Ohno Yusuke 大野祐介

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OHNO Yusuke 大野祐介

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Researcher Number	50611498
Other IDs	https://orcid.org/0000-0003-3702-1043
External Links
Affiliation (Current)	2025: 順天堂大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 北海道大学, 薬学研究院, 助教 2017: 北海道大学, 大学院薬学研究院, 助教 2012 – 2015: 北海道大学, 薬学研究科(研究院), 助教 2011 – 2013: 北海道大学, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Basic Section 43030:Functional biochemistry-related / Functional biochemistry / Cell biology / Biological pharmacy Except Principal Investigator Functional biochemistry
Keywords	Principal Investigator セラミド / ミオパチー / 皮膚バリア / 魚鱗癬 / スフィンゴ脂質 / アシルセラミド / 3-ヒドロキシアシルCoA脱水酵素 / HACD / 筋分化 / 極長鎖脂肪酸 … More / 脂質 / 質量分析 / 結合型セラミド / NAFLD / トリアシルグリセロール / ドルフマン・シャナリン症候群 / リパーゼ / 脂肪滴 / 中性脂質 / トリグリセリド / 皮膚 / アトピー性皮膚炎 / 脂肪酸 / 多価不飽和脂肪酸 / 3-ヒドロキシルアシルCoA脱水酵素 / 不整脈源性右室異形成 / 3-ヒロキシアシルCoA脱水酵素 … More Except Principal Investigator 皮膚 / スフィンゴ脂質 / 極長鎖脂肪酸 / 脂肪酸 / 代謝 / 脂質 / バリア / 小胞体 / 蛋白質 / 生体分子 / 細胞・組織 / 遺伝子 / リポソーム / エンドソーム / 皮膚バリア機能 / 小胞輪送 / 小胞輸送 / ノックアウトマウス / 代謝異常 / 皮膚バリア / 生体膜 Less

The structure and production pathway of skin barrier lipid protein-bound ceramidePrincipal Investigator
- Principal Investigator
  
  大野祐介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
Elucidation of a novel physiolosical function of triglyceride hydrolase activator ABHD5Principal Investigator
- Principal Investigator
  
  Ohno Yusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Hokkaido University
Elucidation of molecular mechanism of skin barrier formation by acylceramide.Principal Investigator
- Principal Investigator
  
  Ohno Yusuke
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolism
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Analysis of molecular mechanisms underlying the diversity of very long-chain fatty acid synthesis and the muscle development.Principal Investigator
- Principal Investigator
  
  OHNO Yusuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Analysis of physiological roles of HACD1 and pathogenesis of myopathies.Principal Investigator
- Principal Investigator
  
  OHNO Yusuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2011 Other

All Journal Article Presentation Book

[Book] セラミド研究の新展開　～基礎から応用へ～2019
- Author(s)
  酒井祥太, 大野祐介
- Total Pages
  337
- Publisher
  食品化学新聞社
- Data Source
  KAKENHI-PROJECT-19K06556
[Book] ここまできたセラミド研究最前線セラミド-基礎と応用-(セラミド研究会編)2011
- Author(s)
  大野祐介,木原章雄
- Publisher
  食品化学新聞社極長鎖脂肪酸伸長とセラミド合成
- Data Source
  KAKENHI-PROJECT-23890001
[Book] 「極長鎖脂肪酸伸長とセラミド合成」ここまできたセラミド研究最前線セラミドー基礎と応用ー2011
- Author(s)
  大野祐介, 木原章雄
- Publisher
  食品化学新聞社
- Data Source
  KAKENHI-PROJECT-23370057
[Book] ここまできたセラミド研究最前線セラミド-基礎と応用-2011
- Author(s)
  大野祐介
- Publisher
  食品化学新聞社
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Determining the structure of protein-bound ceramides, essential lipids for skin barrier function2023
- Author(s)
  Ohno Yusuke, Nakamura Tetsuya, Iwasaki Takafumi, Katsuyama Akira, Ichikawa Satoshi, Kihara Akio
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 11 Pages: 108248-108248
- DOI
  10.1016/j.isci.2023.108248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis2022
- Author(s)
  Bhaduri Satarupa, Aguayo Analine, Ohno Yusuke, Proietto Marco, Jung Jasmine, Wang Isabel, Kandel Rachel, Singh Narinderbir, Ibrahim Ikran, Fulzele Amit, Bennett Eric J, Kihara Akio, Neal Sonya E
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 4
- DOI
  10.15252/embj.2022112275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA12022
- Author(s)
  Nohara Tomohiro, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 107 Issue: 2 Pages: 89-94
- DOI
  10.1016/j.jdermsci.2022.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Ceramide Analysis in Combination With Genetic Testing May Provide a Precise Diagnosis for Self-Healing Collodion Babies2022
- Author(s)
  Takeichi Takuya, Ohno Yusuke, Tanahashi Kana, Ito Yasutoshi, Shiraishi Ken, Utsunomiya Ryo, Yoshida Satoshi, Ikeda Kenta, Nomura Hayato, Morizane Shin, Sayama Koji, Ogi Tomoo, Muro Yoshinao, Kihara Akio, Akiyama Masashi
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 63 Issue: 12 Pages: 100308-100308
- DOI
  10.1016/j.jlr.2022.100308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-21H02941
[Journal Article] Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases2022
- Author(s)
  Suzuki Madoka, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 63 Issue: 7 Pages: 100235-100235
- DOI
  10.1016/j.jlr.2022.100235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS2020
- Author(s)
  Kawana Momoko、Miyamoto Masatoshi、Ohno Yusuke、Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61 Issue: 6 Pages: 884-895
- DOI
  10.1194/jlr.ra120000671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06556, KAKENHI-PROJECT-18H03976
[Journal Article] Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide2020
- Author(s)
  Yamamoto Haruka，Hattori Miku，Chamulitrat Walee，Ohno Yusuke，Kihara Akio
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 117 Issue: 6 Pages: 2914-2922
- DOI
  10.1073/pnas.1917525117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K06556
[Journal Article] Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor2018
- Author(s)
  M.M.M. Swamy, Y Murai, Y Ohno, K Jojima, A Kihara, S Mitsutake, Y Igarashi, J Yu, M Yao, Y Suga, M Anetai and K Monde
- Journal Title
  
  Chem. Commun.
  
  Volume: 54 Issue: 90 Pages: 12758-12761
- DOI
  10.1039/c8cc05595e
- NAID
  120006767539
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07794, KAKENHI-PROJECT-17K19188, KAKENHI-PROJECT-18K14350, KAKENHI-PUBLICLY-17H05424, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-15H05589
[Journal Article] Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals2018
- Author(s)
  Edagawa Mai, Sawai Megumi, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1863 Issue: 12 Pages: 1441-1448
- DOI
  10.1016/j.bbalip.2018.09.002
- NAID
  120006776810
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-15H05589
[Journal Article] Molecular mechanism of the ichthyosis pathology of Chanarin-Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5.2018
- Author(s)
  Ohno Y., Nara A., Nakamichi S., and Kihara A.
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: 92 Issue: 3 Pages: 245-253
- DOI
  10.1016/j.jdermsci.2018.11.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10113, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-15H05589
[Journal Article] Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice.2018
- Author(s)
  Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 4 Pages: 741-749
- DOI
  10.1016/j.jid.2017.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-17K15452
[Journal Article] The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.2017
- Author(s)
  Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 37 Pages: 11538-11551
- DOI
  10.1074/jbc.m117.803171
- NAID
  120006517686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010
[Journal Article] PNPLA1 is a transacylase essential for the generation of the skin barrier lipid omega-O-acylceramide2017
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Journal Title
  
  Nat. Commun.
  
  Volume: 8 Issue: 1 Pages: 14610-14610
- DOI
  10.1038/ncomms14610
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589
[Journal Article] Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia.2017
- Author(s)
  Takeichi T, Torrelo A, Lee JYW, Ohno Y, Lozano ML, Kihara A, Liu L, Yasuda Y, Ishikawa J, Murase T, Rodrigo AB, Fernández-Crehuet P, Toi Y, Mellerio J, Rivera J, Vicente V, Kelsell DP, Nishimura Y, Okuno Y, Kojima D, Ogawa Y, Sugiura K, Simpson MA, McLean WHI, Akiyama M, McGrath JA.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 137 Issue: 11 Pages: 2344-2353
- DOI
  10.1016/j.jid.2017.06.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19717, KAKENHI-PROJECT-15H04887, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-16K15546, KAKENHI-PROJECT-17K16247
[Journal Article] Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.2015
- Author(s)
  Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 25 Pages: 7707-12
- DOI
  10.1073/pnas.1503491112
- NAID
  120005690012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15414, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-26670526
[Journal Article] HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth2015
- Author(s)
  Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthelemy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F
- Journal Title
  
  J. Mol. Cell Biol.
  
  Volume: 7 Issue: 5 Pages: 429-440
- DOI
  10.1093/jmcb/mjv049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589
[Journal Article] A role of the sphingosine-1-phosphate (S1P)- S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC)2015
- Author(s)
  Yamamoto, S., Yako, Y., Fujioka, Y., Kajita, M., Kameyama, T., Kon, S., Ishikawa, S., Ohba, Y., Ohno, Y., Kihara, A., and Fujita, Y.
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 27（3） Issue: 3 Pages: 491-499
- DOI
  10.1091/mbc.e15-03-0161
- NAID
  120005740332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-15K21757, KAKENHI-PLANNED-26114008, KAKENHI-PUBLICLY-26115701, KAKENHI-PROJECT-26250026, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-14J02366, KAKENHI-PROJECT-26860254, KAKENHI-PROJECT-26870004, KAKENHI-ORGANIZER-26114001, KAKENHI-PUBLICLY-15H01248, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-15K15023, KAKENHI-PROJECT-15KK0290
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  Journal of lipid research
  
  Volume: 55 Issue: 3 Pages: 524-530
- DOI
  10.1194/jlr.m044586
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  J. Lipid Res.
  
  Volume: 55 Pages: 524-530
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Congenital myopathy is caused by mutation of HACD12013
- Author(s)
  Muhammad E, Reish O, Ohno Y, Scheetz T, Deluca A, Searby C, Regev M, Benyamini L, Fellig Y, Kihara A, Sheffield VC, Parvari R
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 22 Issue: 25 Pages: 5229-5236
- DOI
  10.1093/hmg/ddt380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-25870001
[Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 33 Issue: 14 Pages: 2787-2796
- DOI
  10.1128/mcb.00192-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249058, KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-25670494
[Journal Article] Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile2013
- Author(s)
  Abe K, Ohno Y, Sassa T, Taguchi R, Çali şkan, M, Ober C, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 51 Pages: 36741-36749
- DOI
  10.1074/jbc.m113.493221
- NAID
  120005385316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PUBLICLY-25116701, KAKENHI-PROJECT-25870001
[Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation2013
- Author(s)
  Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 6 Pages: e67317-e67317
- DOI
  10.1371/journal.pone.0067317
- NAID
  120005322424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Biochemical characterization of the very long-chain fatty acid elongase ELOVL72011
- Author(s)
  Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Issue: 20 Pages: 3337-3341
- DOI
  10.1016/j.febslet.2011.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Biochemical characterization of the very long-chain fatty acid elongase ELOVL72011
- Author(s)
  Naganuma Tatsuro, Sato Yuichiro, Sassa Takayuki, Ohno Yusuke, Kihara Akio
- Journal Title
  
  FEBS Letters
  
  Volume: 585 Pages: 3337-3341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890001
[Presentation] 角質層の遊離セラミド組成と皮膚の乾燥・外観指標との相関解析2023
- Author(s)
  高橋夏海、秋山史成、上田悠人、多田静乃、竹内伸之、大野祐介、木原章雄
- Organizer
  第16回セラミド研究会学術集会、第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22K08372
[Presentation] 表皮結合型セラミドの構造決定：マイケル付加反応により産生されるシステイン結合型セラミド2023
- Author(s)
  大野祐介、中村哲也、勝山彬、市川聡、木原章雄
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K08372
[Presentation] 皮膚バリア形成に重要な結合型セラミドの構造決定2023
- Author(s)
  大野祐介、中村哲也、岩崎貴文、勝山彬、市川聡、木原章雄
- Organizer
  第16回セラミド研究会学術集、第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22K08372
[Presentation] ヒト三次元培養表皮を用いた結合型セラミド組成解析と肌機能評価への活用2022
- Author(s)
  秋山史成, 井野口友紀, 大塚彩加, 竹内伸之, 大野祐介, 木原章雄, 高岡彰子
- Organizer
  第15回セラミド研究会学術集会，第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22K08372
[Presentation] Comprehensive analysis of human stratum corneum ceramides by LC-MS/MS-based targeted lipidomics.2022
- Author(s)
  Ohno Y, Suzuki M, Kawana M, Kihara A.
- Organizer
  10th International Singapore Lipid Symposium (iSLS10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06556
[Presentation] LC-MS/MSを用いたターゲットリピドミクスによるヒト角質層セラミド分子種の包括的解析2022
- Author(s)
  大野祐介, 鈴木まどか, 川名桃子, 木原章雄
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K08372
[Presentation] 長鎖塩基鎖長の多様性を含めたヒト角質層セラミドの包括的解析.2021
- Author(s)
  鈴木まどか, 大野祐介, 木原章雄.
- Organizer
  14回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K06556
[Presentation] LC-MS/MSを用いた測定によるヒトおよびマウス角質層セラミドプロファイルのアップデート2019
- Author(s)
  川名桃子, 宮本政宗, 大野祐介, 木原章雄
- Organizer
  第12回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K06556
[Presentation] ABHD5 stimulates acylceramide synthesis by recruiting PNPLA1 to lipid droplets2018
- Author(s)
  Ohno Y, Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] スフィンガジエン含有スフィンゴ脂質の組織分布と代謝の解明2018
- Author(s)
  枝川茉生, 城島啓佑, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第11回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] ABHD5 promotes acylceramide production by facilitating the access of PNPLA1 to lipid droplets2018
- Author(s)
  Ohno Y, Kihara A
- Organizer
  2nd Japan-Korea Lipid Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア脂質アシルセラミド合成におけるアシルCoA合成酵素ACSVL4の機能解析2018
- Author(s)
  大野祐介, 服部未来, 山本春佳, 木原章雄
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] ABHD5 cooperates with PNPLA1 to produce acylceramides2018
- Author(s)
  Ohno Y, Kihara A
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] Pathological mechanism of congenital ichthyosis revealed by analyses of ichthyosis-causative gene knockout mice2018
- Author(s)
  Sassa T, Ohno Y, Kihara A
- Organizer
  Fall International Convention of The Pharmaceutical Society of Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 哺乳類におけるスフィンガジエン含有スフィンゴ脂質の組織分布と代謝2018
- Author(s)
  城島啓佑, 枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 多価不飽和脂肪酸含有スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第54回支部例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ABHD5 stimulates acylceramide synthesis by recruiting PNPLA1 to lipid droplets2017
- Author(s)
  Yusuke Ohno, Akio Kihara
- Organizer
  Gordon Research Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 哺乳類におけるC24:2多価不飽和脂肪酸含有スフィンゴ脂質の存在と生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子NIPAL4の欠損によるアシルセラミド産生低下と皮膚バリア機能異常2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム2017
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] C24:2多価不飽和スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第10回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア脂質アシルセラミド生合成経路の全容解明2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ミオパチー原因遺伝子HACD1の生理機能と基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア脂質アシルセラミド合成におけるトランスアシラーゼPNPLA1の同定とABHD5の関与2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 多価不飽和脂肪酸含有スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第54回支部例会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア脂質アシルセラミド生合成経路の全容解明2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県，仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] C24:2多価不飽和スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第10回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子Nipal4ノックアウトマウスにおける皮膚バリア脂質アシルセラミドの減少2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 脂肪酸伸長サイクル不全によるミオパチー発症の分子機構およびHACDの基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子Nipal4ノックアウトマウスにおける皮膚バリア脂質アシルセラミドの減少2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ミオパチー原因遺伝子HACD1の生理機能と基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県，仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア脂質アシルセラミド合成におけるトランスアシラーゼPNPLA1 の同定と ABHD5 の関与2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 魚鱗癬原因遺伝子NIPAL4の欠損によるアシルセラミド産生低下と皮膚バリア機能異常.2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 表皮アシルセラミド合成におけるアシル CoA 合成酵素 ACSVL4 の機能解析2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-07-08
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 表皮アシルセラミド合成におけるアシルCoA合成酵素ACSVL4の機能解析2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Epidermal acylceramide: production mechanism and importance in skin barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  1st Korea-Japan Bioactive Lipid Joint Symposium
- Place of Presentation
  チェジュ（韓国）
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 遺伝子欠損マウスを用いた魚鱗癬原因遺伝子 NIPAL4/ICHTHYIN の皮膚バリア形成における機能解析2016
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 木原章雄
- Organizer
  第9回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場 CANVAS（東京都中央区）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] Identification of human CYP4F22 as an ultra-long-chain fatty acid-specific ω-hydroxylase responsible for the synthesis of acylceramide, an essential lipid for skin permeability barrier formation2016
- Author(s)
  Ohno Yusuke, Kamiyama Nozomi, Nakamichi Shota, Kihara Akio.
- Organizer
  21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Davis, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] アシルCoA合成酵素ACSVL4はアシルセラミド合成に関与する2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] アシル CoA 合成酵素 ACSVL4 はアシルセラミド合成に関与する2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県，仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア機能に必須な脂質アシルセラミドの生合成機構の解明2016
- Author(s)
  大野祐介
- Organizer
  日本薬学会北海道支部第143回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] Identification of the genes responsible for the synthesis of acylceramide, an essential ceramide class for skin barrier formation2016
- Author(s)
  Yusuke Ohno, Nozomi Kamiyama, Shota Nakamichi, Akio Kihara
- Organizer
  Gordon Research Conference
- Place of Presentation
  Renaissance Tuscany Il Ciocco (Lucca, Italy)
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] Identification of the genes responsible for the synthesis of acylceramide, an essential ceramide class for skin barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Place of Presentation
  ルッカ（イタリア）
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Identification of human CYP4F22 as an ultra-long-chain fatty acid-specific omega-hydroxylase responsible for the synthesis of acylceramide, an essential lipid for skin permeability barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  デービス（アメリカ）
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Epidermal acylceramide: production mechanism and importance in skin barrier formation.2016
- Author(s)
  Ohno Yusuke, Kamiyama Nozomi, Nakamichi Shota, Kihara Akio.
- Organizer
  1st Korea-Japan Bioactive Lipid Joint Symposium
- Place of Presentation
  Jeju, South Korea
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 遺伝子欠損マウスを用いた魚鱗癬原因遺伝子NIPAL4/ICHTHYINの皮膚バリア形成における機能解析2016
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 木原章雄
- Organizer
  第9回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都中央区）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア形成に必須なアシルセラミドの合成に関与する遺伝子の同定2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  日本生化学会北海道支部第52回支部例会
- Place of Presentation
  北海道大学フロンティア応用科学研究棟鈴木章ホール（北海道札幌市）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Biochemical analysis of the mutation for non-syndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation2015
- Author(s)
  Abe K, Wakashima T, Ohno Y, Kihara A
- Organizer
  6th International Singapore Lipid Symposium
- Place of Presentation
  シンガポール（シンガポール）
- Year and Date
  2015-11-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア形成に必須なアシルセラミドの産生にシトクロームP450 ファミリータンパク質 CYP4F22 が関与する2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリアに重要なアシルセラミドの産生におけるCYP4F22の機能解析2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  日本薬学会北海道支部142回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬の原因遺伝子産物PNPLA1はアシルセラミド合成に関与する2015
- Author(s)
  大野祐介, 神山望, 木原章雄
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリアを形成するアシルセラミドの合成経路解明2015
- Author(s)
  大野祐介, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 魚鱗癬の原因遺伝子産物 PNPLA1 はアシルセラミド合成に関与する2015
- Author(s)
  大野祐介, 神山望, 木原章雄
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリア形成に必須なアシルセラミドの産生にシトクロームP450ファミリータンパク質CYP4F22が関与する2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子産物 PNPLA1 はアシルセラミドの生合成に関与している2015
- Author(s)
  神山望, 大野祐介, 中路翔太, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05589
[Presentation] 皮膚バリアを形成するアシルセラミドの合成経路解明2015
- Author(s)
  大野祐介, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子産物PNPLA1はアシルセラミドの生合成に関与している2015
- Author(s)
  神山望, 大野祐介, 中路翔太, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Fatty acid elongase Elovl1 is essential for the synthesis of ≧C26 ceramides and epidermal permeability barrier formation2014
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 極長鎖脂肪酸伸長酵素Elovl1は表皮において層特異的な制御を受け皮膚バリアに必須の役割を果たす2013
- Author(s)
  佐々貴之, 大野祐介, 鈴木翔多朗, 乃村俊史, 秋山真志, 田口良, 清水宏, 糸原重美, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 家族性精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部140回例会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] and Fanny Pilot-Storck Of Dogs, Mice, and Cells: Role of HACD1 in Muscle Development and Physiology2013
- Author(s)
  Jordan Blondelle, Yusuke Ohno, Marie Maurer, Gemma Walmsley, Sebastien Storck, Laurent Guillaud1, Jean Demarquoy, Richard Piercy, Akio Kihara, Laurent Tiret
- Organizer
  53rd International conference on the Bioscience of Lipids
- Place of Presentation
  Banff, Canada.Banff Centre.
- Data Source
  KAKENHI-PROJECT-23890001
[Presentation] 常染色体劣性遺伝精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘（仙台市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The cytochrome P450 4F subfamily protein CYP4F22 catalyzes omega-hydroxylation of ultra long-chain-containing ceramides in the epidermis2013
- Author(s)
  Ohno Y, Ohkuni A, Kamiyama N, Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 家族性精神遅滞原因遺伝子TER P182L変異体の生化学的解析とスフィンゴ脂質代謝への影響について2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] アシルセラミドの合成に関与するシトクロムP450の同定2013
- Author(s)
  大國礼, 大野祐介, 神山望, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Sphingolipids with different fatty acid composition exhibit distinct physiological functions2011
- Author(s)
  Yusuke Ohno, Akio Kihara
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II]
- Place of Presentation
  Sapporo, Japan. Gateaux Kingdom Sapporo.
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23890001
[Presentation] Sphingolipids with different fatty acid composition exhibit distinct physiological functions2011
- Author(s)
  Ohno, Y.
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II]
- Place of Presentation
  Chateraise Gateaux Kingdom Sapporo (北海道)
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Identification of the cytochrome P450 4F subfamily protein CYP4F22 as a ceramide ω-hydroxylase involved in the synthesis of acylceramide in epidermis
- Author(s)
  Ohno Y, Ohkuni A, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  55th International Conference on the Bioscience of Lipids
- Place of Presentation
  Aberdeen（英国）
- Year and Date
  2014-06-23 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子CYP4F22の皮膚における生理機能解析
- Author(s)
  神山望, 大野祐介, 大國礼, 中路翔太, 木原章雄
- Organizer
  日本薬学会北海道支部141回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] アシルセラミド合成に関与する超長鎖脂肪酸特異的ω水酸化酵素 CYP4F22 の同定
- Author(s)
  大野祐介, 大國礼, 神山望, 中路翔太, 木原章雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26251010

1. KIHARA Akio (50333620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 45 results
2. SASSA Takayuki (20342793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. OBARA Keisuke (30419858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. AKIYAMA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. SUGIURA Kazumitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 光武進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤田恭之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 奈良篤樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 武市拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohno Yusuke 大野 祐介

OHNO Yusuke 大野 祐介

Research Projects

Research Products

Co-Researchers

The structure and production pathway of skin barrier lipid protein-bound ceramidePrincipal Investigator

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Elucidation of a novel physiolosical function of triglyceride hydrolase activator ABHD5Principal Investigator

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Elucidation of molecular mechanism of skin barrier formation by acylceramide.Principal Investigator

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Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolism

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Analysis of molecular mechanisms underlying the diversity of very long-chain fatty acid synthesis and the muscle development.Principal Investigator

Principal Investigator

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Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids

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Analysis of physiological roles of HACD1 and pathogenesis of myopathies.Principal Investigator

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[Book] セラミド研究の新展開 ～基礎から応用へ～2019

Author(s)

Total Pages

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Data Source

[Book] ここまできたセラミド研究最前線セラミド-基礎と応用-(セラミド研究会編)2011

Author(s)

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Data Source

[Book] 「極長鎖脂肪酸伸長とセラミド合成」ここまできたセラミド研究最前線セラミドー基礎と応用ー2011

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[Book] ここまできたセラミド研究最前線 セラミド-基礎と応用-2011

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[Journal Article] Determining the structure of protein-bound ceramides, essential lipids for skin barrier function2023

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[Journal Article] An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis2022

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[Journal Article] Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA12022

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[Journal Article] Ceramide Analysis in Combination With Genetic Testing May Provide a Precise Diagnosis for Self-Healing Collodion Babies2022

Ohno Yusuke 大野祐介

OHNO Yusuke 大野祐介

[Book] セラミド研究の新展開　～基礎から応用へ～2019

[Book] ここまできたセラミド研究最前線セラミド-基礎と応用-2011