SHIRAKAWA RYUTARO 白川龍太郎

… Alternative Names

Researcher Number	50581039
Other IDs
Affiliation (Current)	2020: 東北大学, 加齢医学研究所, 助教
Affiliation (based on the past Project Information) *help	2010 – 2019: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Tumor biology / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator Ral / 低分子量GTP結合蛋白質 / 低分子量GTP結合タンパク質 / 癌 / RalGAP / Ras / シグナル伝達 / GAP / 膀胱癌 / 口腔扁平上皮がん … More

RalGAPとビグアナイドによる腫瘍抑制の分子機構Principal InvestigatorOngoing
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tohoku University
Molecular Mechanisms of Tumorigenesis, Invasion, and Metastasis by the Small GTPase RalPrincipal Investigator
- Principal Investigator
  
  Ryutaro Shirakawa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral SignalingPrincipal Investigator
- Principal Investigator
  
  Shirakawa Ryutaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
癌転移抑制因子RalGAP複合体の構造解析Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Identification of Ral kinase and characterization of its role in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SHIRAKAWA Ryutaro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
ＲａｌＧＡＰ複合体の構造機能解析Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
RalA標的蛋白質による細胞癌化の分子機構Principal Investigator
- Principal Investigator
  
  白川龍太郎
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus2020
- Author(s)
  Shirakawa Ryutaro、Goto‐Ito Sakurako、Goto Kota、Wakayama Shonosuke、Kubo Haremaru、Sakata Natsumi、Trinh Duc Anh、Yamagata Atsushi、Sato Yusuke、Masumoto Hiroshi、Cheng Jinglei、Fujimoto Toyoshi、Fukai Shuya、Horiuchi Hisanori
- Journal Title
  
  The EMBO Journal
  
  Volume: 39
- DOI
  10.15252/embj.2019104120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03162
[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Kazuma Yasuhiro、Matsui Hiroyuki、Horisawa Yoshihito、Stanford Emani、Sarca Anamaria Daniela、Shirakawa Ryutaro、Shindo Keisuke、Takaori-Kondo Akifumi
- Journal Title
  
  PLOS ONE
  
  Volume: 15
- DOI
  10.1371/journal.pone.0223463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation2020
- Author(s)
  Iida Tomoya、Hirayama Daisuke、Minami Naoki、Matsuura Minoru、Wagatsuma Kohei、Kawakami Kentaro、Nagaishi Kanna、Nojima Masanori、Ikeuchi Hiroki、Hirota Seiichi、Shirakawa Ryutaro、Horiuchi Hisanori、Nakase Hiroshi
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 9 Pages: 277-293
- DOI
  10.1016/j.jcmgh.2019.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression2019
- Author(s)
  Gao P.、Liu S.、Yoshida R.、Shi C.Y.、Yoshimachi S.、Sakata N.、Goto K.、Kimura T.、Shirakawa R.、Nakayama H.、Sakata J.、Kawashiri S.、Kato K.、Wang X.Y.、Horiuchi H.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 98 Pages: 1011-1019
- DOI
  10.1177/0022034519860828
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis2019
- Author(s)
  Trinh Duc-Anh、Shirakawa Ryutaro、Kimura Tomohiro、Sakata Natsumi、Goto Kota、Horiuchi Hisanori
- Journal Title
  
  Scientific Reports
  
  Volume: 9
- DOI
  10.1038/s41598-019-53767-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019
- Author(s)
  Yamazaki Hiroyuki、Shirakawa Kotaro、Matsumoto Tadahiko、Hirabayashi Shigeki、Murakawa Yasuhiro、Kobayashi Masayuki、Sarca Anamaria Daniela、Kazuma Yasuhiro、Matsui Hiroyuki、Maruyama Wataru、Fukuda Hirofumi、Shirakawa Ryutaro、Shindo Keisuke、Ri Masaki、Iida Shinsuke、Takaori-Kondo Akifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 7122-7122
- DOI
  10.1038/s41598-019-43575-y
- NAID
  120006629181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07342, KAKENHI-PROJECT-19H03502
[Journal Article] Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis2019
- Author(s)
  Uegaki Masayuki、Kita Yuki、Shirakawa Ryutaro、Teramoto Yuki、Kamiyama Yuki、Saito Ryoichi、Yoshikawa Takeshi、Sakamoto Hiromasa、Goto Takayuki、Akamatsu Shusuke、Yamasaki Toshinari、Inoue Takahiro、Suzuki Akira、Horiuchi Hisanori、Ogawa Osamu、Kobayashi Takashi
- Journal Title
  
  Carcinogenesis
  
  Volume: 40 Pages: 1535-1544
- DOI
  10.1093/carcin/bgz082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07342
[Journal Article] C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.2018
- Author(s)
  Na-Ryum Bin, Ke Ma, Chi-Wei Tien, Siyan Wang, Dan Zhu, Seungmee Park, Ekaterina Turlova, Kyoko Sugita, Ryutaro Shirakawa, Peter van der Sluijs, Hisanori Horiuchi, Hong-Shuo Sun, Philippe P. Monnier, Herbert Y. Gaisano and Shuzo Sugita
- Journal Title
  
  J Immunol.
  
  Volume: 20 Pages: 700-713
- DOI
  10.4049/jimmunol.1800426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis2018
- Author(s)
  Shibata Hirofumi、Yasumi Takahiro、Shimodera Saeko、Hiejima Eitaro、Izawa Kazushi、Kawai Tomoki、Shirakawa Ryutaro、Wada Taizo、Nishikomori Ryuta、Horiuchi Hisanori、Ohara Osamu、Ishii Eiichi、Heike Toshio
- Journal Title
  
  Blood
  
  Volume: 131 Pages: 2016-2025
- DOI
  10.1182/blood-2017-10-812503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis2018
- Author(s)
  Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T
- Journal Title
  
  Blood
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] CD57+ CTL degranulation assay provides sensitive and specific detection of FHL3 patients.2017
- Author(s)
  Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, Eitaro Hiejima, Hirotsugu Oda, Kazushi Izawa, Tomoki Kawai, Masataka Ishimura, Naoko Nakano, Ryutaro Shirakawa, Ryuta Nishikomori, Hidetoshi Takada, Satoshi Morita, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, and Toshio Heike
- Journal Title
  
  J Clin Immunol
  
  Volume: 37 Pages: 92-99
- DOI
  10.1007/s10875-016-0357-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-15K19623, KAKENHI-PROJECT-16K08574, KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-15K09655
[Journal Article] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Horiuchi T, Sakata N, Narumi Y, Kimura T, Hayashi T, Nagano K, Liu K, Nishibori M, Tsukita S, Yamada T, Katagiri H, Shirakawa R, Horiuchi H
- Journal Title
  
  J Biol Chem
  
  Volume: 292 Pages: 8436-8446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08574
[Journal Article] Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP.2016
- Author(s)
  3.K. Shishikura, T. Horiuchi, N. Sakata, D-A Trinh, R. Shirakawa, T. Kimura, Y. Asada, H. Horiuchi*
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 173 Pages: 319-331
- DOI
  10.1111/bph.13373
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15060, KAKENHI-PROJECT-15K19000, KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: Crucial mediators of exocytosis and tumorigenesis. (a review)2015
- Author(s)
  Shirakawa R, Horiuchi H.
- Journal Title
  
  J Biochem (Tokyo)
  
  Volume: 157 Pages: 285-299
- DOI
  10.1093/jb/mvv029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis2015
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis2015
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181
[Journal Article] The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production.2014
- Author(s)
  Kimura T, Shirakawa R, Yaoita N, Hayashi T, Nagano K, Horiuchi H
- Journal Title
  
  FEBS Letter
  
  Volume: 588 Pages: 3673-3676
- DOI
  10.1016/j.febslet.2014.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] GARNL1, a major RalGAP alpha subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins2014
- Author(s)
  Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S
- Journal Title
  
  Cellular Signalling
  
  Volume: 26 Pages: 1636-1648
- DOI
  10.1016/j.cellsig.2014.04.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] Identification of RalGAPs and their downregulation in invasive bladder cancer2014
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  Seikagaku
  
  Volume: 86 Pages: 671-675
- NAID
  40020254531
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181
[Journal Article] Identification of RalGAPs and their downregulation in invasive bladder cancer2014
- Author(s)
  Shirakawa R, Horiuchi H
- Journal Title
  
  Seikagaku
  
  Volume: 86 Pages: 671-675
- NAID
  40020254531
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703
[Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension.2014
- Author(s)
  Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
- Journal Title
  
  Arteriosclerosis Thromb Vasc Biol
  
  Volume: 34 Pages: 2486-2494
- DOI
  10.1161/atvbaha.114.304404
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390193, KAKENHI-PROJECT-24591032, KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-25330032, KAKENHI-PROJECT-25461037, KAKENHI-PROJECT-25670379, KAKENHI-PROJECT-26860181
[Journal Article] Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.2013
- Author(s)
  R.Saito
- Journal Title
  
  Oncogene
  
  Volume: (未定)(In press) Pages: 894-902
- DOI
  10.1038/onc.2012.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-22591766, KAKENHI-PROJECT-24659712, KAKENHI-PROJECT-24700961, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503
[Journal Article] Rab-genome analysis of Weibel Palade body exocytosis reveals an unexpected link between exocytic and endocytic RabGTPases.2012
- Author(s)
  S. Zografou, D. Basagiannis, A.Papafotika, R. Shirakawa, H. Horiuchi, D. Auerbach, M. Fukuda, S. Christoforidis
- Journal Title
  
  J. Cell Sci.
  
  Volume: 125巻 Pages: 4780-4790
- DOI
  10.1242/jcs.104174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-24700961, KAKENHI-PLANNED-20113006, KAKENHI-PUBLICLY-23113702
[Journal Article] Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion2012
- Author(s)
  K Boswell, D James, J Esquibel, S Bruinsma, R Shirakawa, H Horiuchi, T Martin*
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 197 Pages: 301-12
- DOI
  10.1083/jcb.201109132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503, KAKENHI-PROJECT-24700961
[Presentation] 蛍光蛋白質融合Golginを用いたゴルジ内膜輸送機構の解析2018
- Author(s)
  後藤孝太　白川龍太郎　堀内久徳
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  日本生化学会東北支部第83回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  2017年度生命科学系学会合同大会(第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Takashi Hayashi, Keisuke Nagano, Keyue Liu, Masahiro Nishibori, Sohei Tsukita, Tetsuya Yamada, Hideki Katagiri, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  12th International Symposium of the Institute Network
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity2017
- Author(s)
  Natsumi Sakata, Takahiro Horiuchi, Yoshihiro Narumi, Tomohiro Kimura, Ryutaro Shirakawa, and Hisanori Horiuchi
- Organizer
  東北大学知のフォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08574
[Presentation] プロスタグランジンE2はサイクリックAMP産生を介してNETs形成を阻害する2015
- Author(s)
  木村朋寛、宍倉匡祐、堀内嵩弘、坂田菜摘、Trinh Duc-Anh、白川龍太郎、堀内久徳
- Organizer
  日本分子生物学会日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26860181
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価2013
- Author(s)
  白川龍太郎
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Year and Date
  2013-05-11
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] RalGAPの発現喪失は膀胱癌の浸潤・転移を促進する2012
- Author(s)
  白川龍太郎
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] RalGAPの発現低下と膀胱癌悪性化2012
- Author(s)
  白川龍太郎
- Organizer
  第78回日本生化学会東北支部会例会
- Place of Presentation
  山形
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] RalGAPの発現喪失は膀胱癌の浸潤・転移を促進する2012
- Author(s)
  白川龍太郎
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23121503
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価
- Author(s)
  白川龍太郎、矢尾板信裕、木村朋寛、堀内久徳
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24700961
[Presentation] 血小板の低分子量GTP結合蛋白質活性の直接的評価
- Author(s)
  白川龍太郎、矢尾板信裕、木村朋寛、堀内久徳
- Organizer
  第79回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PUBLICLY-25121703

1. OHARA Osamu

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2. YASUMI Takahiro

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3. HORI Masayuki

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4. HIEJIMA Eitaro

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5. SHIBATA Hirofumi

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6. SHIMODERA Saeko

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7. ODA Hirotsugu

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8. FUKUMOTO Yoshihiro

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9. SATOH Kimio

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10. 西小森隆太

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11. 平家俊男

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12. 石村匡崇

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13. 高田英俊

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14. 堀内久徳

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15. 福田光則

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16. 山形敦史

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17. 高折晃史

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18. 白川康太郎

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19. 木村朋寛

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20. 吉村耕治

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21. 小川修

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22. 中村英二郎

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23. 村川泰裕

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24. 杉村宏一郎

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25. 宮田敏

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26. 建部俊介

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27. 下川宏明

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SHIRAKAWA RYUTARO 白川 龍太郎

SHIRAKAWA Ryutaro 白川 龍太郎

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RalGAPとビグアナイドによる腫瘍抑制の分子機構Principal InvestigatorOngoing

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Molecular Mechanisms of Tumorigenesis, Invasion, and Metastasis by the Small GTPase RalPrincipal Investigator

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Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral SignalingPrincipal Investigator

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癌転移抑制因子RalGAP複合体の構造解析Principal Investigator

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Identification of Ral kinase and characterization of its role in tumorigenesisPrincipal Investigator

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ＲａｌＧＡＰ複合体の構造機能解析Principal Investigator

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RalA標的蛋白質による細胞癌化の分子機構Principal Investigator

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[Journal Article] A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus2020

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[Journal Article] APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression2020

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[Journal Article] Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation2020

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[Journal Article] Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression2019

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[Journal Article] Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis2019

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[Journal Article] Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells2019

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NAID

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[Journal Article] Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis2019

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SHIRAKAWA RYUTARO 白川龍太郎

SHIRAKAWA Ryutaro 白川龍太郎