TAKAHASHI Harumi 高橋晴美

Researcher Number	50546489
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 神戸大学, 医学研究科, 特命准教授 2018: 神戸大学, 医学研究科, 特命講師 2017: 神戸大学, 医学研究科, 医学研究員 2016: 神戸大学, 医学研究科, 特命講師 2015: 神戸大学, 医学(系)研究科(研究院), 講師 … More 2014 – 2015: 神戸大学, 医学(系)研究科(研究院), 特命講師 2013: 神戸大学, 医学(系)研究科(研究院), 学術推進研究員 2012: 神戸大学, 医学(系)研究科(研究院), 研究員 2012: 神戸大学, 大学院・医学研究科, 学術推進研究員 2010 – 2011: 神戸大学, 医学研究科, 学術推進研究員 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics / General physiology
Keywords	Principal Investigator cAMP / 糖尿病 / Epac2 / 膵β細胞 / インスリン分泌 / インクレチン / 膵島 / Epac2A / グルタミン酸 / スルホニル尿素薬 … More Except Principal Investigator … More インクレチン / インスリン分泌 / グルタミン酸 / 膵β細胞 / 糖尿病 / エネルギー・糖質代謝異常 / 安定同位体 / 膵島 / モデル動物 / プロテオミクス / グルタミン酸トランスポーター / 血糖値 / 開口分泌 / 開口放出 / インクレチン分泌 / 分泌顆粒 / インスリン / 腸管内分泌細胞 / GIP / GLP-1 Less

The role of Epac2/Rap1 signaling in the three-dimensional construction of pancreatic isletsPrincipal Investigator
- Principal Investigator
  
  Takahashi Harumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kobe University
Mechanism of the regulation of insulin granule exocytosis by glutamate signaling in beta-cells
- Principal Investigator
  
  Bughra Abdughupur
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kobe University
The role of Epac2A/Rap1 signaling in the protection of pancreatic beta-cellPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Harumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
The physiological and pathophysiological roles of glutamate signaling in pancreatic beta-cell
- Principal Investigator
  
  GHENI Ghupurjan
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
The role of Noc2 in incretin secretion
- Principal Investigator
  
  Shibasaki Tadao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kobe University
The role of glutamate signaling in amplification of insulin secretion by cAMPPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI HARUMI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
The Role of Epac2 as a new target of sulfonylurea drugsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Harumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] Annual Review糖尿病・代謝・内分泌分担執筆「膵β細胞におけるEpac2Aの役割」2012
- Author(s)
  高橋晴美, 他
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] Increased glycolysis affects β-cell function and identity in aging and diabetes2022
- Author(s)
  Murao N, Yokoi N, Takahashi H, Hayami T, Minami Y, Seino S
- Journal Title
  
  Mol Metabolism
  
  Volume: 55 Pages: 101014-101014
- DOI
  10.1016/j.molmet.2021.101414
- NAID
  120007188923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-21H02390
[Journal Article] O-GlcNAcylation of myocyte-specific enhancer factor 2D negatively regulates insulin secretion from pancreatic β-cells2022
- Author(s)
  Yoshida M, Yokoi N, Takahashi H, Hatano N, Hayami T, Ogawa W, Seino S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 605 Pages: 90-96
- DOI
  10.1016/j.bbrc.2022.03.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-21H02390
[Journal Article] インスリン分泌機構－糖尿病の膵β細胞におけるGタンパク質シグナル変換の意義2021
- Author(s)
  高橋晴美、オドゥオリ　オケチ、清野　進
- Journal Title
  
  医学のあゆみ
  
  Volume: 276(5) Pages: 364-370
- Data Source
  KAKENHI-PROJECT-19K07400
[Journal Article] Glutamate is an essential mediator in glutamine‐amplified insulin secretion2021
- Author(s)
  Han Guirong、Takahashi Harumi、Murao Naoya、Gheni Ghupurjan、Yokoi Norihide、Hamamoto Yoshiyuki、Asahara Shun‐ichiro、Seino Yutaka、Kido Yoshiaki、Seino Susumu
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: - Issue: 6 Pages: 920-930
- DOI
  10.1111/jdi.13497
- NAID
  120007097043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-21H02390, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] インスリン分泌機構－糖尿病の膵β細胞におけるGタンパク質シグナル変換の意義2021
- Author(s)
  高橋晴美、オドゥオリ　オケチ、清野　進
- Journal Title
  
  医学のあゆみ
  
  Volume: 276(5) Pages: 364-370
- Data Source
  KAKENHI-PROJECT-19K09026
[Journal Article] Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: a study of ZFDM rat.2020
- Author(s)
  Hayami T, Yokoi N, Yamaguchi T, Honda K, Murao N, Takahashi H, Wang S, Seino Y, Kamiya H, Yabe D, Sweet IR, Mizoguchi A, Nakamura J, Seino S
- Journal Title
  
  J Diabetes Investig
  
  Volume: - Issue: 6 Pages: 1434-1447
- DOI
  10.1111/jdi.13272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-18H02864, KAKENHI-PROJECT-17K09825, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-19K09990
[Journal Article] Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes2020
- Author(s)
  Oduori Okechi S.、Murao Naoya、Shimomura Kenju、Takahashi Harumi、Zhang Quan、Dou Haiqiang、Sakai Shihomi、Minami Kohtaro、Chanclon Belen、Guida Claudia、Kothegala Lakshmi、Tol? Johan、Maejima Yuko、Yokoi Norihide、Minami Yasuhiro、Miki Takashi、Rorsman Patrik、Seino Susumu
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 12 Pages: 6639-6655
- DOI
  10.1172/jci140046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07281, KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-20K08865, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-18K08483
[Journal Article] Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells2019
- Author(s)
  Carmean Christopher M.、Yokoi Norihide、Takahashi Harumi、Oduori Okechi S.、Kang Christie、Kanagawa Akiko、Kirkley Andrew G.、Han Guirong、Landeche Michael、Hidaka Shihomi、Katoh Miki、Sargis Robert M.、Seino Susumu
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 316 Issue: 3 Pages: E464-E474
- DOI
  10.1152/ajpendo.00302.2018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02864, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-17K09831
[Journal Article] Glutamate as intracellular and extracellular signals in pancreatic islet functions2019
- Author(s)
  Takahashi H, Yokoi N, Seino S
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 6 Pages: 246-260
- DOI
  10.2183/pjab.95.017
- NAID
  130007662352
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-06-11
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-18H02864
[Journal Article] Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.2019
- Author(s)
  Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q
- Journal Title
  
  J Gen Physiol
  
  Volume: 151(9) Issue: 9 Pages: 1094-1115
- DOI
  10.1085/jgp.201912351
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400, KAKENHI-PROJECT-19K09026, KAKENHI-PROJECT-18H02864
[Journal Article] Characteristics of repaglinide effects on insulin secretion.2018
- Author(s)
  Takahashi H, Hidaka S, Seki C, Yokoi N, Seino S.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 828 Pages: 52-59
- DOI
  10.1016/j.ejphar.2018.03.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-15K08176
[Journal Article] Activation of GLP-1 receptor signaling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome.2018
- Author(s)
  Kondo M, Tanabe K, Amo-Shiinoki K, Hatanaka M, Morii T, Takahashi H, Seino S, Yamada Y, Tanizawa Y
- Journal Title
  
  Diabetologia
  
  Volume: 61 Issue: 10 Pages: 2189-2201
- DOI
  10.1007/s00125-018-4679-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08516, KAKENHI-PROJECT-18H02864, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09752
[Journal Article] Inhibition of SNAT5 Induces Incretin-Responsive State From Incretin-Unresponsive State in Pancreatic β-Cells: Study of β-Cell Spheroid Clusters as a Model2018
- Author(s)
  Hashim Mahira、Yokoi Norihide、Takahashi Harumi、Gheni Ghupurjan、Okechi Oduori S.、Hayami Tomohide、Murao Naoya、Hidaka Shihomi、Minami Kohtaro、Mizoguchi Akira、Seino Susumu
- Journal Title
  
  Diabetes
  
  Volume: 67 Issue: 9 Pages: 1795-1806
- DOI
  10.2337/db17-1486
- NAID
  40022150466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-18H02364, KAKENHI-PROJECT-18H02864, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751
[Journal Article] Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion.2017
- Author(s)
  Murao N, Yokoi N, Honda K, Han G, Hayami T, Gheni G, Takahashi H, Minami K, Seino S.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 11 Pages: e0187213-e0187213
- DOI
  10.1371/journal.pone.0187213
- NAID
  120006373802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-15K08176
[Journal Article] β-cell signaling and insulin secretagogues: a path for improved diabetes therapy.2017
- Author(s)
  Seino S, Sugawara K, Yokoi N, Takahashi H
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09749
[Journal Article] β-cell signaling and insulin secretagogues: a path for improved diabetes therapy2017
- Author(s)
  Seino S, Sugawara K, Yokoi N, Takahashi H
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 印刷中 Issue: S1 Pages: 22-29
- DOI
  10.1111/dom.12995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K09751, KAKENHI-PROJECT-17K09831, KAKENHI-PROJECT-16K19537, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-15K08176
[Journal Article] β-cell signaling and insulin secretagogues: a path for improved diabetes therapy.2017
- Author(s)
  Seino S, Sugawara K, Yokoi N, Takahashi H
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08176
[Journal Article] Beta-cell Glutamate Signaling: Its role in incretin-induced insulin secretion.2016
- Author(s)
  Yokoi N., Gheni G., Takahashi H., Seino S.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 7 Pages: 38-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09751
[Journal Article] A novel diphenylthiosemicarbazide is a potential insulin secretagogue for anti-diabetic agent2016
- Author(s)
  Sugawara k, Honda K, Reien Y, Yokoi N, Seki C, Takahashi H, Minami K, Mori I, Matsumoto A, Nakaya H, Seino S
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0164785-e0164785
- DOI
  10.1371/journal.pone.0164785
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-26460334, KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-15K08176, KAKENHI-PROJECT-16K09749, KAKENHI-PROJECT-16K15315, KAKENHI-PROJECT-16K19537
[Journal Article] Beta-cell gulutamate signaling: Its role in incretin-induced insulin secretion.2016
- Author(s)
  Yokoi N, Gheni G, Takahashi H, Seino S
- Journal Title
  
  J Diabet Investig
  
  Volume: 7 Issue: S1 Pages: 38-43
- DOI
  10.1111/jdi.12468
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06800, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-15K08176, KAKENHI-PROJECT-16K09749
[Journal Article] Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion.2015
- Author(s)
  Takahashi H, Shibasaki T, Park JH, Hidaka S, Takahashi T, Ono A, Song DK, Seino S.
- Journal Title
  
  Diabetes
  
  Volume: 64 Issue: 4 Pages: 1262-1272
- DOI
  10.2337/db14-0576
- NAID
  40020753234
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-24229007
[Journal Article] インクレチンとスルホニル尿素薬の併用によるインスリン分泌増強におけるEpac2Aシグナルの役割2015
- Author(s)
  柴崎忠雄、高橋晴美、清野進
- Journal Title
  
  最新医学　増刊号　糖尿病と合併症（前篇）糖尿病
  
  Volume: 70 Pages: 473-497
- Data Source
  KAKENHI-PROJECT-15K08176
[Journal Article] cAMPとスルホニル尿素薬の相互作用によるEpac2Aの活性化とそのインスリン分泌における役割2015
- Author(s)
  髙橋晴美、高橋利匡、柴崎忠雄、清野　進
- Journal Title
  
  Annual Review 2015糖尿病・代謝・内分泌
  
  Volume: - Pages: 5-11
- Data Source
  KAKENHI-PROJECT-25461351
[Journal Article] Structure and functional roles of Epac2 (Rapgef4)2015
- Author(s)
  Sugawara K, Shibasaki T, Takahashi H, Seino S
- Journal Title
  
  Gene
  
  Volume: 505 Issue: 2 Pages: 577-583
- DOI
  10.1016/j.gene.2015.09.029
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25860749, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-16K09749
[Journal Article] Liraglutide improves pancreatic beta cell mass and function in alloxan-induced diabetic mice2015
- Author(s)
  Tamura K, Minami K, Kudo M, Iemoto K, Takahashi H, Seino S
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: e0126003-e0126003
- DOI
  10.1371/journal.pone.0126003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-25461351
[Journal Article] Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion2014
- Author(s)
  Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S
- Journal Title
  
  Cell Rep
  
  Volume: 9 Issue: 2 Pages: 661-673
- DOI
  10.1016/j.celrep.2014.09.030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24500491, KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-24591330, KAKENHI-PROJECT-25293210, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25640022, KAKENHI-PROJECT-25860749, KAKENHI-PROJECT-26430143
[Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin2013
- Author(s)
  Asahara S
- Journal Title
  
  Diabetologia
  
  Volume: なし Issue: 5 Pages: 1088-1097
- DOI
  10.1007/s00125-013-2849-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300106, KAKENHI-PROJECT-22790860, KAKENHI-PROJECT-23300274, KAKENHI-PROJECT-23650214, KAKENHI-PROJECT-23700832, KAKENHI-PUBLICLY-24116526, KAKENHI-PROJECT-24591348, KAKENHI-PROJECT-24650487, KAKENHI-PROJECT-24657140, KAKENHI-PUBLICLY-25126729, KAKENHI-PROJECT-25461351
[Journal Article] Actin dynamics regulated by the balance of neuronal wiskott-aldrich syndrome protein (N-WASP) and cofilin activities detelmines the biphasic response of glucose-induced insulin secretion2013
- Author(s)
  Uenishi E, Shibasaki T, Takahashi H, Seki C, Hamaguchi H, Yasuda T, Tatebe M, Oiso, Y, Takenawa T, Seino S.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 36 Pages: 25851-25864
- DOI
  10.1074/jbc.m113.464420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02766, KAKENHI-PROJECT-23227005, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-25461351
[Journal Article] Antidiabetic Sulfonylureas and cAMP cooperatively activate Epac2A.2013
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S
- Journal Title
  
  Sci Signal
  
  Volume: 6 Issue: 298
- DOI
  10.1126/scisignal.2004581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24590320, KAKENHI-PROJECT-25461351, KAKENHI-PROJECT-25860749
[Journal Article] Treating Diabetes today : a matter of selectivity of sulfonylureas2012
- Author(s)
  Seino S, et al
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 14 Issue: s1 Pages: 9-13
- DOI
  10.1111/j.1463-1326.2011.01507.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249057, KAKENHI-PROJECT-21590308, KAKENHI-PROJECT-22790860
[Journal Article] 膵β細胞における Epac2Aの役割 Annual Review 糖尿病・代謝・内分泌 20122012
- Author(s)
  高橋晴美、柴崎忠雄、清野進
- Journal Title
  
  中外医学社
  
  Pages: 4-9
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インスリン分泌におけるEpac2Aの役割2011
- Author(s)
  高橋晴美, 他
- Journal Title
  
  Diabetes Journal
  
  Volume: 39 Pages: 151-157
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インスリン分泌における Epac2Aの役割 Diabetes Journal2011
- Author(s)
  高橋晴美、柴崎忠雄、清野進
- Journal Title
  
  協和企画
  
  Volume: 第39巻第4号 Pages: 151-157
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] 新規標的分子Epac:インスリン分泌におけるEpac2Aの役割2011
- Author(s)
  高橋晴美, 他
- Journal Title
  
  月刊Mebio
  
  Volume: 4 Pages: 132-139
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] 新規標的分子Epac:インスリン分泌における Epac2Aの役割 Mebio2011
- Author(s)
  高橋晴美、柴崎忠雄、清野進
- Journal Title
  
  メジカルビュー社
  
  Volume: Vol.28 No.4 Pages: 132-139
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インクレチンによるインスリン分泌増強機構2010
- Author(s)
  高橋晴美, 他
- Journal Title
  
  医学のあゆみ他
  
  Volume: 233 Pages: 346-351
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インクレチンの膵島作用:膵β細胞2010
- Author(s)
  高橋晴美, 他
- Journal Title
  
  月刊糖尿病他
  
  Volume: 14 Pages: 18-25
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インクレチンによるインスリン分泌増強機構2010
- Author(s)
  高橋晴美、柴崎忠雄、藤本和歌子、清野進
- Journal Title
  
  医学のあゆみ医歯薬出版株式会社
  
  Volume: 第233巻第5号 Pages: 341-345
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] インクレチンの膵β細胞におけるインスリン分泌増強機構2010
- Author(s)
  高橋晴美、柴崎忠雄、藤本和歌子、清野進
- Journal Title
  
  月刊糖尿病別冊インクレチン医学出版
  
  Volume: 第2巻第2号 Pages: 29-36
- Data Source
  KAKENHI-PROJECT-22790860
[Journal Article] Rim2a determines docking and priming states in insulin granule exocytosis2010
- Author(s)
  Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki JI, Miki T & Seino S
- Journal Title
  
  Cell Metab.
  
  Volume: 12 Issue: 2 Pages: 117-129
- DOI
  10.1016/j.cmet.2010.05.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249015, KAKENHI-PROJECT-22590970, KAKENHI-PROJECT-22790208, KAKENHI-PROJECT-22790860
[Journal Article] インクレチンの膵島作用:膵β細胞2010
- Author(s)
  高橋晴美、柴崎忠雄、藤本和歌子、清野進
- Journal Title
  
  月刊糖尿病医学出版
  
  Volume: 第2巻第7号 Pages: 18-25
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Improvements of hyperglycemia and insulin secretion by chronic imeglimin treatment in an obese diabetes model KK-Ay mice2021
- Author(s)
  権　映月、高橋晴美、村尾直哉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Metabolic Shift to Cytosolic NAD Production Regulates β-cell Function in Aging and Diabetes2021
- Author(s)
  Naoya Murao, Norihide Yokoi, Harumi Takahashi, Susumu Seino
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 細胞内NAD代謝の変容が膵β細胞老化を制御する -SAMP1, SAMR1系統を用いた検討-2021
- Author(s)
  村尾直哉，横井伯英，高橋晴美，清野　進
- Organizer
  第36回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] インクレチン応答性インスリン分泌障害に関与する候補タンパク質の同定2021
- Author(s)
  吉田　舞、横井伯英、波多野直哉、速水智英、高橋晴美、小川　渉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Metabolic Shift to Cytosolic NAD Production Regulates β-cell Function in Aging and Diabetes2021
- Author(s)
  Naoya Murao, Norihide Yokoi, Harumi Takahashi, Susumu Seino
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] インスリン分泌の分子機構の解明と今後の展望2021
- Author(s)
  高橋晴美、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] インスリン分泌の分子機構の解明と今後の展望2021
- Author(s)
  高橋晴美、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Gs/Gq signaling switch in diabetic β-cells2021
- Author(s)
  高橋晴美、オドゥオリ　オケチ、村尾直哉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Gs/Gq signaling switch in diabetic β-cells2021
- Author(s)
  高橋晴美、オドゥオリ　オケチ、村尾直哉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Improvements of hyperglycemia and insulin secretion by chronic imeglimin treatment in an obese diabetes model KK-Ay mice2021
- Author(s)
  権　映月、高橋晴美、村尾直哉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 細胞内NAD代謝の変容が膵β細胞老化を制御する2021
- Author(s)
  村尾直哉、横井伯英、高橋晴美、清野進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 細胞内NAD代謝の変容が膵β細胞老化を制御する2021
- Author(s)
  村尾直哉、横井伯英、高橋晴美、清野進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 細胞内NAD代謝の変容が膵β細胞老化を制御する -SAMP1, SAMR1系統を用いた検討-2021
- Author(s)
  村尾直哉，横井伯英，高橋晴美，清野　進
- Organizer
  第36回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] インクレチン応答性インスリン分泌障害に関与する候補タンパク質の同定2021
- Author(s)
  吉田　舞、横井伯英、波多野直哉、速水智英、高橋晴美、小川　渉、清野　進
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] グルタミンによるインスリン分泌増強機構の解明2020
- Author(s)
  韓　桂栄、高橋晴美、村尾直哉、ゲニ　グプルジャン、太田新菜、浜本芳之、清野　裕、横井伯英、木戸良明、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 肥満糖尿病の膵島における、タンパク質のO-結合型糖鎖修飾に関連したインクレチン応答性障害の機序の解明2020
- Author(s)
  吉田　舞，横井伯英，速水智英，高橋晴美，小川　渉，清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 耐糖能ならびに膵β細胞機能の加齢性変化の解明2020
- Author(s)
  村尾直哉、横井伯英、速水智英、高橋晴美、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] SGLT2阻害薬が全身の糖代謝に及ぼす影響の検討2020
- Author(s)
  横井伯英、高橋晴美、清野進
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] SGLT阻害剤の全身の糖代謝に及ぼす作用の解明2020
- Author(s)
  横井伯英、高橋晴美、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満糖尿病の膵島におけるインクレチン応答性障害の発症機序2020
- Author(s)
  速水智英、横井伯英、吉田舞、本田洸平、高橋晴美、神谷英紀、溝口明、中村二郎、清野進
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 耐糖能ならびに膵β細胞機能の加齢性変化の解明2020
- Author(s)
  村尾直哉、横井伯英、速水智英、高橋晴美、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満糖尿病の膵島におけるインクレチン応答性障害の発症機序2020
- Author(s)
  速水智英、横井伯英、吉田舞、本田洸平、高橋晴美、神谷英紀、溝口明、中村二郎、清野進
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 耐糖能および膵β細胞機能の加齢性変化の解明 -SAMP1, SAMR1, B6J系統を用いた検討-2020
- Author(s)
  村尾直哉，横井伯英，高橋晴美，清野　進
- Organizer
  第35回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満糖尿病の膵島における、タンパク質のO-結合型糖鎖修飾に関連したインクレチン応答性障害の機序の解明2020
- Author(s)
  吉田　舞，横井伯英，速水智英，高橋晴美，小川　渉，清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 新規Epac2アイソフォームの同定とその膵β細胞機能における役割2020
- Author(s)
  高橋晴美、藤原結花、堰千紘、横井伯英、清野進
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 耐糖能および膵β細胞機能の加齢性変化の解明 -SAMP1, SAMR1, B6J系統を用いた検討-2020
- Author(s)
  村尾直哉，横井伯英，高橋晴美，清野　進
- Organizer
  第35回老化促進モデルマウス（SAM）学会学術大会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 新規Epac2アイソフォームの膵β細胞機能における役割2020
- Author(s)
  高橋晴美、藤原結花、堰　千紘、横井伯英、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] グルタミンによるインスリン分泌増強機構の解明2020
- Author(s)
  韓　桂栄、高橋晴美、村尾直哉、ゲニ　グプルジャン、太田新菜、浜本芳之、清野　裕、横井伯英、木戸良明、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 新規Epac2アイソフォームの膵β細胞機能における役割2020
- Author(s)
  高橋晴美、藤原結花、堰　千紘、横井伯英、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 膵島機能の加齢性変化の解明－B6マウスならびに老化促進モデルマウスを用いた検討－2020
- Author(s)
  村尾直哉、横井伯英、速水智英、高橋晴美、清野進
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] SGLT阻害剤の全身の糖代謝に及ぼす作用の解明2020
- Author(s)
  横井伯英、高橋晴美、清野　進
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 新規インスリン分泌促進薬シード化合物の同定とその作用機序の解明2019
- Author(s)
  村尾直哉、菅原健二、Okechi S Oduori、Christopher M Carmean、横井伯英、高橋晴美、清野進
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Role of glutamine/glutamate signaling in insulin secretion.2019
- Author(s)
  Guirong Han, Harumi Takahashi, Norihide Yokoi, Ghupurjan Gheni, Naoya Murao, Yutama Seino, Yoshiyuki Hamamoto, Yoshiaki Kido, Susumu Seino
- Organizer
  The 11thScientific Meeting of the AASD in conjunction with The 62nd Annual Meeting of the Japan Diabetes Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] How can we improve insulin secretion of diabetic-beta-cells?2019
- Author(s)
  Susumu Seino, Naoya Murao, Harumi Takahashi, Okechi S Oduori
- Organizer
  International Diabetes Federation Congress 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満糖尿病における膵島機能不全の機序の解明2019
- Author(s)
  吉田舞, 横井伯英, 速水智英, 川畑綾子, 高橋晴美, 小川渉, 清野進
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Elucidation of genetic factors and pathogenesis of obese diabetes: Study of ZFDM rat.2019
- Author(s)
  Norihide Yokoi, Tomohide Hayami, Mai Yoshida, Harumi Takahashi, Yukio Taniguchi, Susumu Seino
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 膵β細胞に発現する新たなEpac2アイソフォームとその特異的な役割2019
- Author(s)
  高橋晴美、藤原結花、堰千紘、横井伯英、清野進
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Enhanced β-cell Gq signal underlies improved insulin secretion and glucose tolerance by GLP-1 in Kir6.2 KO diabetic mice.2019
- Author(s)
  Okechi S Oduori，Kenju Shimomura，Harumi Takahashi，Shihomi Hidaka，Naoya Murao，Norihide Yokoi，Susumu Seino
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] 肥満２型糖尿病における肥大膵島は未分化細胞や癌細胞に類似した代謝様式に変化し、インクレチン応答性障害を呈する2019
- Author(s)
  速水智英,　横井伯英,　本田洸平, 高橋晴美,　神谷英紀,　溝口明,　中村二郎, 　清野進
- Organizer
  第33回糖尿病・肥満動物学会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Role of glutamine/glutamate signaling in insulin secretion.2019
- Author(s)
  Guirong Han, Harumi Takahashi, Norihide Yokoi, Ghupurjan Gheni, Naoya Murao, Yutaka Seino, Yoshiyuki Hamamoto, Yoshiaki Kido, Susumu Seino
- Organizer
  The 11th Scientific Meeting of the AASD in conjunction with The 62nd Annual Meeting of the Japan Diabetes Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Age-associated changes of glucose tolerance and pancreatic islet function in mice.2019
- Author(s)
  Naoya Murao, Norihide Yokoi, Tomohide Hayami, Okechi S Oduori, Yingyue Quan, Harumi Takahashi, Susumu Seino
- Organizer
  International Diabetes Federation Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満２型糖尿病における肥大膵島は未分化細胞や癌細胞に類似した代謝様式に変化し、インクレチン応答性障害を呈する2019
- Author(s)
  速水智英,　横井伯英,　本田洸平, 高橋晴美,　神谷英紀,　溝口明,　中村二郎, 　清野進
- Organizer
  第33回糖尿病・肥満動物学会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Enhanced beta-cell Gq signaling underlies improved insulin secretion and glucose tolerance by GLP-1 in beta-cell-specific Kir6.2 knockout diabetic mice2019
- Author(s)
  Naoya Murao, Oduori S. Okechi, Kenju Shimomura, Harumi Takahashi, Norihide Yokoi, Susumu Seino
- Organizer
  20th Servier-IGIS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Tumor-like metabolic feature of enlarged pancreatic islets underlies incretin unresponsiveness in obese type 2 diabetes.2019
- Author(s)
  Tomohide Hayami, Norihide Yokoi, Kohei Honda, Harumi Takahashi, Hideki Kamiya, Akira Mizoguchi, Jiro Nakamura, Susumu Seino
- Organizer
  The 11th Scientific Meeting of the AASD in conjunction with The 62nd Annual Meeting of the Japan Diabetes Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Tumor-like metabolic feature of enlarged pancreatic islets underlies incretin unresponsiveness in obese type 2 diabetes.2019
- Author(s)
  Tomohide Hayami, Norihide Yokoi, Kohei Honda, Harumi Takahashi, Hideki Kamiya, Akira Mizoguchi, Jiro Nakamura, Susumu Seino
- Organizer
  The 11thScientific Meeting of the AASD in conjunction with The 62nd Annual Meeting of the Japan Diabetes Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Enhanced β-cell Gq signal underlies improved insulin secretion and glucose tolerance by GLP-1 in Kir6.2 KO diabetic mice.2019
- Author(s)
  Okechi S Oduori，Kenju Shimomura，Harumi Takahashi，Shihomi Hidaka，Naoya Murao，Norihide Yokoi，Susumu Seino
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] 肥満糖尿病における膵島機能不全の機序の解明2019
- Author(s)
  吉田舞, 横井伯英, 速水智英, 川畑綾子, 高橋晴美, 小川渉, 清野進
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Role of glutamate signaling in insulin secretion.2019
- Author(s)
  Norihide Yokoi, Harumi Takahashi, Susumu Seino
- Organizer
  第62回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Role of glutamate signaling in insulin secretion.2019
- Author(s)
  Norihide Yokoi, Harumi Takahashi, Susumu Seino
- Organizer
  第62回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Enhanced beta-cell Gq signaling underlies improved insulin secretion and glucose tolerance by GLP-1 in beta-cell-specific Kir6.2 knockout diabetic mice2019
- Author(s)
  Naoya Murao, Oduori S. Okechi, Kenju Shimomura, Harumi Takahashi, Norihide Yokoi, Susumu Seino
- Organizer
  20th Servier-IGIS Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] How can we improve insulin secretion of diabetic-beta-cells?2019
- Author(s)
  Susumu Seino, Naoya Murao, Harumi Takahashi, Okechi S Oduori
- Organizer
  International Diabetes Federation Congress 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09026
[Presentation] Role of Noc2 in incretin exocytosis2019
- Author(s)
  Harumi Takahashi
- Organizer
  2019 Asia Islet Biology & Incretin Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] Elucidation of genetic factors and pathogenesis of obese diabetes: Study of ZFDM rat.2019
- Author(s)
  Norihide Yokoi, Tomohide Hayami, Mai Yoshida, Harumi Takahashi, Yukio Taniguchi, Susumu Seino
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07400
[Presentation] GLP-1 receptor agonists and DPP-4 inhibitors both normalize diabetes caused by deletion of β-cell KATP_channels in mice2018
- Author(s)
  Oduori S. Okechi, Harumi Takahashi, Norihide Yokoi, Kohtaro Minami, Yuko Maejima, Kenju Shimomura, Susumu Seino
- Organizer
  The 61st Annual Meeting of the Japan Diabetes Society
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Enhanced Gs- and Gq-signals in β-cells contributes to normalization of glucose tolerance and insulin secretion in β-cell specific Kir6.22018
- Author(s)
  Okechi S. Oduori, Kohtaro Minami, Norihide Yokoi, Harumi Takahashi, Takashi Miki, Yuko Maejima, Kenju Shimomura, Susumu Seino
- Organizer
  Keytsone symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] ZFDMラットにおけるインクレチン応答性インスリン分泌障害機序―オミクス解析による検討2018
- Author(s)
  速水智英、横井伯英、本田洸平、マヒラアシム、高橋晴美、清野進
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Enhanced Gs- and Gq-signals in β-cells contributes to normalization of glucose tolerance and insulin secretion in β-cell specific Kir6.22018
- Author(s)
  Okechi S. Oduori, Kohtaro Minami, Norihide Yokoi, Harumi Takahashi, Takashi Miki, Yuko Maejima, Kenju Shimomura, Susumu Seino
- Organizer
  Keytsone symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] 肥満糖尿病におけるインクレチン応答性インスリン分泌障害機序の解明2018
- Author(s)
  速水智英, 横井伯英, マヒラアシム, 高橋晴美, 清野進
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] The mechanism of impaired incretin responsiveness in the pancreatic islets of obese type 2 diabetes: A study of the ZFDM rat2018
- Author(s)
  Norihide Yokoi, Tomohide Hayami, Shihomi Hidaka, Ayako Kawabata, Harumi Takahashi, Susumu Seino
- Organizer
  The 54th EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 肥満2型糖尿病では肥大した膵島における糖代謝異常とO-GlcNAc化の亢進がインクレチン応答性インスリン分泌障害を引き起こす2018
- Author(s)
  横井　伯英、速水　智英、吉田　舞、高橋　晴美、清野　進
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] The mechanism of impaired incretin responsiveness in the pancreatic islets of obese type 2 diabetes: A study of the ZFDM rat2018
- Author(s)
  Norihide Yokoi, Tomohide Hayami, Shihomi Hidaka, Ayako Kawabata, Harumi Takahashi, Susumu Seino
- Organizer
  The 54th EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] 肥満糖尿病の膵島におけるインクレチン応答性障害-オミクス解析による検討-2018
- Author(s)
  速水智英, 横井伯英, 日高志保美, 川畑綾子, グプルジャンゲニ, マヒラアシム, 高橋晴美, 神谷英紀, 清野裕, 中村二郎, 清野進
- Organizer
  61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 膵β細胞のインクレチン応答性獲得におけるアミノ酸トランスポーターSNAT5の役割2018
- Author(s)
  マヒラ　アシム、横井伯英、グプルジャン　ゲニ、金川章子、星川律子、高橋晴美、清野進
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] グルタミン-グルタミン酸シグナルによるインスリン分泌増強機構の解明2018
- Author(s)
  韓　桂栄、横井　伯英　グプルジャン　ゲニ、村尾　直哉、高橋晴美、清野　裕、木戸　良明、清野　進
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] GLP-1 receptor agonists and DPP-4 inhibitors both normalize diabetes caused by deletion of β-cell KATP_channels in mice2018
- Author(s)
  Oduori S. Okechi, Harumi Takahashi, Norihide Yokoi, Kohtaro Minami, Yuko Maejima, Kenju Shimomura, Susumu Seino
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] ZFDMラットにおけるインクレチン応答性インスリン分泌障害機序―オミクス解析による検討.2018
- Author(s)
  速水智英、横井伯英、本田洸平、マヒラアシム、高橋晴美、清野進.
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] ZFDMラットにおけるインクレチン応答性インスリン分泌障害機序―オミクス解析による検討.2018
- Author(s)
  速水智英、横井伯英、本田洸平、マヒラアシム、高橋晴美、清野進.
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] グルタミン-グルタミン酸シグナルによるインスリン分泌増強機構の解明2018
- Author(s)
  韓　桂栄、横井　伯英　グプルジャン　ゲニ、村尾　直哉、高橋晴美、清野　裕、木戸　良明、清野　進
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 肥満糖尿病の膵島におけるインクレチン応答性障害-オミクス解析による検討-2018
- Author(s)
  速水智英, 横井伯英, 日高志保美, 川畑綾子, グプルジャンゲニ, マヒラアシム, 高橋晴美, 神谷英紀, 清野裕, 中村二郎, 清野進
- Organizer
  61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] 膵β細胞のインクレチン応答性獲得におけるアミノ酸トランスポーターSNAT5の役割2018
- Author(s)
  マヒラ　アシム、横井伯英、グプルジャン　ゲニ、金川章子、星川律子、高橋晴美、清野進
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 肥満糖尿病におけるインクレチン応答性インスリン分泌障害機序の解明2018
- Author(s)
  速水智英, 横井伯英, マヒラアシム, 高橋晴美, 清野進
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 肥満2型糖尿病では肥大した膵島における糖代謝異常とO-GlcNAc化の亢進がインクレチン応答性インスリン分泌障害を引き起こす2018
- Author(s)
  横井　伯英、速水　智英、吉田　舞、高橋　晴美、清野　進
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Insulin secretagogues and their signaling mechanisms.2017
- Author(s)
  Harumi Takahashi, Kenji Sugawara, Norihide Yokoi, Susumu Seino.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] インクレチン応答性インスリン分泌増強機構の解明：インスリン顆粒内グルタミン酸の役割.2017
- Author(s)
  グプルジャン　ゲニ、横井　伯英、波多野　直哉、韓　桂栄、高橋　晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する新規分子の同定2017
- Author(s)
  マヒラ　アシム、横井伯英、グプルジャン　ゲニ、星川律子、高橋晴美、清野進
- Organizer
  第40回日本分子生物学学会年会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Impaired insulin secretion and severe glucose intolerance caused by deleting β-cell specific KATP channels.2017
- Author(s)
  Okechi OS, Minami K, Yokoi N, Takahashi H, Maejima Y, Shimomura K, Herrera PL, Seino S.
- Organizer
  The 9th AASD Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] インクレチン応答性インスリン分泌増強機構の解明：インスリン顆粒内グルタミン酸の役割.2017
- Author(s)
  5.グプルジャンゲニ、横井伯英、波多野直哉、韓桂栄、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Place of Presentation
  名古屋、日本
- Year and Date
  2017-05-18
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Beta-cell specific KATP Channel knockout mouse: diabetes, impaired insulin secretion and enhanced in cretin signalling.2017
- Author(s)
  Oduori O, Minami K, Takahashi H, Yokoi N, Herrera PL, Shimomura K, Seino S
- Organizer
  18th Servier-IGIS Symposium
- Place of Presentation
  St. Jean-Cap-Ferrat, France
- Year and Date
  2017-03-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Beta-cell specific KATP Channel knockout mouse: diabetes, impaired insulin secretion and enhanced incretin signalling.2017
- Author(s)
  Oduori O, Minami K, Takahashi H, Yokoi N, Herrera PL, Shimomura K, Seino S
- Organizer
  18th Servier-IGIS Symposium
- Place of Presentation
  St. Jean-Cap-Ferrat, France
- Year and Date
  2017-03-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Impaired insulin secretion and severe glucose intolerance caused by deleting β-cell specific KATP channels.2017
- Author(s)
  Okechi S. Oduori, Kohtara Minami, Norihide Yokoi, Harumi Takahashi, Yuko Maejima, Kenju Shimomura, Pedro Luis Herrera, Susumu Seino.
- Organizer
  The 9th Scientific Meeting of Asian Association for the Study of Diabetes.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] インクレチン応答性インスリン分泌増強機構の解明：インスリン顆粒内グルタミン酸の役割.2017
- Author(s)
  グプルジャンゲニ、横井伯英、波多野直哉、韓桂栄、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Incretin and beta-cell metabolic signaling.2017
- Author(s)
  横井　伯英、村尾　直哉、高橋　晴美、清野　進.
- Organizer
  第60回日本糖尿病学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Insulin secretagogues and their signaling mechanisms. シンポジウム15「インスリン分泌Update」2017
- Author(s)
  Takahashi H, Sugawara K, Yokoi N, Seino S.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Approaches to identification of novel small molecules that can be insulin secretagogues.2017
- Author(s)
  Harumi Takahashi, Kenji Sugawara, Kohei Honda, Norihide Yokoi, Ichiro Mori, Haruaki Nakaya, Susumu Seino.
- Organizer
  2nd Joint Meeting of the EASD Islet Study Group & Beta Cell Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Approaches to identification of novel small molecules that can be insulin secretagogues2017
- Author(s)
  Harumi Takahashi, Kenji Sugawara, Kohei Honda, Norihide Yokoi, Ichiro Mori, Haruaki Nakaya, Susumu Seino
- Organizer
  2nd Joint Meeting of the EASD Islet Study Group & Beta Cell Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Incretin and beta-cell metabolic signaling.2017
- Author(s)
  横井伯英、村尾直哉、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する新規分子の同定.2017
- Author(s)
  マヒラアシム、横井伯英、グプルジャンゲニ、星川律子、高橋晴美、清野進.
- Organizer
  第40回日本分子生物学学会年会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する新規分子の同定.2017
- Author(s)
  マヒラ　アシム、横井伯英、グプルジャン　ゲニ、星川律子、高橋晴美、清野進.
- Organizer
  第40回日本分子生物学学会年会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Incretin and beta-cell metabolic signaling2017
- Author(s)
  横井　伯英、村尾　直哉、高橋　晴美、清野　進
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] インクレチン応答性インスリン分泌増強機構の解明:インスリン顆粒内グルタミン酸の役割.2017
- Author(s)
  グプルジャンゲニ、横井伯英、波多野直哉、韓桂栄、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Formation of pseudoislets induces incretin responsiveness in incretin-unresponsive clonal beta-cells: Possible role of an amino acid transporter.2017
- Author(s)
  Yokoi N, Hashim M, Gheni G, Takahashi H, Seino S.
- Organizer
  The 53rd EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] グルタミンによるインスリン分泌増強機構の解明.2017
- Author(s)
  韓桂栄、グプルジャンゲニ、横井伯英、村尾直哉、高橋晴美、清野裕、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する分子の同定.2017
- Author(s)
  マヒラアシム、横井伯英、星川律子、グプルジャンゲニ、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] グルタミンによるインスリン分泌増強機構の解明.2017
- Author(s)
  韓　桂栄、グプルジャン　ゲニ、横井伯英、村尾直哉、高橋晴美、清野　裕、清野　進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] グルタミンによるインスリン分泌増強機構の解明.2017
- Author(s)
  韓　桂栄、グプルジャン　ゲニ、横井　伯英、村尾　直哉、高橋晴美、清野　裕、清野　進.
- Organizer
  第60回日本糖尿病学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する分子の同定.2017
- Author(s)
  マヒラ　アシム、横井伯英、星川律子、グプルジャン　ゲニ、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Impaired insulin secretion and severe glucose intolerance caused by deleting β-cell specific KATP channels.2017
- Author(s)
  Okechi S. Oduori, Kohtara Minami, Norihide Yokoi, Harumi Takahashi, Yuko Maejima, Kenju Shimomura, Pedro Luis Herrera, Susumu Seino.
- Organizer
  The 9th Scientific Meeting of Asian Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Insulin secretagogues and their signaling mechanisms.2017
- Author(s)
  Harumi Takahashi, Kenji Sugawara, Norihide Yokoi, Susumu Seino.
- Organizer
  第60回日本糖尿病学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得に関与する分子の同定.2017
- Author(s)
  マヒラ　アシム、横井伯英、星川律子、グプルジャン　ゲニ、高橋晴美、清野進.
- Organizer
  第60回日本糖尿病学会年次学術集会.
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Approaches to identification of novel small molecules that can be insulin secretagogues.2017
- Author(s)
  Harumi Takahashi, Kenji Sugawara, Kohei Honda, Norihide Yokoi, Ichiro Mori, Haruaki Nakaya, Susumu Seino.
- Organizer
  2nd Joint Meeting of the EASD Islet Study Group & Beta Cell Workshop.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Antidiabetic effect of a sulfur compound, trans-S-1-propenyl-l-cysteine sulfoxide, in Allium cepa.2016
- Author(s)
  Oduori OS, Sugawara K, Honda K, Takahashi H, Yokoi N, Nakayama M, Seino S
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Roles of KATP channels in brain-islet axis.2016
- Author(s)
  Susumu Seino, Harumi Takahashi
- Organizer
  21st EASD-Hagedorn Oxford Workshop
- Place of Presentation
  Oxford, UK
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Mechanisms of the induction of incretin/cAMP responsiveness in insulin secretion: study by pseudoislets.2016
- Author(s)
  M. Hashim, N. Yokoi, G. Gheny, R. Hoshikawa, H. Takahashi, S. Seino
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S
- Organizer
  17th Servier-IGIS Symposium
- Place of Presentation
  St. Jean-Cap-Ferrat, France
- Year and Date
  2016-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Mechanisms of the induction of incretin/cAMP responsiveness in insulin secretion: study by pseudoislets.2016
- Author(s)
  M. Hashim, N. Yokoi, G. Gheni, R. Hoshikawa, H. Takahashi, S. Seino
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Deletion of β-cell specific KATP channels causes severe glucose intolerance with impaired insulin secretion and enhanced incretin secretion.2016
- Author(s)
  O.S. Oduori, K. Minami, N. Yokoi, Y. Maejima, H. Takahashi, P.L. Herrera, K. Shimomura, S. Seino
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Antidiabetic effect of a sulfur compound trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa.2016
- Author(s)
  Okechi OS, Sugawara K, Takahashi H, Yokoi N, Nakayama M, Seino S
- Organizer
  The 76th scientific sessions of the American Diabetes Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa, onions, has appreciable antidiabetic potential in streptozotocin-induced diabetic mice.2016
- Author(s)
  Oduori S. O, Sugawara K, Yoshida S, Takahashi H, Yokoi N Nakayama M, Seino S
- Organizer
  The 11th IDF-WPR Congress and 8th AASD Scientific Meeting
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2016-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Deletion of β-cell specific KATP channels causes severe glucose intolerance with impaired insulin secretion and enhanced incretin secretion.2016
- Author(s)
  O.S. Oduori, K. Minami, N. Yokoi, Y. Maejima, H. Takahashi, P.L. Herrera, K. Shimomura, S. Seino
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa, onions, has appreciable antidiabetic potential in streptozotocin-induced diabetic mice.2016
- Author(s)
  Oduori S. O, Sugawara K, Yoshida S, Takahashi H, Yokoi N, Nakayama M, Seino S
- Organizer
  The 11th IDF-WPR Congress and 8th AASD Scientific Meeting
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2016-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得機構の解明　-偽膵島を用いた検討-2016
- Author(s)
  マヒラ　アシム、横井　伯英、グプルジャン　ゲニ、星川律子、高橋晴美、清野進
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] 膵β細胞間の相互作用によるインクレチン応答性獲得機構の解明―偽膵島を用いた検討―.2016
- Author(s)
  マヒラ　アシム、横井伯英、グプルジャン　ゲニ、星川律子、高橋晴美、清野　進.
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都、日本
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Roles of KATP channels in brain-islet axis.2016
- Author(s)
  Susumu Seino, Harumi Takahashi
- Organizer
  21st EASD-Hagedorn Oxford Workshop
- Place of Presentation
  Oxford, UK
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Antidiabetic effect of a sulfur compound, trans-S-1-propenyl-l-cysteine sulfoxide, in Allium cepa2016
- Author(s)
  Oduori S.O, Sugawara K, Honda K, Takahashi H, Yokoi N, Nakayama M, Seino S
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S
- Organizer
  17th International Group on Insulin Secretion Conference
- Place of Presentation
  St. Jean-Cap-Ferrat, France
- Year and Date
  2016-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] Mechanisms of the induction of incretin/cAMP responsiveness in insulin secretion: study by pseudoislets.2016
- Author(s)
  3.Hashim M, Yokoi N, Gheni G, Hoshikawa, R, Takahashi H, Seino S.
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Munich, Germany.
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] Antidiabetic effect of a sulfur compound trans-S-1-propenyl-l-cysteine sulfoxide from Allium cepa2016
- Author(s)
  Okechi OS, Sugawara K, Takahashi H, Yokoi N, Nakayama M, Seino .
- Organizer
  The 76th scientific sessions of the American Diabetes Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08176
[Presentation] Chronic Arsenic Exposure Impairs Pancreatic Function.2016
- Author(s)
  Carmean CM, Kirkley AG, Yokoi N, Hoshikawa R, Honda K, Gheni G, Sugawara K, Takahashi H, Sargis RM, Seino S.
- Organizer
  17th International Group on Insulin Secretion Conference
- Place of Presentation
  Nice, France
- Year and Date
  2016-04-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09751
[Presentation] 膵β細胞間相互作用によるインクレチン応答性獲得機構の解明　-偽膵島を用いた検討-2016
- Author(s)
  マヒラ　アシム、横井　伯英、グプルジャン　ゲニ、星川律子、高橋晴美、清野進
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K09749
[Presentation] インスリン分泌におけるグルタミン酸シグナルの役割2015
- Author(s)
  高橋晴美、グプルジャンゲニ、山口拓郎、横井伯英、清野　進
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Combinatorial effects of incretin and sufonylurea or glinide drugs on insulin secretion.2015
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Seino S
- Organizer
  Incretin 2015
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2015-07-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] DPP-4阻害薬とSU薬の併用効果と重症低血糖：SU薬の種類による層別解析2014
- Author(s)
  岡村香織、矢部大介、久保田章、黒瀬健、高橋晴美、高橋利匡、柴崎忠雄、清野進、清野裕
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Regulation of actin dynamics by N-WASP and cofilin in pancreatic ・-cells and its role in insulin secretion2012
- Author(s)
  Shibasaki T, Uenishi E, Takahashi H, Hamaguchi H, Oiso Y, Seino S
- Organizer
  9th International Diabetes Federation Western Pacific Region Congress/4th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Kyoto
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] 膵β細胞の N-WASPとcofilinによるF-アクチンリモデリングの制御とそのインスリン分泌における役割2012
- Author(s)
  上西栄太、柴崎忠雄、高橋晴美、濱口ひとみ、大磯ユタカ、清野進
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Induction of gastrointestinal hormones in pancreatic islets of a mouse model of beta cell regeneration2012
- Author(s)
  Minami K, Kitanoya H, Takahashi H, Seino S
- Organizer
  48th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-10-04
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] SU薬による Epac2A活性化機構の解明2012
- Author(s)
  高橋利匡、高橋晴美、小野愛夏、柴崎忠雄、清野進
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インクレチンと SU薬によるインスリン顆粒開口分泌2012
- Author(s)
  高橋晴美、柴崎忠雄、高橋利匡、清野進
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Role of actin dynamics regulated by N-WASP and cofilin in insulin secretion in pancreatic・-cells2012
- Author(s)
  Shibasaki T, Uenishi E, Takahashi H, Hamaguchi H, Seino S
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Interaction of incretin and sulfonylurea through Epac2 in insulin secretion2012
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Takahashi T, Ono A, Seino S
- Organizer
  9th International Diabetes Federation Western Pacific Region Congress/4th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Kyoto
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Interaction of cAMP and sulfonylurea through Epac2 in insulin secretion2011
- Author(s)
  Takahashi H, Shibasaki T, Takahashi T, Seino S
- Organizer
  XII Servier-IGIS Symposium
- Place of Presentation
  Saint-Jean-Cap-Ferrat, France
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インクレチンとSU薬によるインスリン分泌におけるEpac2/Rap1シグナルの役割2011
- Author(s)
  高橋晴美, 他
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インクレチンと SU薬によるインスリン分泌における Epac2/Rap1シグナルの役割2011
- Author(s)
  高橋晴美、柴崎忠雄、高橋利匡、清野進
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Molecular Mechanismsof Insulin Granule Exocytosis2011
- Author(s)
  Shibasaki T, Takahashi H, Yasuda T, Zhang C-L, Seino S
- Organizer
  第84回日本薬理学会年次学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Role of actin dynamics regulated by Cdc42/N-WASP signaling in insulin secretion2011
- Author(s)
  Shibasaki T, Uenishi E, Takahashi H, Hamaguchi H, Tatebe M, Oiso Y, Seino S
- Organizer
  71st Scientific Sessions, American Diabetes Association
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インスリン顆粒の開口放出機構におけるRim2αの役割2010
- Author(s)
  安田貴雄、柴崎忠雄、三木隆司、高橋晴美、宮崎純一、南幸太郎、清野進
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Rim2・ determines docking and priming states in insulin granule exocytosis inpancreatic ・-cells2010
- Author(s)
  Yasuda T, Shibasaki T, Minami K, Takahashi H, Miyazaki J-I, Miki T, SeinoS
- Organizer
  Asia Islet Biology & Incretin Symposium
- Place of Presentation
  Kyoto
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インクレチンのインスリン分泌増強作用における Epac2の役割2010
- Author(s)
  高橋晴美
- Organizer
  第47回日本糖尿病学会近畿地方会
- Place of Presentation
  大阪
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] インクレチンのインスリン分泌増強作用におけるEpac2の役割2010
- Author(s)
  高橋晴美
- Organizer
  第47回日本糖尿病学会近畿地方会
- Place of Presentation
  大阪国際会議場(大阪府)(招待講演)
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Epac2 is a direct target of both cAMP and sulfonylurea in insulin secretion2010
- Author(s)
  Shibasaki T, Zhang CL, Takahashi T, Takahashi H, Seino S
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Critical Role of Actin Dynamics Regulated by N-WASP and Cofilin in the Biphasic Response of Glucose-Induced Insulin Secretion
- Author(s)
  Shibasaki T, Uenishi E, Takahashi H, Oiso Y, Seino S
- Organizer
  American Diabetes Association's 73rd Scientific Sessions
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Interplay between incretin and sulfonylurea through Epac2A/Rap1 signaling in insulin secretion.
- Author(s)
  Takahashi H, Shibasaki T, Park J-H, Hidaka S, Takahashi T, Ono A, Song D-K, Seino S
- Organizer
  10th IDF-WPR Congress 2014/ 6th AASD Scientific Meeting
- Place of Presentation
  Singapore
- Year and Date
  2014-11-21 – 2014-11-24
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Interaction of incretin and sulfonylurea through Epac2A signaling in insulin secretion
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Ono A, Takahashi T, Seino S
- Organizer
  49th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] SU薬によるEpac2A活性化機構の解明
- Author(s)
  高橋利匡
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Interaction of incretin and sulfonylurea through Epac2A in insulin secretion
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Takahashi T, Ono A, Seino S
- Organizer
  2013 International Conference on Diabetes and Metsbolism & 5th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Interaction of incretin and sulfonylurea through Epac2A signaling in insulin secretion
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Ono A, Takahashi T, Seino S
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Evaluation of the effect of liraglutide on beta cell fate in alloxan diabetic mice by tamoxifen-inducible Cre/loxP system
- Author(s)
  Tamura K, Minami K, Takahashi H, Kudo M, Kitanoya H, Seino S
- Organizer
  49th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] インクレチンとSU薬の相互作用におけるEpac2A/Rap1シグナルの役割
- Author(s)
  髙橋晴美、柴崎忠雄、日高志保美、小野愛夏、高橋利匡、清野進
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Clarification of molecular mechanism underlying Epac2A activation by antidiabetic sulfonylurea drugs
- Author(s)
  Shibasaki T, Takahashi T, Takahashi H, Sugawara K, Seino S
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] The role of Malate-aspartate shuttle derived glutamate in incretin potentiated insulin secretion
- Author(s)
  Gheni G, Iwasaki M, Ogura M, Minami K, Yokoi N, Shibasaki T, Takahashi H, Sugawara K, Seino S
- Organizer
  5th International Uyghur Academy Conference
- Place of Presentation
  Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Interaction of incretin and sulfonylurea through Epac2 in insulin secretion
- Author(s)
  Takahashi H
- Organizer
  9th International Diabetes Federation Western Pacific Region Congress/4th Scientific Meeting of the Asian Association for the Study of Diabetes
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22790860
[Presentation] Identification and characterization of the binding site and properties of antidiabetic sulfonylurea drugs in the cAMP sensor Epac2A
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Seino S
- Organizer
  Beta Cell Workshop 2013 Kyoto
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Interaction of incretin and sulfonylurea through Epac2 in insulin secretion
- Author(s)
  Takahashi H, Shibasaki T, Hidaka S, Takahashi T, Ono A, Seino S
- Organizer
  Beta Cell Workshop 2013 Kyoto
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] Sulfonylureas act as an enhancer of Epac2 activation in cAMP-induced insulin secretion
- Author(s)
  Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Seino S
- Organizer
  American Diabetes Association's 73rd Scientific Sessions
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-25461351
[Presentation] インクレチンとSU薬によるインスリン顆粒開口分泌
- Author(s)
  高橋晴美
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22790860

1. GHENI Ghupurjan (70750488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
2. Shibasaki Tadao (00323436)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TANABE Katsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 清野進

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. 横井伯英

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
6. 南幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
7. 三木隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 森泰生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Harumi 高橋 晴美

Research Projects

Research Products

Co-Researchers

The role of Epac2/Rap1 signaling in the three-dimensional construction of pancreatic isletsPrincipal Investigator

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Mechanism of the regulation of insulin granule exocytosis by glutamate signaling in beta-cells

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Review Section

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The role of Epac2A/Rap1 signaling in the protection of pancreatic beta-cellPrincipal Investigator

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The physiological and pathophysiological roles of glutamate signaling in pancreatic beta-cell

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The role of Noc2 in incretin secretion

Principal Investigator

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The role of glutamate signaling in amplification of insulin secretion by cAMPPrincipal Investigator

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The Role of Epac2 as a new target of sulfonylurea drugsPrincipal Investigator

Principal Investigator

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[Book] Annual Review糖尿病・代謝・内分泌分担執筆「膵β細胞におけるEpac2Aの役割」2012

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[Journal Article] Increased glycolysis affects β-cell function and identity in aging and diabetes2022

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DOI

NAID

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[Journal Article] O-GlcNAcylation of myocyte-specific enhancer factor 2D negatively regulates insulin secretion from pancreatic β-cells2022

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DOI

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[Journal Article] インスリン分泌機構－糖尿病の膵β細胞におけるGタンパク質シグナル変換の意義2021

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[Journal Article] Glutamate is an essential mediator in glutamine‐amplified insulin secretion2021

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NAID

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[Journal Article] インスリン分泌機構－糖尿病の膵β細胞におけるGタンパク質シグナル変換の意義2021

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[Journal Article] Tumor-like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin-induced insulin secretion in obese diabetes: a study of ZFDM rat.2020

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TAKAHASHI Harumi 高橋晴美