OKU Yusuke 奥裕介

Researcher Number	50626843
Affiliation (based on the past Project Information) *help	2017: 岩手医科大学, 薬学部, 講師 2013 – 2016: 岩手医科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Tumor therapeutics Except Principal Investigator Clinical oncology
Keywords	Principal Investigator YAP/TAZ / 薬学 / シグナル伝達 / 癌 / 既存医薬品 / WNT/beta-catenin / がん分子標的薬 / 細胞内シグナル伝達 / がん遺伝子 / パゾパニブ / ダサチニブ / スタチン / Hippo経路 … More Except Principal Investigator … More 抗がん剤 / 阻害剤 / 薬学 / 細胞接着 / がん / DKK1 / 遺伝子発現 / 造腫瘍性 / 幹細胞 / 乳がん / 遺伝子発現プロファイル / 次世代シークエンサー / 次世代シーケンサー / Wntシグナル / TGF-beta / ドキソルビシン / Her2 / ALDH / CD133 / 乳がん幹細胞 Less

Application of dopamine receptor antagonist inhibiting WNT-YAP/TAZ pathway for colon cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Oku Yusuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Iwate Medical University
Inactivation of YAP/TAZ by approved agents and their application as anti-breast cancer stem cell drugsPrincipal Investigator
- Principal Investigator
  
  Oku Yusuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Iwate Medical University
Study of inhibitors and characterization of naturally occurring spheroids from monolayer culture
- Principal Investigator
  
  UEHARA YOSHIMASA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Iwate Medical University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Sensitisation of cancer cells to MLN8237, an Aurora-A inhibitor, by YAP/TAZ inactivation2018
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Shuhei Sugiyama, Haruka Sato, Yoshimasa Uehara
- Journal Title
  
  Anticancer Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18457
[Journal Article] Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP-E2F1-DNA damage response pathway axis2018
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Takaaki Tazawa, Takaya Kobayashi, Nanami Umezawa, Yasuyo Sugawara, and Yoshimasa Uehara.
- Journal Title
  
  FEBS Open Bio
  
  Volume: in press Issue: 6 Pages: 1001-1012
- DOI
  10.1002/2211-5463.12440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18457
[Journal Article] Dynamic Phenotypic Transition of Breast Cancer Cells In Vitro Revealed by Self-floating Cell Culture.2017
- Author(s)
  Oku Y, Nishiya N, Tsuda K, Shibazaki M, Maesawa C, Uehara Y.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Issue: 4 Pages: 1793-1797
- DOI
  10.21873/anticanres.11513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18457
[Journal Article] JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.2015
- Author(s)
  Naoyuki Nishiya, Yasumitsu Sakamoto, Yusuke Oku, Takamasa Nonaka, Yoshimasa Uehara
- Journal Title
  
  World Journal of Biological Chemistry
  
  Volume: 6 Issue: 4 Pages: 409-418
- DOI
  10.4331/wjbc.v6.i4.409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26830113
[Journal Article] Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers2015
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Toshiya Shito, Reiichiro Yamamoto, Yasufumi Yamamoto, Chihiro Oyama, Yoshimasa Uehara
- Journal Title
  
  FEBS Open Bio
  
  Volume: 5 Issue: 1 Pages: 542-549
- DOI
  10.1016/j.fob.2015.06.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830113
[Journal Article] A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.2014
- Author(s)
  Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y.
- Journal Title
  
  Chem. Biol.
  
  Volume: 21 Issue: 4 Pages: 530-540
- DOI
  10.1016/j.chembiol.2014.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23120008, KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Journal Article] Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents.,2014
- Author(s)
  Oku Y, Tareyanagi C, Takaya S, Osaka S, Ujiie H, Yoshida K, Nishiya N, Uehara Y.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e92402-e92402
- DOI
  10.1371/journal.pone.0092402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Presentation] L858R/T790M/C797S変異に有効なEGFRチロシンキナーゼ阻害剤2017
- Author(s)
  福田勉、石橋郁人、岩尾正倫、奥裕介、西谷直之、上原至雅、旦慎吾、矢守隆夫
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] がん遺伝子産物YAPの不活性化は、Wee1キナーゼ阻害薬AZD1775に対する感受性を導く.2017
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] Chemical suppression of adverse effects induced by EGFR tyrosine kinase inhibitors.2017
- Author(s)
  Naoyuki Nishiya, Yusuke Oku, Yoshimasa Uehara.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] EGFR-TKIの副作用を回避する化合物の表現型基盤探索2017
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] 翻訳調節を介したWnt/β-catenin経路阻害と抗腫瘍作用2017
- Author(s)
  西谷直之、米澤穂波、遠藤春香、奥裕介、上原至雅
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] Inactivation of YAP sensitizes ovarian cancer cells to MLN8237, an Aurora-A inhibitor, through p73-dependent apoptosis.2017
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] がん遺伝子産物YAPによるAurora-A kinase阻害剤MLN8237 (alisertib) 耐性の付与2016
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] Self-floating breast cancer cell populations express cancer stem cell markers and show resistance to anticancer drugs2016
- Author(s)
  Yoshimasa Uehara, Yusuke Oku、Kayoko Tsuda、Masahiko Shibazaki、Chihaya Maesawa、Naoyuki Nishiya
- Organizer
  10th AACR-JCA Joint Conference
- Place of Presentation
  Maui (United States)
- Year and Date
  2016-02-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] がん遺伝子産物YAP/TAZの不活性化は、卵巣がん細胞をAurora-A阻害剤に感受性化する2016
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第76回日本癌学会学述総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] EGFR-TKIによる副作用のモデル化と毒性緩和の分子戦略2016
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-16K18457
[Presentation] Identification of small molecules inhibiting oncogenic transcriptional co-activator, YAP/TAZ2016
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara
- Organizer
  10th AACR-JCA Joint Conference
- Place of Presentation
  Maui (United States)
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] がん幹細胞様細胞集団を濃縮する自発的浮遊培養法2015
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第54回日本薬学会東北支部総会
- Place of Presentation
  岩手医科大学矢巾キャンパス (岩手県、矢巾町)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] Self-floating breast cancer cells elevate aldehyde dehydrogenase activity and show drug resistance2015
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  2015 Annual Meeting of the International Society for Stem Cell Research
- Place of Presentation
  Stockholm (Sweden)
- Year and Date
  2015-06-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] アゾール系抗真菌薬によるWnt/beta-catenin 経路阻害の作用機序の解析2015
- Author(s)
  小川真実，片山綜太，清水優依，奥裕介，上原至雅、西谷直之
- Organizer
  第54回日本薬学会東北支部総会
- Place of Presentation
  岩手医科大学矢巾キャンパス (岩手県、矢巾町)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] Self-floating cell populations express cancer stem cell markers and show resistance to anticancer drugs2015
- Author(s)
  Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場 (愛知県、名古屋市)
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] アゾール系抗真菌薬によるWnt/beta-catenin経路阻害を介した抗腫瘍活性2015
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル (愛媛県　松山市)
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] Regulation of stemness of dental epithelial stem cells by Rho signaling.2015
- Author(s)
  Otsu, K., Oku, Y., Nishiya, N., Fujiwara, N., Harada, H.
- Organizer
  2015 Annual Meeting of the International Society for Stem Cell Research
- Place of Presentation
  Stockholm (Sweden)
- Year and Date
  2015-06-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] がん遺伝子産物YAP・TAZの核移行を阻害する化合物の同定2015
- Author(s)
  小山千尋、奥裕介、西谷直之、志渡俊也、山本礼一朗、山本泰史、上原至雅
- Organizer
  第54回日本薬学会東北支部総会
- Place of Presentation
  岩手医科大学矢巾キャンパス (岩手県、矢巾町)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] イベルメクチンによるWnt/beta-catenin 経路の阻害とその作用機序の解析2015
- Author(s)
  工藤紫乃，堀籠宏稀，奥裕介，上原至雅，西谷直之
- Organizer
  第54回日本薬学会東北支部総会
- Place of Presentation
  岩手医科大学矢巾キャンパス (岩手県、矢巾町)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] YAP・TAZがん遺伝子産物の機能を阻害する化合物の探索2015
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル (愛媛県　松山市)
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] がん遺伝子産物YAP・TAZのユビキチン化の評価系の開発2015
- Author(s)
  阿部佳祐、加藤汐織、沼畑実希、阿部奈美子、村井さとみ、奥裕介、西谷直之、上原至雅
- Organizer
  第54回日本薬学会東北支部総会
- Place of Presentation
  岩手医科大学矢巾キャンパス (岩手県、矢巾町)
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] フルバスタチンによるYAPがん遺伝子産物の不活性化と、その乳がん治療薬としての応用の可能性2014
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（AER）　ホテルメトロポリタン仙台　TKPガーデンシティ仙台 (宮城県仙台市)
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-26830113
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin 核移行の阻害2013
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity.2013
- Author(s)
  ○奥裕介、垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、西谷直之、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora Aを活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  ○奥　裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway2013
- Author(s)
  Nishiya, N., Abe, S., Iwaoka, S., Ohmori, N., Ohnishi, Y., Sasaki, A., Shoji, M., Oku, Y, Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.2013
- Author(s)
  ○西谷直之、阿部早織、岩岡ささの、大森紀和、大西亨美、佐々木朱里、庄司桃子、奥裕介、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御2013
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム「細胞骨格とシグナル伝達の理解からがんに迫る」
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin核移行の阻害2013
- Author(s)
  ○西谷直之、奥　裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora A を活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  ○奥裕介、西谷直之、上原至雅
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Wnt/β-catenin 経路阻害活性をもつGGTI-286 の作用機序の解析2013
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会第72回総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導2013
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity2013
- Author(s)
  Oku, Y., Tareyanagi, C., Ujiie, H., Takaya, S., Yoshida, K., Nishiya, N., Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-catenin シグナル阻害2012
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質脂質修飾による選択的Wnt/β-cateninシグナル制御2012
- Author(s)
  西谷直之, 奥裕介, 上原至雅
- Organizer
  未来医療開発プロジェクト研究成果発表会
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2012-08-09
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1 キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Wnt/β-catenin経路阻害活性をもつGGTI-286の作用機序の解析
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-cateninシグナル阻害
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23501310

1. UEHARA YOSHIMASA (50160213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
2. NISHIYA Naoyuki (10286867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
3. 岡本仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKU Yusuke 奥 裕介

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Application of dopamine receptor antagonist inhibiting WNT-YAP/TAZ pathway for colon cancer treatmentPrincipal Investigator

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Inactivation of YAP/TAZ by approved agents and their application as anti-breast cancer stem cell drugsPrincipal Investigator

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Study of inhibitors and characterization of naturally occurring spheroids from monolayer culture

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[Journal Article] Sensitisation of cancer cells to MLN8237, an Aurora-A inhibitor, by YAP/TAZ inactivation2018

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[Journal Article] Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP-E2F1-DNA damage response pathway axis2018

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[Journal Article] Dynamic Phenotypic Transition of Breast Cancer Cells In Vitro Revealed by Self-floating Cell Culture.2017

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[Journal Article] JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.2015

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[Journal Article] Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers2015

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[Journal Article] A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.2014

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[Journal Article] Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents.,2014

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[Presentation] L858R/T790M/C797S変異に有効なEGFRチロシンキナーゼ阻害剤2017

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[Presentation] がん遺伝子産物YAPの不活性化は、Wee1キナーゼ阻害薬AZD1775に対する感受性を導く.2017

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[Presentation] Chemical suppression of adverse effects induced by EGFR tyrosine kinase inhibitors.2017

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[Presentation] EGFR-TKIの副作用を回避する化合物の表現型基盤探索2017

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[Presentation] 翻訳調節を介したWnt/β-catenin経路阻害と抗腫瘍作用2017

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[Presentation] Inactivation of YAP sensitizes ovarian cancer cells to MLN8237, an Aurora-A inhibitor, through p73-dependent apoptosis.2017

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OKU Yusuke 奥裕介