Hashimoto Shoko 橋本翔子

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Hashimoto ShokoShoko 橋本翔子

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Researcher Number	50632890
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 創発的研究センター, 特任准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 滋賀医科大学, 創発的研究センター, 特任准教授 2022: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 客員研究員 2020 – 2021: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 2019: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 基礎科学特別研究員 2016 – 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 2015: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Transformative Research Areas, Section (II) / Basic Section 46010:Neuroscience-general-related / Pathological medical chemistry Except Principal Investigator Transformative Research Areas, Section (II)
Keywords	Principal Investigator 神経炎症 / アルツハイマー病 / 神経変性疾患 / グルタチオン / 酸化ストレス / タウ / アプタマー / タンパク質間相互作用 / 神経細胞死 / グリア細胞 / 神経変性 / グルタチオン低下 / グルタチオン量低下マウス … More Except Principal Investigator … More 脳内ホメオスタシス / タンパク質間相互作用 / 酵素活性 / 神経炎症 / アミロイド / 脳ホメオスタシス / タンパク質操作 / アプタマー Less

補体C1qによるタウ伝播制御機構の解明Principal Investigator
- Principal Investigator
  
  橋本翔子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Shiga University of Medical Science
アプタマー生物学による神経炎症をトリガーとした神経細胞死からの細胞保護機構の解析Principal Investigator
- Principal Investigator
  
  橋本翔子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Shiga University of Medical Science
  Institute of Physical and Chemical Research
アプタマー生物学の創成による脳内恒常性維持機構の解明
- Principal Investigator
  
  塚越かおり
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tokyo University of Agriculture and Technology
Neuronal glutathione loss leads to neuronal cell death accompanied by neuroinflammationPrincipal Investigator
- Principal Investigator
  
  Hashimoto ShokoShoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Institute of Physical and Chemical Research
Mechanisms of redox perturbation in the mouse model of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Hashimoto Shoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Aging Mechanisms2015
- Author(s)
  Shoko Hashimoto, Per Nilsson, and Takaomi C. Saido
- Total Pages
  437
- Publisher
  Aging Mechanisms: Longevity, Metabolism, and Brain Aging” (Chapter 19 Catabolism and Anabolism of Abeta)
- Data Source
  KAKENHI-PROJECT-15K19036
[Journal Article] Generation of sophisticated Alzheimer’s disease mouse models and research advances utilizing them2023
- Author(s)
  Hashimoto S, Saido TC
- Journal Title
  
  Translational and Regulatory Sciences
  
  Volume: 5 Issue: 2 Pages: 40-52
- DOI
  10.33611/trs.2023-003
- ISSN
  2434-4974
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Journal Article] An isogenic panel of App knock-in mouse models: profiling β-secretase inhibition and endosomal abnormalities2022
- Author(s)
  Watamura, N. Sato, K. Shiihashi, G. Iwasaki, A. Kamano, N. Takahashi, M. Sekiguchi, M. Mihira, N. Fujioka, R. Nagata, K._Hashimoto, S._Saito, T. Ohshima, T. Saido, TC. & Sasaguri, H.
- Journal Title
  
  Sci Adv
  
  Volume: 8 (23) Issue: 23
- DOI
  10.1126/sciadv.abm6155
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Journal Article] Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain2022
- Author(s)
  Ishii, A. Matsuba, Y. Mihira, N. Kamano, N. Saito, T. Muramatsu, S. Yokosuka, M. Saido, TC. & Hashimoto, S.
- Journal Title
  
  J. Biochem.
  
  Volume: 172(4) Issue: 4 Pages: 233-243
- DOI
  10.1093/jb/mvac058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Journal Article] Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation2022
- Author(s)
  Hashimoto S, Matsuba Y, Takahashi M, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 13 Issue: 1 Pages: 1109-1109
- DOI
  10.1038/s41598-023-27653-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22H05035, KAKENHI-PROJECT-21H04788
[Journal Article] Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm2018
- Author(s)
  Shoko Hashimoto, Ayano Ishii, Naoko Kamano, Naoto Watamura, Takashi Saito, Toshio Ohshima, Makoto Yokosuka, and Takaomi C. Saido
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293(9) Issue: 9 Pages: 3118-3125
- DOI
  10.1074/jbc.m117.811315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19036
[Journal Article] Critical Review: Involvement of Endoplasmic reticulum stress in the etiology of Alzheimer’s disease2018
- Author(s)
  Shoko Hashimoto and Takaomi C. Saido
- Journal Title
  
  Open Biology
  
  Volume: 8: 180024 Issue: 4 Pages: 180024-180024
- DOI
  10.1098/rsob.180024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] CAPON-nNOS相互作用による神経変性誘導について2022
- Author(s)
  橋本翔子, 西道隆臣
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Presentation] CAPON-nNOS相互作用による神経変性誘導について2022
- Author(s)
  橋本翔子
- Organizer
  第41回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05037
[Presentation] グルタチオン低下を介した酸化ストレスによる、アルツハイマー病病理形成促進2021
- Author(s)
  橋本翔子、松葉由紀夫、高橋美華、釜野直子、西道隆臣
- Organizer
  第４０回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16271
[Presentation] 酸化ストレス下における神経炎症を介した神経変性メカニズムの解析2020
- Author(s)
  橋本翔子、松葉由紀夫、釜野直子、西道隆臣
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16271
[Presentation] Mechanisms of redox perturbation in the App-knockin mouse model of Alzheimer's disease2020
- Author(s)
  橋本　翔子
- Organizer
  第42回日本神経科学大会（NEURO2019)
- Invited
- Data Source
  KAKENHI-PROJECT-19K16271
[Presentation] The role of a novel Tau binding protein in the progression of Alzheimer's disease2017
- Author(s)
  Shoko Hashimoto, Naoko Kamano, Yukio Matsuba, Per Nilsson, Shin-ichi Muramatsu, Takashi Saito, and Takaomi C. Saido
- Organizer
  EMBL Symposia: Mechanism of Neurodegeneration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] グルタチオン量減少がアルツハイマー病病理に及ぼす影響の解析2017
- Author(s)
  橋本翔子、釜野直子、石井綾乃、斉藤貴志、西道隆臣
- Organizer
  2017年度生命科学系学会合同年次大会(Conbio2017)
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] 新規アルツハイマー病関連因子による神経変性メカニズムの解明2017
- Author(s)
  橋本翔子、釜野直子、松葉由紀夫、村松慎一、斉藤貴志、西道隆臣
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] Mechanism of glutathione reduction in the 2nd generation mouse model of Alzheimer's disease2016
- Author(s)
  Shoko Hashimoto, Takashi Saito, and Takaomi C. Saido
- Organizer
  SOCIETY for NEUROSCIENCE 2016
- Place of Presentation
  サンディエゴ（アメリカ）
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] グルタチオン量減少がアルツハイマー病病理に及ぼす影響の解析2016
- Author(s)
  橋本翔子、斉藤貴志、西道隆臣
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] APPノックインマウスにおけるグルタチオン量減少メカニズムの解析2015
- Author(s)
  橋本翔子、斉藤貴志、西道隆臣
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森・ホテル青森（青森県・青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K19036
[Presentation] 次世代型アルツハイマー病モデルマウス脳におけるグルタチオン量減少メカニズムの解析2015
- Author(s)
  橋本翔子、斉藤貴志、西道隆臣
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸ポートピアホテル・神戸国際会議場・神戸国際展示場・神戸商工会議所（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K19036

1. 塚越かおり (20708474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 堀由起子 (80610683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashimoto Shoko 橋本 翔子

Hashimoto ShokoShoko 橋本 翔子

Research Projects

Research Products

Co-Researchers

補体C1qによるタウ伝播制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アプタマー生物学による神経炎症をトリガーとした神経細胞死からの細胞保護機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アプタマー生物学の創成による脳内恒常性維持機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neuronal glutathione loss leads to neuronal cell death accompanied by neuroinflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of redox perturbation in the mouse model of Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Aging Mechanisms2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Generation of sophisticated Alzheimer’s disease mouse models and research advances utilizing them2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] An isogenic panel of App knock-in mouse models: profiling β-secretase inhibition and endosomal abnormalities2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical Review: Involvement of Endoplasmic reticulum stress in the etiology of Alzheimer’s disease2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] CAPON-nNOS相互作用による神経変性誘導について2022

Author(s)

Organizer

Data Source

[Presentation] CAPON-nNOS相互作用による神経変性誘導について2022

Author(s)

Organizer

Data Source

Hashimoto Shoko 橋本翔子

Hashimoto ShokoShoko 橋本翔子