TSUKIMURA TAKAHIRO 月村考宏

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TSUKIMURA Takahiro 月村考宏

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Researcher Number	50632783
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2021: 明治薬科大学, 薬学部, 講師 2017 – 2019: 明治薬科大学, 薬学部, 助教 2012 – 2015: 明治薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Applied pharmacology Except Principal Investigator Pediatrics
Keywords	Principal Investigator 臨床表現型 / 遺伝子変異 / ライソゾーム病 / ファブリー病 / リソソーム病 / 基質類似体 / 酵素製剤 Except Principal Investigator α-ガラクトシダーゼ / ファブリー病 / バイオテクノロジー … More / 遺伝学 / α-N-アセチルガラクトサミニダーゼ / α-ガラクトシダーゼ A / 改変酵素 / 酵素補充療法 / 分子間相互作用 / 酵素増強療法 / 基質類似体 / リソソーム酵素 / α-グルコシダーゼ / 酸性α-グルコシダーゼ / α‐ガラクトシダーゼ A / ポンペ病 / リソソーム病 Less

Comparison of GLA variants of unknown significance and the specific mutations causing moderate Fabry diseasePrincipal Investigator
- Principal Investigator
  
  Tsukimura Takahiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Meiji Pharmaceutical University
Development of new enzyme replacement therapy for Fabry disease with a high-functioning enzyme expected to escape from harmful immune reaction
- Principal Investigator
  
  SAKURABA HITOSHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Meiji Pharmaceutical University
Effect of co-administration with analogs on enzyme preparationPrincipal Investigator
- Principal Investigator
  
  TSUKIMURA TAKAHIRO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Meiji Pharmaceutical University
Thermodynamic and structural study on the interaction of an enzyme and a substrate analogue for development of new therapy for lysosomal diseases
- Principal Investigator
  
  SAKURABA Hitoshi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Meiji Pharmaceutical University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Genetically Modified Cell Transplantation Through Macroencapsulated Spheroids with Scaffolds to Treat Fabry Disease2021
- Author(s)
  Kami Daisuke、Suzuki Yosuke、Yamanami Masashi、Tsukimura Takahiro、Togawa Tadayasu、Sakuraba Hitoshi、Gojo Satoshi
- Journal Title
  
  Cell Transplantation
  
  Volume: 30 Pages: 096368972110602-096368972110602
- DOI
  10.1177/09636897211060269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071, KAKENHI-PROJECT-19H03742, KAKENHI-PROJECT-19K22667
[Journal Article] Does administration of hydroxychloroquine/amiodarone accelerate accumulation of globotriaosylceramide and globotriaosylsphingosine in Fabry mice?2021
- Author(s)
  Tsukimura Takahiro、Shiga Tomoko、Saito Koki、Ogawa Yasuhiro、Sakuraba Hitoshi、Togawa Tadayasu
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 28 Pages: 100773-100773
- DOI
  10.1016/j.ymgmr.2021.100773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Screening of Fabry disease in patients with chronic kidney disease in Japan2021
- Author(s)
  Nagata Akiko、Nasu Makoto、Kaida Yusuke、Nakayama Yosuke、Kurokawa Yuka、Nakamura Nao、Shibata Ryo、Hazama Takuma、Tsukimura Takahiro、Togawa Tadayasu、Saito Seiji、Sakuraba Hitoshi、Fukami Kei
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 37 Issue: 1 Pages: 115-125
- DOI
  10.1093/ndt/gfaa324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Comparative urinary globotriaosylceramide analysis by thin-layer chromatography-immunostaining and liquid chromatography-tandem mass spectrometry in patients with Fabry disease2021
- Author(s)
  Shiga Tomoko、Tsukimura Takahiro、Namai Yurie、Togawa Tadayasu、Sakuraba Hitoshi
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 29 Pages: 100804-100804
- DOI
  10.1016/j.ymgmr.2021.100804
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Anti-drug antibody formation in Japanese Fabry patients following enzyme replacement therapy2020
- Author(s)
  Tsukimura Takahiro、Tayama Yuya、Shiga Tomoko、Hirai Kanako、Togawa Tadayasu、Sakuraba Hitoshi
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 25 Pages: 100650-100650
- DOI
  10.1016/j.ymgmr.2020.100650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] The study investigating the determination of protamine in seminal plasma from azoospermic donors: Suggestion of new methods to diagnose obstructive azoospermia, and to capture childbearing sperm for testicular sperm extraction (TESE) and insemination sperm injection (ICSI)2020
- Author(s)
  Katayama Masatoki、Kaneko Satoru、Tsukimura Takahiro、Takamatsu Kiyoshi、Togawa Tadayasu
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 604 Pages: 113792-113792
- DOI
  10.1016/j.ab.2020.113792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Surface plasmon resonance analysis of complex formation of therapeutic recombinant lysosomal enzymes with domain 9 of human cation-independent mannose 6-phosphate receptor2020
- Author(s)
  Kanzaki Minori、Tsukimura Takahiro、Chiba Yasunori、Sakuraba Hitoshi、Togawa Tadayasu
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 25 Pages: 100639-100639
- DOI
  10.1016/j.ymgmr.2020.100639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Cell Transplantation Combined with Recombinant Collagen Peptides for the Treatment of Fabry Disease2020
- Author(s)
  Kami D, Yamanami M, Tsukimura T, Maeda H, Togawa T, Sakuraba H, Gojo S.
- Journal Title
  
  Cell Transplant
  
  Volume: 29 Pages: 963689720976362-963689720976362
- DOI
  10.1177/0963689720976362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22667, KAKENHI-PROJECT-18K15071, KAKENHI-PROJECT-19H03742
[Journal Article] Effectiveness of immunosuppressive therapy for nephrotic syndrome in a patient with late-onset Fabry disease: a case report and literature review.2019
- Author(s)
  Fujisawa H, Nakayama Y, Nakao S, Yamamoto R, Kurokawa Y, Nakamura N, Nagata A, Tsukimura T, Togawa T, Sakuraba H, Fukami K.
- Journal Title
  
  BMC Nephrol
  
  Volume: 20 Issue: 1 Pages: 469-469
- DOI
  10.1186/s12882-019-1657-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08693, KAKENHI-PROJECT-18K15071
[Journal Article] Fabry disease in a Japanese population-molecular and biochemical characteristics2018
- Author(s)
  Sakuraba Hitoshi、Tsukimura Takahiro、Togawa Tadayasu、Tanaka Toshie、Ohtsuka Tomoko、Sato Atsuko、Shiga Tomoko、Saito Seiji、Ohno Kazuki
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 17 Pages: 73-79
- DOI
  10.1016/j.ymgmr.2018.10.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15071
[Journal Article] Plasma lyso-Gb3: a biomarker for monitoring fabry patients during enzyme replacement therapy2017
- Author(s)
  Sakuraba H, Togawa T, Tsukimura T, Kato H
- Journal Title
  
  Clin. Exp. Nephrol.
  
  Volume: - Issue: 4 Pages: 843-849
- DOI
  10.1007/s10157-017-1525-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09606
[Journal Article] Differences in cleavage of globotriaosylceramide and its derivatives accumulated in organs of young Fabry mice following enzyme replacement therapy2017
- Author(s)
  Kodama T, Tsukimura T, Kawashima I, Sato A, Sakuraba H, Togawa T
- Journal Title
  
  Mol Genet Metab
  
  Volume: 120 Issue: 1-2 Pages: 116-120
- DOI
  10.1016/j.ymgme.2016.10.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09606
[Journal Article] A heterozygous female with Fabry disease due to a novel α-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes.2015
- Author(s)
  Takahashi N, Yokoi S, Kasuno K, Kogami A, Tsukimura T, Togawa T, Saito S, Ohno K, Hara M, Kurosawa H, Hirayama Y, Kurose T, Yokoyama Y, Mikami D, Kimura H, Naiki H, Sakuraba H, Iwano M.
- Journal Title
  
  Clin Nephrol.
  
  Volume: 83 Issue: 05 Pages: 301-308
- DOI
  10.5414/cn108317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590686, KAKENHI-PROJECT-25860399, KAKENHI-PROJECT-25293094
[Journal Article] Clinical and biochemical investigation of male patients exhibiting membranous cytoplasmic bodies in biopsied kidney tissues - A pitfall in diagnosis of Fabry disease2015
- Author(s)
  Sakuraba H, Tsukimura T, Tanaka T, Togawa T, Takahashi N, et al.
- Journal Title
  
  J . Nephropathol
  
  Volume: 4 Pages: 91-96
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09606
[Journal Article] Thirty-seven amino acids and three related nitrogen compounds in human seminal plasma: multivariate analyses reveal strong correlations among asparagine, glutamine, and ammonia with sperm parameters2015
- Author(s)
  Katayama M., Kaneko S., Tsukimura T., Takamatsu K., Togawa T.
- Journal Title
  
  Indian J. App. Res.
  
  Volume: 5 Pages: 199-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860399
[Journal Article] Nano-LC-MS/MS for quantification of Lyso-Gb3 and its analogues reveals a useful biomarker for Fabry disease2015
- Author(s)
  Sueoka H, Ichihara J, Tsukimura T, Togawa T, Sakuraba H
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 5 Pages: e0127048-e0127048
- DOI
  10.1371/journal.pone.0127048
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09606, KAKENHI-PROJECT-25860399
[Journal Article] Distributions of globotriaosylceramide isoforms, and globotriaosylsphingosine and its analogues in an α-galactosidase A knockout mouse, a model of Fabry disease2015
- Author(s)
  Sueoka H, Aoki M, Tsukimura T, Togawa T, Sakuraba H
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 12 Pages: e0144958-e0144958
- DOI
  10.1371/journal.pone.0144958
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09606, KAKENHI-PROJECT-25860399
[Journal Article] Clinical and biochemical investigation of male patients exhibiting membranous cytoplasmic bodies in biopsied kidney tissues － A pitfall in diagnosis of Fabry disease2015
- Author(s)
  Sakuraba H., Tsukimura T., Tanaka T., Togawa T., Takahashi N., Mikami D., Wakai S., Akai Y.
- Journal Title
  
  J. Nephropathol.
  
  Volume: 4 Pages: 91-96
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860399
[Journal Article] Rapid immunochromatographic detection of serum α-galactosidase A antibodies in Fabry patients after enzyme replacement therapy2015
- Author(s)
  Nakano S, Tsukimura T, Togawa T, Ohashi T, Kobayashi M, et al.
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 6 Pages: e0128351-e0128351
- DOI
  10.1371/journal.pone.0128351
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09606, KAKENHI-PROJECT-25860399
[Journal Article] Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human -galactosidase: Pharmacological chaperoning efficacy on Fabry disease mutants.2014
- Author(s)
  Yu Y,
- Journal Title
  
  ACS Chem Biol
  
  Volume: 9 Issue: 7 Pages: 1460-1469
- DOI
  10.1021/cb500143h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293230, KAKENHI-PROJECT-25860399, KAKENHI-PROJECT-26461525
[Journal Article] Plasma mutant α-galactosidase A protein and globotriaosylsphingosine level in Fabry disease2014
- Author(s)
  Tsukimura T., Nakano S., Togawa T., Tanaka T., Saito S., Ohno K., Shibasaki F., Sakuraba H.
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: １ Pages: 288-298
- DOI
  10.1016/j.ymgmr.2014.07.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860399
[Journal Article] Comparative study on mannose 6-phosphate residue contents of recombinant lysosomal enzymes.2014
- Author(s)
  Togawa T., Takada M., Aizawa Y., Tsukimura T., Chiba Y., Sakuraba H.
- Journal Title
  
  Mol. Genet. Metab.
  
  Volume: 111 Issue: 3 Pages: 369-373
- DOI
  10.1016/j.ymgme.2013.12.296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659527, KAKENHI-PROJECT-25860399
[Journal Article] A case of Fabry nephropathy with histological features of oligonephropathy.2014
- Author(s)
  Nishida M, Kosaka K, Hasegawa K, Nishikawa K, Itoi T, Tsukimura T, Togawa T, Sakuraba H, Hamaoka K.
- Journal Title
  
  Eur J Pediatr
  
  Volume: 173 Issue: 8 Pages: 1111-1114
- DOI
  10.1007/s00431-013-2118-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461627, KAKENHI-PROJECT-25860399
[Journal Article] Screening for Fabry disease in patients with left ventricular hypertrophy.2013
- Author(s)
  Mawatari K, Yasukawa H, Oba T, Nagata T, Togawa T, Tsukimura T, Kyogoku S, Ohshima H, Minami T, Sugi Y, Sakuraba H, Imaizumi T.
- Journal Title
  
  Int J Cardiol
  
  Volume: 167 Issue: 3 Pages: 1059-1061
- DOI
  10.1016/j.ijcard.2012.10.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591094, KAKENHI-PROJECT-23792094, KAKENHI-PROJECT-24791397, KAKENHI-PROJECT-24791957, KAKENHI-PROJECT-25860399
[Journal Article] Development of a highly sensitive immuno-PCR assay for the measurement of alpha-galactosidase A protein levels in serum and plasma2013
- Author(s)
  Nakano, S. Morizane, Y. Makisaka, N. Suzuki, T. Togawa, T. Tsukimura, T. Kawashima, I. Sakuraba, H. Shibasaki, F.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e78588-e78588
- DOI
  10.1371/journal.pone.0078588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659314, KAKENHI-PROJECT-23659527, KAKENHI-PROJECT-24590218, KAKENHI-PROJECT-25670281, KAKENHI-PROJECT-25860399
[Journal Article] Human α-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module2013
- Author(s)
  Maita N, Tsukimura T, Taniguchi T, Saito S, Ohno K, Taniguchi H, Sakuraba H
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 110 Issue: 36 Pages: 14628-14633
- DOI
  10.1073/pnas.1306939110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370042, KAKENHI-PROJECT-23570139, KAKENHI-PROJECT-23659527, KAKENHI-PROJECT-25860399
[Journal Article] Efficient uptakeof recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys.2012
- Author(s)
  Tsukimura T., Kawashima I., Togawa T., Kodama T., Suzuki T., Watanabe T., Chiba Y., Jigami Y., Fukushige T., Kanekura T., Sakuraba H.
- Journal Title
  
  Mol. Med.
  
  Volume: 18 Pages: 76-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Mutant α-galactosidaseA with M296I does not cause elevationof the plasmaglobotriaosylsphingosine level.2012
- Author(s)
  Mitobe S., Togawa T., Tsukimura T., Kodama T., Tanaka T., Doi K., Noiri E.,Akai Y., Saito Y., Yoshino M.,Takenaka T., Saito S., Ohno K.,Sakuraba H.
- Journal Title
  
  Mol.Genet. Metab.
  
  Volume: 107 Pages: 623-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Fabry disease: Biochemical, pathological and structural studies of the α-galactosidase A with E66Q amino acid substitution.2012
- Author(s)
  Togawa T., Tsukimura T., Kodama T., Tanaka T., Kawashima I., Saito S., Ohno K., Fukushige T., Kanekura T., Satomura A., D.-H. Kang, B. H. Lee, H.-W. Yoo, Doi K., Noiri E., SakurabaH.
- Journal Title
  
  Mol. Genet. Metab.
  
  Volume: 105 Pages: 615-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Biochemical and structural study on a S529V mutant acid α -glucosidase responsive to pharmacological chaperones.2011
- Author(s)
  Tajima Y., Saito S., Ohno K., Tsukimura T., Tsujino S., Sakuraba H.
- Journal Title
  
  J. Hum. Genet.
  
  Volume: 56 Pages: 440-446
- NAID
  10030659730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Lyso-GM2 ganglioside: A possible biomarker ofTay-Sachs disease and Sandhoff disease.2011
- Author(s)
  Kodama T., Togawa T., Tsukimura T., Kawashima I., Matsuoka K., Kitakaze K., Tsuji D., Itoh K., Ishida Y., Suzuki M., Suzuki T., Sakuraba H.
- Journal Title
  
  PLoS ONE.
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Molecular mechanism for stabilization of a mutant α-galactosidase A involving M51I amino acid substitution by imino sugars.2011
- Author(s)
  Tsukimura T, et al.
- Journal Title
  
  Mol.Genet.Metab.
  
  Volume: 101(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Molecular mechanism for stabilization of amutant α -galactosidase A involvingM51I amino acid substitution by imino sugars.2011
- Author(s)
  Tsukimura T., Chiba Y., Ohno K., SaitoS., Tajima Y., Sakuraba H.
- Journal Title
  
  Mol. Genet. Metab.
  
  Volume: 103 Pages: 26-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Journal Article] Efficient uptake of recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys2011
- Author(s)
  Tsukimura, et al
- Journal Title
  
  Mol.Med.
  
  Volume: 18 Issue: 1 Pages: 76-82
- DOI
  10.2119/molmed.2011.00248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314, KAKENHI-PROJECT-21591438, KAKENHI-PROJECT-24590218
[Journal Article] Tissue and plasma globortiaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease.2010
- Author(s)
  Togawa T., Kawashima I., Kodama T.,Tsukimura T., Suzuki T., Fukushige T., Kanekura T., Sakuraba H.
- Journal Title
  
  Biochem. Biophys. Res.Commun.
  
  Volume: 399 Pages: 716-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390314
[Presentation] 酵素補充療法を受けたファブリー病1家系のバイオマーカーの解析2021
- Author(s)
  月村考宏、久保田孝雄、志賀智子、兎川忠靖、櫻庭均
- Organizer
  第26回日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] カチオン性両親媒性薬物によるファブリー病モデルマウスの糖脂質代謝への影響2021
- Author(s)
  齋藤光希、月村考宏、志賀智子、中村茜、小川泰弘、櫻庭均、兎川忠靖
- Organizer
  第62回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] ファブリー病患者尿中Gb3の解析におけるTLC免疫染色法とLC-MS/MS法の比較2021
- Author(s)
  小泉舞奈、志賀智子、月村考宏、兎川忠靖、櫻庭均
- Organizer
  第62回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] ファブリー病のデータベースの構築と分子病態の解析2021
- Author(s)
  月村考宏、齋藤静司、兎川忠靖、櫻庭均
- Organizer
  第62回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] Fabry病の一家系の治療経過2020
- Author(s)
  岡本拓也、島久登、土井俊夫、月村考宏、兎川忠靖、櫻庭均、池田ゆか、正木千晶、井上朋子、田代学、髙松典通、川原和彦、岡田一義、水口潤
- Organizer
  第63回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 日本人ファブリー病患者の血漿Lyso-Gb3濃度：治療に伴う変化とそれに影響する因子2019
- Author(s)
  志賀智子、武井加奈子、田山裕也、月村考宏、兎川忠靖、櫻庭均
- Organizer
  第24回日本ライソゾーム病研究会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 酵素補充療法中のファブリー病患者における抗GLA 抗体と血漿中Lyso-Gb3 の解析2019
- Author(s)
  田山裕也、志賀智子、月村考宏、兎川忠靖、鈴木雄貴、片山昌勅、櫻庭均
- Organizer
  薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 日本人ファブリー病患者に対する酵素補充療法での抗GLA 抗体の産生とそのバイオマーカーへの影響2019
- Author(s)
  田山裕也、志賀智子、月村考宏、櫻庭均、兎川忠靖
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] ファブリー病女性患者尿中Gb3 の測定2019
- Author(s)
  生井友里絵、志賀智子、武井加奈子、月村考宏、櫻庭均、兎川忠靖
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 改変型NAGA を用いた新規ファブリー病酵素補充療法の開発2019
- Author(s)
  櫻庭均、兎川忠靖、月村考宏、志賀智子、武井加奈子、齋藤静司、川島育夫、田島陽一
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 不妊治療を目的としたヒト精漿中プロタミンの測定2019
- Author(s)
  片山昌勅、月村考宏、高松潔、兼子智、兎川忠靖
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 表面プラズモン共鳴法によるリソソーム酵素と万ノース６-リン酸受容体との親和性の解析2018
- Author(s)
  神嵜　美慶、生井　友里恵、千葉　靖典、片山　昌勅、月村　考宏、兎川　忠靖、櫻庭　均
- Organizer
  第60回日本先天代謝異常学会総会/第16回アジア先天代謝異常症シンポジウム
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 顕微授精（ICSI）による男性不妊治療への応用を目的とした健常精子選択および精子マーカーとの関連性解析2018
- Author(s)
  片山　昌勅、月村　考宏、高松　潔、兼子　智、兎川忠靖
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] Comparison of GLA variants of unknown significance and the specific mutations causing moderate Fabry disease.2018
- Author(s)
  Tsukimura T, Shigenaga M, Saito S, Togawa T, Sakuraba H
- Organizer
  14th Annual WORLDSymposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09606
[Presentation] 酵素補充療法を受けて抗体陽性となったファブリー病患者の抗GLA抗体と血漿中Lyso-Gb3の解析2018
- Author(s)
  田山　裕也、志賀　智子、月村　考宏、兎川　忠靖、櫻庭　均
- Organizer
  第60回日本先天代謝異常学会総会/第16回アジア先天代謝異常症シンポジウム
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 日本人ファブリー病患者における分子遺伝学的および生化学的基盤2018
- Author(s)
  櫻庭　均、月村　考宏、兎川　忠靖、志賀　智子、齋藤　静司、大野　一樹、田中　利絵、佐藤　温子、大塚　智子
- Organizer
  第60回日本先天代謝異常学会総会/第16回アジア先天代謝異常症シンポジウム
- Data Source
  KAKENHI-PROJECT-18K15071
[Presentation] 血漿Lyso-Gb3の測定は、ファブリー病の診断や酵素補充療法の評価に有用である2016
- Author(s)
  櫻庭　均、兎川忠靖、月村考宏、若村友太郎、加藤　浩
- Organizer
  第21回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵会医科大学（東京都港区）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-15K09606
[Presentation] Comparative study on α-galactosidase A (GLA) genetic variants with unknown clinical significance2016
- Author(s)
  Sakuraba H., Togawa T., Tsukimura T., Saito S., Ohno K
- Organizer
  12th Annual Lysosomal disease network WORLD Symposium 2016
- Place of Presentation
  Manchester Grand Hyatt San Diego（USA, San Diego）
- Year and Date
  2016-02-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Anti-α-galactosidase A antibodies and serum-mediated inhibition in Fabry disease2016
- Author(s)
  Tsukimura T., Shibasaki F., Shigenaga M., Togawa T., Sakuraba H.
- Organizer
  12th Annual Lysosomal disease network WORLD Symposium 2016
- Place of Presentation
  Manchester Grand Hyatt San Diego（USA, San Diego）
- Year and Date
  2016-02-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Measurement of glycosphingolipids by means of tandem mass spectrometry and evaluation of them as a biomarker of Fabry disease2016
- Author(s)
  Togawa T., Kodama T., Tsukimura T., Kawashima I., Tanaka T., Shiga T., Sato A., Sakuraba H.
- Organizer
  12th Annual Lysosomal disease network WORLD Symposium 2016
- Place of Presentation
  Manchester Grand Hyatt San Diego（USA, San Diego）
- Year and Date
  2016-02-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] 酵素製剤に対する抗体を産生したファブリー病患者の血清は酵素製剤の活性を阻害する2015
- Author(s)
  重永　雅志、月村　考宏、佐藤　温子、芝崎　太、兎川　忠靖、櫻庭　均
- Organizer
  第38回日本分子生物学会年会／第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Fabry病患者由来iPS細胞を用いた新規疾患モデルの作製2015
- Author(s)
  那須　誠、天久　朝廷、横路　三有紀、月村　考宏、沖田　圭介、赤井　靖宏、櫻庭　均、深水　圭、奥田　誠也、長船健
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] タンデムマス測定法による血漿lyso-Gb3の高感度測定とそのファブリー病バイオマーカーとしての評価2015
- Author(s)
  兎川　忠靖、田中　利絵、志賀　智子、大塚　智子、佐藤　温子、児玉　敬、月村　考宏、櫻庭　均
- Organizer
  第20回日本ライソゾーム病研究会
- Place of Presentation
  東京慈恵医科大学（東京都港区）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] 男性不妊患者精漿中の金属およびアミノ酸の解析: 加齢の影響2015
- Author(s)
  片山昌勅、月村考宏、高松潔、兼子智、兎川忠靖
- Organizer
  第59回日本薬学会　関東支部大会
- Place of Presentation
  日本大学（千葉県船橋市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] 酵素補充療法を受けたファブリー病患者における抗α-ガラクトシダーゼA抗体産生と酵素活性阻害作用2015
- Author(s)
  重永　雅志、月村　考宏、佐藤　温子、芝崎　太、兎川　忠靖、櫻庭　均
- Organizer
  第57回日本先天代謝異常学会／第13回アジア先天代謝異常症シンポジウム
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] 遅発型ファブリー病の原因変異vs機能的多型2015
- Author(s)
  月村　考宏、田中　利絵、大塚　智子、志賀　智子、末岡　英明、芝崎　太、兎川　忠靖、櫻庭　均
- Organizer
  第57回日本先天代謝異常学会／第13回アジア先天代謝異常症シンポジウム
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] High risk screening for Fabry disease in Japan2015
- Author(s)
  Tsukimura T., Togawa T., Sakuraba H.
- Organizer
  The 3rd Asian Congress for Lysosomal Storage Disease Screening
- Place of Presentation
  品川プリンスホテル（東京都港区）
- Year and Date
  2015-06-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Fabry病モデルマウス腎臓に蓄積する糖脂質の特徴と酵素補充療法による分解効果2015
- Author(s)
  兎川　忠靖、児玉　敬、月村　考宏、川島　育夫、志賀　智子、田中　利絵、櫻庭　均
- Organizer
  第57回日本先天代謝異常学会／第13回アジア先天代謝異常症シンポジウム
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Molecular interaction between a mutant α-galactosidase A and imino sugars2014
- Author(s)
  Tsukimura T, Togawa T, Sakuraba H.
- Organizer
  １0th Annual Lysosomal disease network WORLD Symposium 2014
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] ファブリー病の分子病態研究：遺伝子変異、変異酵素蛋白質及び蓄積糖脂質について2014
- Author(s)
  月村考宏、中野早知栄、兎川忠靖、田中利絵、片山昌勅、齋藤静司、芝崎太、櫻庭均
- Organizer
  薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Comparative study on the content of mannose 6-phosphate residues of recombinant lysosomal enzymes.2013
- Author(s)
  Tsukimura T, Takada M, Aizawa Y, Suzuki T, Katayama M, Sakuraba S, Togawa T.
- Organizer
  The 55th Annula Meeting of The Japanese Society for Inherited Metabolic Disease/The 3rd Asia Congress for Inherited Metabolic Disease
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] マンノース‐6‐リン酸残基の新規定量法の開発：組換えヒトリソソーム酵素解析への応用2013
- Author(s)
  月村考宏、高田大、相澤良明、鈴木俊宏、片山昌勅、櫻庭均、兎川忠靖
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] ファブリー病患者の血漿中のα-ガラクトシダーゼA蛋白質濃度とグロボトリアオシルスヒィンゴシン濃度の相関性
- Author(s)
  月村　考宏、中野　早知栄、兎川　忠靖、田中　利絵、片山　昌勅、齋藤　静司、芝崎　太、櫻庭　均
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] 新規改変酵素の免疫交差性及びiPS細胞由来心筋細胞への取り込み‐ファブリー病治療への応用
- Author(s)
  月村　考宏、小川　泰弘、大石　一彦、重永　雅志、鶴巻　舞子、兎川　忠靖、櫻庭　均
- Organizer
  薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] Comprehensive study of Fabry disease: Gene mutation, GLA activity, GLA protein and globotriaosylsphingosine
- Author(s)
  Tsukimura T., Togawa T., Sakuraba H.
- Organizer
  11th Annual Lysosomal disease network WORLD Symposium 2015
- Place of Presentation
  Orlando
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25860399
[Presentation] ファブリー病患者の遺伝子変異、血漿中GLA蛋白質濃度及びLyso-Gb3濃度の関係
- Author(s)
  月村　考宏、中野　早知栄、兎川　忠靖、田中　利絵、片山　昌勅、齋藤　静司、芝崎　太、櫻庭　均
- Organizer
  第56回日本先天代謝異常学会総会/第12回アジア先天代謝異常症シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-25860399

1. SAKURABA Hitoshi (60114493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TOGAWA Tadayasu (80260983)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TAKAHASHI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. IWANO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KASUNO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KIMURA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. KAMI Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. NISHIDA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 桜庭均

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
10. 安川秀雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 深水圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 五條理志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山南将志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 浜岡建城

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 芝崎太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 真板宣夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 谷口寿章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUKIMURA TAKAHIRO 月村 考宏

TSUKIMURA Takahiro 月村 考宏

Research Projects

Research Products

Co-Researchers

Comparison of GLA variants of unknown significance and the specific mutations causing moderate Fabry diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of new enzyme replacement therapy for Fabry disease with a high-functioning enzyme expected to escape from harmful immune reaction

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Effect of co-administration with analogs on enzyme preparationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Thermodynamic and structural study on the interaction of an enzyme and a substrate analogue for development of new therapy for lysosomal diseases

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

[Journal Article] Genetically Modified Cell Transplantation Through Macroencapsulated Spheroids with Scaffolds to Treat Fabry Disease2021

Author(s)

Journal Title

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[Journal Article] Does administration of hydroxychloroquine/amiodarone accelerate accumulation of globotriaosylceramide and globotriaosylsphingosine in Fabry mice?2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Screening of Fabry disease in patients with chronic kidney disease in Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative urinary globotriaosylceramide analysis by thin-layer chromatography-immunostaining and liquid chromatography-tandem mass spectrometry in patients with Fabry disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-drug antibody formation in Japanese Fabry patients following enzyme replacement therapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The study investigating the determination of protamine in seminal plasma from azoospermic donors: Suggestion of new methods to diagnose obstructive azoospermia, and to capture childbearing sperm for testicular sperm extraction (TESE) and insemination sperm injection (ICSI)2020

Author(s)

Journal Title

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Data Source

[Journal Article] Surface plasmon resonance analysis of complex formation of therapeutic recombinant lysosomal enzymes with domain 9 of human cation-independent mannose 6-phosphate receptor2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell Transplantation Combined with Recombinant Collagen Peptides for the Treatment of Fabry Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effectiveness of immunosuppressive therapy for nephrotic syndrome in a patient with late-onset Fabry disease: a case report and literature review.2019

Author(s)

Journal Title

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Data Source

[Journal Article] Fabry disease in a Japanese population-molecular and biochemical characteristics2018

Author(s)

Journal Title

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Data Source

[Journal Article] Plasma lyso-Gb3: a biomarker for monitoring fabry patients during enzyme replacement therapy2017

TSUKIMURA TAKAHIRO 月村考宏

TSUKIMURA Takahiro 月村考宏

[Journal Article] Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human -galactosidase: Pharmacological chaperoning efficacy on Fabry disease mutants.2014