Kuboki Satoshi 久保木知

… Alternative Names

KUBOKI Satoshi 久保木知

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Researcher Number	50571410
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 千葉大学, 大学院医学研究院, 特任教授 2020 – 2022: 千葉大学, 大学院医学研究院, 講師 2017 – 2019: 千葉大学, 医学部附属病院, 講師 2016: 千葉大学, 医学(系)研究科(研究院), 助教 2016: 千葉大学, 大学院医学研究院, 助教 2011 – 2016: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator Pin1 / 肝内胆管癌 / STAT3 / NF-kappaB / EMT / 肝胆膵領域癌 / 炎症性転写因子 / 癌可塑性 / 癌微小環境 / FAK … More / Cancer stemness / Wnt-β-cateninシグナル / PD-L1 / 転写因子活性 / Wntシグナル / β-catenin / 癌幹細胞能 / GRIM19 / OLFM4 / LGR5 / 加齢 / 肝切除 / 微小循環障害 / NF-kappaB-p65 / 高齢肝 / 肝再生 / 拡大肝切除 / 高齢者 / 腫瘍細胞浸潤 / 腫瘍細胞増殖 / 胆嚢癌 / 膵癌 / 肝細胞癌 / ＳＴＡＴ３ / ＮＦ－ｋａｐｐａＢ / Ｐｉｎ１ / 術後肝再生 / 肝臓外科学 … More Except Principal Investigator 肝内胆管癌 / EMT / 癌間質 / 微小環境 / yes-associated protein / stemness / 上皮間葉転換 / 癌源細胞 / 浸潤 / 転移 / 癌 / 肝再生 / Fn14 / TWEAK / 大腸癌肝転移 / CRLM / TWEAK/Fn14 axis / 組織硬度 / ECM / メカノトランスダクション / p53 / 大腸癌 / apoptosis / cell cycle / Tumor suppressor / RYBP / 肝細胞癌 / Tspan15 / IRG1 / Notch1 / Tetraspanin15 / CSC-like property / NOTCH1 / ADAM10 / TSPAN15 / Gankyrin / IL-32 / 上皮-間葉移行 / Cancer stemness / 細胞遊走能 / 癌幹細胞 / 可塑性 / 胆管細胞 / 肝細胞 / Wnt / Notch / p-FAK / 癌間質微小環境 / Wntシグナル / Notchシグナル / 分化・脱分化 / コンランギオパチー / 脱分化 / 血管新生 / TAZ / YAP / 表面マーカー / KLF / 転移性肝癌 / 増殖 / プロテオーム / 外科 / 肝幹細胞 / 類洞内皮障害 / 肝幹・前駆細胞 / 肝類洞内皮障害 / 胆管炎 / 門脈塞栓術 / 類洞再生 / 血管内皮前駆細胞 / 肝類洞 / 肝硬変 / 黄疸 Less

肝内胆管癌におけるFAKを標的とした癌微小環境の調節による癌可塑性誘導治療の開発Principal Investigator
- Principal Investigator
  
  久保木知
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
肝内胆管癌病態形成におけるメカノトランスダクションの役割
- Principal Investigator
  
  大塚将之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
大腸癌肝転移のTWEAK/Fn14 axisを介した腫瘍進展メカニズムの解明と新規治療薬の開発
- Principal Investigator
  
  松山尚樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
大腸癌におけるRYBP を介した腫瘍制御機構の解明
- Principal Investigator
  
  森中孝至
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Novel therapeutic strategy based on IRG1-mediated anti-inflammatory effects in hepato-biliary-pancreatic cancer
- Principal Investigator
  
  Yoshizumi Arihito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Development of a new therapy targeting LGR5-induced STAT3 activation in hepato-biliary-pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Satoshi Kuboki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Plasticity of cancer-initiating and cancer cells in intrahepatic cholangiocarcinoma and regulation of the cancer stromal microenvironment
- Principal Investigator
  
  Ohtsuka Masayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Tumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer
- Principal Investigator
  
  Sakai Nozomu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
Mechanism of cancer progression mediated by IL-32-Gankyrin axis in intrahepatic cholangiocarcinoma
- Principal Investigator
  
  Mishima Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Chiba University
A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.Principal Investigator
- Principal Investigator
  
  Kuboki Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Elucidation of the role of KLF5, 17 in metastatic cascade of gastrointestinal cancer
- Principal Investigator
  
  Nozomu Sakai
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Role of YAP/TAZ in induction of cancer-initiating cells in cholangiocarcinoma and development of new targeting therapy
- Principal Investigator
  
  OHTSUKA Masayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Identification of novel biomarkers for pancreato-biliary cancer by comprehensive protein profiling analysis
- Principal Investigator
  
  Miyazaki Masaru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  International University of Health and Welfare
  Chiba University
Inflammation-associated NF-kappaB activation promotes tumor progression in hepato-biliary-pancreatic cancer.Principal Investigator
- Principal Investigator
  
  Kuboki Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Analysis of the role hepatic hypertrophy and functional analysis of hepatic stem/progenitor cells after the induction of hypertrophy of the liver
- Principal Investigator
  
  KATO ATSUSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Evaluation of the inhibited hepatic sinusoidal regeneration after hepatectomy in cirrhotic liver and attempt for promoting liver regeneration using endothelial progenitor cells
- Principal Investigator
  
  SHIMIZU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kappaB activation in hepatocytes.Principal Investigator
- Principal Investigator
  
  KUBOKI Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Other

[Journal Article] Tspan15-ADAM10 signalling enhances cancer stem cell-like properties and induces chemoresistance via Notch1 activation in ICC.2023
- Author(s)
  Yoshizumi A, Kuboki S, Takayashiki T, Takano S, Takayanagi R, Sonoda I, Ohtsuka M
- Journal Title
  
  Liver International
  
  Volume: 43 Issue: 10 Pages: 2275-2291
- DOI
  10.1111/liv.15691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08107, KAKENHI-PROJECT-21K08792
[Journal Article] RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity2023
- Author(s)
  Morinaka Takashi、Sakai Nozomu、Takayashiki Tsukasa、Kuboki Satoshi、Takano Shigetsugu、Ohira Gaku、Matsubara Hisahiro、Ohtsuka Masayuki
- Journal Title
  
  International Journal of Oncology
  
  Volume: 63 Issue: 5
- DOI
  10.3892/ijo.2023.5568
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08889
[Journal Article] TRIM27-USP7 complex promotes tumour progression via STAT3 activation in human hepatocellular carcinoma2023
- Author(s)
  Toshiya Sakamoto, Satoshi Kuboki, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Arihito Yoshizumi, Masayuki Ohtsuka
- Journal Title
  
  Liver International
  
  Volume: 43 Issue: 1 Pages: 194-207
- DOI
  10.1111/liv.15346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09049
[Journal Article] Tumor-suppressive role of Smad ubiquitination regulatory factor 2 in patients with colorectal cancer2022
- Author(s)
  Sato N, Sakai N, Furukawa K, Takayashiki T, Kuboki S, Takano S, Ohira G, Miyauchi H, Matsubara H, Ohtsuka M.
- Journal Title
  
  Scientific reports
  
  Volume: 12 Issue: 1 Pages: 5495-5495
- DOI
  10.1038/s41598-022-09390-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09164, KAKENHI-PROJECT-20K09049, KAKENHI-PROJECT-20K17640
[Journal Article] Fat signal fraction assessed with MRI predicts hepatic recurrence following hepatic resection for colorectal liver metastases2022
- Author(s)
  Sakai Nozomu、Hayano Koichi、Mishima Takashi、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Takano Shigetsugu、Kawasaki Yohei、Matsubara Hisahiro、Ohtsuka Masayuki
- Journal Title
  
  Langenbeck's Archives of Surgery
  
  Volume: - Issue: 5 Pages: 1981-1989
- DOI
  10.1007/s00423-022-02482-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09190
[Journal Article] C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer2021
- Author(s)
  Sasaki K, Takano S, Tomizawa S, Miyahara Y, Furukawa K, Takayashiki T, Kuboki S, Takada M, Ohtsuka M
- Journal Title
  
  J Exp Clin Cancer Res
  
  Volume: 40 Issue: 1 Pages: 212-212
- DOI
  10.1186/s13046-021-02019-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-19K16824, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-20K09073, KAKENHI-PROJECT-21K08638
[Journal Article] Outcome of interventional radiology for delayed postoperative hemorrhage in hepatobiliary and pancreatic surgery2020
- Author(s)
  Sakai Nozomu、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Takano Shigetsugu、Suzuki Daisuke、Kagawa Shingo、Mishima Takashi、Nakadai Eri、Ohtsuka Masayuki
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 35 Issue: 12 Pages: 2264-2272
- DOI
  10.1111/jgh.15140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-19H03725
[Journal Article] LGR5 induces β‐catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma2020
- Author(s)
  Kawasaki Ki、Kuboki S、Furukawa K、Takayashiki T、Takano S、Ohtsuka M
- Journal Title
  
  Liver Int
  
  Volume: 41 Issue: 4 Pages: 865-881
- DOI
  10.1111/liv.14747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-20K09049
[Journal Article] Long-term outcomes and significance of preoperative lymphocyte-to-monocyte ratio as a prognostic indicator in patients with invasive pancreatic neoplasms after repeat pancreatectomy2020
- Author(s)
  Takano Shigetsugu、Yoshitomi Hideyuki、Kagawa Shingo、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Suzuki Daisuke、Sakai Nozomu、Mishima Takashi、Nakadai Eri、Miyazaki Masaru、Ohtsuka Masayuki
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Issue: 1 Pages: 111-111
- DOI
  10.1186/s12885-020-6602-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08671, KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725
[Journal Article] Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review.2020
- Author(s)
  Sato N, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Mishima T, Nakadai E, Mikata R, Kato N, Ohtsuka M.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 20 Pages: 13-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09190
[Journal Article] Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review2020
- Author(s)
  Sato Nami、Takano Shigetsugu、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Suzuki Daisuke、Sakai Nozomu、Kagawa Shingo、Mishima Takashi、Nakadai Eri、Mikata Rintaro、Kato Naoya、Ohtsuka Masayuki
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 20 Issue: 1 Pages: 13-13
- DOI
  10.1186/s12876-020-1159-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-19H03725
[Journal Article] High expression of Kruppel‐like factor 5 is associated with poor prognosis in patients with colorectal cancer2020
- Author(s)
  Takagi Yutaka、Sakai Nozomu、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Takano Shigetsugu、Suzuki Daisuke、Kagawa Shingo、Mishima Takashi、Nakadai Eri、Miyauchi Hideaki、Matsubara Hisahiro、Ohtsuka Masayuki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 6 Pages: 2078-2092
- DOI
  10.1111/cas.14411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-19H03725
[Journal Article] OLFM4 Enhances STAT3 Activation and Promotes Tumor Progression by Inhibiting GRIM19 Expression in Human Hepatocellular Carcinoma2019
- Author(s)
  Ashizawa Y, Kuboki S, Nojima H, Takano S, Ohtsuka M, et al
- Journal Title
  
  Hepatology Communications
  
  Volume: 3 Issue: 7 Pages: 954-970
- DOI
  10.1002/hep4.1361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K15040
[Journal Article] 誌上ディベート　肝胆膵外科におけるcontroversial surgery 3. 両葉多発大腸癌肝転移に対する肝切除 2）Major hepatectomyの立場から2019
- Author(s)
  酒井望、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、賀川真吾野島広之、三島敬、中台英里、大塚将之
- Journal Title
  
  手術
  
  Volume: 73 Pages: 290-297
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] The Expression of Yes-Associated Protein (YAP) Maintains Putative Cancer Stemness and Is Associated with Poor Prognosis in Intrahepatic Cholangiocarcinoma2019
- Author(s)
  Sugiura Kensuke、Mishima Takashi、Takano Shigetsugu、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Takada Mamoru、Miyazaki Masaru、Ohtsuka Masayuki
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 189 Issue: 9 Pages: 1863-1877
- DOI
  10.1016/j.ajpath.2019.05.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08671, KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725
[Journal Article] Successful treatment of a locally advanced unresectable pancreatic cancer patient with interstitial pneumonitis by conversion surgery following gemcitabine plus nab-paclitaxel chemotherapy: A case report.2019
- Author(s)
  Yokota T, Takano S, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Nakadai E, Ohtsuka M.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 10 Pages: 419-424
- DOI
  10.3892/mco.2019.1807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-19H03725, KAKENHI-PROJECT-18K15040
[Journal Article] Outcomes of left trisectionectomy and right hepatectomy for perihilar cholangiocarcinoma.2019
- Author(s)
  Hosokawa I, Shimizu H, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Koda K, Miyazaki M, Ohtsuka M.
- Journal Title
  
  HPB (Oxford).
  
  Volume: 21 Issue: 4 Pages: 489-498
- DOI
  10.1016/j.hpb.2018.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19K09134
[Journal Article] A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer.2019
- Author(s)
  Takahashi M, Yoshitomi H, Kato A, Furukawa K, Takayashiki T, Kuboki S, Takano S, Sugiura K, Kawasaki K, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Surg Case Rep.
  
  Volume: 5 Issue: 1 Pages: 21-21
- DOI
  10.1186/s40792-019-0581-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10661
[Journal Article] Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable and unresectable pancreatic body/tail cancer.2019
- Author(s)
  Yoshitomi H, Sakai N, Kagawa S, Takano S, Ueda A, Kato A, Furukawa K, Takayashiki T, Kuboki S, Miyzaki M, Ohtsuka M
- Journal Title
  
  Langenbecks Arch Surg.
  
  Volume: In press Issue: 4 Pages: 1-8
- DOI
  10.1007/s00423-019-01775-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K08671, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725
[Journal Article] Additional effect of perioperative, compared with preoperative, immunonutrition after pancreaticoduodenectomy: A randomized, controlled trial.2019
- Author(s)
  Miyauchi Y, Furukawa K, Suzuki D, Yoshitomi H, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Additional effect of perioperative, compared with preoperative, immunonutrition after pancreaticoduodenectomy: A randomized, controlled trial.
  
  Volume: 61 Pages: 69-75
- DOI
  10.1016/j.ijsu.2018.11.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-16K10564
[Journal Article] Is hepatic artery coil embolization useful in distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer?2019
- Author(s)
  Ueda A, Sakai N, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Kagawa S, Mishima T, Nakadai E, Miyazaki M, Ohtsuka M.
- Journal Title
  
  World J Surg Oncol. 124
  
  Volume: 17 Issue: 1 Pages: 124-124
- DOI
  10.1186/s12957-019-1667-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09190, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-19H03725
[Journal Article] Novel treatment strategy with radiofrequency ablation and surgery for pregnant patients with hepatocellular carcinoma: a case report.2018
- Author(s)
  Matsuo M, Furukawa K, Shimizu H, Yoshitomi H, Takayashiki T, Kuboki S, Takano S, Suzuki D, Sakai N, Kagawa S, Nojima H, Ohsuka M.
- Journal Title
  
  Surg Case Rep.
  
  Volume: 4 Issue: 1 Pages: 43-43
- DOI
  10.1186/s40792-018-0434-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K15040
[Journal Article] 切除不能胆道癌に対するconversion surgeryの意義と今後の課題2018
- Author(s)
  加藤厚、大塚将之、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、首村智久、羽鳥隆、池田佳史、宮崎勝
- Journal Title
  
  胆と膵
  
  Volume: 39 Pages: 887-891
- Data Source
  KAKENHI-PROJECT-16K10589
[Journal Article] Conversion surgery with gemcitabine plus nab-paclitaxel for locally advanced unresectable pancreatic cancer: A case report.2018
- Author(s)
  Okura R, Takano S, Yokota T, Yoshitomi H, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Nojima H, Mishima T, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 9 Pages: 389-393
- DOI
  10.3892/mco.2018.1688
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-16K15607
[Journal Article] Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer.2018
- Author(s)
  Yoneura N, Takano S, Yoshitomi H, Nakata Y, Shimazaki R, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 42 Pages: 821-830
- DOI
  10.3892/ijmm.2018.3652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10661, KAKENHI-PROJECT-18K08671, KAKENHI-PROJECT-17H04287, KAKENHI-PROJECT-16K10564, KAKENHI-PROJECT-16K10589, KAKENHI-PROJECT-16K15607
[Journal Article] 特集外科手術器具の理論と使用法 Ⅷ.その他の手術器具･材料深部生検に用いる超音波プローブと生検針の種類と使用法2017
- Author(s)
  高屋敷吏、三島敬、大塚将之、吉富秀幸、古川勝規、久保木知、高野重紹、鈴木大亮、酒井望、賀川真吾、野島広之
- Journal Title
  
  外科
  
  Volume: 79 Issue: 12 Pages: 1312-1315
- DOI
  10.15106/j_geka79_1312
- ISSN
  0016-593X, 2432-9428
- Year and Date
  2017-11-25
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] FOCUS 血行再建時の静脈グラフト選択のポイント-左腎静脈グラフトによる門脈再建術2017
- Author(s)
  高野重紹、野島広之、宮崎勝、大塚将之、吉富秀幸、清水宏明、古川勝規、高屋敷吏、久保木知、鈴木大亮、酒井望、賀川真吾
- Journal Title
  
  臨床外科
  
  Volume: 72 Issue: 2 Pages: 204-207
- DOI
  10.11477/mf.1407211518
- ISSN
  0386-9857, 1882-1278
- Year and Date
  2017-02-20
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] Postoperative serious complication and emergency treatment:liver abscess2017
- Author(s)
  高屋敷吏、野島広之、細川勇、大塚将之、清水宏明、吉富秀幸、古川勝規、久保木知、高野重紹、鈴木大亮、酒井望、賀川真吾
- Journal Title
  
  臨床外科
  
  Volume: 72 Issue: 6 Pages: 721-724
- DOI
  10.11477/mf.1407211647
- ISSN
  0386-9857, 1882-1278
- Year and Date
  2017-06-20
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] 特集最新の胆道癌診療トピックス-新たな治療戦略の可能性を探る手術手技肝動脈浸潤を伴う胆道癌の切除-右肝動脈浸潤を伴う肝門部領域胆管癌に対する肝左3区域切除術2017
- Author(s)
  久保木知、野島広之、三島敬、宮崎勝、大塚将之、清水宏明、吉富秀幸、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井望、賀川真吾
- Journal Title
  
  臨床外科
  
  Volume: 72 Issue: 13 Pages: 1462-1465
- DOI
  10.11477/mf.1407211880
- ISSN
  0386-9857, 1882-1278
- Year and Date
  2017-12-20
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] 胆膵進行癌に対する外科治療戦略胆道胆道癌に対する術前化学療法　進行胆道癌に対するconversion surgeryをめざした術前化学療法2017
- Author(s)
  久保木知、三島敬、大塚将之、吉富秀幸、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井望、賀川真吾、野島広之
- Journal Title
  
  外科
  
  Volume: 79 Issue: 8 Pages: 738-741
- DOI
  10.15106/J00393.2017324288
- ISSN
  0016-593X, 2432-9428
- Year and Date
  2017-08-01
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] 胆管内腔発育型腫瘍の概念と実際　胆管内，胆道内腫瘍（膵管内腫瘍との比較を含めて）　胆道ITPN2017
- Author(s)
  大塚将之，吉富秀幸，古川勝規，高屋敷　吏，久保木　知，高野重紹，鈴木大亮，酒井　望，賀川真吾，野島広之，三島　敬
- Journal Title
  
  肝胆膵
  
  Volume: 75 Pages: 1071-1076
- Data Source
  KAKENHI-PROJECT-16K10589
[Journal Article] An adequate technique of hepaticojejunostomy for reducing postoperative complications2017
- Author(s)
  久保木知、野島広之、細川勇、宮崎勝、大塚将之、清水宏明、吉富秀幸、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井望、賀川真吾
- Journal Title
  
  臨床外科
  
  Volume: 72 Issue: 4 Pages: 479-481
- DOI
  10.11477/mf.1407211591
- ISSN
  0386-9857, 1882-1278
- Year and Date
  2017-04-20
- Data Source
  KAKENHI-PROJECT-16K10564
[Journal Article] 胆管内乳頭状腫瘍(IPNB)とその外科治療2016
- Author(s)
  大塚将之、清水宏明、加藤　厚、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之、宮崎　勝
- Journal Title
  
  臨床外科
  
  Volume: 71 Pages: 317-321
- NAID
  40020749288
- Data Source
  KAKENHI-PROJECT-16K10589
[Journal Article] 新胆道癌取扱い規約からみた肝内胆管癌の位置づけ2016
- Author(s)
  大塚将之、清水宏明、加藤　厚、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之、宮崎勝
- Journal Title
  
  肝胆膵
  
  Volume: 72 Pages: 23-26
- Data Source
  KAKENHI-PROJECT-16K10589
[Journal Article] Significance of serum TGF-β1 levels for estimating bilirubin decrease following biliary drainage in jaundiced patients caused by biliary tract carcinoma2014
- Author(s)
  Fukada T,　Shimizu H, Kuboki S, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Miyazaki M.
- Journal Title
  
  Hepato-Gastroenterolgy
  
  Volume: 印刷中 Issue: 4 Pages: 428-441
- DOI
  10.1016/j.ccr.2014.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591994
[Journal Article] Chylous ascites after hepatopancreatobiliary surgery2013
- Author(s)
  Kuboki S, Yoshidome H, et al.
- Journal Title
  
  Br J Surg
  
  Volume: 100 Issue: 4 Pages: 522-527
- DOI
  10.1002/bjs.9013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591500, KAKENHI-PROJECT-23591892, KAKENHI-PROJECT-23791516
[Journal Article] Chylous Ascites After Hepato-Pancreato-Biliary Surgery2013
- Author(s)
  Kuboki S, et al
- Journal Title
  
  Br J Surg
  
  Volume: 100(4) Pages: 522-527
- Data Source
  KAKENHI-PROJECT-23791516
[Journal Article] 「炎症と消化器癌」肝におけるPPAR-gamma活性亢進に伴う抗炎症作用の解明及び肝細胞癌におけるPPAR-gamma発現の意義2012
- Author(s)
  久保木知, 他
- Journal Title
  
  消化器内科
  
  Volume: 54(6) Pages: 739-743
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] Tspan15は肝内胆管癌の予後不良因子であり, 化学療法抵抗性を誘導する2023
- Author(s)
  吉住有人, 久保木知, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望,細川勇, 三島敬, 小西孝宜, 西野仁恵, 仲田真一郎, 大塚将之
- Organizer
  第21回消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-21K08792
[Presentation] 肝内胆管癌におけるFAK/phospho-FAKの役割2023
- Author(s)
  髙柳良介、久保木知、高屋敷吏、高野重紹、鈴木大亮、酒井望、細川勇、三島敬、小西孝宜、西野仁惠、仲田真一郎、大塚将之
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-23K08107
[Presentation] 肝内胆管癌におけるFAK/phospho-FAKの役割2023
- Author(s)
  髙柳　良介、久保木　知、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、細川　勇、三島　敬、小西　孝宜、西野　仁恵、仲田　真一郎、大塚　将之
- Organizer
  第123回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09049
[Presentation] 肝胆道癌において炎症性シグナルを介した転写因子活性亢進は浸潤・転移能を高めることにより腫瘍進展を促進する2022
- Author(s)
  久保木　知、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、細川　勇、三島　敬、小西　孝宜、西野　仁恵、仲田　真一郎、大塚　将之
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09049
[Presentation] 肝胆道癌において炎症性シグナルを介した転写因子活性亢進は浸潤・転移能を高めることにより腫瘍進展を促進する2022
- Author(s)
  久保木知, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 細川勇, 三島敬, 小西孝宜, 西野仁恵, 大塚将之
- Organizer
  第122回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09049
[Presentation] 胆嚢癌におけるSTAT3およびNF-ｋB活性亢進を介したEMT誘導に関するPin1の意義2021
- Author(s)
  仲田真一郎、久保木　知、野島広之、吉富秀幸、古川勝規、高屋敷　吏、高野重紹、鈴木大亮、酒井　望、賀川真吾、細川　勇、三島　敬、小西孝宣、宮崎　勝、大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] 胆嚢癌におけるSTAT3およびNF-kB活性亢進を介したEMT誘導に関するPin1の意義2021
- Author(s)
  仲田真一郎, 久保木知, 野島広之, 吉富秀幸, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 細川勇, 三島敬, 小西孝宣, 宮崎勝, 大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] 治療成績向上を目指した肝内胆管癌に対する根治手術と化学療法を組み合わせた集学的治療成績の再考2021
- Author(s)
  久保木　知、古川勝規、高屋敷　吏、高野重紹、鈴木大亮、酒井　望、賀川真吾、細川　勇、三島　敬、小西孝宣、大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] 進行胆嚢癌におけるPD-L1発現の臨床的意義2021
- Author(s)
  佐藤豊, 久保木知, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 細川勇, 三島敬, 小西孝宜, 大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] 肝内胆管癌の外科治療の現状と課題:成績向上はあるのか?　治療成績向上を目指した肝内胆管癌に対する根治手術と化学療法を組み合わせた集学的治療成績の再考2021
- Author(s)
  久保木知, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 細川勇, 三島敬, 小西孝宜, 大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] 進行胆嚢癌におけるPD-L1発現の臨床的意義2021
- Author(s)
  佐藤　豊、久保木　知、古川勝規、高屋敷　吏、高野重紹、鈴木大亮、酒井　望、賀川真吾、細川　勇、三島　敬、小西孝宣、大塚将之
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] 進行胆嚢癌におけるPD-L1発現の臨床的意義2021
- Author(s)
  佐藤豊, 久保木知, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 細川勇, 三島敬, 小西孝宜, 大塚将之
- Organizer
  第121回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09049
[Presentation] Analysis of correlation between resection margin and recurrence in patients with IPMN2020
- Author(s)
  Takashi Mishima, Shigetsugu Takano, Katsunori furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuike Suzuki, Nozomu Sakai, Shingo Kagawa, Isamu Hosokawa, Takanori Konishi, Masayuki Ohtsuka
- Organizer
  The 32nd Meeting of Japanese Society of Hepato Billiary Pancreatic Surgery
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] 高齢胆道癌患者に対する拡大肝切除術を安全に施行するための至適残肝率の再考2020
- Author(s)
  久保木　知
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] LGR5-WntシグナルはSTAT3活性亢進を介して肝内胆管癌のstemness及びEMTを促進することにより腫瘍悪性度を高める2020
- Author(s)
  川崎圭史、久保木知、吉富秀幸、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井望、賀川真吾、三島敬、中台英里、小西孝宣、大塚将之
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] LGR5-WntシグナルはSTAT3活性亢進を介して肝内胆管癌のstemness及びEMTを促進することにより腫瘍悪性度を高める2020
- Author(s)
  川﨑圭史, 久保木知, 吉富秀幸, 古川勝規, 高屋敷吏, 高野重紹, 鈴木大亮, 酒井望, 賀川真吾, 三島敬, 中台英里, 小西孝宣, 大塚将之
- Organizer
  第120回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09049
[Presentation] 肝内胆管癌に対する積極的リンパ節郭清の予後延長効果を再考する2020
- Author(s)
  久保木知、古川勝規、高屋敷吏、高野重紹、鈴木大亮、酒井望、賀川真吾、細川勇、小西孝宣、大塚将之
- Organizer
  第82回日本臨床外科学会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] 肝内胆管癌におけるYAP発現の臨床病理学的意義と機能解析2019
- Author(s)
  杉浦謙典、三島　敬、高野重紹、久保木　知、中台英里、大塚将之、他
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] 局所進行切除不能肝内胆管癌に対するDownsizing chemotherapyとConversion surgeryの意義2019
- Author(s)
  中台英里、久保木　知、高野重紹、三島　敬、大塚将之、他
- Organizer
  第81回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] OLFM4 enhances STAT3 activation and promotes tumor progression by inhibiting GRIM-19 expression in human hepatocellular carcinoma2019
- Author(s)
  Ashizawa Y, Kuboki S, Takano S, Mishima T, Nakadai E, Ohtsuka M, et al.
- Organizer
  第31回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] The clinical impact and analysis for neoadjuvant chemotherapy against borderline resectable pancreatic cancer: gemcitabine plus S-1 vs gemcitabine plus nab-paclitaxel.2019
- Author(s)
  Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Furukawa Katsunori, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masayuki Ohtsuka
- Organizer
  AACR special conference Pancreatic Cancer: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] Small-for-size graftにおける脾摘の類洞内皮障害軽減効果に関するmolecular mechanismの解明2019
- Author(s)
  久保木　知
- Organizer
  第37回日本肝移植学会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] The impact of Lymphocyte-to-monocyte ratio (LMR) in patients with borderline resectable pancreatic head cancer after curative surgery.2019
- Author(s)
  Yoji Miyahara, Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masayuki Ohtsuka
- Organizer
  AACR special conference Pancreatic Cancer: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] C4BPA identified as a novel biomarker is associated with favorable outcome of patients with pancreatic cancer.2019
- Author(s)
  Kosuke Sasaki, Shigetsugu Takano, Hideyuki Yoshitomi, Kazuyuki Sogawa, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masayuki Ohtsuka
- Organizer
  AACR special conference Pancreatic Cancer: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09190
[Presentation] 肝内胆管癌に対する積極的リンパ節郭清はR0切除後の予後改善に寄与する2019
- Author(s)
  佐藤　豊、久保木　知、高野重紹、三島　敬、中台英里、他
- Organizer
  第81回日本臨床外科学会
- Data Source
  KAKENHI-PROJECT-19K09113
[Presentation] Clinical outcome of ALPPS -A Single Institute Experience-2018
- Author(s)
  Nozomu Sakai, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Hiroyuki Nojima Takashi Mishima, Masaru Miyazaki, Masayuki Ohtsuka
- Organizer
  13th IHPBA World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 肝門部領域胆管癌に対する手術を加味した適切な術前減黄strategyの検証2018
- Author(s)
  久保木　知
- Organizer
  第54回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 肝内胆管癌におけるYAP/TAZ発現の意義2018
- Author(s)
  杉浦謙典、三島敬、高野重紹、酒井望、鈴木大亮、久保木知、高屋敷吏、古川勝規、吉富秀幸、大塚将之
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] 大腸癌多発肝転移に対する治療成績2018
- Author(s)
  酒井望、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、賀川真吾野島広之、三島敬、大塚将之
- Organizer
  第54回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 進行肝内胆管癌に対する術前化学療法の施行およびR0切除を目指した積極的外科治療の意義を再考する2018
- Author(s)
  久保木　知
- Organizer
  第16回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 大腸癌肝転移に対するConversion surgeryの治療成績2018
- Author(s)
  酒井望、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮賀川真吾、野島広之、三島敬、中台英里、大塚将之
- Organizer
  第80回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 進行胆嚢癌に対する根治的外科切除を目指した集学的治療戦略2018
- Author(s)
  久保木　知
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 高齢胆道癌患者に対する拡大肝切除術を安全に施行するための新たな残肝率基準の提唱2018
- Author(s)
  久保木　知
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] Outcome of patients with initially unresectable locally advanced intrahepatic cholangiocarcinoma treated by downsizing chemotherapy and subsequent surgical resection2018
- Author(s)
  Ohtsuka M, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Sakai N, Kagawa S, Nojima H, Mishima T, Kato A, Miyazaki M
- Organizer
  13th IHPBA World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] 切除不能局所進行肝内胆管癌に対するR0切除を目指したdownsizing chemotherapyおよび積極的リンパ節郭清は予後改善に寄与する2018
- Author(s)
  久保木知、吉富秀幸、古川勝規、高屋敷吏、鈴木大亮、酒井望、賀川真吾、野島広之、三島敬、中台英里、宮崎勝、大塚将之
- Organizer
  第80回日本臨床外科学会
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] Prognostic impact of preoperative chemotherapy for resectable colorectal liver metastases2018
- Author(s)
  Nozomu Sakai, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Hiroyuki Nojima、Takashi Mishima Masayuki Ohtsuka
- Organizer
  第30回日本肝胆膵外科学会・学術集会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 進行肝内胆管癌に対する術前化学療法の施行およびR0切除を目指した積極的外科治療の意義を再考する2018
- Author(s)
  久保木知、宮崎勝、大塚将之
- Organizer
  JDDW2018
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] Treatment strategy for multiple colorectal liver metastases2018
- Author(s)
  Nozomu Sakai, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Hiroyuki Nojima Masayuki Ohtsuka
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] Multidisciplinary treatment combined with neoadjuvant downsizing chemotherapy and aggressive regional lymph node dissection to achieve R0 resection improves prognosis in patients with advanced intrahepatic cholangiocarcinoma.2018
- Author(s)
  久保木　知
- Organizer
  13th IHPBA World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 大腸癌肝肺転移に対する切除成績2018
- Author(s)
  酒井望、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、賀川真吾野島広之、三島敬、大塚将之
- Organizer
  第26回日本消化器関連学会週間 (JDDW)
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 大腸癌多発肝転移に対する治療戦略2018
- Author(s)
  酒井望、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、賀川真吾野島広之、三島敬、大塚将之
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 高齢ドナー肝における肝障害増強・肝再生抑制機序に関する基礎的・臨床的検討2017
- Author(s)
  久保木知、吉富　秀幸、古川　勝規、高屋敷　吏、仲田　真一郎、松尾　めぐみ、川崎　圭史、大塚　将之
- Organizer
  第53回日本移植学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 残肝容量不足時のshare stress増強に伴う類洞内皮障害軽減に対する脾摘の意義に関する基礎的研究2017
- Author(s)
  久保木　知、清水　宏明、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、野島　広之、宮崎　勝、大塚　将之
- Organizer
  第35回日本肝移植研究会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 術後肝再生シグナル誘導に関するkey moleculeとしてのPin1の有用性2017
- Author(s)
  久保木　知、宮崎　勝、大塚　将之
- Organizer
  第15回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 大腸癌肝転移に対する治療戦略大腸癌肝転移切除後再発に対するrepeat resectionの意義2017
- Author(s)
  酒井望, 清水宏明, 吉富秀幸, 古川勝規, 高屋敷吏, 久保木知, 高野重紹, 鈴木大亮, 宮崎勝, 大塚将之
- Organizer
  日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 高齢胆道癌患者に対する拡大肝切除術を安全に施行するための至適残肝率の再考2017
- Author(s)
  久保木　知、渡邉　善寛、野島　広之、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、三島　敬、宮崎　勝、大塚　将之
- Organizer
  第79回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10661
[Presentation] 術後再発からみた大腸癌肝転移に対するconversion surgeryの治療成績2017
- Author(s)
  酒井望, 吉富秀幸, 古川勝規, 高屋敷吏, 久保木知, 高野重紹, 鈴木大亮, 賀川真吾, 野島広之, 三島敬, 大塚将之
- Organizer
  日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 大腸癌肝転移切除後の肝再発、肝外再発に対する外科治療成績の検討2017
- Author(s)
  酒井望、清水宏明, 吉富秀幸, 古川勝規, 高屋敷吏, 高野重紹, 久保木知, 鈴木大亮, 賀川真吾, 野島広之, 宮崎勝, 大塚将之
- Organizer
  日本外科学会定期学術集会抄録集
- Data Source
  KAKENHI-PROJECT-16K10564
[Presentation] 肝内胆管癌の局在によるリンパ節転移分布とそれに基づく治療戦略2017
- Author(s)
  大塚将之、清水宏明、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之、宮崎　勝
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] Clinicopathological Features and Surgical Outcome of Intraductal Papillary Neoplasm of the Bile Duct (IPNB)2017
- Author(s)
  大塚将之、清水宏明、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] 肝細胞癌におけるPin1を介した腫瘍進展機序に基づいた系統的肝切除の有用性の検討2016
- Author(s)
  久保木　知、篠田　公男、野島　広之、清水　宏明、大塚　将之、加藤　厚、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、宮崎　勝
- Organizer
  第25回日本癌病態治療研究会
- Place of Presentation
  三井ガーデンホテル(千葉県千葉市）
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] Regulation of STAT3 activity by controlling the functions of Pin1 or DRAC effectively inhibits tumor proliferation/invasiveness in human pancreatic ductal adenocarcinoma2016
- Author(s)
  Satoshi Kuboki, Shintaro Maeda, Takayuki Suzuki, Hiroyuki Nojima, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
- Organizer
  第47回日本膵臓学会大会・第20回国際膵臓学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] 肝内胆管癌の治療方針拡大切除に意義があるとの立場から2016
- Author(s)
  大塚将之、清水宏明、加藤　厚、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之、宮崎　勝
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  アスティ徳島（徳島県徳島市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] 浸潤性膵管癌の悪性度評価におけるPin1発現の有用性および治療標的因子としての可能性の検討2016
- Author(s)
  久保木　知、鈴木　崇之、野島　広之、清水　宏明、大塚　将之、加藤　厚、吉富　秀幸、古川　勝規、高屋敷　吏、高野　重紹、鈴木　大亮、酒井　望、賀川　真吾、宮崎　勝
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] 進行肝内胆管癌に対する血管合併切除を伴う外科治療の意義2016
- Author(s)
  大塚将之、清水宏明、加藤　厚、吉富秀幸、古川勝規、高屋敷　吏、久保木　知、高野重紹、鈴木大亮、酒井　望、賀川真吾、野島広之、宮崎　勝
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K10589
[Presentation] Annexin II induces gemcitabine resistance via Akt/mTOR signaling pathway and predicts rapid recurrence after surgery in pancreatic cancer.2016
- Author(s)
  S. Takano, H. Yoshitomi, S. Kagawa, H. Shimizu, M. Ohtsuka, A. Kato, K. Furukawa, T. Takayashiki, S. Kuboki, D. Suzuki, N. Sakai, H. Nojima and M. Miyazaki.
- Organizer
  第47回日本膵臓学会大会、第20回国際膵臓学会、第6回アジアオセアニア膵臓学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293299
[Presentation] Annexin II発現における膵癌バイオマーカーの臨床学的意義2016
- Author(s)
  高野重紹、吉富秀幸、賀川真吾、清水宏明、大塚将之、加藤　厚、古川勝規、高屋敷　吏、久保木　知、鈴木大亮、酒井　望、野島広之、宮崎　勝
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26293299
[Presentation] A new multidisciplinary approach for initially unresectable locally advanced biliary tract cancer2015
- Author(s)
  Atsushi Kato, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daiki Okamura, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
- Organizer
  第27回日本肝胆膵外科学会・学術集会
- Place of Presentation
  ホテルグランパシフィック（東京都港区）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25462079
[Presentation] Identification of Cofilin as a useful biomarker in pancreatic cancer progression.2015
- Author(s)
  Shigetsugu Takano, Mamoru Satoh, Kazuyuki Sogawa, Hideyuki Yoshitomi, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Satoshi Kuboki, Shingo Kagawa, Kazuyuki Matsushita, Fumio Nomura and Masaru Miyazaki
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26293299
[Presentation] 自己免疫複合体測定法による膵癌バイオマーカーの臨床学的意義2015
- Author(s)
  Shingo Kagawa, Shigetsugu Takano, Mamoru Satoh, Kazuyuki Sogawa, Hideyuki Yoshitomi, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daiki Okamura, Daisuke Suzuki, Nozomu Sakai, Fumio Nomura, Masaru Miyazaki
- Organizer
  第23回日本消化器関連学会週間 (JDDW2015)
- Place of Presentation
  グランドプリンスホテル新高輪・国際パミール・グランドプリンスホテル高輪（東京都品川区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26293299
[Presentation] Downsizing chemotherapy followed by surgical resection for patients with initially unresectable locally advanced biliary tract cancer2015
- Author(s)
  Atsushi Kato, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daiki Okamura, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25462079
[Presentation] 高度血管侵襲を有する切除不能局所進行胆道癌に対するConversion Therapyの有用性2015
- Author(s)
  加藤　厚、清水宏明、大塚将之、吉富秀幸、古川勝規、高屋敷吏、久保木知、高野重紹、鈴木大亮、酒井　望、賀川真吾、宮崎　勝
- Organizer
  第77回日本臨床外科学会総会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-25462079
[Presentation] Pin1 promotes HCC progression and predicts poor prognosis by regulating NF-kappaB-PPAR-gamma axis2015
- Author(s)
  Satoshi Kuboki
- Organizer
  JDDW 2015
- Place of Presentation
  グランドプリンスホテル新高輪（東京都品川区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] 肝内胆管癌に対する外科切除を中心とした治療戦略.2015
- Author(s)
  大塚将之, 清水宏明, 加藤　厚, 吉富秀幸, 古川勝規, 高屋敷吏, 久保木知, 高野重紹, 岡村大樹, 鈴木大亮, 酒井望, 賀川真吾, 宮崎勝.
- Organizer
  第27回日本肝胆膵外科学会・学術集会
- Place of Presentation
  ホテルグランパシフィック（東京都港区）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25462079
[Presentation] 阻血障害肝切除後の転写因子活性抑制に伴う肝再生遅延機序へのPinlの関与の解明及びその対策2013
- Author(s)
  久保木知, 他
- Organizer
  第113回日本外科学会総会
- Place of Presentation
  パネルディスカッション
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kappaB activation in hepatocytes2013
- Author(s)
  Kuboki S, et al
- Organizer
  48^<th> EASL 2013 (Oral e-poster session 選出)
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 拡大肝切除及び肝移植術後の阻血障害肝再生抑制に伴う肝不全発生機序の解明及びその対策2012
- Author(s)
  久保木知, 他
- Organizer
  第112回日本外科学会総会
- Place of Presentation
  サージカルフォーラム
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 肝細胞癌における抗Pin1抗体のNF-kappaB活性抑制とPPAR-gamma活性亢進を介した腫瘍増殖抑制機序の解明及び分子標的治療薬としての可能性の追求2012
- Author(s)
  久保木知, 他
- Organizer
  第67回日本消化器外科学会総会
- Place of Presentation
  ワークショップ
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] Inhibitory effects of peroxisome proliferator-activated receptor-gamma on tumor growth in human hepatocellular carcinoma: Usefulness as a prognostic predictor and therapeutic target2012
- Author(s)
  Kuboki S, et al
- Organizer
  DDW 2013 (Poster session)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 肝でのPin1を介したNF-kappaB活性とPPAR-gamma活性の均衡調節による酸化ストレス制御及び抗Pin1抗体の肝細胞癌に対する腫瘍増殖抑制機序の解明2012
- Author(s)
  久保木知, 他
- Organizer
  JDDW2012
- Place of Presentation
  パネルディスカッション
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 肝におけるPPAR-gamma活性亢進に伴う抗炎症作用の解明および肝細胞癌におけるPPAR-gamma発現の意義の検討2011
- Author(s)
  久保木知, 他
- Organizer
  JDDW2011
- Place of Presentation
  シンポジウム
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 阻血障害肝における切除後の転写因子活性抑制に伴う肝再生遅延機序へのPin1 の関与の解明及びその対策
- Author(s)
  久保木　知
- Organizer
  第113回日本外科学会総会（パネルディスカッション）
- Place of Presentation
  福岡（博多）
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 拡大肝切除及び肝移植術後の阻血障害肝再生抑制に伴う肝不全発生機序の解明及びその対策
- Author(s)
  久保木　知
- Organizer
  第112回日本外科学会総会（サージカルフォーラム）
- Place of Presentation
  千葉（幕張）
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] 肝細胞癌におけるPin1発現の肝切除術後の予後予測因子・早期再発予測因子としての有用性の検討
- Author(s)
  久保木　知
- Organizer
  JDDW 2014
- Place of Presentation
  神戸国際会議場　（兵庫県神戸市）
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] 肝胆膵領域癌におけるPin1を介したNF-kappaB活性亢進に伴う腫瘍増殖抑制機序の解明及び治療標的としての可能性の追求
- Author(s)
  久保木　知
- Organizer
  第69回日本消化器外科学会総会
- Place of Presentation
  ホテルハマツ　（福島県郡山市）
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-26462036
[Presentation] Pin1 is decreased in ischemically damaged liver and suppressed liver regeneration after hepatectomy through the inhibition of Pin1-mediated NF-kB activation in hepatocytes.
- Author(s)
  Satoshi Kuboki
- Organizer
  48th EASL、oral e-Poster presentation
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23791516
[Presentation] Pin1 inhibitorによるNF-kappaB活性制御を介した肝細胞癌に対する分子標的治療の可能性の追求
- Author(s)
  久保木　知
- Organizer
  第50回肝癌研究会
- Place of Presentation
  京都国際会館　（京都府京都市）
- Year and Date
  2014-06-05 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-26462036
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1. OHTSUKA Masayuki (90334185)

# of Collaborated Projects: 13 results

# of Collaborated Products: 65 results
2. Nozomu Sakai (70436385)

# of Collaborated Projects: 8 results

# of Collaborated Products: 27 results
3. 高野重紹 (20436380)

# of Collaborated Projects: 7 results

# of Collaborated Products: 56 results
4. MIYAZAKI Masaru (70166156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
5. Mishima Takashi (70802560)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
6. 高屋敷吏 (30456024)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
7. SHIMIZU Hiroaki (80272318)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
8. 賀川真吾 (90507302)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
9. KATO ATSUSHI (70344984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
10. OKAMURA DAIKI (50375698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. 吉富秀幸 (60375631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
12. 野島広之 (10507320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
13. 小西孝宜 (80865882)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. KIMURA Fumio (70334208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Yoshizumi Arihito (90895856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 中台英里 (60831500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. 古川勝規 (00400987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 鈴木大亮 (90422229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. 細川勇 (60623676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 森中孝至 (70895854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 佐藤豊 (90867285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 仲田真一郎 (90971292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 松山尚樹 (20971724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUGIURA kaneyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 吉留博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuboki Satoshi 久保木 知

KUBOKI Satoshi 久保木 知

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肝内胆管癌におけるFAKを標的とした癌微小環境の調節による癌可塑性誘導治療の開発Principal Investigator

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Development of a new therapy targeting LGR5-induced STAT3 activation in hepato-biliary-pancreatic cancerPrincipal Investigator

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A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.Principal Investigator

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Inflammation-associated NF-kappaB activation promotes tumor progression in hepato-biliary-pancreatic cancer.Principal Investigator

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Kuboki Satoshi 久保木知

KUBOKI Satoshi 久保木知