Inoue Hiroyuki 井上裕幸

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INOUE Hiroyuki 井上裕幸

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Researcher Number	50601548
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員
Affiliation (based on the past Project Information) *help	2017: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 2016: 公益財団法人微生物化学研究会, 微生物化学研究所動物施設, 研究員 2013: 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員
Review Section/Research Field	Except Principal Investigator Tumor therapeutics / Experimental pathology / Clinical oncology
Keywords	Except Principal Investigator 天然物 / がん間質 / 抗がん剤 / 足場非依存性 / 治療標的 / 自然転移モデル / 癌転移 / 小細胞肺癌 / 間質 / 生理活性物質 / 癌

Development and mechanism analysis of small molecules affecting tumor-stromal cell interactions
- Principal Investigator
  
  KAWADA Manabu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Microbial Chemistry Research Foundation
Search for therapeutic targets for small cell lung cancer using a new orthotopic transplantation model.
- Principal Investigator
  
  SAKAMOTO Shuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Microbial Chemistry Research Foundation
Discovery of a new antitumor drug targeting the tumor-stromal cell interactions
- Principal Investigator
  
  KAWADA Manabu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Microbial Chemistry Research Foundation

All 2017 2016 2015 2013

All Journal Article Presentation Patent

[Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.2017
- Author(s)
  2.Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 4 Pages: 772-784
- DOI
  10.1111/cas.13172
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H03116, KAKENHI-PROJECT-15K06888, KAKENHI-PROJECT-16H06276
[Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.2017
- Author(s)
  Kawada, M., Inouea, H., Kajikawa, M., Sugiura, M., Sakamoto, S., Urano, S., Karasawa, C., Usami, I., Futakuchi, M., and Masuda, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 40400-40400
- DOI
  10.1038/srep40400
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-15K06888
[Journal Article] New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.2016
- Author(s)
  Atsumi, S., Nosaka, C., Adachi, H., Kimura, T., Kobayashi, Y., Takada, H., Watanabe, T., Ohba, S., Inoue, H., Kawada, M., Shibasaki, M., Shibuya, M.
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 496-496
- DOI
  10.1186/s12885-016-2521-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06888
[Journal Article] New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice2015
- Author(s)
  Shuichi Sakamoto, Hiroyuki Inoue, Shunichi Ohba, Yasuko Kohda, Ihomi Usami, Tohru Masuda, Manabu Kawada and Akio Nomoto
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 4 Pages: 367-374
- DOI
  10.1111/cas.12624
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460481, KAKENHI-PROJECT-15K06888
[Journal Article] Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.2015
- Author(s)
  Kawada, M., Inoue, H., Ohba, S., Yoshida, J., Masuda, T., Yamasaki, M., Usami, I., Sakamoto, S., Abe, H., Watanabe, T., Yamori, T., Shibasaki, M., Nomoto, A.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0119415-e0119415
- DOI
  10.1371/journal.pone.0119415
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06888
[Journal Article] Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.2013
- Author(s)
  Abe, H., Kawada, M., Inoue, H., Ohba, S., Nomoto, A., Watanabe, T., and Shibasaki M.
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 9 Pages: 2124-2127
- DOI
  10.1021/ol400587a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501321
[Journal Article] Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.2013
- Author(s)
  Kawada, M., Inoue, H., Ohba, S., Hatano, M., Amemiya, M., Hayashi, C., Usami, I., Abe, H., Watanabe, T., Kinoshita, N., Igarashi, M., Masuda, T., Ikeda, D., and Nomoto, A.
- Journal Title
  
  J. Antibiot.
  
  Volume: 66 Issue: 9 Pages: 543-548
- DOI
  10.1038/ja.2013.42
- NAID
  10031201650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501321, KAKENHI-PROJECT-221S0001
[Journal Article] Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities.2013
- Author(s)
  Abe, H., Kawada, M., Inoue, H., Ohba, S., Masuda, T., Hayashi, C., Igarashi, M., Nomoto, A., Watanabe, T., and Shibasaki M.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 36 Pages: 7608-7617
- DOI
  10.1016/j.tet.2013.05.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501321
[Patent] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013
- Inventor(s)
  川田学、井上裕幸、大庭俊一、波多野和樹、阿部光、他３名
- Industrial Property Rights Holder
  公益財団法人微生物化学研究会
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-035731
- Filing Date
  2013-02-26
- Data Source
  KAKENHI-PROJECT-23501321
[Patent] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013
- Inventor(s)
  川田学、井上裕幸、大庭俊一、波多野和樹、阿部光、林千草、渡辺匠、五十嵐雅之
- Industrial Property Rights Holder
  公益財団法人微生物化学研究会
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-035731
- Filing Date
  2013-02-26
- Data Source
  KAKENHI-PROJECT-23501321
[Presentation] Anti-Helicobacter pylori activity of a novel derivative of intervenolin2017
- Author(s)
  Manabu Kawada, Tomokazu Ohishi, Hikaru Abe, Chigusa Hayashi, Chiharu Sakashita, Shun-ichi Ohba, Hiroyuki Inoue, Masayuki Igarashi, Takumi Watanabe, and Masakatsu Shibasaki
- Organizer
  AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06888
[Presentation] Ertredin, a new inhibitor of sphere & tumor growth, regulates mitochondrial respiration and glycolysis in EGFRvIII-transformed cells.2016
- Author(s)
  Atsumi, S., Nosaka, C., Adachi, H., Kimura, T., Kobayashi, Y., Takada, H., Watanabe, T., Ohba, S., Inoue, H., Kawada, M., Shibasaki, M., Shibuya, M.
- Organizer
  The 21st JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC)
- Place of Presentation
  日本科学未来館（東京都江東区）
- Year and Date
  2016-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06888
[Presentation] Mechanism of action of a novel anti-tumor antibody, anti-CXADR 6G10A2016
- Author(s)
  Kawada, M., Inoue, H., Kajikawa, M., Sugiura, M., Sakamoto, S., Urano, S., Karasawa, C., Usami, I., Futakuchi, M.
- Organizer
  28th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
- Place of Presentation
  ICM International Congress Center Munich, Munich (Germany)
- Year and Date
  2016-12-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06888
[Presentation] Stromal cells suppress cancer development by secreted GAPDH-E-cadherin interaction2015
- Author(s)
  Manabu Kawada, Junjiro Yoshida, Hiroyuki Inoue, Shun-ichi Ohba, Manabu Yamasaki, Ihomi Usami, Shuichi Sakamoto, Hikaru Abe, Takumi Watanabe, Akio Nomoto, Masakatsu Shibasaki
- Organizer
  27th AACR- NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Hynes Convention Center, Boston (U.S.A.)
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06888

1. KAWADA Manabu (20300808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. AMEMIYA Masahide (10232000)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. SAKAMOTO Shuichi (60346070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. YOSHIDA Junjiro (20712706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 井本正哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 二口充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoue Hiroyuki 井上 裕幸

INOUE Hiroyuki 井上 裕幸

Research Projects

Research Products

Co-Researchers

Development and mechanism analysis of small molecules affecting tumor-stromal cell interactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for therapeutic targets for small cell lung cancer using a new orthotopic transplantation model.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of a new antitumor drug targeting the tumor-stromal cell interactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities.2013

Author(s)

Journal Title

DOI

Data Source

[Patent] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 新規化合物、その製造方法、及びその用途、並びに、新規微生物2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] Anti-Helicobacter pylori activity of a novel derivative of intervenolin2017

Author(s)

Inoue Hiroyuki 井上裕幸

INOUE Hiroyuki 井上裕幸