Yamaguchi Tomoko 山口朋子

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YAMAGUCHI Tomoko 山口朋子

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Researcher Number	50580130
Other IDs
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬資源研究支援センター, 研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬資源研究支援センター, 研究員 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬細胞モデル研究プロジェクト, 研究員 2018 – 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所幹細胞制御プロジェクト, 研究員 2012: 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクト研究員 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Medical pharmacy Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator P-糖タンパク / iPS細胞 / P-gp / BBB / Gfi1 / 分化 / マスト細胞 / 自然免疫 / 小分子RNA / アデノウイルス Except Principal Investigator ワクチン / iPS細胞 / 免疫学

次世代型in vitro 血液ー脳関門モデルの開発Principal Investigator
- Principal Investigator
  
  山口朋子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Differentiation of brain microvascular endothelial cells from human iPS cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomoko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
The role of Gfi1 in the differentiation of mast cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Differentiation of plasmacytoid dendritic cells from iPS cells and its application for Vaccine development
- Principal Investigator
  
  KAWABATA Kenji
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  独立行政法人医薬基盤研究所
Elucidation of the mechanism of VA-RNA-induced innate immune responsePrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Tomoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  独立行政法人医薬基盤研究所

All 2023 2022 2020 2019 2013 2012 2011

All Journal Article Presentation

[Journal Article] The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression2023
- Author(s)
  Zhang Hongyan、Yamaguchi Tomoko、Kawabata Kenji
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 20 Issue: 1 Pages: 10-10
- DOI
  10.1186/s12987-023-00408-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20736, KAKENHI-PROJECT-23K06273
[Journal Article] Inhibition of Glycogen Synthase Kinase 3ß Enhances Functions of Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells in the Blood–Brain Barrier2022
- Author(s)
  Yamaguchi Tomoko、Nishijima Misae、Kawabata Kenji
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 10 Pages: 1525-1530
- DOI
  10.1248/bpb.b22-00393
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K20736
[Journal Article] The role of galanin in the differentiation of mucosal mast cells in mice.2020
- Author(s)
  Yamaguchi T., Ikeda Y., Tashiro K., Ohkawa Y., Kawabata K.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 50 Issue: 1 Pages: 110-118
- DOI
  10.1002/eji.201848061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06650, KAKENHI-PUBLICLY-18H04802, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-20H04846, KAKENHI-PROJECT-20H00456
[Journal Article] Two-step differentiation of mast cells from induced pluripotent stem cells2013
- Author(s)
  Yamaguchi T, Tashiro K, Tanaka S, Katayama S, Ishida W, Fukuda K, Fukushima A, Araki R, Abe M, Mizuguchi H, Kawabata K
- Journal Title
  
  Stem Cells Dev
  
  Volume: 22 Pages: 726-734
- Data Source
  KAKENHI-PROJECT-24659040
[Journal Article] Two-step differentiation of mast cells from induced pluripotent stem cells.2013
- Author(s)
  Yamaguchi, T., Yamaguchi, T., Tashiro, K., Tanaka, S., Katayama, S., Ishida, W., Fukuda, K., Fukushima, A., Araki, R., Abe, M., Mizuguchi, H., Kawabata, K.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: 22 Issue: 5 Pages: 726-734
- DOI
  10.1089/scd.2012.0339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590077, KAKENHI-PROJECT-24659040
[Journal Article] Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation2012
- Author(s)
  Tashiro K, Omori M, Kawabata K, Hirata N, Yamaguchi T, Sakurai F, Takaki S, Mizuguchi H
- Journal Title
  
  Stem Cells Dev
  
  Volume: 21 Pages: 3381-3390
- Data Source
  KAKENHI-PROJECT-24659040
[Journal Article] Development of an adenovirus vector lacking the expression of virus-associated RNAs2011
- Author(s)
  Machitani M, et al
- Journal Title
  
  J Control Release
  
  Volume: 154 Issue: 3 Pages: 285-289
- DOI
  10.1016/j.jconrel.2011.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02506, KAKENHI-PROJECT-22390030, KAKENHI-PROJECT-23790215
[Journal Article] Adenovirus vector-derived VA-RNA-mediated innate immune responses2011
- Author(s)
  Machitani M, et al
- Journal Title
  
  Pharmaceutics
  
  Volume: 3 Issue: 3 Pages: 338-353
- DOI
  10.3390/pharmaceutics3030338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390030, KAKENHI-PROJECT-23790215
[Presentation] 創薬に適したiPS細胞由来脳血管内皮細胞の改良2023
- Author(s)
  山口朋子、西島美妙江、張鴻燕、川端健二
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K20736
[Presentation] 薬物動態評価系への応用を目指したヒトiPS細胞由来脳血管内皮細胞の作製2022
- Author(s)
  山口朋子、張鴻燕、西島美妙江、川端健二
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K20736
[Presentation] マスト細胞分化における転写因子Gfi1の役割2019
- Author(s)
  山口朋子、田中智之、西島美妙江、長竹貴広、國澤純、川端健二
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06650
[Presentation] アデノウイルスベクターワクチンによる抗原特異的な獲得免疫応答のメカニズム解明2013
- Author(s)
  辺見昌久、続木沙也加、立花雅史、山口朋子、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] マウスiPS細胞から成熟したマスト細胞の分化誘導法の開発2013
- Author(s)
  山口朋子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659040
[Presentation] アデノウイルスベクターが惹起する自然免疫応答メカニズムの解析2013
- Author(s)
  立花雅史、続木沙也加、山口朋子、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] アデノウイルスベクターが惹起する自然免疫応答メカニズムの解析2013
- Author(s)
  立花雅史、続木沙也加、山口朋子、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] アデノウイルス由来小分子RNA (VA-RNA) の機能解析に向けた新規ベクターの開発2011
- Author(s)
  町谷充洋、形山和史、櫻井文教、立花雅史、山口朋子、鈴木孝幸、川端健二、水口裕之
- Organizer
  第11回遺伝子デリバリー研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] Development of a virus-associated RNA-deleted adenovirus vector.2011
- Author(s)
  Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Kenji Kawabata, Hiroyuki Mizuguchi
- Organizer
  American society of gene & cell therapy 14th Annual Meeting
- Place of Presentation
  シアトル（米国）
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] アデノウイルス由来小分子RNA(VA-RNA)の機能解析に向けた新規ベクターの開発2011
- Author(s)
  町谷充洋、形山和史、櫻井文教、立花雅史、山口朋子、鈴木孝幸、川端健二、水口裕之
- Organizer
  第11回遺伝子デリバリー研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] Development of a virus-associated RNA-deleted adenovirus vector2011
- Author(s)
  Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Kenji Kawabata, Hiroyuki Mizuguchi
- Organizer
  American society of gene & cell therapy 14^<th> Annual Meeting
- Place of Presentation
  Seattle
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] evelopment of adenovirus vector lacking the expression of virus-associated RNAs.2011
- Author(s)
  Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Kenji Kawabata, Hiroyuki Mizuguchi
- Organizer
  The 6th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  ソウル（韓国）
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] Development of adenovirus vector lacking the expression of virus-associated RNAs2011
- Author(s)
  Mitsuhiro Machitani, Kazufunli Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Kenji Kawabata, Hiroyuki Mizuguchi
- Organizer
  The 6~<th> Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-23790215
[Presentation] アデノウイルスベクターによる自然免疫誘導メカニズムの解明2011
- Author(s)
  山口朋子
- Organizer
  第36回製剤セミナー, Postdoctoral Presentation Award受賞
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23790215

1. KAWABATA Kenji (50356234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 田中智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Tomoko 山口 朋子

YAMAGUCHI Tomoko 山口 朋子

Research Projects

Research Products

Co-Researchers

次世代型in vitro 血液ー脳関門モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation of brain microvascular endothelial cells from human iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of Gfi1 in the differentiation of mast cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation of plasmacytoid dendritic cells from iPS cells and its application for Vaccine development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of VA-RNA-induced innate immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Glycogen Synthase Kinase 3ß Enhances Functions of Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells in the Blood–Brain Barrier2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The role of galanin in the differentiation of mucosal mast cells in mice.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-step differentiation of mast cells from induced pluripotent stem cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Two-step differentiation of mast cells from induced pluripotent stem cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation2012

Author(s)

Journal Title

Data Source

[Journal Article] Development of an adenovirus vector lacking the expression of virus-associated RNAs2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenovirus vector-derived VA-RNA-mediated innate immune responses2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] 創薬に適したiPS細胞由来脳血管内皮細胞の改良2023

Author(s)

Organizer

Data Source

Yamaguchi Tomoko 山口朋子

YAMAGUCHI Tomoko 山口朋子