KANO KUNIYUKI 可野邦行

… Alternative Names

Researcher Number	50636404
Other IDs
Affiliation (Current)	2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2020 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教 2016 – 2020: 東北大学, 薬学研究科, 助教 2012 – 2013: 東北大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy / Basic Section 46030:Function of nervous system-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Physical pharmacy / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 52030:Psychiatry-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator 迷走神経 / リゾホスファチジン酸 / リゾリン脂質 / 虚血性心疾患 / LPA3 / 心筋梗塞 / ドコサヘキサエン酸 / 求心性迷走神経 / 生理活性脂質 / Gタンパク質共役型受容体 … More Except Principal Investigator スフィンゴ脂質 / MALDI / MSイメージング / 質量分析計 / S1P / 凍結組織切片 / 粘着性導電性フィルム / イメージングMS / 組織切片 / 立体可視化 / DESI / DIUTHAME / IMS / スフィンゴシン一リン酸 / イオンモビリティ / イメージング MS / LC-MS/MS / 肝癌 / MSイメージング法 / 一細胞 / 誘導体化 / ドラッグ・リポジショニング / 抗うつ薬 / 間質性膀胱炎 / リゾリン脂質 / 血液バイオマーカー Less

ドラッグ・リポジショニングによるLPA1受容体を標的とした新規抗うつ薬の開発
- Principal Investigator
  
  梶谷直人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
高空間分解能MSイメージング法によるS1P組織分布の高感度可視化
- Principal Investigator
  
  三枝大輔
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Teikyo University
  Tohoku University
イメージング技術を基盤とした局所リゾリン脂質の新規機能の解明Principal Investigator
- Principal Investigator
  
  可野邦行
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
間質性膀胱炎の脂質代謝に着目した病態解明と血液バイオマーカー開発
- Principal Investigator
  
  鳥本一匡
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nara Medical University
Screening and profiling of GPCRs in vagal afferent nervePrincipal Investigator
- Principal Investigator
  
  Kano Kuniyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tohoku University
Development of tree-dimensional MS imaging for sphingolipids
- Principal Investigator
  
  Saigusa Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tohoku University
The mechanism of novel LPA3-mediated activation of vagal afferent nervePrincipal Investigator
- Principal Investigator
  
  Kano Kuniyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
New function of LPA3 receptor that regulates vagal afferent nerves activationPrincipal Investigator
- Principal Investigator
  
  KANO KUNIYUKI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

All 2021 2020 2019 2018 2017 2016 2014 2013 2012

All Journal Article Presentation Book

[Book] リゾリン脂質に対する受容体, 242013
- Author(s)
  可野邦行、井上飛鳥、石黒純、青木淳賢
- Publisher
  遺伝子医学MOOK
- Data Source
  KAKENHI-PROJECT-24890014
[Journal Article] Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis2021
- Author(s)
  Uranbileg Baasanjav、Ito Nobuko、Kurano Makoto、Kano Kuniyuki、Uchida Kanji、Sumitani Masahiko、Aoki Junken、Yatomi Yutaka
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Pages: 3984-3984
- DOI
  10.1038/s41598-021-83569-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07047, KAKENHI-PROJECT-20K09190
[Journal Article] Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag2021
- Author(s)
  Iwama Taiga、Kano Kuniyuki、Saigusa Daisuke、Ekroos Kim、van Echten-Deckert Gerhild、Vogt Johannes、Aoki Junken
- Journal Title
  
  Analytical Chemistry
  
  Volume: 93 Pages: 3867-3875
- DOI
  10.1021/acs.analchem.0c04479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07047, KAKENHI-PROJECT-20K21379, KAKENHI-PROJECT-20H03374
[Journal Article] Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification2021
- Author(s)
  Kano Kuniyuki、Matsumoto Hirotaka、Kono Nozomu、Kurano Makoto、Yatomi Yutaka、Aoki Junken
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 62 Pages: 100029-100029
- DOI
  10.1016/j.jlr.2021.100029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07047
[Journal Article] Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model2020
- Author(s)
  Uranbileg B, Ito N, Kurano M, Saigusa D, Saito R, Uruno A, Kano K, Ikeda H, Yamada Y, Sumitani M, Sekiguchi M, Aoki J, Yatomi Y.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Pages: 16578-16578
- DOI
  10.1038/s41598-019-52999-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K08233, KAKENHI-PROJECT-17K11103, KAKENHI-PROJECT-16KK0195
[Journal Article] Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection2019
- Author(s)
  Wang Jiao、Kano Kuniyuki、Saigusa Daisuke、Aoki Junken
- Journal Title
  
  Mass Spectrometry
  
  Volume: 8 Issue: 1 Pages: A0072-A0072
- DOI
  10.5702/massspectrometry.a0072
  10.5702/massspectrometry.A0072
- NAID
  130007594456
- ISSN
  2186-5116, 2187-137X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08233
[Journal Article] Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging2019
- Author(s)
  Saigusa D, Saito R, Kawamoto K, Uruno A, Kano K, Aoki J, Yamamoto M, Kawamoto T.
- Journal Title
  
  Analytical Chemistry
  
  Volume: 91 Pages: 8979-8986
- DOI
  10.1021/acs.analchem.9b01159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K08233, KAKENHI-PROJECT-16KK0195
[Journal Article] Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging2018
- Author(s)
  Abe T, Niizuma K, Kanoke A, Saigusa D, Saito R, Uruno A, Fujimura M, Yamamoto M, Tominaga T.
- Journal Title
  
  Neurologia medico-chirurgica
  
  Volume: 58 Issue: 9 Pages: 384-392
- DOI
  10.2176/nmc.oa.2018-0054
- NAID
  130007484209
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K08233
[Journal Article] Different Origins of Lysophospholipid Mediators between Coronary and Peripheral Arteries in Acute Coronary Syndrome2017
- Author(s)
  Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
- Journal Title
  
  J Lipid Res.
  
  Volume: 58 Pages: 433-442
- DOI
  10.1194/jlr.p071803
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-16H06236, KAKENHI-PROJECT-16K18870
[Journal Article] Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls2017
- Author(s)
  Aikawa Shizu、Kano Kuniyuki、Inoue Asuka、Wang Jiao、Saigusa Daisuke、Nagamatsu Takeshi、Hirota Yasushi、Fujii Tomoyuki、Tsuchiya Soken、Taketomi Yoshitaka、Sugimoto Yukihiko、Murakami Makoto、Arita Makoto、Kurano Makoto、Ikeda Hitoshi、Yatomi Yutaka、Chun Jerold、Aoki Junken
- Journal Title
  
  EMBO Journal
  
  Volume: 36 Pages: 2146-2160
- DOI
  10.15252/embj.201696290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08233, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-16H02613, KAKENHI-PROJECT-15H04648, KAKENHI-PROJECT-15H04979, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-16K15122, KAKENHI-PROJECT-16K15700, KAKENHI-PROJECT-16K15701, KAKENHI-PROJECT-26670030
[Journal Article] Autotaxin-lysophosphatidic acid signaling attenuates sphingosine-1-phosphate signaling leading to cardia bifida in zebrafish embryos.2014
- Author(s)
  Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A, Aoki J
- Journal Title
  
  Journal of biochemistry
  
  Volume: 155 Pages: 235-241
- DOI
  10.1093/jb/mvt114
- NAID
  40020035029
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-11J05211, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-24770114, KAKENHI-PROJECT-24790064, KAKENHI-PROJECT-24890014, KAKENHI-PROJECT-25430135, KAKENHI-PROJECT-25860021, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-26640064
[Presentation] リゾホスファチジン酸はLPA2受容体を介して精子形成細胞のアポトーシスを抑制する2020
- Author(s)
  可野邦行、菅原拓海、青木淳賢
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-20K07047
[Presentation] リン脂質および脂質メディエーターの質量分析イメージング2020
- Author(s)
  可野邦行、岩間大河、青木淳賢
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-20K07047
[Presentation] MALDI-MSI分析における導電性粘着フィルムの生体組織切片作成への有用性について2019
- Author(s)
  三枝大輔、齋藤律水、川本孔明、宇留野晃、可野邦行、青木淳賢、山本雅之、川本忠文
- Organizer
  第44回医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K08233
[Presentation] 迷走神経とGPCR2019
- Author(s)
  可野邦行
- Organizer
  第18回生物化学若手研究者セミナー
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] Screening of novel G protein-coupled receptors regulating afferent vagal activity2019
- Author(s)
  Kuniyuki Kano
- Organizer
  ICBL 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] Imaging MS analysis of lysophospholipids using AP-MALDI-MS2019
- Author(s)
  Kuniyuki Kano
- Organizer
  International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] 迷走神経を制御する新規GPCRの探索2018
- Author(s)
  佐藤悠喜飛、可野邦行、菅野真由、青木淳賢
- Organizer
  第４０回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] 求心性迷走神経を活性化する新規GPCRの探索2018
- Author(s)
  菅野真由、可野邦行、佐藤悠喜飛、青木淳賢
- Organizer
  第57回日本薬学会東北支部会
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] 迷走神経におけるGPCRを介した新規受容機構の解析2018
- Author(s)
  佐藤悠喜飛、可野邦行、青木淳賢
- Organizer
  第17回次世代を担う若手ファーマ・バイオフォーラム2018
- Data Source
  KAKENHI-PROJECT-18K14845
[Presentation] Lysophosphatidic acid enhances IL-10 production in a mouse LPS model2017
- Author(s)
  Jiao Wang, Kuniyuki Kano, Kyoko Satake, Junken Aoki
- Organizer
  Keystone Symposia on Lipidomics and Bioactive Lipids in Metabolism and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] Imaging MS analysis of lysophospholipids using AP-MALDI-MS2017
- Author(s)
  Kuniyuki Kano, Daisuke Saigusa and Junken Aoki
- Organizer
  Bioactive lipids conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] Preventive and alleviative effects of LPA3 signaling in a novel mouse model of acute exacerbation of idiopathic pulmonary fibrosis2017
- Author(s)
  Naoki Omae, Kuniyuki Kano, Junken Aoki
- Organizer
  FASEB Science Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] Imaging MS analysis of lysophospholipids using AP-MALDI-MS2017
- Author(s)
  Kuniyuki Kano, Daisuke Saigusa and Junken Aoki
- Organizer
  FASEB Science Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] An emerging role of DHA-containing LPA in myocardial infarction2017
- Author(s)
  Kuniyuki Kano, Junken Aoki
- Organizer
  International Conference on Lipoquality
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] Lysophosphatidic acid stimulates IL-10 production from murine peritoneal macrophage2017
- Author(s)
  Jiao Wang, Kuniyuki Kano, Junken Aoki
- Organizer
  BMB2017
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] Imaging MS analysis of lysophospholipids using AP-MALDI-MS2017
- Author(s)
  Kuniyuki Kano, Daisuke Saigusa and Junken Aoki
- Organizer
  Keystone symposia
- Place of Presentation
  California (USA)
- Year and Date
  2017-02-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] リゾリン脂質メディエーターリゾホスファチジン酸の新規迷走神経刺激因子としての機能2016
- Author(s)
  可野邦行
- Organizer
  日本薬学会東北支部若手研究者セミナー
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-16K18870
[Presentation] 迷走神経の新規制御因子としてのリゾホスファチジン酸2013
- Author(s)
  可野邦行
- Organizer
  医療系薬学若手研究者セミナー
- Place of Presentation
  仙台
- Year and Date
  2013-10-19
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] Lysophosphatidic acid in blood regulates vagal afferent nerves through LPA3 receptor2013
- Author(s)
  Junken Aoki, Kuniyuki Kano
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Niseko, Japan
- Year and Date
  2013-09-05
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸受容体LPA3をターゲットとした創薬のためのハイスループットスクリーニング2013
- Author(s)
  可野邦行、濱直人、岩渕好治、青木淳賢
- Organizer
  公開シンポジウム東北からの創薬
- Place of Presentation
  仙台
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸受容体 LPA3 をターゲットとした創薬のためのハイスループットスクリーニング2013
- Author(s)
  可野邦行、濱直人、岩渕好治、青木淳賢
- Organizer
  公開シンポジウム東北からの創薬
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] New function of LPA3 receptor that regulates vagal afferent nerves activation2013
- Author(s)
  可野邦行、青木淳賢
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸の新規迷走神経調節機能2013
- Author(s)
  可野邦行
- Organizer
  新学術領域研究若手ワークショップ
- Place of Presentation
  鳴門
- Year and Date
  2013-07-02
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸受容体LPA3の活性化は迷走神経刺激の感受性を亢進させる2012
- Author(s)
  可野邦行（代表者）、遠藤智子、濱弘太郎、新井洋由、Jerold Chun、青木淳賢
- Organizer
  第85会日本生化学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸受容体LPA3の活性化は迷走神経刺激の感受性を亢進させる2012
- Author(s)
  可野邦行,遠藤智子,濱弘太郎,新井洋由,Jerold Chun,青木淳賢
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24890014
[Presentation] リゾホスファチジン酸受容体LPA3を介した迷走神経活性化作用の解析2012
- Author(s)
  可野邦行,遠藤智子,濱弘太郎,山田哲也,片桐秀樹,新井洋由,Jerold Chun,青木淳賢
- Organizer
  第78回日本生化学会東北支部会例会
- Place of Presentation
  山形、山形大学医学部
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-24890014

1. Saigusa Daisuke (90545237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. 元池育子 (70347178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松本洋太郎 (90420041)

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4. 梶谷直人 (60755742)

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5. 鳥本一匡 (10382293)

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6. 藤本清秀 (50264867)

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7. KURANO Makoto

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8. NAGAMATSU Takeshi

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9. TAKETOMI Yoshitaka

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10. MURAKAMI Makoto

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11. KAWAHARA Atsuo

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12. HAMA Kotaro

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13. INOUE Asuka

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14. 矢富裕

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15. 宇留野晃

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16. 有田誠

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17. 有田正規

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18. 岡村孝司

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19. 杉本幸彦

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20. 廣田泰

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21. 藤井知行

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22. 大須賀穣

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23. 青木淳賢

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24. 富岡佳久

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25. 仁科博史

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26. 伊藤伸子

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27. 山田芳嗣

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# of Collaborated Products: 1 results

KANO KUNIYUKI 可野 邦行

Kano Kuniyuki 可野 邦行

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ドラッグ・リポジショニングによるLPA1受容体を標的とした新規抗うつ薬の開発

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高空間分解能MSイメージング法によるS1P組織分布の高感度可視化

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イメージング技術を基盤とした局所リゾリン脂質の新規機能の解明Principal Investigator

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間質性膀胱炎の脂質代謝に着目した病態解明と血液バイオマーカー開発

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Screening and profiling of GPCRs in vagal afferent nervePrincipal Investigator

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Development of tree-dimensional MS imaging for sphingolipids

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The mechanism of novel LPA3-mediated activation of vagal afferent nervePrincipal Investigator

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New function of LPA3 receptor that regulates vagal afferent nerves activationPrincipal Investigator

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[Book] リゾリン脂質に対する受容体, 242013

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[Journal Article] Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis2021

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[Journal Article] Development of an On-Tissue Derivatization Method for MALDI Mass Spectrometry Imaging of Bioactive Lipids Containing Phosphate Monoester Using Phos-tag2021

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[Journal Article] Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification2021

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[Journal Article] Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model2020

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[Journal Article] Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection2019

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KANO KUNIYUKI 可野邦行

Kano Kuniyuki 可野邦行