Miyauchi Kosuke 宮内浩典

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MIYAUCHI Kosuke 宮内浩典

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Researcher Number	50619856
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター 2025: 国立健康危機管理研究機構, 国立感染症研究所エイズ研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー 2023: 国立感染症研究所, エイズ研究センター, 客員研究員 2022: 国立感染症研究所, エイズ研究センター, 主任研究官 2018 – 2021: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー 2016 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー … More 2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 2014: 理化学研究所, 統合生命医科学研究センター, 研究員 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2012 – 2013: 独立行政法人理化学研究所, その他部局等, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy Except Principal Investigator Basic Section 49070:Immunology-related / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 中和抗体 / Tfh / インフルエンザウイルス / ADE / 抗デングウイルス抗体 / デング熱 / T細胞 / 新型コロナウイルス / TFH細胞 / Tfh細胞 … More / T cell / CoV-2 / SARS-CoV-2 / ヘルパーT細胞 / ワクチン / 抗ウイルス抗体 / 広域中和抗体 / 抗インフルエンザウイルス抗体 / 濾胞性ヘルパーT細胞 / ウイルス中和抗体 / Lung / Th1 / Influenza virus / サイトカイン / IgA / 炎症制御 / 感染防御 / ウイルス増殖 / 肥満細胞 / ウイルス性肺炎 … More Except Principal Investigator T細胞 / T細胞抗原決定基 / B細胞抗原決定基 / B細胞 / 広域中和抗体 / ワクチン / インフルエンザ / 免疫関連疾患 / アレルギー / 免疫学 Less

デングウイルスに対する中和抗体およびADE抗体の研究Principal Investigator
- Principal Investigator
  
  宮内浩典
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Functional analysis of SARS CoV-2 specific T cellsPrincipal Investigator
- Principal Investigator
  
  Miyauchi Kosuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Infectious Diseases
  Institute of Physical and Chemical Research
Innovative viral vaccine strategy promoting broad-reactive neutralizing antibodies.
- Principal Investigator
  
  Masato Kubo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Tokyo University of Science
The mechanism of broadly reactive anti-influenza virus antibody responsesPrincipal Investigator
- Principal Investigator
  
  Miyauchi Kosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
The mechanism of anti-viral IgA production in respiratory tractPrincipal Investigator
- Principal Investigator
  
  Miyauchi Kosuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute of Physical and Chemical Research
Mechanisms of lung inflammation induced by viral infectionPrincipal Investigator
- Principal Investigator
  
  MIYAUCHI Kosuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of cytokines behavior in allergic disorder using in vivo imaging system
- Principal Investigator
  
  KUBO Masato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo University of Science

All 2021 2020 2019 2017 2016 2013 2012 Other

All Journal Article Presentation

[Journal Article] Essential role of STAT3 signaling in hair follicle homeostasis2021
- Author(s)
  Miyauchi, K., Ki, S., Ukai, M., Suzuki, Y., Inoue, K., Suda, W., Matsui, T.,　Ito,Y., Honda, K., Koseki, H., Ohara, O., Tanaka, R. J., Okada-Hatakeyama, M., Kubo, M.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: -
- DOI
  10.3389/fimmu.2021.663177
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03491
[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells.2021
- Author(s)
  Miyauchi, K., Adachi, Y., Tonouchi, K., Yajima, T., Harada, Y., Fukuyama, H., Deno, S., Iwakura, Y., Yoshimura, A., Hasegawa, H., Yugi, K., Fujii, S., Ohara, O., Takahashi, Y., Kubo, M.
- Journal Title
  
  Nature Communication
  
  Volume: 18;12(1) Pages: 3789-3789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03491
[Journal Article] Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location.2020
- Author(s)
  Sarkander, J., Hojyo, S., Mursell, M., Yamasaki, Y., Wu, TY., Tumes, DJ., Miyauchi, K., Tran, CL., Zhu, J., Löhning, M., Hutloff, A., Mashreghi, MF., Kubo, M., Radbruch, A., Tokoyoda, K
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10:3113. Pages: 0-1
- DOI
  10.3389/fimmu.2019.03113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03491
[Journal Article] Breadth of Antibody Responses during Influenza Virus Infection and Vaccination2020
- Author(s)
  Kubo Masato、Miyauchi Kosuke
- Journal Title
  
  Trends in Immunology
  
  Volume: 41 Issue: 5 Pages: 394-405
- DOI
  10.1016/j.it.2020.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06647, KAKENHI-PROJECT-19H03491
[Journal Article] Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.2019
- Author(s)
  Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Masumoto, T., Katsushima, A., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M. & Miyazawa, M.
- Journal Title
  
  J Exp Med.
  
  Volume: 216 Issue: 12 Pages: 2736-2747
- DOI
  10.1084/jem.20190557
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19K16622, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-19H03481, KAKENHI-PROJECT-19H03491, KAKENHI-PROJECT-16H06276
[Journal Article] Is germinal center selection required for influenza vaccination?2017
- Author(s)
  Miyauchi Kosuke、Kubo Masato
- Journal Title
  
  Cellular & Molecular Immunology
  
  Volume: 14 Issue: 8 Pages: 655-657
- DOI
  10.1038/cmi.2017.40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07958
[Journal Article] Helper T Cell Responses to Respiratory Viruses in the Lung: Development, Virus Suppression, and Pathogenesis2017
- Author(s)
  Miyauchi Kosuke
- Journal Title
  
  Viral Immunology
  
  Volume: 30 Issue: 6 Pages: 421-430
- DOI
  10.1089/vim.2017.0018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07958
[Journal Article] Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines2012
- Author(s)
  Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., and Kubo, M
- Journal Title
  
  PLoS One
  
  Volume: 7(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249058
[Journal Article] Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells2012
- Author(s)
  Miyauchi, K., Urano, E., Takeda, S., Murakami, T., Okada, Y., Cheng, K., Yin, H., Kubo, M., and Komano, J
- Journal Title
  
  Biochem. Biophys. Res .Commun
  
  Volume: 424(3) Pages: 519-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] NFIL3 is an important switcher to control ILC2 and ILC1 function2021
- Author(s)
  Bohio, A. A., Miyauchi, K., and Kubo, M.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03491
[Presentation] Role of germinal center response in the antibody responses against SARS-CoV-2 spike protein2021
- Author(s)
  Miyauchi, K., Hashimoto, R., Takayama K., and Kubo, M.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-19H03491
[Presentation] ウイルス感染によって誘導されるIL-4依存的な広域中和抗体産生2021
- Author(s)
  宮内浩典、久保允人
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03491
[Presentation] ROLE OF SARS-CoV-2 SPIKE PROTEIN CROSS-REACTIVE CTL EPITOPES IN T CELL IMMUNITY2021
- Author(s)
  Abubakar, S. D., Miyauchi, K., Kubo, M.
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03491
[Presentation] Virus replication drive mucosal antibody against heterologous influenza viruses2017
- Author(s)
  Miyauchi Kosuke、Kubo Masato
- Organizer
  第46回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K07958
[Presentation] IFN-γ and IL-6-dependent production of influenza virus specific IgA2016
- Author(s)
  Kosuke Miyauchi, Toshitada Takemori and Masato Kubo
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K07958
[Presentation] Role of follicular helper T (TFH) cell in humeral responses against influenza A virus infection2013
- Author(s)
  Kosuke Miyauchi, Tomohiro Kaji, Toshitada Takemori, Masato Kubo
- Organizer
  第78回日本インターフェロン・サイトカイン学会/第21回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  都市センターホテル（東京都）
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] Distinct roles of TFH and TH1 cells in humoral responses against influenza A virus infection2013
- Author(s)
  Kosuke Miyauchi, Akiko Ishige, Tomohiro Kaji, Yohsuke Harada, Hideki Hasegawa, Yoshimasa Takahashi, Toshitada Takemori, Masato Kubo
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] :Critical role of follicular helper T cells in the IgE response to T-D antigens and serum neutralization activity in virus infection2012
- Author(s)
  Miyauchi, K., Harada, Y., Motomura, Y., Kaji, T., Takemori, T., Kubo, M
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] Role of follicular helper T (TFH) cell in influenza A virus infection and vaccination2012
- Author(s)
  Miyauchi, K., Kaji, T., Takemori, T., and Kubo, M
- Organizer
  Keystone Symposia Vaccination Conference
- Place of Presentation
  Ottawa
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] Functions of Tfh cells in influenza virus infection and airway hyperreactivity2012
- Author(s)
  宮内浩典、原田康代、加地友弘、鈴木芳枝、井上博雅、竹森利忠、久保允人
- Organizer
  第22回京都T細胞会議
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24249058
[Presentation] Influenza A virus (IAV) vaccination effectively induces germinal center
- Author(s)
  MIYAUCHI Kosuke, SUGIMOTO-ISHIGE Akiko, TAKAHASHI Yoshimasa, HASEGAWA Hideki, TAKEMORI Toshitada, KUBO Masato
- Organizer
  第４３回日本免疫学会学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860058
[Presentation] Nasal vaccine with live influenza virus specifically induces Bcl-6 independent and IFN-γ-dependent IgA response in the lung.
- Author(s)
  Kosuke Miyauchi, Masato Kubo
- Organizer
  第25回KTCC学術集会
- Place of Presentation
  京都大学芝蘭会館
- Year and Date
  2015-05-15 – 2015-05-16
- Data Source
  KAKENHI-PROJECT-25860058
[Presentation] The role of IFNg producing Th cells in protective humoral immune responses against influenza virus infection
- Author(s)
  宮内　浩典
- Organizer
  第24回KTCC学術集会
- Place of Presentation
  京都平安ホテル
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25860058
[Presentation] Influenza A virus (IAV) vaccination effectively induces germinal center
- Author(s)
  MIYAUCHI Kosuke, SUGIMOTO-ISHIGE Akiko, TAKAHASHI Yoshimasa, HASEGAWA Hideki, TAKEMORI Toshitada, KUBO Masato
- Organizer
  第43回日本免疫学会総会
- Place of Presentation
  京都府（国立京都国際会館）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24249058

1. KUBO Masato (40277281)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. HARADA Yohsuke (20328579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 本園千尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyauchi Kosuke 宮内 浩典

MIYAUCHI Kosuke 宮内 浩典

Research Projects

Research Products

Co-Researchers

デングウイルスに対する中和抗体およびADE抗体の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of SARS CoV-2 specific T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovative viral vaccine strategy promoting broad-reactive neutralizing antibodies.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of broadly reactive anti-influenza virus antibody responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of anti-viral IgA production in respiratory tractPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of lung inflammation induced by viral infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cytokines behavior in allergic disorder using in vivo imaging system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Essential role of STAT3 signaling in hair follicle homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells.2021

Author(s)

Journal Title

Data Source

[Journal Article] Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Breadth of Antibody Responses during Influenza Virus Infection and Vaccination2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Is germinal center selection required for influenza vaccination?2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Helper T Cell Responses to Respiratory Viruses in the Lung: Development, Virus Suppression, and Pathogenesis2017

Author(s)

Journal Title

DOI

Miyauchi Kosuke 宮内浩典

MIYAUCHI Kosuke 宮内浩典