SHIRAKAWA RYUTARO 白川龍太郎

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SHIRAKAWA Ryutaro 白川龍太郎

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Researcher Number	50581039
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細胞科学部, 室長 2025: 東北大学, 加齢医学研究所, 非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 東北大学, 加齢医学研究所, 講師 2010 – 2021: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related / Tumor biology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator Ral / 低分子量GTP結合タンパク質 / 低分子量GTP結合蛋白質 / RalGAP / Ras / 癌 / 膵臓がん / phenformin / pancreatic cancer / metformin … More / biguanide / 転移 / PDAC / 口腔扁平上皮がん / 膀胱癌 / GAP / シグナル伝達 … More Except Principal Investigator 血小板 / 第VIII因子 / 凝固第VIII因子 / ずり応力 / フォンウィルブランド因子 / 血行力学的環境応答 / 補助循環 / 血液剪断負荷 / 非臨床評価 / 後天性von Willebrand症候群 Less

Ykt6による細胞内クリアランスの分子機構Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tohoku University
Research of high-shear stress-induced hemostatic disorder
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist
- Principal Investigator
  
  白石泰之
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tohoku University
Molecular Mechanism of Tumor Supression by RalGAP and BiguanidesPrincipal Investigator
- Principal Investigator
  
  Shirakawa Ryutaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Molecular Mechanisms of Tumorigenesis, Invasion, and Metastasis by the Small GTPase RalPrincipal Investigator
- Principal Investigator
  
  Ryutaro Shirakawa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral SignalingPrincipal Investigator
- Principal Investigator
  
  Shirakawa Ryutaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
癌転移抑制因子RalGAP複合体の構造解析Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Identification of Ral kinase and characterization of its role in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SHIRAKAWA Ryutaro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
ＲａｌＧＡＰ複合体の構造機能解析Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
RalA標的蛋白質による細胞癌化の分子機構Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma2021
- Author(s)
  Yoshimachi Shingo、Shirakawa Ryutaro、Cao Mingxin、Trinh Duc Anh、Gao Pan、Sakata Natsumi、Miyazaki Kento、Goto Kota、Miura Takayuki、Ariake Kyohei、Maeda Shimpei、Masuda Kunihiro、Ishida Masaharu、Ohtsuka Hideo、Unno Michiaki、Horiuchi Hisanori
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 8 Pages: 3064-3073
- DOI
  10.1111/cas.14970
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-21H02996
[Journal Article] Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation2020
- Author(s)
  Iida Tomoya、Hirayama Daisuke、Minami Naoki、Matsuura Minoru、Wagatsuma Kohei、Kawakami Kentaro、Nagaishi Kanna、Nojima Masanori、Ikeuchi Hiroki、Hirota Seiichi、Shirakawa Ryutaro、Horiuchi Hisanori、Nakase Hiroshi
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 9 Issue: 2 Pages: 277-293
- DOI
  10.1016/j.jcmgh.2019.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-18H02799
[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Kazuma Yasuhiro、Matsui Hiroyuki、Horisawa Yoshihito、Stanford Emani、Sarca Anamaria Daniela、Shirakawa Ryutaro、Shindo Keisuke、Takaori-Kondo Akifumi
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 1 Pages: e0223463-e0223463
- DOI
  10.1371/journal.pone.0223463
- NAID
  120006786934
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus2020
- Author(s)
  Shirakawa Ryutaro、Goto‐Ito Sakurako、Goto Kota、Wakayama Shonosuke、Kubo Haremaru、Sakata Natsumi、Trinh Duc Anh、Yamagata Atsushi、Sato Yusuke、Masumoto Hiroshi、Cheng Jinglei、Fujimoto Toyoshi、Fukai Shuya、Horiuchi Hisanori
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 8
- DOI
  10.15252/embj.2019104120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03162
[Journal Article] Double prenylation of SNARE protein Ykt6 is required for lysosomal hydrolase trafficking2020
- Author(s)
  Sakata Natsumi、Shirakawa Ryutaro、Goto Kota、Trinh Duc Anh、Horiuchi Hisanori
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 169 Issue: 3 Pages: 363-370
- DOI
  10.1093/jb/mvaa111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis2019
- Author(s)
  Trinh Duc-Anh、Shirakawa Ryutaro、Kimura Tomohiro、Sakata Natsumi、Goto Kota、Horiuchi Hisanori
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-53767-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis2019
- Author(s)
  Uegaki Masayuki、Kita Yuki、Shirakawa Ryutaro、Teramoto Yuki、Kamiyama Yuki、Saito Ryoichi、Yoshikawa Takeshi、Sakamoto Hiromasa、Goto Takayuki、Akamatsu Shusuke、Yamasaki Toshinari、Inoue Takahiro、Suzuki Akira、Horiuchi Hisanori、Ogawa Osamu、Kobayashi Takashi
- Journal Title
  
  Carcinogenesis
  
  Volume: 40 Pages: 1535-1544
- DOI
  10.1093/carcin/bgz082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Hirabayashi Shigeki、Murakawa Yasuhiro、Kobayashi Masayuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Fukuda Hirofumi、Shirakawa Ryutaro、Shindo Keisuke、Ri Masaki、Iida Shinsuke、Takaori-Kondo Akifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 7122-7122
- DOI
  10.1038/s41598-019-43575-y
- NAID
  120006629181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression2019
- Author(s)
  Gao P.、Liu S.、Yoshida R.、Shi C.Y.、Yoshimachi S.、Sakata N.、Goto K.、Kimura T.、Shirakawa R.、Nakayama H.、Sakata J.、Kawashiri S.、Kato K.、Wang X.Y.、Horiuchi H.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 98 Issue: 9 Pages: 1011-1019
- DOI
  10.1177/0022034519860828
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis2018
- Author(s)
  Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T
- Journal Title
  
  Blood
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis2018
- Author(s)
  Shibata Hirofumi、Yasumi Takahiro、Shimodera Saeko、Hiejima Eitaro、Izawa Kazushi、Kawai Tomoki、Shirakawa Ryutaro、Wada Taizo、Nishikomori Ryuta、Horiuchi Hisanori、Ohara Osamu、Ishii Eiichi、Heike Toshio
- Journal Title
  
  Blood
  
  Volume: 131 Issue: 18 Pages: 2016-2025
- DOI
  10.1182/blood-2017-10-812503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.2018
- Author(s)
  Na-Ryum Bin, Ke Ma, Chi-Wei Tien, Siyan Wang, Dan Zhu, Seungmee Park, Ekaterina Turlova, Kyoko Sugita, Ryutaro Shirakawa, Peter van der Sluijs, Hisanori Horiuchi, Hong-Shuo Sun, Philippe P. Monnier, Herbert Y. Gaisano and Shuzo Sugita
- Journal Title
  
  J Immunol.
  
  Volume: 20 Issue: 2 Pages: 700-713
- DOI
  10.4049/jimmunol.1800426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] A CD57+ CTL degranulation assay effectively identifies familial hemophagocytic lymphohistiocytosis type 3 patients2017
- Author(s)
  Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, Eitaro Hiejima, Hirotsugu Oda, Kazushi Izawa, Tomoki Kawai, Masataka Ishimura, Naoko Nakano, Ryutaro Shirakawa, Ryuta Nishikomori, Hidetoshi Takada, Satoshi Morita, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, and Toshio Heike
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 37 Issue: 1 Pages: 92-99
- DOI
  10.1007/s10875-016-0357-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-15K19623, KAKENHI-PROJECT-16K08574, KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-15K09655
[Journal Article] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Horiuchi T, Sakata N, Narumi Y, Kimura T, Hayashi T, Nagano K, Liu K, Nishibori M, Tsukita S, Yamada T, Katagiri H, Shirakawa R, Horiuchi H
- Journal Title
  
  J Biol Chem
  
  Volume: 292 Pages: 8436-8446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP2016
- Author(s)
  3.K. Shishikura, T. Horiuchi, N. Sakata, D-A Trinh, R. Shirakawa, T. Kimura, Y. Asada, H. Horiuchi*
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 2 Pages: 319-331
- DOI
  10.1111/bph.13373
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15060, KAKENHI-PROJECT-15K19000, KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis2015
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis.2015
- Author(s)
  Shirakawa R, Horiuchi H.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 157 Issue: 5 Pages: 285-299
- DOI
  10.1093/jb/mvv029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis2015
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703
[Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension2014
- Author(s)
  Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 34 Issue: 11 Pages: 2486
- DOI
  10.1161/atvbaha.114.304404
- URL
  https://pure.teikyo.jp/en/publications/1cd583b9-53c8-43fb-9623-40a38c842780
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390193, KAKENHI-PROJECT-24591032, KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-25330032, KAKENHI-PROJECT-25461037, KAKENHI-PROJECT-25670379, KAKENHI-PROJECT-26860181
[Journal Article] The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production2014
- Author(s)
  Kimura T, Shirakawa R, Yaoita N, Hayashi T, Nagano K, Horiuchi H
- Journal Title
  
  FEBS letters
  
  Volume: 588 Issue: 20 Pages: 3673-3676
- DOI
  10.1016/j.febslet.2014.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins2014
- Author(s)
  Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S
- Journal Title
  
  Cellular Signalling
  
  Volume: 26 Issue: 8 Pages: 1636-1648
- DOI
  10.1016/j.cellsig.2014.04.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] Identification of RalGAPs and their downregulation in invasive bladder cancer2014
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  Seikagaku
  
  Volume: 86 Pages: 671-675
- NAID
  40020254531
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181
[Journal Article] Identification of RalGAPs and their downregulation in invasive bladder cancer2014
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  Seikagaku
  
  Volume: 86 Pages: 671-675
- NAID
  40020254531
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703
[Journal Article] Rab-genome analysis of Weibel Palade body exocytosis reveals an unexpected linkbetween exocytic and endocytic RabGTPases2012
- Author(s)
  S. Zografou, D. Basagiannis, A.Papafotika, R. Shirakawa, H. Horiuchi, D. Auerbach, M. Fukuda, S. Christoforidis
- Journal Title
  
  J Cell Sci 25
  
  Volume: 125巻 Pages: 4780-4790
- DOI
  10.1242/jcs.104174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-24700961, KAKENHI-PLANNED-20113006, KAKENHI-PUBLICLY-23113702
[Journal Article] Munc13-4 reconstitutes Ca^<2+>-dependent SNARE-mediated membrane fusion2012
- Author(s)
  K Boswell, D James, J Esquibel, S Bruinsma, R Shirakawa, H Horiuchi, T Martin*
- Journal Title
  
  J Cell Biol 197
  
  Volume: 197 Issue: 2 Pages: 301-312
- DOI
  10.1083/jcb.201109132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503, KAKENHI-PROJECT-24700961
[Journal Article] Downregulation of Ral GTPase-activating-protein causes tumor invasion and metastasis of bladder cancer2012
- Author(s)
  R.Saito
- Journal Title
  
  Oncogene
  
  Volume: (未定)(In press) Issue: 7 Pages: 894-902
- DOI
  10.1038/onc.2012.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-22591766, KAKENHI-PROJECT-24659712, KAKENHI-PROJECT-24700961, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503
[Presentation] ダブルプレニルYkt6はリソソーム水解酵素の輸送を制御する2021
- Author(s)
  坂田菜摘, 白川龍太郎, 後藤孝太, Duc Anh Trinh, 堀内久徳
- Organizer
  日本生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-19K07342
[Presentation] 新規ゲラニルゲラニル転移酵素GGT3によるYkt6のダブルプレニル化はゴルジ体の構造と機能の維持に必須である2020
- Author(s)
  白川龍太郎、後藤-伊藤桜子、後藤孝太、深井周也、堀内久徳
- Organizer
  日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-19K07342
[Presentation] 新規プレニル転移酵素GGT3の分子機能解析2020
- Author(s)
  白川龍太郎
- Organizer
  日本生化学会東北支部会例会
- Data Source
  KAKENHI-PROJECT-19K07342
[Presentation] 蛍光蛋白質融合Golginを用いたゴルジ内膜輸送機構の解析2018
- Author(s)
  後藤孝太　白川龍太郎　堀内久徳
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  12th International Symposium of the Institute Network
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  東北大学知のフォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  日本生化学会東北支部第83回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  2017年度生命科学系学会合同大会(第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] プロスタグランジンE2はサイクリックAMP産生を介してNETs形成を阻害する2015
- Author(s)
  木村朋寛、宍倉匡祐、堀内嵩弘、坂田菜摘、Trinh Duc-Anh、白川龍太郎、堀内久徳
- Organizer
  日本分子生物学会日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26860181
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価2013
- Author(s)
  白川龍太郎
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Year and Date
  2013-05-11
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] RalGAPの発現低下と膀胱癌悪性化2012
- Author(s)
  白川龍太郎
- Organizer
  第78回日本生化学会東北支部会例会
- Place of Presentation
  山形
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] RalGAPの発現喪失は膀胱癌の浸潤・転移を促進する2012
- Author(s)
  白川龍太郎
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23121503
[Presentation] RalGAPの発現喪失は膀胱癌の浸潤・転移を促進する2012
- Author(s)
  白川龍太郎
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価
- Author(s)
  白川龍太郎、矢尾板信裕、木村朋寛、堀内久徳
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価
- Author(s)
  白川龍太郎、矢尾板信裕、木村朋寛、堀内久徳
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PUBLICLY-25121703
[]

1. 堀内久徳 (90291426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 白石泰之 (00329137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 深谷碧 (20826060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 早川正樹 (30516729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松本雅則 (60316081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山家智之 (70241578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山田昭博 (40781448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHARA Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YASUMI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HORI Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. HIEJIMA Eitaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. SHIBATA Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SHIMODERA Saeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 西小森隆太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 平家俊男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRAKAWA RYUTARO 白川 龍太郎

SHIRAKAWA Ryutaro 白川 龍太郎

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Ykt6による細胞内クリアランスの分子機構Principal Investigator

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Research of high-shear stress-induced hemostatic disorder

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Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist

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Molecular Mechanism of Tumor Supression by RalGAP and BiguanidesPrincipal Investigator

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Molecular Mechanisms of Tumorigenesis, Invasion, and Metastasis by the Small GTPase RalPrincipal Investigator

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Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral SignalingPrincipal Investigator

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癌転移抑制因子RalGAP複合体の構造解析Principal Investigator

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Identification of Ral kinase and characterization of its role in tumorigenesisPrincipal Investigator

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ＲａｌＧＡＰ複合体の構造機能解析Principal Investigator

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RalA標的蛋白質による細胞癌化の分子機構Principal Investigator

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[Journal Article] Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma2021

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[Journal Article] Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation2020

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[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020

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NAID

SHIRAKAWA RYUTARO 白川龍太郎

SHIRAKAWA Ryutaro 白川龍太郎