MUROYAMA Ryosuke 室山良介

… Alternative Names

Ryosuke MUROYAMA 室山良介

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Researcher Number	50549459
Other IDs
Affiliation (Current)	2025: 獨協医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 獨協医科大学, 医学部, 教授 2018 – 2023: 千葉大学, 大学院医学研究院, 助教 2010 – 2012: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator B型肝癌 / B型肝炎ウイルス / 自然免疫 / NKG2Dリガンド / 自然免疫システム / 肝細胞癌 / 発現調節 / microRNA Except Principal Investigator 自然免疫 / MICA … More / 肝癌 / ERストレス応答 / DNA損傷応答 / 口腔癌 / 腫瘍溶解性ウイルス / NK細胞 / 腫瘍 / シェダ－ぜ阻害薬 / シェダーゼ阻害薬 / 大規模化合物ライブラリ / シェダーゼ阻害 / がん薬物療法 / 新規薬剤開発 / 肝細胞癌 / RNA干渉 / 2-5AS / TLR3 / MxA / SNP / GWAS / コア蛋白 / OAS / PKR / インターフェロン / C型肝炎ウイルス Less

Elucidation of the escape mechanism by HBV aganst innate immune response in HBV-induced HCCPrincipal Investigator
- Principal Investigator
  
  室山良介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Dokkyo Medical University
Development of a novel oncolytic viral therapy with application of synthetic lethal therapy for oral cancer
- Principal Investigator
  
  齋藤謙悟
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Exploration of Novel Therapeutic Agents Based on Sheddase Inhibition of the Hepatocarcinoma Susceptibility Gene MICA
- Principal Investigator
  
  Tawada Akinobu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Prefectural University of Health Sciences
  Chiba University
Elucidation of the role of NKG2D ligands in HBV-related hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Ryosuke MUROYAMA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
The regulation of miR-122 which is involved in Hepatitis C virus replication and interferon treatment responsePrincipal Investigator
- Principal Investigator
  
  MUROYAMA Ryosuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Interferon stimulated genes and its polymorphisms determining Hepatitis C virus replication and pathogenesis of hepatitis C
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding2021
- Author(s)
  Arai J, Goto K, Otoyama Y, Nakajima Y, Sugiura I, Kajiwara A, Tojo M, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Nozawa H, Nakagawa R, Muroyama R, Kato N, Yoshida H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 70 Issue: 1 Pages: 203-213
- DOI
  10.1007/s00262-020-02660-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03633, KAKENHI-PROJECT-18K07996, KAKENHI-PROJECT-19K16723
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011
- Author(s)
  Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
- Journal Title
  
  Nat Genet 43
  
  Pages: 455-458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Double-stranded-RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.2010
- Author(s)
  Chang J-H, Kato N, Muroyama R, Taniguchi H, Guleng B, Dharel N, Shao R-X, Tateishi K, Jazag A, Kawabe T, Omata M
- Journal Title
  
  Liver Int 30
  
  Pages: 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.2009
- Author(s)
  Li C-Z, Kato N, Chang J-H, Muroyama R, Shao R-X, Dharel N, Sermsathanasawadi R, Kawabe T, Omata M
- Journal Title
  
  Liver Int 29
  
  Pages: 1413-1421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.2009
- Author(s)
  Hu Z, Muroyama R, Kowatari N, Chang J, Omata M, Kato N
- Journal Title
  
  Cancer Sci 100
  
  Pages: 2465-2468
- NAID
  10027198911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Journal Article] Association of IRF-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients.2008
- Author(s)
  Sermasathanasawadi R, Kato N, Muroyama R, Dharel N, Shao R-X, Chang J-H, Li C-Z, Kawabe T, Omata M
- Journal Title
  
  Liver Int 28
  
  Pages: 798-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] ADAM9酵素活性阻害によるMICA-NK axisを標的とした肝癌治療戦略2020
- Author(s)
  荒井潤, 後藤覚,音山裕美, 杉浦育也, 中島陽子, 梶原敦, 市川雪, 魚住祥二郎, 下間祐, 打越学, 坂木理, 中川良, 室山良介, 加藤直也,吉田仁
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] レゴラフェニブ治療が大腸癌に与えるNK細胞活性化シグナルへの影響2020
- Author(s)
  荒井潤, 後藤覚, 音山裕美, 杉浦育也, 中島陽子, 梶原敦, 市川雪, 魚住祥二郎, 下間祐, 打越学, 坂木理, 中川良, 室山良介, 加藤直也, 吉田仁
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] レチノイン酸による肝発癌感受性分子MICAの制御効果2020
- Author(s)
  音山裕美, 荒井潤, 杉浦育也, 中島陽子, 梶原敦, 市川雪, 魚住祥二郎, 下間祐, 打越学, 坂木理, 後藤覚, 中川良, 室山良介, 加藤直也, 吉田仁
- Organizer
  56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] NGSデータを用いた網羅的ゲノム解析による肝癌関連遺伝子の探索2019
- Author(s)
  室山良介、神﨑洋彰、加藤直也
- Organizer
  第55回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] Identification of modules and hub genes associated with HBV-HCC by gene co-expression analysis2019
- Author(s)
  Ryosuke Muroyama, Hiroaki Kanzaki, Tetsuhiro Chiba, Masato Nakamura, Shingo Nakamoto, Hiroshi Shirasawa, Naoya Kato
- Organizer
  International HBV meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] 2.The exploration of cancer-related gene alterations using whole-genome sequencing data in HBV-related hepatoma cell line2018
- Author(s)
  Ryosuke Muroyama, Hiroaki Kanzaki, Tetsuhiro Chiba, Ryo Nakagawa, Masato Nakamura, Shingo Nakamoto, Shin Yasui, Hiroshi Shirasawa, Naoya Kato
- Organizer
  International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] NGSデータを用いたゲノム異常解析に基づく肝癌関連遺伝子の探索2018
- Author(s)
  室山良介, 神崎洋彰, 加藤直也
- Organizer
  第42回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-18K07996
[Presentation] C型肝炎の病態と治療効果を規定するmiR122の発現調節機構の解明2011
- Author(s)
  室山良介
- Organizer
  日本肝臓学会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23790774
[Presentation] C 型肝炎の病態と治療効果を規定する miR122 の発現調節機構の解明。2011
- Author(s)
  室山良介、後藤覚、Li Wenwen、古渡礼恵、加藤直也
- Organizer
  第15回日本肝臓学会(第 19回日本消化器関連学会週間)、肝 P-272
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790774
[Presentation] Core mutant ratio is associated with response to PEG-IFN/RBV treatment in HCV genotype 1b patients.2011
- Author(s)
  Li W, Muroyama R, Hu Z, Kowatari N, Goto T, Yoshida H, Li Q, Omata M, Koike K, Kato N
- Organizer
  The 21st Conference of the Asian Pacific Association for the Study of the Liver.
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] A genome-wide study identifies susceptibility loci for hepatitis C virus induced hepatocellular carcinoma.2011
- Author(s)
  Kato N, Kumar V, Muroyama R, Kowatari N, Li W, Otsuka M, Tateishi R, Yoshida H, Omata M, Koike K, Nakamura Y, Matsuda K
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver.
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20590760
[Presentation] Amino acid substitutions at position 70 of HCV genotype 1b core region is related to the increased HCC risk and non-virological response to PEG-IFN plus RBV combination therapy.2009
- Author(s)
  Kato N, Hu Z, Muroyama R, Goto T, Kowatari N, Chang J, Omata M
- Organizer
  16th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-20590760

1. KATO Naoya (90313220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. Tawada Akinobu (10596159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 荒井潤 (30766176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 齋藤謙悟 (70451755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MUROYAMA Ryosuke 室山 良介

Ryosuke MUROYAMA 室山 良介

Research Projects

Research Products

Co-Researchers

Elucidation of the escape mechanism by HBV aganst innate immune response in HBV-induced HCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel oncolytic viral therapy with application of synthetic lethal therapy for oral cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of Novel Therapeutic Agents Based on Sheddase Inhibition of the Hepatocarcinoma Susceptibility Gene MICA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of NKG2D ligands in HBV-related hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation of miR-122 which is involved in Hepatitis C virus replication and interferon treatment responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interferon stimulated genes and its polymorphisms determining Hepatitis C virus replication and pathogenesis of hepatitis C

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011

Author(s)

Journal Title

Data Source

[Journal Article] Double-stranded-RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.2010

Author(s)

Journal Title

Data Source

[Journal Article] Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.2009

Author(s)

Journal Title

Data Source

[Journal Article] Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Association of IRF-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients.2008

Author(s)

Journal Title

Data Source

[Presentation] ADAM9酵素活性阻害によるMICA-NK axisを標的とした肝癌治療戦略2020

Author(s)

Organizer

Data Source

[Presentation] レゴラフェニブ治療が大腸癌に与えるNK細胞活性化シグナルへの影響2020

Author(s)

Organizer

Data Source

[Presentation] レチノイン酸による肝発癌感受性分子MICAの制御効果2020

Author(s)

Organizer

Data Source

[Presentation] NGSデータを用いた網羅的ゲノム解析による肝癌関連遺伝子の探索2019

MUROYAMA Ryosuke 室山良介

Ryosuke MUROYAMA 室山良介