Iijima koichi 飯島浩一

… Alternative Names

Koichi Iijima 飯島浩一

IIJIMA Koichi 飯島浩一

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Researcher Number	50632535
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 部長 2022: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター神経遺伝学研究部, 部長 2020 – 2022: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 部長 2021: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター神経遺伝学研究部, 部長 2018: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センターアルツハイマー病研究部, 部長 2016 – 2017: 国立研究開発法人国立長寿医療研究センター, アルツハイマー病研究部, 室長
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Studies on the Super-Aging Society / Pathological medical chemistry Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator グリア細胞 / 認知症 / 老化 / 神経変性 / ショウジョウバエ / アルツハイマー病 / 神経炎症 / 神経軸索変性 / ノルアドレナリン神経 / 青斑核 … More / アミノ酸 / 貪食活性 / 遺伝子発現 / 栄養 / 貪食 / アストロサイト / マウス / アミロイドβ / グリア / タウ / Toll様受容体 / 自然免疫 / 加齢 / 神経変性疾患 … More Except Principal Investigator 神経血管ユニット / マウスモデル / ショウジョウバエ / グリア細胞 / アルツハイマー病 Less

アルツハイマー病初期の神経血管ユニットの破綻と青斑核神経細胞の軸索変性の機序解明Principal Investigator
- Principal Investigator
  
  飯島浩一
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
脳の浄化機能を司るグリア細胞の貪食活性を制御するアミノ酸の同定と健康寿命の増進Principal Investigator
- Principal Investigator
  
  飯島浩一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
神経血管ユニットを構成するグリア終足分子のアルツハイマー病病理形成における役割
- Principal Investigator
  
  関谷倫子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
Roles of reactive astrocyte in AD pathogenesisPrincipal Investigator
- Principal Investigator
  
  IIJIMA Koichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center for Geriatrics and Gerontology
The effects of dietary restriction on age-related decline in glial engulfmentPrincipal Investigator
- Principal Investigator
  
  Koichi Iijima
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  National Center for Geriatrics and Gerontology
Roles of glial innate immunity in age-related neurodegenerationPrincipal Investigator
- Principal Investigator
  
  IIJIMA Koichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology

All 2024 2023 2022 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] アルツハイマー病の遺伝学的リスク因子と診断・治療への薬理遺伝学的な意義2024
- Author(s)
  関谷倫子、飯島浩一
- Journal Title
  
  Farumashia
  
  Volume: 60 Issue: 3 Pages: 197-202
- DOI
  10.14894/faruawpsj.60.3_197
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24224
[Journal Article] Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration2023
- Author(s)
  Sakakibara Yasufumi、Yamashiro Risa、Chikamatsu Sachie、Hirota Yu、Tsubokawa Yoko、Nishijima Risa、Takei Kimi、Sekiya Michiko、Iijima Koichi M.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 2 Pages: 105968-105968
- DOI
  10.1016/j.isci.2023.105968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224
[Journal Article] Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology2023
- Author(s)
  Hirota Yu、Sakakibara Yasufumi、Takei Kimi、Nishijima Risa、Sekiya Michiko、Iijima Koichi M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 93 Issue: 3 Pages: 1065-1081
- DOI
  10.3233/jad-230121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224
[Journal Article] Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in <i>App</i> knock-in mouse models of amyloid-β amyloidosis2022
- Author(s)
  Hirota Yu、Sakakibara Yasufumi、Ibaraki Kyoko、Takei Kimi、Iijima Koichi M、Sekiya Michiko
- Journal Title
  
  Brain Communications
  
  Volume: 4 Issue: 6
- DOI
  10.1093/braincomms/fcac286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17655, KAKENHI-PROJECT-23K24224
[Journal Article] Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease2019
- Author(s)
  Yasufumi Sakakibara、Michiko Sekiya、Takashi Saito、Takaomi C. Saido、Koichi M. Iijima
- Journal Title
  
  BMC Neuroscience
  
  Volume: 20 Issue: 1 Pages: 13-13
- DOI
  10.1186/s12868-019-0496-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15381, KAKENHI-PROJECT-16K08637
[Journal Article] Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models2018
- Author(s)
  Sekiya Michiko、Wang Minghui、Fujisaki Naoki、Sakakibara Yasufumi、Quan Xiuming、Ehrlich Michelle E.、De Jager Philip L.、Bennett David A.、Schadt Eric E.、Gandy Sam、Ando Kanae、Zhang Bin、Iijima Koichi M.
- Journal Title
  
  Genome Medicine
  
  Volume: 10 Issue: 1 Pages: 26-26
- DOI
  10.1186/s13073-018-0530-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637, KAKENHI-PUBLICLY-17H05703, KAKENHI-PROJECT-15K06712
[Journal Article] Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila2018
- Author(s)
  Sakakibara Yasufumi、Sekiya Michiko、Fujisaki Naoki、Quan Xiuming、Iijima Koichi M.
- Journal Title
  
  PLOS Genetics
  
  Volume: 14 Issue: 1 Pages: e1007196-e1007196
- DOI
  10.1371/journal.pgen.1007196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08637
[Journal Article] Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis2018
- Author(s)
  Yasufumi Sakakibara、Michiko Sekiya、Takashi Saito、Takaomi C. Saido、Koichi M. Iijima
- Journal Title
  
  BMC Neuroscience
  
  Volume: 19 Issue: 1 Pages: 46-46
- DOI
  10.1186/s12868-018-0446-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15381, KAKENHI-PROJECT-16K08637
[Journal Article] S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy2018
- Author(s)
  Chiku Tomoki、Hayashishita Motoki、Saito Taro、Oka Mikiko、Shinno Kanako、Ohtake Yosuke、Shimizu Sawako、Asada Akiko、Hisanaga Shin-ichi、Iijima Koichi M.、Ando Kanae
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 71 Pages: 255-264
- DOI
  10.1016/j.neurobiolaging.2018.07.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05703, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-16K08637
[Journal Article] Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer’s disease pathogenesis: Potential strategies to protect the LC against aging2017
- Author(s)
  Satoh Akiko、Iijima Koichi M.
- Journal Title
  
  Brain Research
  
  Volume: 印刷中 Pages: 30562-0
- DOI
  10.1016/j.brainres.2017.12.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08637, KAKENHI-PROJECT-17H07417
[Journal Article] 神経細胞内のミトコンドリア局在異常と認知症2017
- Author(s)
  岡未来子, 飯島浩一, 安藤香奈絵
- Journal Title
  
  実験医学, 認知症: 発症前治療のために解明すべき分子病態は何か？
  
  Volume: 35 Pages: 182-185
- Data Source
  KAKENHI-PROJECT-16K08637
[Journal Article] Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy2017
- Author(s)
  Oka Mikiko、Fujisaki Naoki、Maruko-Otake Akiko、Ohtake Yosuke、Shimizu Sawako、Saito Taro、Hisanaga Shin-Ichi、Iijima Koichi M、Ando Kanae
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 162 Issue: 5 Pages: 335-342
- DOI
  10.1093/jb/mvx038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08637, KAKENHI-PUBLICLY-17H05703, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K06712
[Journal Article] EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila2017
- Author(s)
  Sekiya Michiko、Maruko-Otake Akiko、Hearn Stephen、Sakakibara Yasufumi、Fujisaki Naoki、Suzuki Emiko、Ando Kanae、Iijima Koichi M.
- Journal Title
  
  Developmental Cell
  
  Volume: 41 Issue: 6 Pages: 652-664
- DOI
  10.1016/j.devcel.2017.05.019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637, KAKENHI-PUBLICLY-17H05703, KAKENHI-PROJECT-15K06712
[Journal Article] 統合生物学的手法を用いて遺伝子ネットワークの変化からアルツハイマー病発症機序に迫る2016
- Author(s)
  関谷倫子, 飯島浩一
- Journal Title
  
  Dementia Japan
  
  Volume: 30(2) Pages: 246-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08637
[Journal Article] Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.2016
- Author(s)
  Ando K, Oka M, Ohtake M, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 478 (2) Issue: 2 Pages: 929-934
- DOI
  10.1016/j.bbrc.2016.08.053
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01564, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K06712, KAKENHI-PROJECT-16K08637
[Presentation] Mechanisms underlying reductions of serotonergic axon projections to the cortex in App knock-in mouse model of Aβ pathology2024
- Author(s)
  Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iiji
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau 181 signals localize to demyelinated axons of parvalbumin-positive GABAergic interneurons in App knock-in mouse2023
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Koichi M. Iijima, Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference 2023 (AAIC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] 脳内のAβ病理を反映する血液・髄液バイオマーカーリン酸化タウの脳内局在解析2023
- Author(s)
  廣田湧，榊原泰史，茨木京子，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Reduced density of serotonergic axons without prominent neuron loss or tau pathology in the dorsal raphe nucleus in App knock-in mouse models of amyloid-β pathology2023
- Author(s)
  Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's Association International Conference 2023 (AAIC2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau181 signals are localized to myelinated axons of parvalbumin-positive interneurons in an App knock-in mouse model of amyloid-β pathology2023
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] アミロイド病理モデルマウスにおける縫線核セロトニン作動性神経の変性機序の解析2023
- Author(s)
  榊原泰史，廣田湧，茨木京子，竹井喜美，西島里咲，関谷倫子，飯島浩一
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Alzheimer’s disease biomarker-related phospho-tau 181 signals localize to demyelinated axons of parvalbumin-positive GABAergic interneurons in App knock-in mouse models of amyloid-β amyloidosis2023
- Author(s)
  Hirota Y., Sakakibara, Y., Takei, K., Nishijima, R., Sekiya, M., Iijima, K.M.
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Aβ病理を呈するAppノックインマウスにおけるコリン作動性神経軸索の変性2022
- Author(s)
  廣田　湧，榊原泰史，茨木京子，竹井喜美，西島里咲，飯島浩一，関谷倫子
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Reduced density of cholinergic fibers in App knock-in mouse models of Aβ amyloidosis2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Risa Nishijima, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] アミロイド病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析2022
- Author(s)
  関谷倫子，廣田　湧，榊原泰史，茨木京子，竹井喜美，飯島浩一
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] A Drosophila ortholog of Toll-like receptors modulates c-Jun N-terminal kinase signaling and protects against tau-mediated neurodegeneration independent of innate immune response2022
- Author(s)
  Yasufumi Sakakibara，Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Koichi M. Iijima，Michiko Sekiya
- Organizer
  Alzheimer's Association International Conference (AAIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Aβ病理モデルマウスを用いたアルツハイマー病血液バイオマーカーリン酸化タウ181，217，231の脳内局在解析2022
- Author(s)
  Yu Hirota，Yasufumi Sakakibara，Kyoko Ibaraki，Kimi Takei，Koichi M. Iijima，Michiko Sekiya
- Organizer
  Neuro2022（第45回日本神経科学大会，第65回日本神経化学会大会，第32回日本神経回路学会大会，合同）
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Biomarker-related phospho-tau 181 signals localize to axons of myelinated neurons but not unmyelinated neurons in App knock-in mouse2022
- Author(s)
  Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Risa Nishijima, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Toll-like receptor exerts neuroprotection through p38 MAPK/SAPK in Drosophila model of tauopathy2022
- Author(s)
  Yasufumi Sakakibara, Risa Yamashiro, Sachie Chikamatsu, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Michiko Sekiya, Koichi M. Iijima
- Organizer
  Alzheimer's & Parkinson's Diseases Conference (AD/PD 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24224
[Presentation] Studying mechanisms underlying hippocampal sclerosis of aging in Drosophila2019
- Author(s)
  Iijima, KM Quan, X Salkakibara, Y Sekiya, M
- Organizer
  ADPD2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Roles of EDEM family proteins in APP metabolism2019
- Author(s)
  Sekiya, M Iijima, KM
- Organizer
  ADPD2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 生物学的手法を用いてアルツハイマー病発症機序を読み解く2018
- Author(s)
  飯島浩一
- Organizer
  第91回日本生化学会大会　シンポジウム　1S10m「多様性に富むアルツハイマー病発症リスク:最適化先制医療への最前線」
- Invited
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 加齢性海馬硬化症モデルショウジョウバエの解析2018
- Author(s)
  飯島浩一　権秀明榊原泰史　関谷倫子
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 加齢性海馬硬化症発症機序の解明2018
- Author(s)
  権秀明　関谷倫子榊原泰史　飯島浩一
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Deciphering Alzheimer's Disease Pathogenesis from Gene Co-expression Network.2018
- Author(s)
  Iijima, K.M.
- Organizer
  Cutting Edge of Aging Research, The 13th International Symposium on Geriatrics and Gerontology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] AβアミロイドーシスモデルであるAppノックインマウスにおける情動および認知機能に関する行動解析2018
- Author(s)
  榊原泰史　関谷倫子　斎藤貴志　西道隆臣　飯島浩一
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 早期診断から先制治療に向けたアルツハイマー病に対する新たな研究アプローチ2018
- Author(s)
  飯島浩一
- Organizer
  第41回日本分子生物学会年会　セッションチェア、オーガナイザー
- Invited
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Protective roles of SUR, a fly homologue of Sulfonylurea receptors, ABCC8/SUR1 and ABCC9/SUR2, against age-associated neurodegenration in Drosophila2017
- Author(s)
  Quan, X., Fujisaki, N., Sakakibara, Y., Sekiya, M. & Iijima, K.M.
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 転写因子NPAS3/trhの欠損がAD型神経変性を増悪化させるメカニズムの解析2017
- Author(s)
  Fujisaki, N., Sakakibara, Y., Sekiya, M. & Iijima, K.M.
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] S6 kinase and insulin/IGF signaling regulates accumulation and toxicity of tau through Ser262 phosphorylation in a Drosophila model of tauopathy.2017
- Author(s)
  Ando, K., Hayashishita, M., Chiku, T., Saito, T., Asada, A., Hisanaga, S., and Iijima K.M.
- Organizer
  第60回日本神経化学会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] CaMKII enhances tau-mediated neurodegeneration downstream of tau phosphorylation in transgenic Drosophila models of tauopathy.2017
- Author(s)
  Ando, K., Oka, M., Maruko-Otake, A., Ohtake, Y., Sekiya, M., Hisanaga, S., Iijima, K.M.
- Organizer
  The 4th Asia-Pacific Drosophila Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] システム生物学によるAβ，tau，TREM2/TYROBPの遺伝子相互作用解析2017
- Author(s)
  Sekiya, M., Wang, M., Fujisaki, N., Sakakibara, Y., Zhang, B. & Iijima, K.M.
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Ectopic expression of human TREM2/TYROBP in Drosophila glial cells negatively affects transcriptional programs induced by Aβ42 and worsens tau-mediated neurodegeneration.2017
- Author(s)
  Sekiya, M., Wang, M., Fujisaki, N., Sakakibara, Y., Ehrlich, M.E., Schadt, E.E., Gandy, S., Ando, K., Zhang, B. & Iijima, K.M.
- Organizer
  AD/PD2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] ENHANCED ER PROTEIN QUALITY CONTROL SELECTIVELY TARGETS APP SUBJECTED TO ETA-SITE PROCESSING PATHWAYS AND REDUCES AMYLOID-ETA AND AMYLOID-BETA2017
- Author(s)
  Sekiya, M. & Iijima, K.M.
- Organizer
  AD/PD2017
- Place of Presentation
  Vienna
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Neuroprotective roles of Toll-like receptors in glial cells during aging in Drosophila2017
- Author(s)
  Sakakibara, Y., Sekiya, M. & Iijima, K.M.
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Ribosomal protein S6 kinaseはアルツハイマー病関連Ser262サイトのリン酸化を介してタウタンパク質を安定化し毒性を悪化させる。2016
- Author(s)
  林下幹輝，斎藤太郎，久永眞市，飯島浩一，安藤香奈絵
- Organizer
  第59回　日本神経化学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] The mechanism underlying neurodegeneration in a Drosophila model of Wolfram syndrome2016
- Author(s)
  藤崎尚規，榊原泰史，関谷倫子，飯島浩一
- Organizer
  第39回　日本分子生物学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] 軸索での加齢依存的なATP量減少とミトコンドリア分布の関係2016
- Author(s)
  岡未来子, 鈴木えみ子, 久永眞市, 飯島浩一, 安藤香奈絵
- Organizer
  第59回　日本神経化学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Suatained activation of CaMKII caused by depletion of mitochondria from the axons enhances tau toxicity2016
- Author(s)
  Ando, K., Maruko-Otake, A., Hayashishita, M., Oka, M., Ohtake, Y., Sekiya, M., Saito, T., Hisanaga, S.I. & Iijima, K.M.
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] The mechanism underlying neurodegeneration in a Drosophila model of Wolfram syndrome2016
- Author(s)
  榊原泰史，藤崎尚規，関谷倫子，飯島浩一
- Organizer
  第39回　日本神経科学大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-16K08637
[Presentation] Reduction in ATP levels in the axon during aging and the role of mitochondrial distribution.2016
- Author(s)
  Oka, M., Suzuki, E., Hisanaga, S.I., Iijima, K. & Ando, K.
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08637

1. 関谷倫子 (40367412)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. 榊原泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 飯島香奈絵

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Iijima koichi 飯島 浩一

Koichi Iijima 飯島 浩一

IIJIMA Koichi 飯島 浩一

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アルツハイマー病初期の神経血管ユニットの破綻と青斑核神経細胞の軸索変性の機序解明Principal Investigator

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脳の浄化機能を司るグリア細胞の貪食活性を制御するアミノ酸の同定と健康寿命の増進Principal Investigator

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神経血管ユニットを構成するグリア終足分子のアルツハイマー病病理形成における役割

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Roles of reactive astrocyte in AD pathogenesisPrincipal Investigator

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The effects of dietary restriction on age-related decline in glial engulfmentPrincipal Investigator

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Roles of glial innate immunity in age-related neurodegenerationPrincipal Investigator

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[Journal Article] アルツハイマー病の遺伝学的リスク因子と診断・治療への薬理遺伝学的な意義2024

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[Journal Article] Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration2023

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[Journal Article] Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology2023

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[Journal Article] Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in <i>App</i> knock-in mouse models of amyloid-β amyloidosis2022

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[Journal Article] Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease2019

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[Journal Article] Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models2018

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[Journal Article] Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila2018

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[Journal Article] Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis2018

Iijima koichi 飯島浩一

Koichi Iijima 飯島浩一

IIJIMA Koichi 飯島浩一