Hosoya Kenji 細谷謙次

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HOSOYA Kenji 細谷謙次

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Researcher Number	50566156
Other IDs	https://orcid.org/0000-0002-6489-0327
Affiliation (Current)	2025: 北海道大学, 獣医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 北海道大学, 獣医学研究院, 准教授 2013 – 2014: 北海道大学, (連合)獣医学研究科, 准教授 2012: 北海道大学, (連合)獣医学研究科, 助教 2010 – 2012: 北海道大学, 大学院・獣医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Veterinary medical science / Clinical veterinary science Except Principal Investigator Clinical veterinary science
Keywords	Principal Investigator ミトコンドリア / 分子標的療法 / 放射線治療 / メトフォルミン / がん幹細胞 / イヌ / 腫瘍 / mTOR / 遺伝子導入 / 放射線耐性 … More / グルタチオン / 免疫チェックポイント阻害剤 / 放射線科学 / 活性酸素 / Metformin / PI3K/ｍTOR経路 / ゲダトリシブ / 増感剤 / ｍTOR / 放射線療法 / がん治療 / 新規治療 / 抗がん剤 / 犬 / アルテミシニン / 組織球性肉腫 … More Except Principal Investigator 軟骨細胞 / グリコサミノグリカン / 滑膜細胞 / グリコサミノグリカン軟骨細胞 / 関節疾患 Less

Stem cell targetting radiosensitization by mitochondria-targeted strategy with metoformin in dogsPrincipal Investigator
- Principal Investigator
  
  細谷謙次
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Isolation of cancer stem cells and radiosensitizing effects of mTOR inhibitors in canine tumor cell lines.Principal Investigator
- Principal Investigator
  
  Hosoya Kenji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Evaluation of antineoplastic activity of antimalarial drug artemisinin against canine histiocytic proliferative complex.Principal Investigator
- Principal Investigator
  
  HOSOYA Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Hokkaido University
Structural protective effects of glycosaminoglycans on articular distraction in joint diseases in animals
- Principal Investigator
  
  OKUMURA Masahiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2013 2012

All Journal Article Presentation

[Journal Article] Enhanced Systemic Antitumour Immunity by Hypofractionated Radiotherapy and Anti-PD-L1 Therapy in Dogs with Pulmonary Metastatic Oral Malignant Melanoma.2023
- Author(s)
  Deguchi T, Maekawa N, Konnai S, Owaki R, Hosoya K, Morishita K, Nakamura M, Okagawa T, Takeuchi H, Kim S, Kinoshita R, Tachibana Y, Yokokawa M, Takagi S, Kato Y, Suzuki Y, Murata S, Ohashi K.
- Journal Title
  
  Cancers (Basel).
  
  Volume: 11 Issue: 11 Pages: 3013-3013
- DOI
  10.3390/cancers15113013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06424, KAKENHI-PROJECT-23K23768
[Journal Article] Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines.2023
- Author(s)
  Owaki R, Deguchi T, Konnai S, Maekawa N, Okagawa T, Hosoya K, Kim S, Sunaga T, Okumura M.
- Journal Title
  
  Vet Comp Oncol.
  
  Volume: 2 Issue: 2 Pages: 279-290
- DOI
  10.1111/vco.12886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06424
[Journal Article] Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells2022
- Author(s)
  YUSUKE MURASE, KENJI HOSOYA, TAKACHIKA SATO, SANGHO KIM and MASAHIRO OKUMURA
- Journal Title
  
  ONCOLOGY REPORTS
  
  Volume: 47 Issue: 4 Pages: 61-61
- DOI
  10.3892/or.2022.8272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06424
[Journal Article] Visualizing the cancer stem-like properties of canine tumour cells with low proteasome activity2022
- Author(s)
  Koangyong Sung 1, Kenji Hosoya 2, Yusuke Murase 1, Tatsuya Deguchi 2, Sangho Kim 1, Takafumi Sunaga 1, Masahiro Okumura 1
- Journal Title
  
  Veterinary and Comparative Oncology
  
  Volume: 20 Issue: 1 Pages: 324-335
- DOI
  10.1111/vco.12779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06424
[Journal Article] Glutathione Associated Redox Regulation Alleviates Radio-resistance of Canine Cancer Stem-like Cells with Low Proteasome Activity2022
- Author(s)
  Koangyong Sung1, Kenji Hosoya2,3*, Tatsuya Deguchi2, Koya Yamashita4, Sangho Kim1, Takafumi Sunaga1, Hironobu Yasui4, Osamu Inanami4, Masahiro Okumura1
- Journal Title
  
  Frontiers
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06424
[Journal Article] Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS2021
- Author(s)
  Deguchi Tatsuya、Hosoya Kenji、Kim Shango、Murase Yusuke、Yamamoto Kumiko、Bo Tomoki、Yasui Hironobu、Inanami Osamu、Okumura Mahiro
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 22 Pages: 143-151
- DOI
  10.1016/j.omto.2021.08.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00443, KAKENHI-PROJECT-20K06424, KAKENHI-PROJECT-20KK0250
[Journal Article] Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines.2018
- Author(s)
  Deguchi T, Hosoya K, Murase Y, Koangyong S, Kim S, Okumura M.
- Journal Title
  
  Veterinary and Comparative Oncology
  
  Volume: 17 Issue: 2 Pages: 119-129
- DOI
  10.1111/vco.12452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15375
[Journal Article] Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors2014
- Author(s)
  Hosoya K, Couto CG, London CA, Kisseberth WC, Phelps MA, Dalton JT
- Journal Title
  
  Journal of American Animal Hospital Association
  
  Volume: 50 Pages: 390-395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780304
[Journal Article] Antiproliferative action of metformin in human lung cancer cell lines2012
- Author(s)
  H Ashinuma, Y Takiguchi, S Kitazono, M Kitazono-Saitoh, A Kitamura, T Chiba, Y Tada, K Kurosu, E Sakaida, I Sekine, N Tanabe, A Iwama, O Yokosuka, K Tatsumi
- Journal Title
  
  Oncology Reports
  
  Volume: in press Issue: 5 Pages: 2118-2126
- DOI
  10.3892/or_xxxxxxxx
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-20K06424
[Presentation] Enhancement of radiotherapy by oclacitinib-mediated inhibition of JAK signaling in a canine osteosarcoma cell line2024
- Author(s)
  Ryo Owaki, Kenji Hosoya, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Masahiro Okumura
- Organizer
  World Veterinary Cancer Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06424
[Presentation] Visualization and characterization of cancer stem cells with low proteasome activity in a canine osteosarcoma cell line2020
- Author(s)
  Koangyong Sung, Yusuke Murase, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Kenji Hosoya, Masahiro Okumura
- Organizer
  World Veterinary Cancer Congress (Accepted by the congress was Cancelled due to COVID-19 issue)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] イヌ骨肉腫細胞株由来Cancer stem-like cellsのミトコンドリアの放射線反応性の解析2019
- Author(s)
  出口辰弥、細谷謙次、金尚昊、山本久美子、房知輝、安井博宣、稲波修、奥村　正裕
- Organizer
  第72回酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] ABCB1-mediated acquired resistance to a dual PI3K/mTOR inhibitor gedatolisib in canine tumor cell lines2019
- Author(s)
  Yusuke Murase, Kenji Hosoya, Takachika Sato, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Masahiro Okumura
- Organizer
  The 7th Sapporo Summer Seminar for One Health 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] ABCB1-mediated acquired resistance to a dual PI3K/mTOR inhibitor gedatolisib in a canine transitional cell carcinoma cell line2019
- Author(s)
  村瀬優介、細谷謙次、出口辰弥、金尚昊、奥村正裕
- Organizer
  第78回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Establishment of the visualization system for cancer stem cells with low proteasome activity in a canine osteosarcoma cell line2019
- Author(s)
  Koangyong Sung, Kenji Hosoya, Yusuke Murase, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Masahiro Okumura
- Organizer
  SaSSOH (7th Sapporo Summer Symposium for One Health) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] メトホルミンのイヌ骨肉腫細胞株由来のCancer stem-like cellsにおける放射線増感効果の解析2019
- Author(s)
  出口辰弥、細谷謙次、金尚昊、山本久美子、房　知輝、安井博宣、稲波　修、奥村正裕
- Organizer
  第21回癌治療増感研究シンポジウム 2019年2月
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] メトホルミンのイヌ骨肉腫細胞株由来のCancer stem-like cellsにおける放射線増感効果の解析2019
- Author(s)
  出口辰弥、細谷謙治、山本久美子、房知輝、安井博宣、稲波修、金尚昊、奥村正裕
- Organizer
  第22回菅原・大西記念癌治療増感シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] ABCB1-mediated acquired resistance to a dual PI3K/mTOR inhibitor gedatolisib in canine tumor cell lines2019
- Author(s)
  Yusuke Murase, Kenji Hosoya, Takachika Sato, Tatsuya Deguchi, Sangho Kim, Takafumi Sunaga, Masahiro Okumura
- Organizer
  Veterinary Cancer Society 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Metformin radio-sensitizes cancer stem-like cells but not no-stem cells in canine osteosarcoma cell line by AMPK/mTOR-independent mechanism.2018
- Author(s)
  Deguchi T, Hosoya K, Murase Y, Kim S, Okumura M.
- Organizer
  2018 Veterinary Cancer Society (VCS) Annual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Gedatolisib (PF-05212384) induces anti-tumor activity against various types of canine tumor in vitro2018
- Author(s)
  Yusuke Murase, Kenji Hosoya, Takachika Sato, Sangho Kim, and Masahiro Okumura
- Organizer
  第77回日本癌学会学術総会 (The 77th Annual Meeting of the Japanese Cancer Association)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Metformin radio-sensitizes cancer stem-like cells derived from canine osteosarcoma cell line.2018
- Author(s)
  Deguchi T, Hosoya K, Murase Y, Kim S, Okumura M.
- Organizer
  The 6th Sapporo Summer Seminar for One Health (SaSSOH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Gedatolisib (PF-05212384), a dual PI3K/mTOR Inhibitor, induces anti-tumor activity and P-glycoprotein and is involved in the resistance in canine tumors in vitro2018
- Author(s)
  Yusuke Murase, Kenji Hosoya, Takachika Sato, Sangho Kim, and Masahiro Okumura
- Organizer
  Veterinary Cancer Society Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] メトホルミンのイヌ骨肉腫細胞株由来のCancer stem-like cellsに対する放射線増感効果の解析2018
- Author(s)
  出口辰弥、細谷謙次、村瀬優介、金尚昊、奥村正裕
- Organizer
  第161回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Gedatolisib (PF-05212384), a dual PI3K/mTOR inhibitor, induces anti-tumor activity and P-glycoprotein is involved in the resistance in canine tumors in vitro2018
- Author(s)
  Yusuke Murase, Kenji Hosoya, Takachika Sato, Sangho Kim, and Masahiro Okumura
- Organizer
  The 6th Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Metformin radiosensitizes cancer stem-like cells but not non-stem cells in canine osteosarcoma cell line by AMPK/mTOR-independent mechanism.2018
- Author(s)
  Tatsuya Deguchi, Kenji Hosoya, Yusuke Murase, Sangho Kim, Masahiro Okumura
- Organizer
  Veterinary Cancer Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] イヌの腫瘍細胞株由来Cancer stem-like cellsの放射線反応性の解析2017
- Author(s)
  出口辰弥、細谷謙次、村瀬優介、金　尚昊、奥村正裕
- Organizer
  第160回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] Analysis of cancer stem-like cells derived from canine cancer cell lines.2017
- Author(s)
  Tatsuya DEGUCHI, Yusuke MURASE, Sangho KIM, Kenji HOSOYA and Masahiro OKUMURA
- Organizer
  The 5th annual meeting of Sapporo Summer Seminar for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15375
[Presentation] 犬組織球性肉腫の細胞内鉄量および鉄反応性薬剤ジヒドロアルテミシニンの細胞傷害効果の検討2013
- Author(s)
  永田理沙、細谷謙次、星野有希、高木哲、奥村正裕
- Organizer
  日本比較薬理学・毒性学会
- Place of Presentation
  東京大学（東京都）
- Data Source
  KAKENHI-PROJECT-24780304

1. OKUMURA Masahiro (80260397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TAKAGI Satoshi (50396305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KATSUSHI Kurosu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TADA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 安井博宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 稲波修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 田辺信宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 巽浩一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoya Kenji 細谷 謙次

HOSOYA Kenji 細谷 謙次

Research Projects

Research Products

Co-Researchers

Stem cell targetting radiosensitization by mitochondria-targeted strategy with metoformin in dogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Isolation of cancer stem cells and radiosensitizing effects of mTOR inhibitors in canine tumor cell lines.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of antineoplastic activity of antimalarial drug artemisinin against canine histiocytic proliferative complex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural protective effects of glycosaminoglycans on articular distraction in joint diseases in animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Enhanced Systemic Antitumour Immunity by Hypofractionated Radiotherapy and Anti-PD-L1 Therapy in Dogs with Pulmonary Metastatic Oral Malignant Melanoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visualizing the cancer stem-like properties of canine tumour cells with low proteasome activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutathione Associated Redox Regulation Alleviates Radio-resistance of Canine Cancer Stem-like Cells with Low Proteasome Activity2022

Author(s)

Journal Title

Data Source

[Journal Article] Metformin preferentially enhances the radio-sensitivity of cancer stem-like cells with highly mitochondrial respiration ability in HMPOS2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of radiosensitivity of cancer stem-like cells derived from canine cancer cell lines.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of high-dose intermittent and low-dose continuous oral artemisinin in dogs with naturally occurring tumors2014

Author(s)

Journal Title

Data Source

[Journal Article] Antiproliferative action of metformin in human lung cancer cell lines2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] Enhancement of radiotherapy by oclacitinib-mediated inhibition of JAK signaling in a canine osteosarcoma cell line2024

Author(s)

Organizer

Data Source

[Presentation] Visualization and characterization of cancer stem cells with low proteasome activity in a canine osteosarcoma cell line2020

Author(s)

Organizer

Data Source

Hosoya Kenji 細谷謙次

HOSOYA Kenji 細谷謙次

[Presentation] イヌ骨肉腫細胞株由来Cancer stem-like cellsのミトコンドリアの放射線反応性の解析2019

[Presentation] メトホルミンのイヌ骨肉腫細胞株由来のCancer stem-like cellsにおける放射線増感効果の解析2019