HINOHARA KUNIHIKO 日野原邦彦

… Alternative Names

Researcher Number	50549467
Other IDs
Affiliation (Current)	2019: 名古屋大学, 医学系研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2010 – 2013: The University of Tokyo, 医科学研究所, 特任助教 2010: 東京大学, 医科学研究所, 特任教授 2009: The University of Tokyo, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator NF-κB / 乳癌 / 癌幹細胞 / GSEA解析 / PI3K/Akt / GSEA / breast cancer / cancer stem cells / HRG / ErbB … More Except Principal Investigator がん幹細胞 / 受容体 / チロシンキナーゼ / 乳がん / 増殖因子 / アダプター / スフィア培養 / PDX / マウス乳がんモデル / HER2 / ErbB2 / 癌 / 遺伝子 / 蛋白質 / 細胞・組織 / トランスレーショナル研究 Less

Functional analysis of key molecule of breast cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  HINOHARA Kunihiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Analysis of novel molecular targets of cancer stem cells by systems analysis
- Principal Investigator
  
  GOTOH Noriko
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
  The University of Tokyo
Analysis of the molecular mechanisms controlling self-renewal and differentiation of breast cancer stem cells using systems biological methodologyPrincipal Investigator
- Principal Investigator
  
  HINOHARA Kunihiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 実験医学　カレントトピックス2012
- Author(s)
  日野原邦彦、後藤典子
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790357
[Book] NF-kB pathways in breast cancer stem cells for tumorigenesis2012
- Author(s)
  後藤典子・日野原邦彦
- Publisher
  Breast cancer, Bentham eBooks, Bentham Science(in press)
- Data Source
  KAKENHI-PLANNED-22130009
[Book] 受容体型チロシンキナーゼErbBと転写因子NF-κBによる乳がん幹細胞維持の分子機構実験医学Vol.30 No.14 (9月号)2012
- Author(s)
  日野原邦彦、後藤典子
- Data Source
  KAKENHI-PROJECT-23790357
[Book] 実験医学2012 Vol302012
- Author(s)
  日野原　邦彦
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-22130009
[Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.2014
- Author(s)
  Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S.
- Journal Title
  
  Neuro Oncol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790357
[Journal Article] Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma.2014
- Author(s)
  Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S.
- Journal Title
  
  Neuro. Oncol.
  
  Volume: 16 Pages: 960-970
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22130009
[Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013
- Author(s)
  Kano Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432 Pages: 175-181
- DOI
  10.1016/j.bbrc.2013.01.034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790357, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer.2012
- Author(s)
  Hinohara, K.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: (in press) Pages: 6584-6589
- DOI
  10.1073/pnas.1113271109
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22117001, KAKENHI-PLANNED-22117002, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23591373, KAKENHI-PROJECT-23790357, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130005
[Journal Article] NFkB pathways in breast cancer stem cells for tumorigenesis2012
- Author(s)
  日野原　邦彦
- Journal Title
  
  Breast cancer, Bentham eBooks, Bentham Science
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009
[Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer2012
- Author(s)
  日野原邦彦
- Journal Title
  
  Proc.Natl.Acad.Sci., USA
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009
[Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells.2010
- Author(s)
  Murohashi M., Hinohara K., Kuroda M., Isagawa T., Tsuji S., Kobayashi S., Umezawa K., Tojo A., Aburatani H., Gotoh N.
- Journal Title
  
  British J.Cancer 102
  
  Pages: 206-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890048
[Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells2010
- Author(s)
  Hinohara K, Gotoh N
- Journal Title
  
  Current opinion in pharmacology
  
  Volume: 10 Pages: 650-654
- Data Source
  KAKENHI-PROJECT-21890048
[Journal Article] Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells2010
- Author(s)
  Murohashi M, Hinohara K, et al.
- Journal Title
  
  British Journal of Cancer 102
  
  Pages: 206-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890048
[Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells.2010
- Author(s)
  Hinohara K, Gotoh N
- Journal Title
  
  Curr Opin Pharmacol. 10
  
  Pages: 650-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] ErbB signaling regulates the mammosphere formation of breast cancer2013
- Author(s)
  Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Tada K, Ogawa T, Miyano S, Gotoh N
- Organizer
  The 10th Japan Research Association For Immunotherapeutics
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells.2013
- Author(s)
  Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Tada K, Ogawa T, Miyano S, Gotoh N.
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  tokyo
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2013
- Author(s)
  Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Tada K, Ogawa T, Miyano S, Gotoh N
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] Insulin-like growth factor signaling regulates breast cancer stem cell properties.2013
- Author(s)
  Hinohara K, Shimamura T, Kanauchi H, Niida A, Tuji E, Nishioka K, Tada K, Mori M, Ogawa T, Miyano S, Tojo A, Gotoh N.
- Organizer
  The 36th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  kobe
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] Insulin-like growth factor signaling regulates breast cancer stem cell properties2013
- Author(s)
  Hinohara K, Shimamura T, Kanauchi H, Niida A, Tuji E, Nishioka K, Tada K, Mori M, Ogawa T, Miyano S, Tojo A, Gotoh N
- Organizer
  The 72nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] Insulin-like growth factor signaling regulates breast cancer stem cell properties.2013
- Author(s)
  Hinohara K, Shimamura T, Kanauchi H, Niida A, Tuji E, Nishioka K, Tada K, Mori M, Ogawa T, Miyano S, Tojo A, Gotoh N.
- Organizer
  The 72nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  yokohama
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] ErbB/NF-κB signaling controls mammosphere formation in human breast cancer2012
- Author(s)
  日野原邦彦、小林誠一郎、金内一、梅澤一夫、森正樹、小川利久、井上純一郎、東條有伸、後藤典子
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] ErbB/NF-κB signaling controls mammosphere formation in human breast cancer2012
- Author(s)
  日野原　邦彦
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路夢舞台国際会議場
- Data Source
  KAKENHI-PLANNED-22130009
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012
- Author(s)
  日野原邦彦、島村徹平、福田裕章、富永香菜、金内一、新井田厚司、山口類、井元清哉、多田敬一郎、小川利久、宮野悟、後藤典子
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012
- Author(s)
  Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Tada K, Ogawa T, Miyano S, Gotoh N
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012
- Author(s)
  日野原邦彦、島村徹平、金内一、新井田厚司、山口類、井元清哉、小川利久、宮野悟、後藤典子
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012
- Author(s)
  Hinohara K, Shimamura T, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Ogawa T, Miyano S, Gotoh N
- Organizer
  The 71nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] Heregulin-β1/ErbB signaling regulates self-renewal of breast cancer stem cells through activation of NF-κB2011
- Author(s)
  Hinohara K, Kobayashi S, Umezawa K, Tojo A, Inoue J, Masaki Mori, Kanauchi H, Ogawa T, Gotoh N
- Organizer
  The 70nd Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] ErbB/NF-κB signaling controls self-renewal of breast cancer stem cells2011
- Author(s)
  Hinohara K, Kobayashi S, Umezawa K, Masaki Mori, Kanauchi H, Ogawa T, Inoue J, Tojo A, Gotoh N
- Organizer
  The 34th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] EGF receptor/ErbB-NFκB signaling for self-renewal of breast cancer stem cells2011
- Author(s)
  Hinohara K, Kobayashi S, Umezawa K, Tojo A, Inoue J, Kanauchi H, Ogawa T, Gotoh N
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] ErbB/NF-κB signaling controls self-renewal of breast cancer stem cells2011
- Author(s)
  日野原　邦彦
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PLANNED-22130009
[Presentation] ErbB/NF-κB signaling controls mammosphere formation in human breast cancer2011
- Author(s)
  Hinohara K, Kobayashi S, Kanauchi H, Umezawa K, Masaki Mori, Ogawa T, Inoue J, Tojo A, Gotoh N
- Organizer
  The 10th Stem Cell Research Symposium
- Place of Presentation
  Japan
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] NF-kappaBシグナルによる乳がん幹細胞制御2010
- Author(s)
  日野原邦彦
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪・リーガロイヤルホテル大阪大阪国際会議場
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-kappa B pathways in breast cancer stem cells2010
- Author(s)
  日野原邦彦、室橋道子、砂川孝行、辻真吾、小林誠一郎、梅澤一夫、東條有伸、油谷浩幸、井上純一郎、後藤典子
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-kappa B pathways in breast cancer-initiating cells2010
- Author(s)
  日野原邦彦
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路・淡路夢舞台国際会議場
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] NF-kappaB regulates the self-renewal of breast cancer stem cells2010
- Author(s)
  日野原邦彦、小林誠一郎、梅澤一夫、東條有伸、井上純一郎、後藤典子
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-κB pathways in breast cancer-initiating cells2010
- Author(s)
  日野原邦彦、室橋道子、黒田雅彦、砂川孝行、辻真吾、小林誠一郎、梅澤一夫、東條有伸、油谷浩幸、後藤典子
- Organizer
  American Association for Cancer Research 101th Annual Meeting 2010
- Place of Presentation
  Walter E.Washington Convention Center, Washington D.C., USA
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-kappa B pathways in breast cancer-initiating cells2010
- Author(s)
  日野原邦彦
- Organizer
  AACR 101^<st> Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] NF-kappaB regulates the self-renewal of breast cancer stem cells2010
- Author(s)
  日野原邦彦
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸・神戸-ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-κB pathways in breast cancer stem cells2010
- Author(s)
  日野原邦彦、室橋道子、黒田雅彦、砂川孝行、辻真吾、小林誠一郎、梅澤一夫、東條有伸、油谷浩幸、後藤典子
- Organizer
  第8回幹細胞シンポジウム
- Place of Presentation
  淡路
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] Potential roles of NF-κB pathways in breast cancer-initiating cells2009
- Author(s)
  日野原邦彦、室橋道子、黒田雅彦、砂川孝行、辻真吾、小林誠一郎、梅澤一夫、東條有伸、油谷浩幸、後藤典子
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] ヒト乳癌細胞株における癌幹細胞の分子シグネチャー2009
- Author(s)
  室橋道子、日野原邦彦、黒田雅彦、砂川孝行、辻真吾、小林誠一郎、梅澤一夫、東條有伸、油谷浩幸、後藤典子
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21890048
[Presentation] ErbB/NF-κB signaling controls self-renewal of breast cancer stem cells
- Author(s)
  日野原邦彦
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] Heregulin-β1/ErbB signaling regulates self-renewal of breast cancer stem cells through activation of NF-κB
- Author(s)
  日野原邦彦
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790357
[Presentation] EGF receptor/ErbB-NFκB signaling for self-renewal of breast cancer stem cells
- Author(s)
  日野原邦彦
- Organizer
  第9回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790357

1. GOTOH Noriko (10251448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. OKAMOTO Ryuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 東條有伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小林誠一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 土屋輝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HINOHARA KUNIHIKO 日野原 邦彦

HINOHARA Kunihiko 日野原 邦彦

Research Projects

Research Products

Co-Researchers

Functional analysis of key molecule of breast cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of novel molecular targets of cancer stem cells by systems analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the molecular mechanisms controlling self-renewal and differentiation of breast cancer stem cells using systems biological methodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学 カレントトピックス2012

Author(s)

Total Pages

Publisher

Data Source

[Book] NF-kB pathways in breast cancer stem cells for tumorigenesis2012

Author(s)

Publisher

Data Source

[Book] 受容体型チロシンキナーゼErbBと転写因子NF-κBによる乳がん幹細胞維持の分子機構実験医学Vol.30 No.14 (9月号)2012

Author(s)

Data Source

[Book] 実験医学2012 Vol302012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.2014

Author(s)

Journal Title

Data Source

[Journal Article] Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma.2014

Author(s)

Journal Title

Data Source

[Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NFkB pathways in breast cancer stem cells for tumorigenesis2012

Author(s)

Journal Title

Data Source

[Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells.2010

Author(s)

HINOHARA KUNIHIKO 日野原邦彦

HINOHARA Kunihiko 日野原邦彦

[Book] 実験医学　カレントトピックス2012