Irie Takuma 入江拓磨

Researcher Number	50625944
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2014 – 2015: 東京大学, 新領域創成科学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / System genome science
Keywords	Principal Investigator ATAC-seq / PD-1 / 腫瘍免疫学 / 腫瘍微少環境 / 腫瘍浸潤リンパ球 / シングルセルATAC-seq / シングルセルRNA-seq / scATAC-seq / scRNA-seq / シングルセル解析 … More / 腫瘍浸潤T細胞 / 制御性T細胞 / プロモーター活性予測 / レポーターアッセイ / 次世代シークエンサー, / 線形モデル / エラープローンPCR / バーコード配列 / 転写因子結合配列 / プロモーター / 超並列レポーターアッセイ / 次世代シークエンサー Less

Elucidating the differentiation mechanisms of PD-1 positive regulatory T cells in the tumor microenvironment by single-cell analysis.Principal Investigator
- Principal Investigator
  
  Irie Takuma
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
High-throughput analysis for mutant promoter using massively parallel sequencerPrincipal Investigator
- Principal Investigator
  
  Irie Takuma
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  The University of Tokyo

All 2022 2021 2016 2015 Other

All Journal Article Presentation Book

[Book] RNA-Seq実験ハンドブック第2章 12.超並列レポーターアッセイによる転写制御解析2016
- Author(s)
  入江拓磨
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26830137
[Journal Article] Regulatory T‐cell development in the tumor microenvironment2022
- Author(s)
  Itahashi Kota、Irie Takuma、Nishikawa Hiroyoshi
- Journal Title
  
  European Journal of Immunology
  
  Volume: 52 Issue: 8 Pages: 1216-1227
- DOI
  10.1002/eji.202149358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21K15542
[Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes2022
- Author(s)
  Nagasaki Joji、Inozume Takashi、Yosuke Togashi et al.
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 5 Pages: 110331-110331
- DOI
  10.1016/j.celrep.2022.110331
- NAID
  120007192058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K08152, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-22H00455
[Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022
- Author(s)
  Masuhiro Kentaro、Tamiya Motohiro、Fujimoto Kosuke
- Journal Title
  
  JCI Insight
  
  Volume: 1 Issue: 9 Pages: 1-1
- DOI
  10.1172/jci.insight.157915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-22H00477, KAKENHI-PROJECT-21H03538, KAKENHI-PROJECT-21K19495
[Journal Article] BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors2022
- Author(s)
  Itahashi Kota、Irie Takuma、Yuda Junichiro、Kumagai Shogo、Tanegashima Tokiyoshi、Lin Yi-Tzu、Watanabe Sho、Goto Yasushi、Suzuki Jun、Aokage Keiju、Tsuboi Masahiro、Minami Yosuke、Ishii Genichiro、Ohe Yuichiro、Ise Wataru、Kurosaki Tomohiro、Suzuki Yutaka、Koyama Shohei、Nishikawa Hiroyoshi
- Journal Title
  
  Science Immunology
  
  Volume: 7 Issue: 76 Pages: 1-20
- DOI
  10.1126/sciimmunol.abk0957
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-20K17391, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-20H03503, KAKENHI-PROJECT-21K15542
[Journal Article] Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape2021
- Author(s)
  Takeuchi Y, Tanegashima T, Sato E, Irie T, Sai A, Itahashi K, Kumagai S, Tada Y, Togashi Y, Koyama S, Akbay EA, Karasaki T, Kataoka K, Funaki S, Shintani Y, Nagatomo I, Kida H, Ishii G, Miyoshi T, Aokage K, Kakimi K, Ogawa S, Okumura M, Eto M, Kumanogoh A, Tsuboi M, Nishikawa H
- Journal Title
  
  Science Immunology
  
  Volume: 6 Issue: 65
- DOI
  10.1126/sciimmunol.abc6424
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21K07112
[Journal Article] Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab2021
- Author(s)
  Maeda Yuka、Wada Hisashi、Sugiyama Daisuke、Saito Takuro、Irie Takuma、Itahashi Kota、Minoura Kodai、Suzuki Susumu、Kojima Takashi、Kakimi Kazuhiro、Nakajima Jun、Funakoshi Takeru、Iida Shinsuke、Oka Mikio、Shimamura Teppei、Doi Toshihiko、Doki Yuichiro、Nakayama Eiichi、Ueda Ryuzo、Nishikawa Hiroyoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12(1) Issue: 1 Pages: 7280-7280
- DOI
  10.1038/s41467-021-27574-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04841, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-20K21832
[Presentation] Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors2022
- Author(s)
  Takuma Irie、Itahashi Kota、Yuda Junichiro、Kumagai Shogo、Tanegashima Tokiyoshi、Lin Yi-Tzu、Watanabe Sho、Goto Yasushi、Suzuki Jun、Aokage Keiju、Tsuboi Masahiro、Minami Yosuke、Ishii Genichiro、Ohe Yuichiro、Ise Wataru、Kurosaki Tomohiro、Suzuki Yutaka、Koyama Shohei、Nishikawa Hiroyoshi
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07112
[Presentation] 変異導入プロモーターの転写活性データを用いて転写制御コードを解読する2015
- Author(s)
  劉瑩，入江拓磨，門城拓，矢田哲士，鈴木穣
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸　ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830137
[Presentation] 次世代型シークエンサーを用いた変異プロモーターの網羅的解析2015
- Author(s)
  入江拓磨，劉瑩，門城拓，関真秀，榊原雄太，菅野純夫，矢田哲士，鈴木穣
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸　ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26830137
[Presentation] 次世代シークエンサーを用いた変異ヒトプロモーターの網羅的解析2015
- Author(s)
  入江拓磨，鈴木穣
- Organizer
  日本進化学会第17回
- Place of Presentation
  東京　中央大学後楽園キャンパス
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-26830137
[Presentation] 次世代シークエンサーによる変異プロモーターの網羅的解析
- Author(s)
  入江拓磨, 門城拓, 劉エイ, 関真秀, 菅野純夫, 矢田哲士, 鈴木穰
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26830137

1. 猪爪隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 島村徹平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Irie Takuma 入江 拓磨

Research Projects

Research Products

Co-Researchers

Elucidating the differentiation mechanisms of PD-1 positive regulatory T cells in the tumor microenvironment by single-cell analysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

High-throughput analysis for mutant promoter using massively parallel sequencerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] RNA-Seq実験ハンドブック 第2章 12.超並列レポーターアッセイによる転写制御解析2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Regulatory T‐cell development in the tumor microenvironment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Integrated multiomics profiling identifies the differentiation program of regulatory T cells in human tumors2022

Author(s)

Organizer

Data Source

[Presentation] 変異導入プロモーターの転写活性データを用いて転写制御コードを解読する2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 次世代型シークエンサーを用いた変異プロモーターの網羅的解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 次世代シークエンサーを用いた変異ヒトプロモーターの網羅的解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 次世代シークエンサーによる変異プロモーターの網羅的解析

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Irie Takuma 入江拓磨

[Book] RNA-Seq実験ハンドブック第2章 12.超並列レポーターアッセイによる転写制御解析2016