Hayashi Mikihito 林幹人

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HAYASHI Mikihito 林幹人

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Researcher Number	50581914
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授 2021 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2016 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2014 – 2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Functional basic dentistry / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 骨細胞 / 骨生物学 / 破骨細胞 / 細胞・組織 / Creマウス / シグナル伝達 / 免疫学 / ストレス / 運動器 / メカニカルストレス … More Except Principal Investigator … More 骨リモデリング分子による人為的制御法 / 細胞系譜特異的な遺伝子改変マウス / 骨構成細胞の細胞間クロストーク / 骨細胞サブセット / 骨リモデリング Less

Elucidation of the regulatory mechanism of bone remodeling based on the determination of osteocyte subsets
- Principal Investigator
  
  中島友紀
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Institute of Science Tokyo
エグザカイン・ロコモカインの加齢性変化とそれらによる運動ベネフィットの理解Principal Investigator
- Principal Investigator
  
  林幹人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Analysis of functional subpopulations of osteocytesPrincipal Investigator
- Principal Investigator
  
  HAYASHI MIKIHITO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Regulation of nurturing by osteocytesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Mikihito
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokyo Medical and Dental University
Human osteoclast biologyPrincipal Investigator
- Principal Investigator
  
  Hayashi Mikihito
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Tokyo Medical and Dental University
Generation of osteocyte-specific Cre mousePrincipal Investigator
- Principal Investigator
  
  Hayashi Mikihito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Homeostatic interaction between locomotor and immune system induced with mechanical stressPrincipal Investigator
- Principal Investigator
  
  Hayashi Mikihito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University

All 2024 2022 2021 2015 2014

All Journal Article Presentation

[Journal Article] The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis2024
- Author(s)
  Liu A, Hayashi M, Ohsugi Y, Katagiri S, Akira S, Iwata T, Nakashima T.
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1-18
- DOI
  10.1038/s41467-024-46746-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17152, KAKENHI-PROJECT-21K19590, KAKENHI-PROJECT-20H03863, KAKENHI-PROJECT-20H00551, KAKENHI-PROJECT-21H03051
[Journal Article] Osteoblast Lineage Cell-derived Sema3A Regulates Bone Homeostasis Independently of Androgens2022
- Author(s)
  Yamashita Yu、Hayashi Mikihito、Saito Mitsuru、Nakashima Tomoki
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 10 Pages: 1-7
- DOI
  10.1210/endocr/bqac126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00551, KAKENHI-PROJECT-21H03051, KAKENHI-PROJECT-21K19554, KAKENHI-PROJECT-21K19555
[Journal Article] Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion2014
- Author(s)
  Nakamura H, Nakashima T, Hayashi M, Izawa N, Yasui T, Aburatani H, Tanaka S, Takayanagi H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 455 Issue: 3-4 Pages: 305
- DOI
  10.1016/j.bbrc.2014.11.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390412, KAKENHI-PROJECT-25670773, KAKENHI-PROJECT-26713052
[Presentation] ローヤルゼリーに含まれる10-ヒドロキシ-2-デセン酸はFFAR4を介してNF-kB活性化および破骨細胞分化を抑制することで閉経後骨粗鬆症モデルマウスにおける骨量を維持する2021
- Author(s)
  林幹人、土谷洋輔、中島友紀
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-21K19555
[Presentation] ローヤルゼリー構成成分10-ヒドロキシ-2-デセン酸はFFAR4を介したNF-kB抑制により骨量減少を抑制する2021
- Author(s)
  林幹人、土谷洋輔、永松剛、中島友紀
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21H03051
[Presentation] ローヤルゼリーに含まれる10-ヒドロキシ-2-デセン酸はFFAR4を介してNF-kB活性化および破骨細胞分化を抑制することで閉経後骨粗鬆症モデルマウスにおける骨量を維持する2021
- Author(s)
  林幹人、土谷洋輔、中島友紀
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-21H03051
[Presentation] ローヤルゼリー構成成分10-ヒドロキシ-2-デセン酸はFFAR4を介したNF-kB抑制により骨量減少を抑制する2021
- Author(s)
  林幹人、土谷洋輔、永松剛、中島友紀
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21K19555
[Presentation] 骨細胞が産生するSema3Aによる骨代謝制御2015
- Author(s)
  林幹人、中島友紀、高柳広
- Organizer
  第1回日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（沖縄県宮古島市）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K15682
[Presentation] 骨細胞が産生するSema3Aによる骨代謝制御2015
- Author(s)
  林幹人、中島友紀、高柳広
- Organizer
  第1回日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（沖縄県宮古島市）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-26713052
[Presentation] Sema3Aによる骨代謝制御2014
- Author(s)
  林幹人、中島友紀、高柳広
- Organizer
  第35回日本炎症・再生医学会
- Place of Presentation
  沖縄、万国津梁館
- Year and Date
  2014-07-02
- Data Source
  KAKENHI-PROJECT-26713052
[Presentation] Regulation of bone metabolism by Semaphorin 3A derived from osteoblast lineage cells.2014
- Author(s)
  M. Hayashi, T. Nakashima, and H. Takayanagi
- Organizer
  ASBMR 2014 Annual Meeting
- Place of Presentation
  George R. Brown Convention Center, Houston, USA
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26713052
[Presentation] Sema3Aによる骨代謝制御2014
- Author(s)
  林幹人、中島友紀、高柳広
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都、京都国際会館
- Year and Date
  2014-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26713052
[Presentation] Regulation of bone metabolism by Semaphorin 3A2014
- Author(s)
  M. Hayashi, T. Nakashima, and H. Takayanagi
- Organizer
  5th International Conference on Osteoimmunology
- Place of Presentation
  Kos, Greece
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26713052

1. 中島友紀 (00346959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 大杉勇人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Mikihito 林 幹人

HAYASHI Mikihito 林 幹人

Research Projects

Research Products

Co-Researchers

Elucidation of the regulatory mechanism of bone remodeling based on the determination of osteocyte subsets

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

エグザカイン・ロコモカインの加齢性変化とそれらによる運動ベネフィットの理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of functional subpopulations of osteocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of nurturing by osteocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Human osteoclast biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of osteocyte-specific Cre mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Homeostatic interaction between locomotor and immune system induced with mechanical stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Osteoblast Lineage Cell-derived Sema3A Regulates Bone Homeostasis Independently of Androgens2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] ローヤルゼリーに含まれる10-ヒドロキシ-2-デセン酸はFFAR4を介してNF-kB活性化および破骨細胞分化を抑制することで閉経後骨粗鬆症モデルマウスにおける骨量を維持する2021

Author(s)

Organizer

Data Source

[Presentation] ローヤルゼリー構成成分10-ヒドロキシ-2-デセン酸はFFAR4を介したNF-kB抑制により骨量減少を抑制する2021

Author(s)

Organizer

Data Source

[Presentation] ローヤルゼリーに含まれる10-ヒドロキシ-2-デセン酸はFFAR4を介してNF-kB活性化および破骨細胞分化を抑制することで閉経後骨粗鬆症モデルマウスにおける骨量を維持する2021

Author(s)

Organizer

Data Source

[Presentation] ローヤルゼリー構成成分10-ヒドロキシ-2-デセン酸はFFAR4を介したNF-kB抑制により骨量減少を抑制する2021

Author(s)

Organizer

Data Source

[Presentation] 骨細胞が産生するSema3Aによる骨代謝制御2015

Author(s)

Hayashi Mikihito 林幹人

HAYASHI Mikihito 林幹人