KO Minoru 洪実

Researcher Number	50631199
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2019: 慶應義塾大学, 医学部(信濃町), 教授 2017: 慶應義塾大学, 医学部, 教授 2012 – 2015: 慶應義塾大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Developmental biology / Molecular biology Except Principal Investigator Kidney internal medicine / Gastroenterology
Keywords	Principal Investigator Zscan4 / マウス胚性幹細胞 / ノックアウト / マウス発生学 / 遺伝子機能解析 / テロメア伸長 / ゲノム安定化 / 若返り / 組織幹細胞 / ZSCAN4 … More / 減数分裂 / ES細胞 / 減数分裂関連因子 / GV oocytes / Zygotic genss … More Except Principal Investigator 転写因子 / 尿細管細胞 / 転写調節因子 / 腎臓 / 尿細管 / ES細胞 / EMT / 再生 / 腎線維化 / micro RNA / miRNA / 腎臓尿細管 / iPS細胞 / 肝細胞 / ヒト多能性幹細胞 / 腎尿細管細胞 / 再生医療 / 多能制幹細胞 / 腎臓再生 / リプログラミング / ヒトES細胞 / BMI1 / LGR5 / 膵炎 / ZSCAN4 / 幹/前駆細胞 / 膵臓 / 幹細胞マーカー / 膵組織幹細胞 / 組織幹細胞 / 膵組織再生 Less

Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cellsPrincipal Investigator
- Principal Investigator
  
  KO Minoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Keio University
Renal tubular cells derived from human ES cells and hepatocytes by transcription factor administration
- Principal Investigator
  
  Hiratsuka Ken
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Functional analysis of meiosis-related factors in ES cellsPrincipal Investigator
- Principal Investigator
  
  Ko Minoru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Keio University
Master regulatory factors for regeneration and EMT of kidney tubular cells
- Principal Investigator
  
  Monkawa Toshiaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank
- Principal Investigator
  
  Hiroshi Itoh
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Identification of endocrine and exocrine stem/protenitor cells in the pancreas.
- Principal Investigator
  
  KO Shigeru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2019 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos2017
- Author(s)
  Ishiguro K., Nakatake Y., Chikazawa-Nohtomi N., Kimura H., Akiyama T., Oda M., Ko SBH., Ko MSH.
- Journal Title
  
  In Vitro Cell.Dev.Biol.-Anim.
  
  Volume: 53 Issue: 2 Pages: 179-190
- DOI
  10.1007/s11626-016-0097-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440003, KAKENHI-PROJECT-15K14431, KAKENHI-PROJECT-15K14453, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-16H01221, KAKENHI-PUBLICLY-16H01257, KAKENHI-PROJECT-15H04812
[Journal Article] Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis2017
- Author(s)
  Ishiguro K., Monti M., Akiyama T., Kimura H., Chikazawa-Nohtomi N., Sakota M., Sato S., Redi CA., Ko SBH., Ko MSH.
- Journal Title
  
  In Vitro Cell.Dev.Biol.-Anim.
  
  Volume: 53 Issue: 2 Pages: 167-178
- DOI
  10.1007/s11626-016-0096-z
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440003, KAKENHI-PROJECT-15K14453, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-16H01221, KAKENHI-PUBLICLY-16H01257, KAKENHI-PROJECT-15H04812, KAKENHI-INTERNATIONAL-15K21737
[Journal Article] Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression.2014
- Author(s)
  Kato, Y., T. Miyauchi, Y. Abe, D. Koji´c, M. Tanaka, N. Chikazawa, Y. Nakatake, S. B. H. Ko, D. Kobayashi, A. Hazama, S. Fujiwara, T. Uchida, M. Yasui
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 2 Pages: e87644-e87644
- DOI
  10.1371/journal.pone.0087644
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24570114, KAKENHI-PROJECT-24591023, KAKENHI-PROJECT-24792152
[Journal Article] Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas2013
- Author(s)
  Ko SB, Azuma S, Yokoyama Y, Yamamoto A, Kyokane K, Niida S, Ishiguro H, Ko MS
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 304 Issue: 12 Pages: 1103-1116
- DOI
  10.1152/ajpgi.00299.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591010, KAKENHI-PROJECT-24591023
[Journal Article] 膵臓の組織修復と組織幹細胞2013
- Author(s)
  洪　繁、洪　実
- Journal Title
  
  実験医学増刊
  
  Volume: 31 Pages: 50-54
- Data Source
  KAKENHI-PROJECT-24591023
[Journal Article] Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.2013
- Author(s)
  Mizuno N, Yatabe Y, Hara K, Hijioka S, Imaoka H, Shimizu Y, Ko SB, Yamao K.
- Journal Title
  
  Front Physiol.
  
  Volume: 4 Pages: 269-269
- DOI
  10.3389/fphys.2013.00269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591023
[Presentation] （仮題）幹細胞におけるZSCAN4の役割2019
- Author(s)
  洪実
- Organizer
  第４２回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01433
[Presentation] Multi-segmented kidney organoids derived from human ES cells by stepwise transcription factor administration2017
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week 2017(ASN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] Multi-segmented kidney organoids derived from human ES cells by stepwise transcription factor administration2017
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week(ASN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07177
[Presentation] ヒト尿細管マスター制御因子の検索と、転写因子をコードする修飾合成mRNAを用いたヒト多能性幹細胞から尿細管様細胞への分化誘導方法の開発2016
- Author(s)
  平塚　健, 門川俊明, 秋山智彦, 中武悠樹, Sravan Kumar Goparaju, 小林紗恵子, 納富奈々, 木村寛美, 山口慎太郎, 森實隆司, 鈴木さゆり, 洪　繁, 洪　実, 伊藤　裕
- Organizer
  第7回分子腎臓フォーラム
- Place of Presentation
  ベルサール八重洲
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-16H07177
[Presentation] A novel method to differentiate human ES cells into renal tubule-like cells by a combination of transcription factors administration2016
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week2016(ASN)
- Place of Presentation
  シカゴ（米国）
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] A novel method to differentiate human ES cells into renal tubule-like cells by a combination of transcription factors administration2016
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.H. Ko, Hiroshi Itoh, Minoru S.H. Ko
- Organizer
  Kidney Week2016(ASN)
- Place of Presentation
  Chicago, IL
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07177
[Presentation] ヒト多能性幹細胞から腎尿細管様細胞への分化誘導法の開発2016
- Author(s)
  平塚　健, 門川俊明, 秋山智彦, 中武悠樹, Sravan Kumar Goparaju, 相馬淳美, 小林紗恵子, 納富奈々, 木村寛美, 山口慎太郎, 森實隆司, 鈴木さゆり, 松下美紗子, 平山雅敏, 洪　繁, 伊藤　裕、洪　実
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場(大阪府大阪市)
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-26670432
[Presentation] ヒト尿細管マスター制御因子の検索と、転写因子をコードする修飾合成mRNAを用いたヒト多能性幹細胞から尿細管様細胞への分化誘導方法の開発2016
- Author(s)
  平塚　健, 門川俊明, 秋山智彦, 中武悠樹, Sravan Kumar Goparaju, 小林紗恵子, 納富奈々, 木村寛美, 山口慎太郎, 森實隆司, 鈴木さゆり, 洪　繁, 洪　実, 伊藤　裕
- Organizer
  第7回分子腎臓フォーラム
- Place of Presentation
  ベルサール八重洲（東京都中央区）
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] The Direct Differentiation Method of Renal Tubular Cells by Synthetic mRNAs of Transcription Factors Identi ed from TF-Inducible Human ES Bank2015
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.h. Ko, Minoru S.h. Ko, Hiroshi Itoh
- Organizer
  Kidney Week 2015
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09273
[Presentation] The direct differentiation method of renal tubular cells by synthetic mRNAs of transcription factors identified from TF-inducible human ES bank2015
- Author(s)
  Ken Hiratsuka, Toshiaki Monkawa, Shintaro Yamaguchi, Ryuji Morizane, Shigeru B.h. Ko, Minoru S.h. Ko, Hiroshi Itoh
- Organizer
  the ASN Kidney Week 2015 Annual Meeting
- Place of Presentation
  San Diego, CA(USA)
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670432
[Presentation] Autoimmune pancreatitis: Reorienting the goals of steroid therapy to repair, regeneration, and functional recovery of pancreatic tissues2014
- Author(s)
  1. Ko SB
- Organizer
  Second International Symposium on IgG4&Related disease.
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-24591023
[Presentation] ARHGAP9はSLC26 STASドメインを介してCFTRクロライドチャネル活性を抑制する2013
- Author(s)
  5. 洪　繁
- Organizer
  2013年度生理学研究所研究会
- Place of Presentation
  自然科学研究機構、生理学研究所、岡崎、愛知
- Data Source
  KAKENHI-PROJECT-24591023
[Presentation] 自己免疫性膵炎の治療―個別化治療の提案2013
- Author(s)
  洪　繁、佐伯恵太、樋口肇
- Organizer
  JDDW2013
- Place of Presentation
  高輪プリンスホテル、品川、東京
- Data Source
  KAKENHI-PROJECT-24591023
[Presentation] 慢性膵炎組織における幹細胞マーカーの発現2012
- Author(s)
  洪　繁、京兼和宏、山田理、松浦俊博
- Organizer
  第43回日本膵臓学会大会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24591023

1. KO Shigeru (90402578)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. NAKATAKE Yuhki (20415251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Monkawa Toshiaki (80286484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. Hiratsuka Ken (80594481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. ISHIGURO Hiroshi (90303651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YAMAMOTO Akiko (60402385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NIIDA Shunpei (10137630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUURA Toshihiro (80501626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Hiroshi Itoh (40252457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 石黒啓一郎 (30508114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 秋山智彦 (20570691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小田真由美 (80567511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUJIWARA Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KO Minoru 洪 実

Research Projects

Research Products

Co-Researchers

Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Renal tubular cells derived from human ES cells and hepatocytes by transcription factor administration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of meiosis-related factors in ES cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Master regulatory factors for regeneration and EMT of kidney tubular cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of endocrine and exocrine stem/protenitor cells in the pancreas.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 膵臓の組織修復と組織幹細胞2013

Author(s)

Journal Title

Data Source

[Journal Article] Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] （仮題）幹細胞におけるZSCAN4の役割2019

Author(s)

Organizer

Data Source

[Presentation] Multi-segmented kidney organoids derived from human ES cells by stepwise transcription factor administration2017

Author(s)

Organizer

Data Source

[Presentation] Multi-segmented kidney organoids derived from human ES cells by stepwise transcription factor administration2017

Author(s)

Organizer

KO Minoru 洪実