INOBE Tomonao 伊野部智由

Researcher Number	50568855
Other IDs
Affiliation (Current)	2025: 富山大学, 学術研究部工学系, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 富山大学, 学術研究部工学系, 准教授 2016 – 2018: 富山大学, 大学院理工学研究部(工学), 准教授 2014 – 2015: 富山大学, 先端ライフサイエンス拠点, 特命助教 2012: 富山大学, 学内共同利用施設等, その他 2011: 富山大学, 先端ライフサイエンス拠点, 特命助教 2010: 独立行政法人理化学研究所, 構造神経病理研究チーム, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Biological Sciences / Functional biochemistry / Basic Section 43030:Functional biochemistry-related / Basic Section 43040:Biophysics-related / Science and Engineering Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Medium-sized Section 37:Biomolecular chemistry and related fields
Keywords	Principal Investigator プロテアソーム / Unstructured領域 / ユビキチン / 細胞内タンパク質分解 / タンパク質分解 / 蛋白質分解 / ユビキチン-プロテアソーム系 / ユビキチン－プロテアソーム系 / 新生鎖 / 分子シャペロン … More / 天然変性領域 / 分解 / 蛋白質 / リン酸化 / 翻訳後修飾 / タンパク質工学 / 分子夾雑 / 細胞内蛋白質分解 / 抗体 / シャペロン / 品質管理 / 凝集体 / 新生鎖分解 / 凝集 / CAT-tail / リボソーム品質管理 / ハンチンチン / ハンチントン病 / 天然変性蛋白質 / 神経変性疾患 / ポリグルタミン病 … More Except Principal Investigator プロテアソーム / 健康寿命 / 老化 / アルツハイマー病 / ユビキチン Less

プロテアソームによる異常タンパク質分解を活性化して健康寿命を伸ばす
- Principal Investigator
  
  甲斐田大輔
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Toyama
Regulation of proteasome-mediated proteolysis by non-ubiquitin protein modificationPrincipal Investigator
- Principal Investigator
  
  伊野部智由
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  University of Toyama
Development of anti-Alzheimer's disease based on a ubiquitin-proteasome activator
- Principal Investigator
  
  KAIDA Daisuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  University of Toyama
Endogenous degradation signals in proteasome substratePrincipal Investigator
- Principal Investigator
  
  Inobe Tomonao
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  University of Toyama
Artificial regulation of selective protein degradation in cellular crowding systemsPrincipal Investigator
- Principal Investigator
  
  伊野部智由
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  University of Toyama
Multi-layered degradation of nascent chain through unstructured regionPrincipal Investigator
- Principal Investigator
  
  伊野部智由
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
プロテアソームによる新生鎖分解の分子シャペロンによる制御Principal Investigator
- Principal Investigator
  
  伊野部智由
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
Development of innovative methods for regulating protein concentration using the ubiquitin-proteasome systemPrincipal Investigator
- Principal Investigator
  
  INOBE Tomonao
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Toyama
揺らぎを介したプロテアソームの基質認識機構Principal Investigator
- Principal Investigator
  
  伊野部智由
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  University of Toyama
The role of an unstructured region in the proteasome inhibitionPrincipal Investigator
- Principal Investigator
  
  INOBE Tomonao
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  University of Toyama
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Unstructured領域から始まるプロテアソームによる蛋白質分解2020
- Author(s)
  伊野部智由
- Journal Title
  
  日本応用酵素協会誌
  
  Volume: 54 Pages: 19-24
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Journal Article] Unstructured領域から始まるプロテアソームによる蛋白質分解2020
- Author(s)
  伊野部智由
- Journal Title
  
  日本応用酵素協会誌
  
  Volume: 54 Pages: 19-24
- Data Source
  KAKENHI-PROJECT-19K06595
[Journal Article] N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression2018
- Author(s)
  Matsumoto Gen、Inobe Tomonao、Amano Takanori、Murai Kiyohito、Nukina Nobuyuki、Mori Nozomu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-018-27872-6
- NAID
  120006988003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PUBLICLY-17H05664, KAKENHI-PUBLICLY-18H04544, KAKENHI-PROJECT-17H01564
[Journal Article] Proteasome-mediated protein degradation is enhanced by fusion ubiquitin with unstructured degron2018
- Author(s)
  Inobe Tomonao、Tsukamoto Masayuki、Nozaki Miyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 4 Pages: 948-954
- DOI
  10.1016/j.bbrc.2018.05.088
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05664, KAKENHI-PUBLICLY-18H04544
[Journal Article] Rapamycin-induced oligomer formation system of FRB-FKBP fusion proteins2016
- Author(s)
  Inobe, T. and Nukina, N.
- Journal Title
  
  J. Biosci. Bioeng.
  
  Volume: 121 Issue: 1 Pages: 40-46
- DOI
  10.1016/j.jbiosc.2015.12.004
- NAID
  40020885821
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] Proteasomal degradation of damaged polyubiquitin2016
- Author(s)
  Inobe, T. and Nozaki, M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 471 Issue: 1 Pages: 34-40
- DOI
  10.1016/j.bbrc.2016.02.006
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] Novel method for the high-throughput production of phosphorylation site-specific monoclonal antibodies2016
- Author(s)
  Nobuyuki Kurosawa, Yuka Wakata, Tomonao Inobe, Haruki Kitamura, Megumi Yoshioka, Shun Matsuzawa, Yoshihiro Kishi & Masaharu Isobe
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25174-25174
- DOI
  10.1038/srep25174
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14405, KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] Conserved sequence preferences contribute to substrate recognition by the proteasome2016
- Author(s)
  Yu, H., Singh Gautam AK., Wilmington, S., Wylie, D., Martinez-Fonts, K., Kago, G., Warburton, M., Chavali, S., Inobe, T., Finkelstein, I., Babu, MM., and Matouschek, A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 28 Pages: 14526-39
- DOI
  10.1074/jbc.m116.727578
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01531
[Journal Article] Regulation of proteasomal degradation modulating an unstructured proteasomal initiation region of a substrate2015
- Author(s)
  Takahashi, K., Matouschek, A. and Inobe, T.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 10 Issue: 11 Pages: 2537-2543
- DOI
  10.1021/acschembio.5b00554
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] N-terminal coiled-coil structure of ATPase subunits of 26S proteasome is crucial for proteasome function2015
- Author(s)
  Inobe, T. and Genmei, R.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 7 Pages: e0134056-e0134056
- DOI
  10.1371/journal.pone.0134056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] Inhibition of the 26S proteasome by peptide mimics of the coiled-coil region of its ATPase subunits2015
- Author(s)
  Inobe, T. and Genmei, R.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 468 Issue: 1-2 Pages: 143-150
- DOI
  10.1016/j.bbrc.2015.10.144
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] The sequence composition of disordered regions affects protein half-life by controlling the initiation step of proteasomal degradation.2015
- Author(s)
  Fishbain, S., Inobe, T., Israeli, E., Chavali, S., Yu, H., Zokarkar, A., Babu, MM., and Matouschek, A.
- Journal Title
  
  Nature Struct. Mol. Biol.
  
  Volume: 22 Issue: 3 Pages: 214-221
- DOI
  10.1038/nsmb.2958
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870216
[Journal Article] Artificial regulation of p53 function by modulating its assembly2015
- Author(s)
  Inobe, T., Nozaki, M. and Nukina, N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 467 Issue: 2 Pages: 322-327
- DOI
  10.1016/j.bbrc.2015.09.162
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01531, KAKENHI-PROJECT-26870216
[Journal Article] Paradigms of protein degradation by the proteasome2014
- Author(s)
  Inobe, T. and Matouschek A.
- Journal Title
  
  Curr. Opin. Struct. Biol.
  
  Volume: 24 Pages: 156-164
- DOI
  10.1016/j.sbi.2014.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870216
[Journal Article] Sequence- and Species-Dependence of Proteasomal Processivity.2012
- Author(s)
  Kraut, DA., Israeli, E., Schrader, E., Patil, A., Nakai, K., Nanavati, D., Inobe, T. Matouschek, A.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 7 Issue: 8 Pages: 1444-1453
- DOI
  10.1021/cb3001155
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23107733
[Journal Article] Sequence-and Species-Dependence of Proteasomal Processivity2012
- Author(s)
  Kraut, DA., Israeli, E., Schrader, E., Patil, A., Nakai, K., Nanavati, D., Inobe, T. and Matouschek, A.
- Journal Title
  
  ACS Chem. Biol.(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] Dissecting a biomolecular process of MgATP2-binding to the chaperonin GroEL2011
- Author(s)
  Chen, J., Makabe, K., Nakamura, T., Inobe, T. and Kuwajima, K.
- Journal Title
  
  J. Mol. Biol
  
  Volume: 410 Pages: 343-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] Unstructured Region-mediated Substrate Recognition by the Proteasome2011
- Author(s)
  伊野部智由
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 51 Issue: 6 Pages: 276-277
- DOI
  10.2142/biophys.51.276
- NAID
  10030038026
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23107733
[Journal Article] 変性領域を介したプロテアソームの基質認識機構2011
- Author(s)
  伊野部智由
- Journal Title
  
  生物物理
  
  Volume: 51 Pages: 276-277
- NAID
  10030038026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] Dissecting a biomolecular process of MgATP^<2-> binding to the chaperonin GroEL2011
- Author(s)
  Chen, J., Makabe, K., Nakamura, T., Inobe, T., Kuwajima, K.
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 410 Issue: 2 Pages: 343-356
- DOI
  10.1016/j.jmb.2011.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137, KAKENHI-PUBLICLY-23107733
[Journal Article] プロテアソームによるタンパク質分解に必要な分解シグナルの配置2011
- Author(s)
  伊野部智由
- Journal Title
  
  実験医学
  
  Volume: 29 Pages: 2135-2138
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] Defining the geometry of the two-component proteasome degron2011
- Author(s)
  Tomonao Inobe
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 7 Pages: 161-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] Defining the Geometry of the Two-component Proteasome Degron2011
- Author(s)
  Inobe, T., Fishbain, S., Prakash, S. and Matouschek, A.
- Journal Title
  
  Nature Chem. Biol
  
  Volume: 7 Pages: 161-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770137
[Journal Article] プロテアソームによるタンパク質分解に必要な分解シグナルの配置2011
- Author(s)
  伊野部智由
- Journal Title
  
  実験医学
  
  Volume: 29 Pages: 2135-2138
- Data Source
  KAKENHI-PUBLICLY-23107733
[Journal Article] 蛋白質分解系活性化による神経変性疾患治療2010
- Author(s)
  伊野部智由、貫名信行
- Journal Title
  
  実験医学
  
  Volume: 28 Pages: 788-794
- Data Source
  KAKENHI-PROJECT-22770137
[Patent] ユビキチン－プロテアソーム系の活性化剤、およびその利用2020
- Inventor(s)
  甲斐田大輔、東田千尋、伊野部智由
- Industrial Property Rights Holder
  甲斐田大輔、東田千尋、伊野部智由
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-114185
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K21247
[Presentation] 遺伝子つなひき法による異常翻訳停滞タンパク質の毒性評価2022
- Author(s)
  柳澤厚樹、伊野部智由
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K06140
[Presentation] FRB-FKBP融合蛋白質のラパマイシン誘導型多量体の構造解析2022
- Author(s)
  坂口瑠菜、伊野部智由
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K06140
[Presentation] FRB-FKBP融合タンパク質によるラパマイシン依存的多量体形成システムの開発2021
- Author(s)
  坂口瑠菜、伊野部智由
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06595
[Presentation] 抗体を用いた前立腺がん抑制因子NKX3.1分解阻害2021
- Author(s)
  原理華、土居信英、伊野部智由
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06595
[Presentation] CGK733がユビキチン-プロテアソーム系によるタンパク質分解を促進する機構の解析2021
- Author(s)
  桒田桜子、伊野部智由、東田千尋、石神健、甲斐田大輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K21247
[Presentation] リン酸化によるタンパク質分解制御2021
- Author(s)
  伊野部智由、澤田大輔
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06595
[Presentation] プロテアソームの分解は基質タンパク質の電荷の違いに依存する2019
- Author(s)
  大沼幸平，伊野部智由
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] GFPを用いた26Sプロテアソームのハイスループットアッセイシステムの開発2019
- Author(s)
  山本啓暉，伊野部智由
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06595
[Presentation] 基質タンパク質の電荷の違いがプロテアソームの分解に与える影響2019
- Author(s)
  大沼幸平、伊野部智由
- Organizer
  平成30年度生物物理学会中部支部講演会
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] プロテアソームの分解は基質タンパク質の電荷の違いに依存する2019
- Author(s)
  大沼幸平，伊野部智由
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06595
[Presentation] GFPを用いた26Sプロテアソームのハイスループットアッセイシステムの開発2019
- Author(s)
  山本啓暉，伊野部智由
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] 基質タンパク質の電荷の違いがプロテアソームの分解に与える影響2019
- Author(s)
  大沼幸平、伊野部智由
- Organizer
  平成30年度生物物理学会中部支部講演会
- Data Source
  KAKENHI-PUBLICLY-17H05664
[Presentation] Regulation of proteasomal degradation.2018
- Author(s)
  Inobe Tomonao
- Organizer
  The 18th KIAS Conference on “Protein Structure and Function”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05664
[Presentation] Regulation of proteasomal degradation.2018
- Author(s)
  Inobe Tomonao
- Organizer
  The 18th KIAS Conference on “Protein Structure and Function”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] Regulation of proteasomal degradation by utilizing the unstructured region2018
- Author(s)
  Inobe Tomonao、Takahashi Kazunobu、Tsukamoto Masayuki
- Organizer
  International Symposium on “Proteins; from the Cradle to the Grave”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05664
[Presentation] Proteasome-mediated protein degradation is enhanced by fusion ubiquitin with unstructured degron2018
- Author(s)
  Inobe Tomonao、Tsukamoto Masayuki、Nozaki Miyuki
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05664
[Presentation] Regulation of proteasomal degradation by utilizing the unstructured region.2018
- Author(s)
  Inobe Tomonao、Takahashi Kazunobu、Tsukamoto Masayuki
- Organizer
  International Symposium on “Proteins; from the Cradle to the Grave”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] Proteasome-mediated protein degradation is enhanced by fusion ubiquitin with unstructured degron2018
- Author(s)
  Inobe Tomonao、Tsukamoto Masayuki、Nozaki Miyuki
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04544
[Presentation] Regulation of proteasomal degradation by molecular chaperone.2016
- Author(s)
  Inobe, T., and Takahashi, K.
- Organizer
  Nascent Chain Biology Meeting 2016
- Place of Presentation
  Lake Kawaguchi
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01531
[Presentation] プロテアソームによる新生鎖の分解制御2016
- Author(s)
  伊野部智由
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01531
[Presentation] プロテアソームによる新生鎖の分解制御2016
- Author(s)
  伊野部智由
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2016-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-26870216
[Presentation] Regulation of protein degradation.2016
- Author(s)
  Inobe, T.
- Organizer
  The 54th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Tsukuba
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01531
[Presentation] Regulation of the protein degradation by the proteasome. The 4th International Symposium of Life Sciences2014
- Author(s)
  Inobe, T.
- Organizer
  The 4th International Symposium of Life Sciences
- Place of Presentation
  富山大学
- Year and Date
  2014-12-11
- Invited
- Data Source
  KAKENHI-PROJECT-26870216
[Presentation] Protein unfolding for proteasome-mediated degradation.2013
- Author(s)
  Inobe, T.
- Organizer
  International Symposium on Protein Folding and its Biological Significance
- Place of Presentation
  岡崎コンファレンスセンター
- Year and Date
  2013-03-04
- Invited
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] 揺らぎのある変性領域を介したプロテアソームの基質認識2012
- Author(s)
  高橋一暢、伊野部智由
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] Fluctuation-mediated substrate recognition by the proteasome2012
- Author(s)
  Inobe, T. and Takahashi, K.
- Organizer
  The 5th International Symposium on Molecular Science of Fluctuations toward Biological Functions
- Place of Presentation
  Nara, Japan
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] Selective proteasomal degradation of the mutant huntingtin protein by an artificial adapter protein.2012
- Author(s)
  Inobe, T., Takahashi, K., Matouschek A. and Nukina N.
- Organizer
  FASEB Science Research Conference "Protein Folding in the Cell"
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2012-07-29
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] Fluctuation-mediated regulation of the protein degradation by the proteasome.2012
- Author(s)
  Inobe, T., Takahashi, K., and Matouschek A.
- Organizer
  The 6th International Symposium “Molecular Science of Fluctuations toward Biological Functions"
- Place of Presentation
  京都テルサ
- Year and Date
  2012-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] 人工アダプター蛋白質による変異ハンチンチンの選択的プロテアソーム分解2012
- Author(s)
  伊野部智由、高橋一暢、Matouschek, Andreas、貫名信行
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] プロテアソームによる蛋白質アンフォールディングと分解:その初期過程2011
- Author(s)
  伊野部智由
- Organizer
  日本物理学会2011年秋季大会
- Place of Presentation
  富山大学
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] プロテアソームによる蛋白質アンフォールディングと分解:その初期過程2011
- Author(s)
  伊野部智由
- Organizer
  日本物理学会
- Place of Presentation
  富山大学
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PUBLICLY-23107733
[Presentation] 生体内蛋白質アンフォールディングの分子機構2010
- Author(s)
  伊野部智由
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] Defining the geometry of the two-component proteasome degron2010
- Author(s)
  Tomonao Inobe
- Organizer
  48th Annual meeting of the Biophysical society of Japan
- Place of Presentation
  仙台
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] Defining the geometry of the two-component proteasome degron2010
- Author(s)
  Inobe, T., Fishbain, S., Prakash, S., and Matouschek, A.
- Organizer
  48th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Sendai, Japan
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] Molecular mechanism of protein unfolding in the cell2010
- Author(s)
  Inobe, T., Fishbain, S., Prakash, S. and Matouschek, A.
- Organizer
  The 10th Annual Meeting of The Protein Science Society of Japan
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] プロテアソームATPaseリングN末端突起の蛋白質分解における役割
- Author(s)
  伊野部智由
- Organizer
  第１４回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26870216
[Presentation] プロテアソームによる蛋白質アンフォールディングと分解:その初期過程
- Author(s)
  伊野部智由
- Organizer
  日本物理学会
- Place of Presentation
  富山大学
- Data Source
  KAKENHI-PROJECT-22770137
[Presentation] Inhibition of proteasome-mediated degradation through an unstructured initiation site of a targeted protein
- Author(s)
  Takahashi, K., and Inobe, T.
- Organizer
  FASEB Science Research Conference "Ubiquitin and Cellular Regulation"
- Place of Presentation
  Saxtons River
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-26870216
[Presentation] 不規則領域をターゲットとしたプロテアソームによる蛋白質分解の制御
- Author(s)
  高橋一暢、伊野部智由
- Organizer
  第１４回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26870216

1. KAIDA Daisuke (60415122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 東田千尋 (10272931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 石神健 (70292787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 飯島香奈絵 (40632500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUMOTO Gen

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 磯部正治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOBE Tomonao 伊野部 智由

Research Projects

Research Products

Co-Researchers

プロテアソームによる異常タンパク質分解を活性化して健康寿命を伸ばす

Principal Investigator

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Regulation of proteasome-mediated proteolysis by non-ubiquitin protein modificationPrincipal Investigator

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Development of anti-Alzheimer's disease based on a ubiquitin-proteasome activator

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Endogenous degradation signals in proteasome substratePrincipal Investigator

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Artificial regulation of selective protein degradation in cellular crowding systemsPrincipal Investigator

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Multi-layered degradation of nascent chain through unstructured regionPrincipal Investigator

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プロテアソームによる新生鎖分解の分子シャペロンによる制御Principal Investigator

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Development of innovative methods for regulating protein concentration using the ubiquitin-proteasome systemPrincipal Investigator

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揺らぎを介したプロテアソームの基質認識機構Principal Investigator

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The role of an unstructured region in the proteasome inhibitionPrincipal Investigator

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[Journal Article] Unstructured領域から始まるプロテアソームによる蛋白質分解2020

Author(s)

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Data Source

[Journal Article] Unstructured領域から始まるプロテアソームによる蛋白質分解2020

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[Journal Article] N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression2018

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DOI

NAID

Data Source

[Journal Article] Proteasome-mediated protein degradation is enhanced by fusion ubiquitin with unstructured degron2018

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INOBE Tomonao 伊野部智由