Okuno Alato 奥野海良人

… Alternative Names

OKUNO Alato 奥野海良人

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Researcher Number	50623980
Other IDs
Affiliation (Current)	2025: 柴田学園大学, 生活創生学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 柴田学園大学, 生活創生学部, 准教授 2021 – 2023: 柴田学園大学, 生活創生学部, 准教授 2018 – 2020: つくば国際大学, 医療保健学部, 講師(移行) 2017: 国立研究開発法人国立長寿医療研究センター, その他部局等, その他 2016: 国立研究開発法人国立長寿医療研究センター, ラジオアイソトープ管理室, 外来研究員 … More 2015: 国立研究開発法人国立長寿医療研究センター, ラジオアイソトープ管理室, 特任研究員 2015: 国立研究開発法人国立長寿医療研究センター, ラジオアイソトープ管理室, 研究員 2014: 独立行政法人国立長寿医療研究センター, 長寿医療研究センター・ラジオアイソトープ管理室, 特任研究員 2012 – 2014: 独立行政法人国立長寿医療研究センター, ラジオアイソトープ管理室, 特任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 38050:Food sciences-related / 0601:Agricultural chemistry and related fields / Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits Except Principal Investigator Pathological medical chemistry / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator トリプトファン / キヌレニン / プロバイオティクス / 脳神経疾患 / プレバイオティクス / TDO / IDO / インドール-3-プロピオン酸 / インドール-3-酢酸 / 腸内環境 … More / トリプトファン代謝 / 腸脳相関 / 神経疾患 / 免疫 / 樹状細胞 / アミロイドβ / アルツハイマー病 / 栄養 / キノリン酸 / キヌレン酸 … More Except Principal Investigator アルツハイマー病 / Aig1l遺伝子 / 東洋医学 / 漢方 / 鍼灸 / 膜タンパク質 / Aig1l / 疾患エクソソーム / 代謝異常学 / 軽度認知症障害 / オミックス解析 / 脳リキッドバイオプシー / アストロサイト由来エクソソーム / 神経細胞由来エクソソーム / 多層的オミックス解析 / リキッドバイオプシー / エクソソーム / 認知症 / ＩＤＯ / IDO / 神経毒 / キノリン酸 / アミロイドβペプチド / トリプトファン代謝 Less

うつ病の原因物質キヌレニンの調節に関わる肝臓と腎臓の役割Principal Investigator
- Principal Investigator
  
  奥野海良人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shibata Gakuen University
精神疾患に関連する中枢トリプトファン代謝の末梢調節Principal Investigator
- Principal Investigator
  
  奥野海良人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Shibata Gakuen University
Suppression of brain inflammation through induction of endogenous anti-inflammatory compound by prebiotics and probioticsPrincipal Investigator
- Principal Investigator
  
  Okuno Alato
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0601:Agricultural chemistry and related fields
- Research Institution
  Shibata Gakuen University
トリプトファン摂取による腸管IDO誘導機構の解明Principal Investigator
- Principal Investigator
  
  奥野海良人
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Tsukuba International University
Relationship between the biological function and/or effect of acupuncture of Aig1l gene discovered by acupuncture stimulation
- Principal Investigator
  
  Takaoka Yutaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Kobe University
Pathological analysis of Alzheimer`s disease through multi-layered omics study of blood exosomes derived from brain
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
The Alzheimer's disease prevention and treatment by nutritional increase in endogenous neuro-protective mediator, kynurenic acid in brainPrincipal Investigator
- Principal Investigator
  
  OKUNO Alato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  National Center for Geriatrics and Gerontology
The mechanisms of quinolinic acid-induced infiltration of reactive astrocytes and the amyloid beta peptide production in the activated glial cells
- Principal Investigator
  
  TAKIKAWA Osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology

All 2024 2023 2022 2018 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells2024
- Author(s)
  Saito Suguru、Okuno Alato、Peng Zhenzi、Cao Duo-Yao、Tsuji Noriko M.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15
- DOI
  10.3389/fimmu.2024.1335975
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05543
[Journal Article] Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate2022
- Author(s)
  SAITO Suguru、CAO Duo-Yao、OKUNO Alato、LI Xiaomo、PENG Zhenzi、KELEL Musin、TSUJI Noriko M
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 41 Issue: 4 Pages: 185-194
- DOI
  10.12938/bmfh.2022-018
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20573
[Journal Article] <i>Lactococcus lactis</i> subsp. <i>cremoris</i> C60 induces macrophages activation that enhances CD4+ T cell-based adaptive immunity2022
- Author(s)
  SAITO Suguru、OKUNO Alato、KAKIZAKI Nanae、MAEKAWA Toshio、TSUJI Noriko M.
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 41 Issue: 3 Pages: 130-136
- DOI
  10.12938/bmfh.2021-057
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20573
[Journal Article] Lymphocyte antigen 6 complex locus G6D downregulation is a novel parameter for functional impairment of neutrophils in aged mice2022
- Author(s)
  Suguru Saito, Alato Okuno, Toshio Maekawa, Ryoki Kobayashi, Osamu Yamashita, Noriyuki Tsujimura, Morihiko Inaba, Yasushi Kageyama, Noriko M. Tsuji.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1001179-1001179
- DOI
  10.3389/fimmu.2022.1001179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09846, KAKENHI-PROJECT-22K05543
[Journal Article] Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice2022
- Author(s)
  Yajima Yuhei、Okuno Alato、Nakamura Isamu、Miyazaki Teruo、Honda Akira、Toyoda Atsushi
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 15 Pages: 1-9
- DOI
  10.1177/11786469211066285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11219, KAKENHI-PROJECT-21K20573
[Journal Article] Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice2022
- Author(s)
  Sato Mizuho、Okuno Alato、Ishisono Keita、Yajima Yuhei、Toyoda Atsushi
- Journal Title
  
  International Journal of Tryptophan Research
  
  Volume: 15
- DOI
  10.1177/11786469221128697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05543, KAKENHI-PROJECT-21K17587, KAKENHI-PROJECT-21K20573
[Journal Article] Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.2016
- Author(s)
  Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T.
- Journal Title
  
  Hepatology
  
  Volume: 63 Issue: 1 Pages: 83-94
- DOI
  10.1002/hep.28282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08326, KAKENHI-PROJECT-25860574
[Journal Article] New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation.2016
- Author(s)
  Coluccia A, Passacantilli S, Famiglini V, Sabatino M, Patsilinakos A, Ragno R, Mazzoccoli C, Sisinni L, Okuno A, Takikawa O, Silvestri R, La Regina G.
- Journal Title
  
  J Med Chem.
  
  Volume: 59 Pages: 9760-9773
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08326
[Journal Article] Affinity imaging mass spectrometry (AIMS): high-throughput screening for specific small molecule interactions with frozen tissue sections.2015
- Author(s)
  Yoshimi T, Kawabata S, Taira S, Okuno A, Mikawa R, Murayama S, Tanaka K, Takikawa O.
- Journal Title
  
  Analyst
  
  Volume: 140 Issue: 21 Pages: 7202-7208
- DOI
  10.1039/c5an01381j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08326
[Journal Article] Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection.2013
- Author(s)
  Higashitani K, Kanto T, Kuroda S, Yoshio S, Matsubara T, Kakita N, Oze T, Miyazaki M, Sakakibara M, Hiramatsu N, Mita E, Imai Y, Kasahara A, Okuno A, Takikawa O, Hayashi N, Takehara T.
- Journal Title
  
  J Gastroenterol.[Epub ahead of print]
  
  Volume: 未定
- NAID
  10031177017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590397
[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013
- Author(s)
  Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 52 Issue: 2 Pages: 133-138
- DOI
  10.3164/jcbn.12-118
- NAID
  130004466706
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24590397
[Journal Article] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.2013
- Author(s)
  Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
- Journal Title
  
  Lipids Health Dis
  
  Volume: 12 Issue: 1 Pages: 68-68
- DOI
  10.1186/1476-511x-12-68
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116006, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24590397, KAKENHI-PROJECT-24619007, KAKENHI-PUBLICLY-25116702, KAKENHI-PROJECT-25750068
[Patent] 化学・物理現象検出方法及びその装置2014
- Inventor(s)
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Holder
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Type
  特許
- Filing Date
  2014-05-28
- Overseas
- Data Source
  KAKENHI-PROJECT-24590397
[Patent] 化学・物理現象検出方法及びその装置2013
- Inventor(s)
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Holder
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-112444
- Filing Date
  2013-05-29
- Data Source
  KAKENHI-PROJECT-25750068
[Patent] 化学・物理現象検出方法及びその装置2013
- Inventor(s)
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Holder
  滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
- Industrial Property Rights Type
  特許
- Filing Date
  2013-05-29
- Data Source
  KAKENHI-PROJECT-24590397
[Patent] アルツハイマー病の発症を予測する方法2012
- Inventor(s)
  滝川修・奥野海良人・その他５名
- Industrial Property Rights Holder
  滝川修・奥野海良人・その他５名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-151620
- Filing Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] 乳酸菌X株の死菌体投与がトリプトファン-キヌレニン代謝に及ぼす影響2023
- Author(s)
  一戸唯華、前多隼人、織田夏美、奥野海良人
- Organizer
  日本トリプトファン研究会
- Data Source
  KAKENHI-PROJECT-22K05543
[Presentation] GAN誘導性NASHモデルマウスでは膵臓のキヌレニン代謝関連遺伝子が軒並み増加する2022
- Author(s)
  橘髙　充加、髙橋　万由花、土屋　友梨華、奥野　海良人、安原　香子、小林　謙一
- Organizer
  日本トリプトファン研究会
- Data Source
  KAKENHI-PROJECT-22K05543
[Presentation] Kynurenine metabolism is involved in the link between nonalcoholic fatty liver disease (NASH) and chronic kidney disease (CKD)2022
- Author(s)
  Mayuka Takahashi, Misaki Suzuki, Maiko Takasuga, Mika Kittaka, Mamiko Ishikawa, Junko Ohki, Alato Okuno, Yoshiko Mori, Ken-Ichi Kobayashi
- Organizer
  IUNS-ICN 22nd International Congress of Nutrition in Tokyo, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05543
[Presentation] 飼料の摂取がトリプトファン‐キヌレニン代謝に及ぼす影響2022
- Author(s)
  木村仁実、織田夏海、佐藤梨沙、奥野海良人
- Organizer
  日本トリプトファン研究会
- Data Source
  KAKENHI-PROJECT-22K05543
[Presentation] 幼若期のマウスを用いた社会的敗北モデルの作成と評価2018
- Author(s)
  大澤夏樹、奥野海良人、豊田淳
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K02211
[Presentation] ヘスペリジンの給与は慢性社会的敗北ストレスによる脳内キヌレニンの増加を抑制し、社会的ストレスに対する抵抗性（レジリエンス）を付与する2018
- Author(s)
  佐藤瑞穂、奥野海良人、鈴木一徳、大澤夏樹、井上栄一、宮口右二、豊田淳
- Organizer
  第24回 Hindgut Club Japanシンポジウム
- Data Source
  KAKENHI-PROJECT-18K02211
[Presentation] Dietary intake of hesperidin suppresses brain kynurenine levels and social avoidance behavior in the depression model of mouse2018
- Author(s)
  Mizuho Sato, Alato Okuno, Kazunori Suzuki, Natsuki Ohsawa, Eiichi Inoue, Yuji Miyaguchi , Atsushi Toyoda
- Organizer
  The 15th Meeting of International Society for Tryptophan Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K02211
[Presentation] 切皮刺激による皮下組織への治療効果の検討（第一報）2018
- Author(s)
  奥野海良人、大田美香、高岡裕
- Organizer
  第67回全日本鍼灸学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07414
[Presentation] ヘスペリジンの慢性給与は心理社会的ストレスに対する抵抗性を向上させる2018
- Author(s)
  佐藤瑞穂、鈴木一徳、大澤夏樹、奥野海良人、井上栄一、宮口右二、豊田淳
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K02211
[Presentation] Relationship between non-B, non-C hepatocellular carcinoma and tryptophan-kynurenine metabolism2018
- Author(s)
  Okuno A, Kamiya S, Watanabe Y, Kobayashi K, Yamamoto Y, Tsuji MN
- Organizer
  The 15th Meeting of International Society for Tryptophan Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K02211
[Presentation] ヒト血清中のアミロイドβ分解活性の性状解析2015
- Author(s)
  三河隆太、奥野海良人、吉見立也、滝川修
- Organizer
  第38回日本基礎老化学会大会
- Place of Presentation
  横浜
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] Development of High-speed and Super Sensitive Device for Detection of Amyloid-β Peptide Using an Ion Image Sensor.2015
- Author(s)
  Okuno A, Yoshimi T, Okumura K, Sawada K, Takikawa O.
- Organizer
  26th IEEE International Symposium on Micro-NanoMehatronics and Human Science in 2015
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2015-11-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] マウスにおけるトリプトファン摂取が神経保護物質キヌレン酸および神経毒キノリン酸の脳内および血液レベルに及ぼす影響2015
- Author(s)
  奥野海良人，三河隆太，吉見立也，滝川修
- Organizer
  日本アミノ酸学会第9回学術大会（JSAAS2015）
- Place of Presentation
  滋賀県彦根市
- Year and Date
  2015-10-23
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] Trp supplementation decreases KYNA/QA ratio in the mouse brain.2015
- Author(s)
  Okuno A, Yoshimi T, Mikawa R and Takikawa O.
- Organizer
  The 14th Meeting of International Society for Tryptophan Research
- Place of Presentation
  アメリカ（ミシガン）
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] Trp supplementation decreases KYNA/QA ratio in the mouse brain.2015
- Author(s)
  Okuno A, Yoshimi T, Mikawa R, Takikawa O.
- Organizer
  2015 ISTRY Conference
- Place of Presentation
  Grand Rapids, USA.
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] マウスにおけるトリプトファン摂取が神経保護物質キヌレン酸および神経毒キノリン酸の脳内および血液レベルに及ぼす影響2015
- Author(s)
  奥野海良人、三河隆太、吉見立也、滝川修
- Organizer
  日本アミノ酸学会第9回学術大会（JSAAS2011）
- Place of Presentation
  彦根
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] AIMS: 親和性化合物イメージング質量分析スクリーニングシステム2015
- Author(s)
  吉見立也、川畑慎一郎、奥野海良人、三河隆太、田中耕一、滝川修
- Organizer
  BMB2015（分子生物学会、生化学会合同大会）
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] マイクロバイオ化学センサによる健康管理2015
- Author(s)
  澤田和明、奥野海良人、滝川修、奥村弘一、服部敏明
- Organizer
  日本機械学会第7回マイクロ・ナノ工学シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-15K08326
[Presentation] Characterization of Amyloid-β Degrading Activity in Human Serum.2014
- Author(s)
  Mikawa R, Okuno A, Takayanagi A, Okada K, Yoshimi T, Takikawa O.
- Organizer
  日本基礎老化学会第37回大会
- Place of Presentation
  東浦
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] イオンイメージセンサを用いたアルツハイマー病原因物質の高速高感度測定装置の開発2014
- Author(s)
  奥野海良人
- Organizer
  中部地区　医療・バイオ系シーズ発表会新技術説明会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] New modulator of the tumoural immuno escape via Indoleamin 2,3-dioxygenase (IDO) inhibition.2014
- Author(s)
  Antonio Coluccia, Giuseppe La Regina, Okuno A, Takikawa O, Romano Silvestri.
- Organizer
  XXV CONGRESSO NAZIONALE DELLA SCI “SCI2014”
- Place of Presentation
  Rend CS, Italy.
- Year and Date
  2014-09-07
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] ヒト血清中のアミロイドβ分解活性の同定2014
- Author(s)
  三河隆太、奥野海良人、高柳亜紀子、吉見立也、滝川修
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Kinetic and protein-ligand interaction studies of human tryptophan 2,3-dioxygenase, identified the modulation of enzymatic reactions by tryptophan.2013
- Author(s)
  岡田健、三河隆太、奥野海良人、高柳亜紀子、山岸まゆみ、吉見立也、滝川修
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] ヒトTryptophan 2,3-dioxygenaseのアロステリック効果による酵素反応調節機構2013
- Author(s)
  岡田健、三河隆太、奥野海良人、吉見立也、滝川修
- Organizer
  第35回日本トリプトファン研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] 経管栄養施行中の重症心身障害児(者)の栄養障害と免疫機能 -インドールアミン酸素添加酵素(IDO)との関連について-2013
- Author(s)
  大森啓充、滝川修、眞山義民、奥野海良人、山﨑雅美、福場浩正、村田芳夫、松本信夫、品川友江、宮地隆史、住元了、鈴木修一、宮野前健、児玉浩子
- Organizer
  第35回日本臨床栄養学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Implications of brain microvessel endothelial cell-derived amyloid β peptide in cerebral amyloid angiopathy associated with Alzheimer’s disease.2013
- Author(s)
  Takikawa O, Mikawa R, Okuno A, Yoshimi T, Okada K, Takayanagi A.
- Organizer
  Alzheimer’s disease Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, America
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] 経管栄養施行中の重症心身障害児(者)の栄養障害と免疫機能 – インドールアミン酸素添加酵素(IDO)との関連について–2013
- Author(s)
  大森啓充、滝川修、眞山義民、奥野海良人、山﨑雅美、福場浩正、村田芳夫、松本信夫、品川友江、宮地隆史、住元了、鈴木修一、宮野前健、児玉浩子
- Organizer
  第35回日本臨床栄養学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] 血管内皮細胞によるAβ産生調節機構：脳アミロイド血管症におけるその病態生理学的意義2013
- Author(s)
  三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
- Organizer
  第86回日本生化学会大会、2013年9月11日、
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] 血管内皮細胞におけるAβ産生機構と脳アミロイド血管症2013
- Author(s)
  三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
- Organizer
  第36回日本基礎老化学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] 脳血管細胞によるAβ産生と脳アミロイド血管症2013
- Author(s)
  三河隆太、奥野海良人、岡田健、高柳亜紀子、吉見立也、滝川修
- Organizer
  第35回神経組織培養研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease.2013
- Author(s)
  Tajima Y, Maekawa Keiko, Ishikawa M, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Kazutaka I, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
- Organizer
  The 9th Annual Conference of the Metabolomics Society
- Place of Presentation
  Glasgow, Scotland
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] NMRを用いたアルツハイマー病モデルマウスのメタボローム解析2012
- Author(s)
  福原　潔、大野彰子、太田庸介、前川京子、奥田晴宏、栗原正明、奥野海良人、新飯田俊平、斎藤嘉朗、滝川　修
- Organizer
  第65回日本酸化ストレス学会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] 脳血管細胞によるAβ産生と脳アミロイド血管症
- Author(s)
  三河隆太、奥野海良人、岡田健、高柳亜紀子、吉見立也、滝川修
- Organizer
  第35回神経組織培養研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] 反応性アストロサイトによるアミロイドβペプチド産生機構
- Author(s)
  吉見立也、奥野海良人、岡田健、三河隆太、高柳亜紀子、滝川修
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Development of High-speed and Super Sensitive Device for Detection of Amyloid-β Peptide Using an Ion Image Sensor.
- Author(s)
  Okuno A, Yoshimi T, Okumura K, Sawada K, Takikawa O.
- Organizer
  IEEE International Symposium on Micro-NanoMechatronics and Human Science(MHS) 2014
- Place of Presentation
  Nagoya,Japan.
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Kinetic and protein-ligand interaction studies of human tryptophan 2,3-dioxygenase, identified the modulation of enzymatic reactions by tryptophan.
- Author(s)
  岡田健、三河隆太、奥野海良人、高柳亜紀子、山岸まゆみ、吉見立也、滝川修
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Characterization of Amyloid-βDegrading Activity in Human Serum.
- Author(s)
  三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
- Organizer
  第6回NAGOYAグローバルリトリート
- Place of Presentation
  東浦
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] 血管内皮細胞におけるAβ産生機構と脳アミロイド血管症
- Author(s)
  三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
- Organizer
  第36回日本基礎老化学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Lipidomic analysis of brain and plasma from a mouse model of Alzheimer’s disease.
- Author(s)
  Tajima Y, Maekawa K, Ishikawa M, Murayama M, Nishimaki-Mogami T, Nakanishi1 H, Ikeda K, Arita M, Taguchi R, Gong J, Okuno A, Niida S, Takikawa O, Saito Y.
- Organizer
  第53回国際脂質生化学会
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Characterization of Amyloid-β Degrading Activity in Human Serum.
- Author(s)
  Mikawa R, Okuno A, Takayanagi A, Okada K, Yoshimi T, Takikawa O.
- Organizer
  日本基礎老化学会第37回大会
- Place of Presentation
  愛知県知多郡
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] Implications of brain microvessel endothelial cell-derived amyloid β peptide in cerebral amyloid angiopathy associated with Alzheimer’s disease.
- Author(s)
  Takikawa O, Mikawa R, Okuno A, Yoshimi T, Okada K, Takayanagi A.
- Organizer
  Alzheimer’s disease Association International Conference (AAIC) 2013
- Place of Presentation
  Boston, America.
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] 血管内皮細胞によるAβ産生調節機構：脳アミロイド血管症におけるその病態生理学的意義
- Author(s)
  三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] ヒトTryptophan 2,3-dioxygenaseのアロステリック効果による酵素反応調節機構
- Author(s)
  岡田健、三河隆太、奥野海良人、吉見立也、滝川修
- Organizer
  第35回日本トリプトファン研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease.
- Author(s)
  Tajima Y, Maekawa Keiko, Ishikawa M, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Kazutaka I, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
- Organizer
  The 9th Annual Conference of the Metabolomics Society
- Place of Presentation
  Glasgow, Scotland
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Aβ Production from Reactive Astrocytes Induced by Endogenous Neurotoxin Quinolinic Acid : A New Aspect of Alzheimer’s Disease.
- Author(s)
  Okuno A, Zhang G, Yoshimi T, Mikawa R, Takikawa O.
- Organizer
  Alzheimer’s disease Association International Conference (AAIC) 2012
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Pathogenic role of IDO in Alzheimer’s disease: Astrocytes but not neurons are responsible for the increase of amyloid β peptide induced by neurotoxin quinolinic acid.
- Author(s)
  Okuno A, Yoshimi T, Okada K, Mikawa R, Takayanagi A, Takikawa O.
- Organizer
  第13回国際トリプトファン研究会
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-24590397
[Presentation] Development of High-speed and Super Sensitive Device for Detection of Amyloid-β Peptide Using an Ion Image Sensor.
- Author(s)
  Okuno A, Yoshimi T, Okumura K, Sawada K, Takikawa O.
- Organizer
  IEEE International Symposium on Micro-NanoMechatronics and Human Science(MHS) 2014
- Place of Presentation
  Nagoya, Aichi, Japan
- Year and Date
  2014-11-23 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] New modulator of the tumoural immuno escape via Indoleamin 2,3-dioxygenase (IDO) inhibition.
- Author(s)
  Antonio Coluccia, Giuseppe La Regina, Okuno A, Takikawa O, Romano Silvestri.
- Organizer
  XXV CONGRESSO NAZIONALE DELLA SCI “SCI2014”
- Place of Presentation
  Rend CS, Italy
- Year and Date
  2014-09-07 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25750068
[Presentation] アルツハイマー病モデルマウスの脳組織及び血漿における脂質メタボローム解析
- Author(s)
  田島陽子、前川京子、石川将己、村山真由子、妹尾勇弥、最上(西巻)知子、中西広樹、池田和貴、有田誠、田口良、檜垣小百合、奥野海良人、新飯田俊平、滝川修、斎藤嘉朗
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590397

1. TAKIKAWA Osamu (70163342)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
2. Takaoka Yutaka (20332281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 大田美香 (20274706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 菅野亜紀 (20457039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 鈴木高史 (70305530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOBAYASHI Ryoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中村勇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okuno Alato 奥野 海良人

OKUNO Alato 奥野 海良人

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うつ病の原因物質キヌレニンの調節に関わる肝臓と腎臓の役割Principal Investigator

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精神疾患に関連する中枢トリプトファン代謝の末梢調節Principal Investigator

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Suppression of brain inflammation through induction of endogenous anti-inflammatory compound by prebiotics and probioticsPrincipal Investigator

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トリプトファン摂取による腸管IDO誘導機構の解明Principal Investigator

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Relationship between the biological function and/or effect of acupuncture of Aig1l gene discovered by acupuncture stimulation

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Pathological analysis of Alzheimer`s disease through multi-layered omics study of blood exosomes derived from brain

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The Alzheimer's disease prevention and treatment by nutritional increase in endogenous neuro-protective mediator, kynurenic acid in brainPrincipal Investigator

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The mechanisms of quinolinic acid-induced infiltration of reactive astrocytes and the amyloid beta peptide production in the activated glial cells

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[Journal Article] Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells2024

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[Journal Article] Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate2022

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[Journal Article] <i>Lactococcus lactis</i> subsp. <i>cremoris</i> C60 induces macrophages activation that enhances CD4+ T cell-based adaptive immunity2022

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[Journal Article] Lymphocyte antigen 6 complex locus G6D downregulation is a novel parameter for functional impairment of neutrophils in aged mice2022

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[Journal Article] Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice2022

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Okuno Alato 奥野海良人

OKUNO Alato 奥野海良人