OKAMOTO Yuka 岡本有加

… Alternative Names

Okamoto Yuka 岡本有加

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Researcher Number	50625217
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 客員研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 客員研究員 2016 – 2022: 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics
Keywords	Principal Investigator DNA相同組換え修復 / ストレス応答 / 合成致死 / がん代謝 / 相同組換え修復 / 統合ストレス応答 / ストレス適応応答 / シスプラチン / グルタミン代謝 / 解糖系 … More / がん / 核酸医薬 / lncRNA / DNA損傷修復 / 分子標的治療 / マイクロRNA / non-coding RNA / マイクロRNA阻害剤 / 抗がん治療 / DNA損傷応答 / がん細胞 / miRNA阻害剤 Less

がん細胞の代謝可塑性制御機構の解明と制御破綻に基づく新規治療法の考案Principal Investigator
- Principal Investigator
  
  岡本有加
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Analysis of mechanisms underlying homologous recombination deficiency induced by cancer metabolism inhibitionPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Yuka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Perturbation of homologous recombination repair in tumor through inhibition of lncRNA functionPrincipal Investigator
- Principal Investigator
  
  Okamoto Yuka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Development of molecular-targeted therapy with miRNA inhibitors modifying DNA-Damage-ResponsePrincipal Investigator
- Principal Investigator
  
  Okamoto Yuka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Induction of stearoyl‐CoA desaturase confers cell density‐dependent ferroptosis resistance in melanoma2024
- Author(s)
  Shirahama Hitomi、Tani Yuri、Tsukahara Satomi、Okamoto Yuka、Hasebe Akiko、Noda Tomomiki、Ando Shuji、Ushijima Masaru、Matsuura Masaaki、Tomida Akihiro
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 125 Issue: 4
- DOI
  10.1002/jcb.30542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06707, KAKENHI-PROJECT-21K15539
[Journal Article] Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation2023
- Author(s)
  Mizuki Takahashi, Yuka Okamoto, Yu Kato, Hitomi Shirahama, Satomi Tsukahara, Yoshikazu, Sugimoto, Akihiro Tomida
- Journal Title
  
  Heliyon
  
  Volume: Vol.9 Issue: 4 Pages: e14799-e14799
- DOI
  10.1016/j.heliyon.2023.e14799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07689, KAKENHI-PROJECT-23K24193
[Journal Article] The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.2020
- Author(s)
  Okamoto Y, Saito T, Tani Y, Toki T, Hasebe A, Koido M, Tomida A.
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 14 Pages: 4591-4603
- DOI
  10.1074/jbc.ra119.010655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K15293
[Presentation] グルタミン代謝阻害によるシスプラチン高感受性化におけるアルファケトグルタル酸の減少の関与2023
- Author(s)
  岡本　有加、冨田　章弘
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06707
[Presentation] Analysis of the regulatory mechanisms of ATF4 expression by the PI3K-mTOR pathway in lung cancer cell lines2022
- Author(s)
  髙橋瑞希、加藤優、岡本有加、杉本芳一、冨田章弘
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07689
[Presentation] Involvement of the integrated stress response in cisplatin sensitization by metabolic inhibitors2022
- Author(s)
  岡本有加、冨田章弘
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07689
[Presentation] 肺がん細胞株におけるがん代謝阻害剤による相同組換え修復不全様効果の誘導2021
- Author(s)
  岡本　有加、冨田　章弘
- Organizer
  日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-20K07689
[Presentation] 肺がん細胞株におけるシスプラチン感受性を増強する代謝阻害剤2020
- Author(s)
  岡本　有加、冨田　章弘
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07689
[Presentation] Involvement of homologous recombination repair deficiency in cisplatin sensitization by 2-deoxy-D-glucose2019
- Author(s)
  Yuka Okamoto, Akihiro Tomida
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15293
[Presentation] Involvement of PERK in LGR5 depletion under endoplasmic reticulum stress condition2019
- Author(s)
  Yuka Okamoto, Masaru Koido, and Akihiro Tomida
- Organizer
  the 11th AACR-JCA Joint Conference
- Data Source
  KAKENHI-PROJECT-18K15293
[Presentation] 解糖系阻害剤2DGによるcisplatin高感受性化へのDNA2本鎖切断の蓄積の関与2019
- Author(s)
  岡本　有加、冨田　章弘
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15293
[Presentation] 解糖系阻害剤2-Deoxy-D-glucoseによるシスプラチン高感受性化2018
- Author(s)
  岡本有加、小井土大、冨田章弘
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15293
[Presentation] PERKによる小胞体ストレス下に置けるLGR5不良タンパク質蓄積の防止2018
- Author(s)
  岡本有加、冨田章弘
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15293
[Presentation] 小胞体ストレス下におけるPERK活性依存的なLGR5生合成の制御2017
- Author(s)
  岡本有加、小井土大、冨田章弘
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18465
[Presentation] 抗がん剤作用において影響力のある遺伝子を推定するための遺伝子発現データの統合解析アルゴリズム2017
- Author(s)
  小井土大、岡本有加、冨田章弘
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18465
[Presentation] Involvement of PERK in metabolic stress-induced downregulation of cancer stem marker LGR52016
- Author(s)
  岡本　有加、小井土　大、永澤　生久子、冨田　章弘
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K18465
[Presentation] 小胞体ストレス下におけるがん幹細胞マーカー分子LGR5の発現制御に対するPERKの関与2016
- Author(s)
  岡本　有加，永澤　生久子，冨田　章弘
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター(大分県別府市)
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K18465

1. KOIDO Masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 冨田章弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKAMOTO Yuka 岡本 有加

Okamoto Yuka 岡本 有加

Research Projects

Research Products

Co-Researchers

がん細胞の代謝可塑性制御機構の解明と制御破綻に基づく新規治療法の考案Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mechanisms underlying homologous recombination deficiency induced by cancer metabolism inhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Perturbation of homologous recombination repair in tumor through inhibition of lncRNA functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of molecular-targeted therapy with miRNA inhibitors modifying DNA-Damage-ResponsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of stearoyl‐CoA desaturase confers cell density‐dependent ferroptosis resistance in melanoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] グルタミン代謝阻害によるシスプラチン高感受性化におけるアルファケトグルタル酸の減少の関与2023

Author(s)

Organizer

Data Source

[Presentation] Analysis of the regulatory mechanisms of ATF4 expression by the PI3K-mTOR pathway in lung cancer cell lines2022

Author(s)

Organizer

Data Source

[Presentation] Involvement of the integrated stress response in cisplatin sensitization by metabolic inhibitors2022

Author(s)

Organizer

Data Source

[Presentation] 肺がん細胞株におけるがん代謝阻害剤による相同組換え修復不全様効果の誘導2021

Author(s)

Organizer

Data Source

[Presentation] 肺がん細胞株におけるシスプラチン感受性を増強する代謝阻害剤2020

Author(s)

Organizer

Data Source

[Presentation] Involvement of homologous recombination repair deficiency in cisplatin sensitization by 2-deoxy-D-glucose2019

Author(s)

Organizer

Data Source

[Presentation] Involvement of PERK in LGR5 depletion under endoplasmic reticulum stress condition2019

Author(s)

Organizer

Data Source

[Presentation] 解糖系阻害剤2DGによるcisplatin高感受性化へのDNA2本鎖切断の蓄積の関与2019

Author(s)

Organizer

Data Source

[Presentation] 解糖系阻害剤2-Deoxy-D-glucoseによるシスプラチン高感受性化2018

Author(s)

Organizer

Data Source

OKAMOTO Yuka 岡本有加

Okamoto Yuka 岡本有加