KAWARAI Toshitaka 瓦井俊孝

Researcher Number	50614137
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 徳島大学, 大学院医歯薬学研究部(医学域), 講師 2016: 徳島大学, 大学院医歯薬学研究部(医学系), 講師 2015: 徳島大学, 大学院医歯薬学研究部, 講師 2013 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 講師 2013 – 2014: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator HDAC阻害薬 / KMT2B / モデルマウス / ジストニア / 線条体 / 末梢神経障害 / 痙性対麻痺 / 筋萎縮性側索硬化症 / ゴルジ体 / 小胞体 … More / 凝集体形成 / 細胞内輸送 / 運動ニューロン死 / TFG / 運動ニューロン病 … More Except Principal Investigator GLUD1 / DYT6 / ＧＬＵＤ１ / ＤＹＴ６ / ゾルピデム / ﾎﾞﾂﾘﾇｽ毒素 / ｽﾄﾘｵｿﾞｰﾑ / ｼﾞｽﾄﾆｱ / ボツリヌス毒素 / 基底核 / ストリオゾーム / A2-NTX / ジストニア / SOD1 tansgenic mouse / therapy / ALS / adalizumab / ＳＯＤ１ / ＡＬＳ / ＴＮＦα Less

Investigation of molecular pathogenesis and therapeutic development for DYT-KMT2B by analysis of animal modelsPrincipal Investigator
- Principal Investigator
  
  瓦井俊孝
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  The University of Tokushima
Analysis of TFG gene and development of treatment for motor neuron diseasesPrincipal Investigator
- Principal Investigator
  
  KAWARAI Toshitaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Research on molecular pathogenesis and next-generation therapeutic agent for dystonia-parkinsonism
- Principal Investigator
  
  KAJI Ryuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Development of a novel therapeutic approach for ALS using anti-TNF antibody
- Principal Investigator
  
  KAJI Ryuji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] ブレインサイエンス・レビュー20152015
- Author(s)
  瓦井俊孝
- Total Pages
  252
- Publisher
  ブレインサイエンス振興財団
- Data Source
  KAKENHI-PROJECT-26461294
[Book] 神経内科2015
- Author(s)
  瓦井俊孝, 森垣龍馬, 沖良祐, 和泉唯信, 後藤惠, 梶龍兒
- Total Pages
  456
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26461294
[Book] 新規運動ニューロン病遺伝子TFGの機能解析2015
- Author(s)
  瓦井俊孝
- Total Pages
  256
- Publisher
  ブレインサイエンス振興財団
- Data Source
  KAKENHI-PROJECT-26461294
[Book] 神経内科2015
- Author(s)
  瓦井俊孝
- Total Pages
  456
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26461294
[Book] 神経内科2013
- Author(s)
  瓦井俊孝、森垣龍馬、藤田浩司、和泉唯信、梶　龍兒
- Total Pages
  766
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23659458
[Book] 神経内科2013
- Author(s)
  藤田浩司、瓦井俊孝、和泉唯信、後藤惠、梶龍兒
- Total Pages
  766
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23659458
[Book] 神経内科2013
- Author(s)
  藤田浩司、瓦井俊孝、和泉唯信、後藤惠、梶　龍兒
- Total Pages
  766
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23659458
[Book] 神経内科2013
- Author(s)
  瓦井俊孝、森垣龍馬、藤田浩司、和泉唯信、梶龍兒
- Total Pages
  766
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23659458
[Journal Article] Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.2017
- Author(s)
  Murakami N, Imamura K, Izumi Y, Egawa N, Tsukita K, Enami T, Yamamoto T, Kawarai T, Kaji R, Inoue H.
- Journal Title
  
  Mol Brain
  
  Volume: 10 Issue: 1 Pages: 1-7
- DOI
  10.1186/s13041-017-0286-y
- NAID
  120005971847
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461294
[Journal Article] Exome sequencing identifies a novel intronic mutation in ENG that cause recurrence of pulmonary arteriovenous malformations.2015
- Author(s)
  Kawarai T, Saji N, Miyamoto R, Sato T, Morino H, Orlacchio A, Oki R, Kimura K and Kaji R.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 351 Issue: 1-2 Pages: 231-233
- DOI
  10.1016/j.jns.2015.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461294, KAKENHI-PROJECT-15K15083
[Journal Article] DYT6 in Japan-genetic screening and clinical characteristics of the patients.2014
- Author(s)
  Miyamoto R, Koizumi H, Morino H, Kawarai T, Maruyama H, Mukai Y, Miyashiro A, Sako W, Izumi Y, Kawakami H, Kaji R.
- Journal Title
  
  Mov Disord.
  
  Volume: 29 Issue: 2 Pages: 278-280
- DOI
  10.1002/mds.25745
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111008, KAKENHI-PROJECT-23591246, KAKENHI-PROJECT-24390223, KAKENHI-PROJECT-26461294
[Journal Article] Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms.2014
- Author(s)
  Temistocle Lo Giudice, Federica Lombardi, Filippo Maria Santorelli, Toshitaka Kawarai and Antonio Orlacchio.
- Journal Title
  
  Exp Neurol.
  
  Volume: 261 Pages: 518-539
- DOI
  10.1016/j.expneurol.2014.06.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461294
[Journal Article] Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10.2014
- Author(s)
  Laura Carosi,Temistocle Lo Giudice, Martina Di Lullo, Federica Lombardi, Carla Babalini, Fabrizio Gaudiello, Girolama Alessandra Marfia, Roberto Massa, Toshitaka Kawarai, Antonio Orlacchio.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 85 Issue: 6 Pages: 989-921
- DOI
  10.1136/jnnp-2014-308625
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461294
[Journal Article] Efficacy of deep brain stimulation in an adolescent patient with DYT11 myoclonus-dystonia2014
- Author(s)
  2.Kimura Y, Mihara M, Kawarai T, Kishima H, Sakai N, Takahashi M and Mochizuki H
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 2 Issue: 2 Pages: 57-59
- DOI
  10.1111/ncn3.75
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461543, KAKENHI-PROJECT-26461294
[Journal Article] Defects in the striatal neuropeptide Y system in X-limked dystonia-parkinsonism.2013
- Author(s)
  Goto S, et al
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 5 Pages: 1555-1567
- DOI
  10.1093/brain/awt084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500428, KAKENHI-PROJECT-24390223
[Journal Article] Application of long-range polymerase chain reaction in the diagnosis of f X-linked dystonia-parkinsonism2013
- Author(s)
  Kawarai T, et al.
- Journal Title
  
  Neurogenetics
  
  Volume: 14 Pages: 168-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390223
[Journal Article] The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.2012
- Author(s)
  Ishiura H
- Journal Title
  
  Am J Hum Genet.
  
  Volume: 91(2) Issue: 2 Pages: 320-9
- DOI
  10.1016/j.ajhg.2012.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-23500428, KAKENHI-PROJECT-23591233, KAKENHI-PROJECT-23659458, KAKENHI-PROJECT-23790384, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24390220, KAKENHI-PROJECT-24406030, KAKENHI-PROJECT-24790348, KAKENHI-ORGANIZER-22129001, KAKENHI-PLANNED-22129002
[Presentation] Animal model of HMSN-P2016
- Author(s)
  Ryosuke Oki, Akie Tanabe, Toshitaka Kawarai, Nobuyuki Oka, Yuishin Izumi and Ryuji Kaji
- Organizer
  The 57th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461294
[Presentation] Clinicopathological features of HMSN-P in the Kansai area of Japan.2016
- Author(s)
  Toshitaka Kawarai, Koji Fujita, Yuishin Izumi, Mari Yoshida and Ryuji Kaji. Clinicopathological features of HMSN-P in the Kansai area of Japan
- Organizer
  The 57th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461294
[Presentation] TFG変異による運動ニューロン疾患2015
- Author(s)
  瓦井俊孝
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟朱鷺メッセ(新潟県新潟市)
- Year and Date
  2015-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-26461294
[Presentation] TFG 変異による運動ニューロン死のメカニズム2013
- Author(s)
  梶龍兒、森田光哉、瓦井俊孝、森垣龍馬、藤田浩司、野寺裕之、和泉唯信、後藤惠、中野今治
- Organizer
  第54回日本神経学会学術大会2013
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23659458
[Presentation] TFG変異による運動ニューロン死のメカニズム
- Author(s)
  梶　龍兒、森田光哉、瓦井俊孝、森垣龍馬、藤田浩司、野寺裕之、和泉唯信、後藤　惠、中野今治
- Organizer
  第54回日本神経学会学術大会 2013
- Place of Presentation
  東京国際フォーラム(東京都)
- Data Source
  KAKENHI-PROJECT-23659458
[Presentation] VWA3B mutated in a family with cerebellar ataxia with psychomotor retardation
- Author(s)
  Toshitaka Kawarai, Atsushi Tajima, Yukiko Kuroda, Naoki Saji, Hideo Terasawa, Hirotaka Shimizu, Yasushi Kita, Antonio Orlacchio, Ryosuke Miyamoto, Yuishin Izumi, Takao Mitsui, Issei Imoto and Ryuji Kaji.
- Organizer
  55th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461294
[Presentation] 精神運動発育遅滞を伴う家族性小脳失調症で見つかったVWA3B遺伝子変異
- Author(s)
  瓦井俊孝、田嶋敦、黒田由紀子、佐治直樹、寺澤英夫、清水洋孝、喜多也寸志、Antonio Orlacchio、宮本亮介、和泉唯信、三ツ井貴夫、井本逸勢、梶龍兒
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  タワーホテル船堀 (東京都江戸川区）
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26461294

1. GOTO Satoshi (50240916)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. KAJI Ryuji (00214304)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. IMOTOI Issei (30258610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAJIMA Atsushi (10396864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 川上秀史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 橘逸勢

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 酒井規夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWARAI Toshitaka 瓦井 俊孝

Research Projects

Research Products

Co-Researchers

Investigation of molecular pathogenesis and therapeutic development for DYT-KMT2B by analysis of animal modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of TFG gene and development of treatment for motor neuron diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on molecular pathogenesis and next-generation therapeutic agent for dystonia-parkinsonism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel therapeutic approach for ALS using anti-TNF antibody

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ブレインサイエンス・レビュー20152015

Author(s)

Total Pages

Publisher

Data Source

[Book] 神経内科2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 新規運動ニューロン病遺伝子TFGの機能解析2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 神経内科2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 神経内科2013

Author(s)

Total Pages

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Data Source

[Book] 神経内科2013

Author(s)

Total Pages

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Data Source

[Book] 神経内科2013

Author(s)

Total Pages

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Data Source

[Book] 神経内科2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Exome sequencing identifies a novel intronic mutation in ENG that cause recurrence of pulmonary arteriovenous malformations.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DYT6 in Japan-genetic screening and clinical characteristics of the patients.2014

KAWARAI Toshitaka 瓦井俊孝