Yamanishi Kyosuke 山西恭輔

Researcher Number	50626786
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 兵庫医科大学, 医学部, 助教 2019 – 2021: 兵庫医科大学, 医学部, 特任助教 2017 – 2018: 兵庫医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator うつ病 / インターロイキン18 / ストレス / 脳内炎症 / インフラマソーム / 末梢炎症 / 神経免疫 / ストレス反応 / 精神ストレス / 神経科学 … More / 海馬 / 精神医学 / interleukin-18 / hippocampus / learning and memory / neurogenesis / hippocampas / mitochondria / depression / IL-18 … More Except Principal Investigator トゥレット症候群 / 自閉症スペクトラム障害 / 注意欠陥多動性障害 / 神経発達障害 / 強迫症 Less

Exploring immunological and molecular mechanisms involved in obsessive-compulsive disorder with comorbid neurodevelopmental disorders.
- Principal Investigator
  
  松永寿人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hyogo Medical University
インフラマソームを中心とした末梢炎症がうつ病を引き起こす機序解明と治療戦略の模索Principal Investigator
- Principal Investigator
  
  山西恭輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hyogo Medical University
The investigation between psychiatric disorders and neuroinflammation focused by interleukin 18Principal Investigator
- Principal Investigator
  
  YAMANISHI KYOSUKE
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hyogo Medical University
The investigation between depression and interleukin 18 targeting for new therapy.Principal Investigator
- Principal Investigator
  
  Yamanishi Kyosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hyogo Medical University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Molecular Mechanisms of IL18 in Disease2023
- Author(s)
  Yamanishi Kyosuke、Hata Masaki、Gamachi Naomi、Watanabe Yuko、Yamanishi Chiaki、Okamura Haruki、Matsunaga Hisato
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17170-17170
- DOI
  10.3390/ijms242417170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06999
[Journal Article] Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice2022
- Author(s)
  Yamanishi Kyosuke、Doe Nobutaka、Mukai Keiichiro、Hashimoto Takuya、Gamachi Naomi、Hata Masaki、Watanabe Yuko、Yamanishi Chiaki、Yagi Hideshi、Okamura Haruki、Matsunaga Hisato
- Journal Title
  
  Translational Psychiatry
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41398-022-02175-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16680
[Journal Article] Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice2021
- Author(s)
  Yamanishi Kyosuke、Miyauchi Masahiro、Mukai Keiichiro、Hashimoto Takuya、Uwa Noriko、Seino Hitomi、Li Wen、Gamachi Naomi、Hata Masaki、Kuwahara-Otani Sachi、Maeda Seishi、Watanabe Yuko、Yamanishi Hiromichi、Yagi Hideshi、Okamura Haruki、Matsunaga Hisato
- Journal Title
  
  BioMed Research International
  
  Volume: 2021 Issue: 1 Pages: 1-11
- DOI
  10.1155/2021/9975865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16680
[Journal Article] Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors2019
- Author(s)
  Yamanishi Kyosuke, Doe Nobutaka, Mukai Keiichiro, Ikubo Kaoru, Hashimoto Takuya, Uwa Noriko, Sumida Miho, El-Darawish Yosif, Gamachi Naomi, Li Wen, Kuwahara-Otani Sachi, Maeda Seishi, Watanabe Yuko, Hayakawa Tetsu, Yamanishi Hiromichi, Matsuyama Tomohiro, Yagi Hideshi, Okamura Haruki, & Matsunaga Hisato
- Journal Title
  
  Neuroscience
  
  Volume: 408 Pages: 147-160
- DOI
  10.1016/j.neuroscience.2019.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07100, KAKENHI-PROJECT-17K16404
[Journal Article] Analysis of genes linked to depressive-like behaviors in interleukin?18?deficient mice: Gene expression profiles in the brain2019
- Author(s)
  Yamanishi Kyosuke、Hashimoto Takuya、Miyauchi Masahiro、Mukai Keiichiro、Ikubo Kaoru、Uwa Noriko、Watanabe Yuko、Ikawa Takashi、Okuzaki Daisuke、Okamura Haruki、Yamanishi Hiromichi、Matsunaga Hisato
- Journal Title
  
  Biomedical Reports
  
  Volume: 12(1) Pages: 3-10
- DOI
  10.3892/br.2019.1259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] Impaired neural inflammation and stress tolerance against acute restraint stress in Interleukin-18-deficient mice2022
- Author(s)
  Kyosuke Yamanishi, Nobutaka Doe, Kiichiro Mukai, Takuya Hashimoto, Naomi Gamachi, Masaki Hata, Yuko Watanabe, Chiaki Yamanishi, Haruki Okamura, Hisato Matsunaga
- Organizer
  33rd CINP World Congress of Neuropsychopharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16680
[Presentation] インターロイキン18の急性ストレス下での脳内炎症と精神症状への影響について2022
- Author(s)
  山西恭輔、土江伸誉、向井馨一郎、橋本卓也、蒲池直美、秦正樹、渡辺優子、山西千晶、岡村春樹、松永寿人
- Organizer
  第118回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16680
[Presentation] インターロイキン18 (IL-18) の欠損状態がうつ病様行動変化を誘導する前頭前野を中心とした分子メカニズムの探索2021
- Author(s)
  山西恭輔、宮内雅弘、向井馨一郎、橋本卓也、宇和典子、大谷(桑原)佐知、前田誠司、蒲池直美、李文、秦正樹、渡辺優子、山西博道、八木秀司、岡村春樹、松永寿人
- Organizer
  第117回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16680
[Presentation] Transthyretin and Alpha-2-HS-glycoprotein were candidate genes involved in the development of depression in Interleukin-18-deficient mice2021
- Author(s)
  Kyosuke Yamanishi, Masahiro Miyauchi, Keiichiro Mukai, Takuya Hashimoto, Noriko Uwa, Naomi Gamachi, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga
- Organizer
  15th World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16680
[Presentation] Exploring molecular mechanisms involved in the development of depression in Interleukin-18-deficient mice2020
- Author(s)
  Kyosuke Yamanishi, Masahiro Miyauchi, Keiichiro Mukai, Takuya Hashimoto, Noriko Uwa, Naomi Gamachi, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga
- Organizer
  CINP 2021 Virtual World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16680
[Presentation] Epigenetic analysis of depression-like behavior in interleukin-18-deficient mice.2019
- Author(s)
  K. Yamanishi, K. Mukai, T. Hashimoto, M. Miyauchi, K. Ikubo, N. Uwa, Y. Watanabe, C. Yamanishi, H. Okamura, H. Matsunaga
- Organizer
  24th International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] Neurogenesis and histone acetylation are associated with hippocampal abnormalities and depression-like behavioral changes in interleukin-18-deficient mice2019
- Author(s)
  Kyosuke Yamanishi, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Noriko Uwa, Wen Li, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, and Hisato Matsunaga
- Organizer
  14th World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] Molecular analysis causing depressive-like behaviors in interleukin-18-deficient mice: Gene expression profiles in the brain.2019
- Author(s)
  T. Ikawa, K. Yamanishi, K. Mukai, T. Hashimoto, M. Miyauchi, K. Ikubo, N. Uwa, Y. Watanabe, C. Yamanishi, H. Okamura, H. Matsunaga
- Organizer
  24th International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] IL-18 の欠損状態がうつ病など精神症状発現に及ぼす影響について～神経再生と Epigenetics な視点から～2019
- Author(s)
  山西恭輔、土江伸誉、橋本卓也、井窪薫、向井馨一郎、李文、渡辺優子、宇和典子、山西博道、岡村春樹、松永寿人
- Organizer
  第115回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] Histone acetylation and neurogenesis are associated with hippocampal abnormalities in interleukin-18-deficient mice.2018
- Author(s)
  Kyosuke Yamanishi, Nobutaka Doe, Kaoru Ikubo, Miho Sumida, Sachi Kuwahara-Otani, Seishi Maeda, Yuko Watanabe, Momoko Yoshida, Wen Li, Tetsu Hayakawa, Haruki Okamura, Hiromichi Yamanishi, Hisato Matsunaga
- Organizer
  22nd International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] インターロイキン18 (IL-18) の欠損状態がうつ病など精神症状発現に及ぼす影響について～免疫と精神のクロストーク～2018
- Author(s)
  山西恭輔、土江伸誉、橋本卓也、井窪薫、澄田美保、大谷(桑原)佐知、前田誠司、李文、渡辺優子、宇和典子、早川徹、山西博道、岡村春樹、松永寿人
- Organizer
  第114回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] An investigation regarding the causal effect of interleukin-18-deficient condition on hippocampal abnormalities and depression-like behavioral changes2018
- Author(s)
  Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Kaoru Ikubo, Takuya Hashimoto, Noriko Uwa, Miho Sumida, Haruki Okamura, and Hisato Matsunaga
- Organizer
  WFSBP 2018 KOBE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404
[Presentation] Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in depression-like behavior2017
- Author(s)
  Kyosuke Yamanishi, Nobutaka Doe, Kaoru Ikubo, Miho Sumida, Sachi Kuwahara-Otani, Seishi Maeda, Yuko Watanabe, Momoko Yoshida, Wen Li, Tetsu Hayakawa, Haruki Okamura, Hiromichi Yamanishi, Hisato Matsunaga
- Organizer
  WPA XVII World Congress of Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16404

1. 松永寿人 (20254394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. DOE Nobutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamanishi Kyosuke 山西 恭輔

Research Projects

Research Products

Co-Researchers

Exploring immunological and molecular mechanisms involved in obsessive-compulsive disorder with comorbid neurodevelopmental disorders.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インフラマソームを中心とした末梢炎症がうつ病を引き起こす機序解明と治療戦略の模索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation between psychiatric disorders and neuroinflammation focused by interleukin 18Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation between depression and interleukin 18 targeting for new therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular Mechanisms of IL18 in Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute stress induces severe neural inflammation and overactivation of glucocorticoid signaling in interleukin-18-deficient mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of genes linked to depressive-like behaviors in interleukin?18?deficient mice: Gene expression profiles in the brain2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Impaired neural inflammation and stress tolerance against acute restraint stress in Interleukin-18-deficient mice2022

Author(s)

Organizer

Data Source

[Presentation] インターロイキン18の急性ストレス下での脳内炎症と精神症状への影響について2022

Author(s)

Organizer

Data Source

[Presentation] インターロイキン18 (IL-18) の欠損状態がうつ病様行動変化を誘導する前頭前野を中心とした分子メカニズムの探索2021

Author(s)

Organizer

Data Source

[Presentation] Transthyretin and Alpha-2-HS-glycoprotein were candidate genes involved in the development of depression in Interleukin-18-deficient mice2021

Author(s)

Organizer

Data Source

[Presentation] Exploring molecular mechanisms involved in the development of depression in Interleukin-18-deficient mice2020

Author(s)

Organizer

Data Source

[Presentation] Epigenetic analysis of depression-like behavior in interleukin-18-deficient mice.2019

Author(s)

Organizer

Data Source

[Presentation] Neurogenesis and histone acetylation are associated with hippocampal abnormalities and depression-like behavioral changes in interleukin-18-deficient mice2019

Author(s)

Organizer

Yamanishi Kyosuke 山西恭輔

[Presentation] IL-18 の欠損状態がうつ病など精神症状発現に及ぼす影響について～神経再生と Epigenetics な視点から～2019