / シグナル伝達 / がん予防 / 固形がん / 管腔形成 / レスベラトロールオリゴマー / 食品機能 / レスベラトロール / がん / 血管内皮細胞 / 血管新生 … More Except Principal Investigator シグナル伝達 / アポトーシス / 分子細胞生物学 / 食品成分 / 血管新生 / 癌予防 / 健康と食生活 Less

薬剤感受性及びオミクスデータを用いたミトコンドリア代謝脆弱性因子の同定と治療応用Principal Investigator
- Principal Investigator
  
  國政和宏
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Molecular basis of oncogenic mutation-associated resistance to endoplasmic reticulum stresses and their applications to cancer chemotherapyPrincipal Investigator
- Principal Investigator
  
  KUNIMASA Kazuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Identification and characterization of mitochondrial regulators modulating the unfolded protein responsePrincipal Investigator
- Principal Investigator
  
  KUNIMASA KAZUHIRO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition
- Principal Investigator
  
  OHTA Toshiro
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
Cancer Preventive Effects of Resveratrol Oligomer-Rich Food Factors with an Antiangiogenic ActivityPrincipal Investigator
- Principal Investigator
  
  KUNIMASA Kazuhiro
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  公益財団法人がん研究会
   Mukogawa Women's University

All 2022 2020 2018 2016 2015 2013 2011 2010

All Journal Article Presentation

[Journal Article] Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation2022
- Author(s)
  Kunimasa Kazuhiro、Ikeda-Ishikawa Chika、Tani Yuri、Tsukahara Satomi、Sakurai Junko、Okamoto Yuka、Koido Masaru、Dan Shingo、Tomida Akihiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11533-11533
- DOI
  10.1038/s41598-022-15673-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07312, KAKENHI-PROJECT-23K24193
[Journal Article] Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy2020
- Author(s)
  Nagasawa Ikuko、Koido Masaru、Tani Yuri、Tsukahara Satomi、Kunimasa Kazuhiro、Tomida Akihiro
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 4 Pages: 101028-101028
- DOI
  10.1016/j.isci.2020.101028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K19486
[Journal Article] GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress2020
- Author(s)
  Kato Yu、Kunimasa Kazuhiro、Takahashi Mizuki、Harada Ayaka、Nagasawa Ikuko、Osawa Masanori、Sugimoto Yoshikazu、Tomida Akihiro
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 6 Pages: 669-676
- DOI
  10.1124/molpharm.120.000070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16339, KAKENHI-PUBLICLY-19H04973, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-18K19486
[Journal Article] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.2018
- Author(s)
  Kato Y, Kunimasa K, Sugimoto Y, Tomida A.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 4 Pages: 721-726
- DOI
  10.1016/j.bbrc.2018.09.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-16H04717
[Journal Article] Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo2015
- Author(s)
  Narayanan K. Narayanan, Kazuhiro Kunimasa, Yukio Yamori, Mari Mori, Hideki Mori, Kazuki Nakamura, George Miller, Upender Manne, Amit K. Tiwari and Bhagavathi Narayanan
- Journal Title
  
  Cancer Medicine
  
  Volume: 4 Issue: 11 Pages: 1767-1780
- DOI
  10.1002/cam4.520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460244, KAKENHI-PROJECT-25430120
[Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation2015
- Author(s)
  Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A
- Journal Title
  
  Cancer Science
  
  Volume: in press Issue: 7 Pages: 909-920
- DOI
  10.1111/cas.12682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430120, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26640109, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061
[Journal Article] Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals2013
- Author(s)
  Tsuchiya I, Hosoya T, Ushida M, Kunimasa K, Ohta T, Kumazawa S.
- Journal Title
  
  Evid Based Complement Alternat Med
  
  Volume: 2013 Pages: 826245-826245
- DOI
  10.1155/2013/826245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782, KAKENHI-PROJECT-21700773, KAKENHI-PROJECT-23580180
[Journal Article] Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis.2011
- Author(s)
  Kunimasa K, Ohta T, Tani H, Kato E, Eguchi R, Kaji K, Ikeda K, Mori H, Mori M, Tatefuji T, Yamori Y
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 55(11) Issue: 11 Pages: 1730-4
- DOI
  10.1002/mnfr.201100098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782, KAKENHI-PROJECT-21700773, KAKENHI-PROJECT-22500787
[Journal Article] Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/22011
- Author(s)
  Kunimasa K, Ahn MR, Kobayashi T, Eguchi R, Kumazawa S, Fujimori Y, Nakano T,Nakayama T, Kaji K, Ohta T.
- Journal Title
  
  Evid Based Complement Alternat Med
  
  Volume: 2011 Issue: 1 Pages: 870753-870753
- DOI
  10.1093/ecam/nep024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782, KAKENHI-PROJECT-21700773
[Journal Article] Antiangiogenic effects of Indole-3-carbinol and 3, 3'-Diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC2010
- Author(s)
  Kunimasa K, et al.
- Journal Title
  
  J Nutr 140
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782
[Journal Article] Antiangiogenic effects of indole-3-carbinol and 3, 3'-diindolylmethane are associated with their differential regulation of extracellular signal-regulated kinase 1/2 and Akt in tube-forming human umbilical vein endothelial cells2010
- Author(s)
  K.Kunimasa, et al.
- Journal Title
  
  The Journal of Nutrition 1
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo.2010
- Author(s)
  Kunimasa K., et al.
- Journal Title
  
  Cancer Sci.
  
  Volume: 101 Pages: 2462-9
- NAID
  10027833899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] High susceptibility of obese hypertensive SHRSP.Z-Lepr^<fa>/IzmDmcr rats to lipid deposition in the mesenteric artery.2010
- Author(s)
  Kunimasa K., et al.
- Journal Title
  
  Clin.Exp.Pharmacol.Physiol.
  
  Volume: 37 Pages: 1102-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions_and angiogenesis in vivo.2010
- Author(s)
  Kunimasa K, et al.
- Journal Title
  
  Cancer Sci.
  
  Volume: 101(11) Pages: 2462-2469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782
[Journal Article] Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model2010
- Author(s)
  Eguchi R, Fujimori Y, Ohta T, Kunimasa K, Nakano T
- Journal Title
  
  Int J Oncol
  
  Volume: 37(5) Pages: 1289-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] High susceptibility of obese hypertensive SHRSP.Z-Lepr(fa) /IzmDmcr rats to lipid deposition in the mesenteric artery2010
- Author(s)
  Kunimasa K, Yoshitomi H, Miura C, Mori H, Tsuchikura S, Ikeda K, Gao M, Yamori Y, Mori M
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 37(11) Issue: 11 Pages: 1102-4
- DOI
  10.1111/j.1440-1681.2010.05440.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model.2010
- Author(s)
  Eguchi R., Kunimasa K., (4番目), et al.
- Journal Title
  
  Int.J.Oncol.
  
  Volume: 37 Pages: 1289-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700773
[Journal Article] Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo2010
- Author(s)
  Kunimasa K, Ikekita M, Sato M, Ohta T, Yamori Y, Ikeda M, Kuranuki S, Oikawa T.
- Journal Title
  
  Cancer Sci
  
  Volume: 101(11) Issue: 11 Pages: 2462-9
- DOI
  10.1111/j.1349-7006.2010.01668.x
- NAID
  10027833899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782, KAKENHI-PROJECT-21590598, KAKENHI-PROJECT-21700773
[Journal Article] Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC.2010
- Author(s)
  Kunimasa K, Kobayashi T, Kaji K, Ohta T.
- Journal Title
  
  J Nutr
  
  Volume: 140(1) Issue: 1 Pages: 1-6
- DOI
  10.3945/jn.109.112359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500782, KAKENHI-PROJECT-21700773
[Presentation] 1.Inhibitory effects of mubritinib, a novel UPR inhibitor, on mitochondrial respiratory chain2020
- Author(s)
  國政和宏, 塚原里美, 冨田章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07309
[Presentation] 膵がん細胞株におけるグルコース飢餓下でのミトコンドリア機能の重要性2018
- Author(s)
  國政和宏、冨田章弘
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07309
[Presentation] ミトコンドリア機能はグルコース飢餓下での膵がん細胞の生存に必須である2018
- Author(s)
  國政和宏、塚原里美、冨田章弘
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07309
[Presentation] Selective cancer cell killing by spautin-1, a USP10/USP13 inhibitor, under glucose starvation2016
- Author(s)
  Kazuhiro Kunimasa, Masaru Koido, Chika Ikeda, Satomi Tsukahara, Junko Sakurai, Shingo Dan, Takao Yamori, Akihiro Tomida
- Organizer
  AACR-JCA 10th Joint Conference
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430120
[Presentation] Antiangiogenic properties of resveratrol dimers isolated from ethanol extract of melinjo (Gnetum gnemon L.) seed.2010
- Author(s)
  Kunimasa K., et al.
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700773
[Presentation] Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model.2010
- Author(s)
  Eguchi R., Kunimasa K., (4番目), et al.
- Organizer
  第18回日本血管生物医学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700773
[Presentation] Antiangiogenic properties of resveratrol dimers isolated from ethanol extract of melinjo (Gnetum gnemon L.) seed2010
- Author(s)
  Kunimasa K, Eguchi R, Ohta T
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700773
[Presentation] Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model2010
- Author(s)
  Eguchi R, Fujimori Y, Ohta T, Kunimasa K, Nakano T
- Organizer
  第18回日本血管生物医学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700773
[Presentation] Obese Hypertensive SHR.Cg-Lepr^<cp>/NDmcr and SHRSP.Z-Lepr^<fa>/IzmDmcr as Models for Atherosclerotic Disease.2010
- Author(s)
  Kunimasa K., et al.
- Organizer
  The 6^<th> International Congress of Pathophysiology and the 14^<th> International SHR Symposium
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-21700773
[Presentation] High susceptibility of obese hypertensive SHRSP.Z-Lepr^<fa>/IzmDmcr rats to lipid deposition in the mesenteric artery.2010
- Author(s)
  Kunimasa K., et al.
- Organizer
  第18回日本血管生物医学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700773

1. OHTA Toshiro (40285193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. KUMAZAWA Shigenori (10295561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. TOMIDA AKIHIRO (40251483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 加藤優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 杉本芳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中村一基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUNIMASA Kazuhiro 國政 和宏

Research Projects

Research Products

Co-Researchers

薬剤感受性及びオミクスデータを用いたミトコンドリア代謝脆弱性因子の同定と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of oncogenic mutation-associated resistance to endoplasmic reticulum stresses and their applications to cancer chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and characterization of mitochondrial regulators modulating the unfolded protein responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cancer Preventive Effects of Resveratrol Oligomer-Rich Food Factors with an Antiangiogenic ActivityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/22011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiangiogenic effects of Indole-3-carbinol and 3, 3'-Diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC2010

KUNIMASA Kazuhiro 國政和宏