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Fujisawa Takao  藤澤 貴央

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… Alternative Names

FUJISAWA Takao  藤澤 貴央

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Researcher Number 50636644
Affiliation (Current) 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help 2017 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
2017: 東京大学, 大学院薬学系研究科, 助教
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Complex systems
Except Principal Investigator
Biological pharmacy / Biological Sciences
Keywords
Principal Investigator
亜鉛 / ALS / SOD1 / 筋萎縮性側索硬化症 / シグナル伝達 / 脳神経疾患
Except Principal Investigator
シグナル伝達 / ストレス / ASK1 / ASKファミリー … More / 酸化ストレス / 浸透圧ストレス / 小胞体ストレス / ミトコンドリアストレス Less
  • Research Projects

    (6 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (18 People)
  •  亜鉛によるヒストンアセチル化酵素KAT7の活性制御機構の解析Principal Investigator

    • Principal Investigator
      藤澤 貴央
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      The University of Tokyo
  •  亜鉛シグナルによるヒストンH3K14のアセチル化制御機構と病態生理学的意義の解析Principal Investigator

    • Principal Investigator
      藤澤 貴央
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of conformational alteration in SOD1 and its disruption in the pathogenesis of ALSPrincipal Investigator

    • Principal Investigator
      Fujisawa Takao
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      The University of Tokyo
  •  変異型化したSOD1のクリアランス機構とその破綻によるALS発症機構の解明Principal Investigator

    • Principal Investigator
      藤澤 貴央
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Signal transduction by redox sensor molecules

    • Principal Investigator
      Miki Hiroaki
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

    • Principal Investigator
      ICHIJO Hidenori
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo

All 2021 2020 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

  • [Journal Article] Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process2021

    • Author(s)
      H. Matsui, T. Iriyama, S. Sayama, N. Inaoka, K. Suzuki, M. Yoshikawa, M. Ichinose, K. Sone, K. Kumasawa, T. Nagamatsu, T. Fujisawa, I. Naguro, H. Ichijo, T. Fujii, Y. Osuga
    • Journal Title

      Placenta

      Volume: 115 Pages: 60-69

    • DOI

      10.1016/j.placenta.2021.09.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15358, KAKENHI-PROJECT-21H04760, KAKENHI-PROJECT-20H03820, KAKENHI-PROJECT-20K18158
  • [Journal Article] The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 12020

    • Author(s)
      Sugawara, S., Kanamaru, Y., Sekine, S., Maekawa, L., Takahashi, A., Yamamoto, T., Watanabe, K., Fujisawa, T., Hattori, K. and Ichijo, H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Pages: 5588-5601

    • DOI

      10.1074/jbc.ra119.011508

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15358, KAKENHI-PROJECT-18J14879, KAKENHI-PROJECT-18K19469, KAKENHI-PROJECT-18H03995
  • [Journal Article] Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase2020

    • Author(s)
      Homma, K., Takahashi, H., Tsuburaya, N., Naguro, I., Fujisawa, T. and Ichijo, H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Pages: 3148-3158

    • DOI

      10.1074/jbc.ra119.010239

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15358, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-18H02569, KAKENHI-PROJECT-18K19469, KAKENHI-PROJECT-18H03995
  • [Journal Article] Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains2019

    • Author(s)
      Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uuskula-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC
    • Journal Title

      Mol Cell

      Volume: 73 Pages: 1-18

    • DOI

      10.1016/j.molcel.2018.11.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15358, KAKENHI-PLANNED-26111007
  • [Journal Article] A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.2018

    • Author(s)
      Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T., and Ichijo, H.
    • Journal Title

      Nat Commun

      Volume: 9 Pages: 1-12

    • DOI

      10.1038/s41467-018-05127-2

    • NAID

      120006546002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19469, KAKENHI-PROJECT-18K15358, KAKENHI-PLANNED-17H06419, KAKENHI-PLANNED-26114009, KAKENHI-PROJECT-16K08172, KAKENHI-PLANNED-26111007, KAKENHI-PROJECT-18H03995
  • [Journal Article] The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis2017

    • Author(s)
      Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
    • Journal Title

      Sci. Transl. Med.

      Volume: 9 Pages: 391-391

    • DOI

      10.1126/scitranslmed.aaf3962

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-17KT0108, KAKENHI-PUBLICLY-17H05670, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H05019, KAKENHI-PROJECT-17H06622, KAKENHI-PROJECT-15K06921, KAKENHI-PLANNED-26114009
  • [Journal Article] Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors2017

    • Author(s)
      Fujisawa, T.
    • Journal Title

      Adv. Biol. Regul.

      Volume: 66 Pages: 85-90

    • DOI

      10.1016/j.jbior.2017.10.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H06622
  • [Journal Article] The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.2016

    • Author(s)
      Fujisawa, T., Yamaguchi, N., Kadowaki, H., Tsukamoto, Y., Tsuburaya, N., Tsubota, A., Takahashi, H., Naguro, I., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Homma, K. and Ichijo, H.
    • Journal Title

      Hum. Mol. Genet.

      Volume: 82 Pages: 245-253

    • DOI

      10.1093/hmg/ddv467

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-13J10826, KAKENHI-PLANNED-26114009, KAKENHI-PROJECT-25221302, KAKENHI-PUBLICLY-15H01539, KAKENHI-PROJECT-15H05019, KAKENHI-PROJECT-15K15685
  • [Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants2015

    • Author(s)
      Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto T, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H
    • Journal Title

      Neurobiol.Dis.

      Volume: 82 Pages: 478-486

    • DOI

      10.1016/j.nbd.2015.08.010

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11080, KAKENHI-PROJECT-15K15685, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-13J10655, KAKENHI-PLANNED-26114009
  • [Journal Article] SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.2013

    • Author(s)
      Homma, K., Fujisawa. T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
    • Journal Title

      Mol. Cell

      Volume: 52 Pages: 75-86

    • DOI

      10.1016/j.molcel.2013.08.038

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J10655, KAKENHI-PROJECT-13J10826, KAKENHI-PROJECT-20229004, KAKENHI-PROJECT-24390418, KAKENHI-PROJECT-24659027, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-25650004, KAKENHI-PROJECT-25650061, KAKENHI-PROJECT-25870562
  • [Presentation] 亜鉛欠乏依存的なヒストンH3K14ac減弱メカニズムの解析2021

    • Author(s)
      藤澤貴央, 一條秀憲
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 亜鉛欠乏依存的なヒストンH3K14ac減弱メカニズムの解析2021

    • Author(s)
      藤澤貴央, 一條秀憲
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 亜鉛欠乏刺激下におけるSOD1の新規結合因子からALSの病態分子機構に迫る2021

    • Author(s)
      田中志和, 藤澤貴央, 一條秀憲
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 亜鉛欠乏下における H3K14ac 認識タンパク質の機能解析2021

    • Author(s)
      竹中哲, 藤澤貴央, 一條秀憲
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 亜鉛欠乏刺激下におけるSOD1の新規結合因子からALSの病態分子機構に迫る2021

    • Author(s)
      田中志和, 藤澤貴央, 一條秀憲
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] MEK-ERK経路は亜鉛欠乏ストレス依存的なSOD1の構造変化を制御する2020

    • Author(s)
      竹中哲, 藤澤貴央, 坪田充司, 一條秀憲
    • Organizer
      第43回日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] MEK-ERK経路は亜鉛欠乏ストレス依存的なSOD1の構造変化を制御する2020

    • Author(s)
      藤澤貴央, 竹中哲, 坪田充司, 一條秀憲
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 栄養飢餓状態におけるMBD3の発現量低下とその生理的意義の解析2020

    • Author(s)
      若月大晃, 藤澤貴央, 一條秀憲
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] Molecular mechanism of zinc deficiency-induced structural change of SOD1 explored by a genome-wide siRNA screen2019

    • Author(s)
      Tsubota, A., Fujisawa, T., Ichijo, H.
    • Organizer
      ISZB2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 筋萎縮性側索硬化症で見られるSOD1遺伝子変異の毒性発揮機構の解析2019

    • Author(s)
      田淵璃子, 藤澤貴央, 一條秀憲
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] Analysis of Quality Control Autophagy of Aberrant ER Membrane Proteins Using a Novel Model Substrate2019

    • Author(s)
      Hayashi, Y., Fujisawa,T., Ichijo, H.
    • Organizer
      Gordon Research Conference -Stress Proteins in Growth, Development and Disease-
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 小胞体における膜タンパク質の品質管理機構としての選択的オートファジー2019

    • Author(s)
      林裕輝, 藤澤貴央, 一條秀憲
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 亜鉛欠乏依存的に構造変化したSOD1の機能解析2019

    • Author(s)
      前川リラ, 竹中哲, 坪田充司, 藤澤貴央, 一條秀憲
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 筋萎縮性側索硬化症を引き起こすSOD1遺伝子変異に共通する構造変化2019

    • Author(s)
      田淵璃子, 藤澤貴央, 一條秀憲
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] ゲノムワイドsiRNAスクリーニングによる亜鉛欠乏依存的なSOD1構造変化制御機構の解明2019

    • Author(s)
      坪田充司, 藤澤貴央, 一條秀憲
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] 新規モデル基質を用いた小胞体における不良膜タンパク質のオートファジー分解機構の解析2019

    • Author(s)
      林裕輝, 藤澤貴央, 一條秀憲
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] SOD1-Derlin-1結合を標的とした低分子化合物によるALS病態モデルの改善2018

    • Author(s)
      藤澤貴央、圓谷奈保美、本間謙吾、一條秀憲
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PLANNED-26111007
  • [Presentation] SOD1-Derlin-1結合を標的とした低分子化合物によるALS病態モデルの改善2018

    • Author(s)
      藤澤貴央、圓谷奈保美、本間謙吾、一條秀憲
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K15358
  • [Presentation] Time resolved fluorescence-based screening assay for iidentification of chemical compounds that inhibit the interaction between ALS-related SOD1 Mutants

    • Author(s)
      Tsuburaya, N., Homma, K., Fujisawa, T., Ichijo, H.
    • Organizer
      RICT2013
    • Place of Presentation
      ニース, France
    • Year and Date
      2013-07-03 – 2013-07-05
    • Data Source
      KAKENHI-PROJECT-25221302
  • 1.  SEKINE Shiori (70612654)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  ICHIJO Hidenori (00242206)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 3.  NAGURO Isao (80401222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  Miki Hiroaki (80302602)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  服部 一輝 (40708575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KADOWAKI Hisae
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  HOSOKAWA Masato
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  TAKUMA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  KITAOKA Shiho
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  WATANABE Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  SONE Kembun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  武田 弘資
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  西頭 英起
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 14.  玉岡 晃
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  井上 治久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  高橋 良輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  伊東 秀文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  佐山 晴亮
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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