Hanaya Kengo 花屋賢悟

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HANAYA Kengo 花屋賢悟

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Researcher Number	50637262
Other IDs	https://orcid.org/0000-0003-3622-8106
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 慶應義塾大学, 薬学部(芝共立), 講師 2016 – 2018: 慶應義塾大学, 薬学部(芝共立), 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry
Keywords	Principal Investigator 化学修飾 / トリプトファン / 銅 / タンパク質 / ペプチド / 金属錯体 / 配向基 / ペプチド結合 / 遷移金属イオン / ヨウ素 … More / 銅イオン / アルドール反応 / N末端アミノ酸 / 金属イオン / アミノ酸 / チオエーテル / 遷移金属 / ラジカル反応 / ニッケル / ボロン酸 / クロスカップリング / 薬学 / Thorpe-Ingold効果 / スルタム / チオール応答性蛍光プローブ / 1，4-付加 / 1,4-付加 / チオール / 刺激応答性リンカー / 自己分解 / γ-スルタム / 分子内環化 / スルホン酸エステル / プロドラッグ Less

金属結合モチーフの構築を志向したポリペプチド化学修飾Principal Investigator
- Principal Investigator
  
  花屋賢悟
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Keio University
Chemical modification of polypeptides via metal-mediated reactionPrincipal Investigator
- Principal Investigator
  
  Hanaya Kengo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Keio University
Development of metal-mediated cross-coupling reactions for protein modificationPrincipal Investigator
- Principal Investigator
  
  Kengo Hanaya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Keio University
Development of sulfonylester-based self-immolative likers with higher degradation ratesPrincipal Investigator
- Principal Investigator
  
  HANAYA Kengo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Selective modification of tryptophan in polypeptides via C-N coupling with azoles using in situ-generated iodine-based oxidants in aqueous media2023
- Author(s)
  Shunsuke Watanabe, Yuki Wada, Masaki Kawano, Shuhei Higashibayashi, Takeshi Sugai, and Kengo Hanaya
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 87 Pages: 13026-13029
- DOI
  10.1039/d3cc03731b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06482
[Journal Article] Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper(II)‐Mediated Aldol Reaction2022
- Author(s)
  Hanaya Kengo、Yamoto Kaho、Taguchi Kazuaki、Matsumoto Kazuaki、Higashibayashi Shuhei、Sugai Takeshi
- Journal Title
  
  Chemistry A European Journal
  
  Volume: 28 Issue: 47
- DOI
  10.1002/chem.202201677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06482
[Journal Article] Nickel(II)‐Mediated C-S Cross‐Coupling Between Thiols and ortho‐Substituted Arylboronic Acid2021
- Author(s)
  Hanaya Kengo、Ohtsu Hiroyoshi、Kawano Masaki、Higashibayashi Shuhei、Sugai Takeshi
- Journal Title
  
  Asian Journal of Organic Chemistry
  
  Volume: 10 Issue: 3 Pages: 582-587
- DOI
  10.1002/ajoc.202000724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16321
[Journal Article] Synthesis of 5-hydroxy-3’,4’,7-trimethoxyflavone (HTMF) and related compounds and elucidation of their reversal effects on BCRP/ABCG2-mediated anticancer drug resistance.2019
- Author(s)
  Tsunekawa R, KatayamaK, Hanaya K, Higashibayashi S, Sugimoto Y, Sugai T.
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Issue: 2 Pages: 210-220
- DOI
  10.1002/cbic.201800431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-16K21362
[Journal Article] Nickel(II)-Promoted Amide N-H Arylation of Pyroglutamate-Histidine with Arylboronic Acid Reagents2019
- Author(s)
  Kengo Hanaya, Mary K. Miller, Zachary T. Ball
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 7 Pages: 2445-2448
- DOI
  10.1021/acs.orglett.9b00759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21362
[Journal Article] Rapid nickel(II)-promoted cysteine S-arylation with arylboronic acids2019
- Author(s)
  Kengo Hanaya, Jun Ohata, Mary K. Miller, Alicia E. Mangubat-Medina, Michael J. Swierczynski, David C. Yang, Reece M. Rosenthal, Brian V. Popp, Zachary T. Ball
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 19 Pages: 2841-2844
- DOI
  10.1039/c9cc00159j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21362
[Journal Article] A Vinylogous Photocleavage Strategy Allows Direct Photocaging of Backbone Amide Structure2018
- Author(s)
  Alicia E. Mangubat-Medina, Samuel C. Martin, Kengo Hanaya, Zachary T. Ball
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 140 Issue: 27 Pages: 8401-8404
- DOI
  10.1021/jacs.8b04893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] アルドール反応を用いたN末端アミノ酸の化学修飾2024
- Author(s)
  花屋賢悟、和田雄貴、河野正規、田口和明、松元一明、東林修平、須貝威
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 超原子価ヨウ素試薬を用いた、水中での酸化的カップリング反応によるトリプトファン含有ペプチドの化学修飾2024
- Author(s)
  花屋賢悟、渡邉俊佑、和田雄貴、河野正規、東林修平、須貝威
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 酸化的カップリング反応によるトリプトファン含有ペプチドの化学修飾2023
- Author(s)
  花屋賢悟、渡邉俊佑、東林修平、須貝威
- Organizer
  第67回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] タンパク質N末端アミノ酸に複数の人工分子を導入する手法の開発2023
- Author(s)
  花屋賢悟・森見優希・田口和明・松元一明・東林修平・須貝威
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] タンパク質N末端に対するアルドール反応を活用した化学修飾法の開発2022
- Author(s)
  花屋賢悟、八本果歩、田口和明、松元一明、東林修平、須貝威
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 金属イオンを用いたアルドール反応によるN末端アミノ酸の化学修飾2022
- Author(s)
  花屋賢悟・森見優希・田口和明・松元一明・東林修平・須貝威
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 金属イオンを用いたアルドール反応によるペプチド・タンパク質のN末端アミノ酸の化学修飾2022
- Author(s)
  花屋賢悟・森見優希・田口和明・松元一明・和田雄貴・河野正規・東林修平・須貝威
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 銅(II)を用いたペプチドN末端化学修飾法の開拓2021
- Author(s)
  八本果歩、花屋賢悟、東林修平、須貝威
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 銅(II)イオンを用いたアルドール反応によるN末端アミノ酸選択的化学修飾法の開発2021
- Author(s)
  花屋賢悟、八本果歩、東林修平、須貝威
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] ヨウ素を酸化剤とする炭素－窒素結合形成反応を利用したトリプトファン化学修飾法の開拓2021
- Author(s)
  渡邉俊佑、東林修平、須貝威、花屋賢悟
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06482
[Presentation] 3-カルバモイル-2,4-ジニトロフェニルピリジニウムのDiels-Alder反応に関する計算化学的考察2020
- Author(s)
  中原正貴, 花屋賢悟, 須貝威, 東林修平
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16321
[Presentation] Synthetic study on tetrapetalne A by a intramolecular oxidative phenol-alkene coupling reaction2020
- Author(s)
  Hiroki Deguchi, Kengo Hanaya, Takeshi Sugai, Shuhei Higashibayashi,
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K16321
[Presentation] Selective chemical protein modification with nickel(II) and arylboronic acid2019
- Author(s)
  花屋　賢悟, 大畠　潤, Mary K. Miller, Alicia E. Mangubat-Medina, Zachary T. Ball
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] ニッケル触媒を用いたシステイン選択的アリール化2019
- Author(s)
  花屋賢悟, 大畠潤, Mary K. MILLER, Alicia E. MANGUBAT-MEDINA, Zachary T. BALL
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] Nickel(II)-mediated rapid protein modification with arylboronic acid2019
- Author(s)
  Kengo Hanaya, Mary K. Miller, Jun Ohata, Alicia E. Mangubat-Medina, and Zachary T. Ball
- Organizer
  15th International Symposium on Applied Bioinorganic Chemistry (ISABC15)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16321
[Presentation] 配糖体から出発するメチル化フラボノイドの位置選択的合成2018
- Author(s)
  藤田理愛, Mandal Susanta, 花屋賢悟, 東林修平, 須貝威
- Organizer
  第５３回天然物化学談話会
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] 環状カルバゾール化合物の新規酸化的転位2018
- Author(s)
  安井将満, 大津博義, 河野正規, 花屋賢悟, 須貝威, 東林修平
- Organizer
  第５３回天然物化学談話会
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] 刺激応答性リンカーを有するチオール応答性蛍光プローブの創製2017
- Author(s)
  蜂須賀ナナ、佐々木昭郎、庄司満、須貝威、花屋賢悟
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] Development of self-immolative aminosulfonate linker for prodrug2016
- Author(s)
  Kengo Hanaya, Akio Sasaki, Mitsuru Shoji, Takeshi Sugai
- Organizer
  17th Tetrahedron Symposium
- Place of Presentation
  Sitges, Spain
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] Development of enzyme-activatable sulfonate-based prodrugs for active targeting therapy2016
- Author(s)
  Akio Sasaki, Mitsuru Shoji, Takeshi Sugai, Kengo Hanya
- Organizer
  ICC05-AEM2016
- Place of Presentation
  Kurobe Unazuki International Hall Selena, Kurobe-shi, Toyama, Japan
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21362
[Presentation] Development of Aminosulfonate Ester-based Self-immolative linker for Application in Prodrug2016
- Author(s)
  Kengo Hanaya, Akio Sasaki, Nana Hachisuka, Shin Aoki, Mitsuru Shoji
- Organizer
  ISPAC2016
- Place of Presentation
  Kuching, Malaysia
- Year and Date
  2016-08-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21362

1. 杉本芳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hanaya Kengo 花屋 賢悟

HANAYA Kengo 花屋 賢悟

Research Projects

Research Products

Co-Researchers

金属結合モチーフの構築を志向したポリペプチド化学修飾Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chemical modification of polypeptides via metal-mediated reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of metal-mediated cross-coupling reactions for protein modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of sulfonylester-based self-immolative likers with higher degradation ratesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selective modification of tryptophan in polypeptides via C-N coupling with azoles using in situ-generated iodine-based oxidants in aqueous media2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper(II)‐Mediated Aldol Reaction2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nickel(II)‐Mediated C-S Cross‐Coupling Between Thiols and ortho‐Substituted Arylboronic Acid2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of 5-hydroxy-3’,4’,7-trimethoxyflavone (HTMF) and related compounds and elucidation of their reversal effects on BCRP/ABCG2-mediated anticancer drug resistance.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nickel(II)-Promoted Amide N-H Arylation of Pyroglutamate-Histidine with Arylboronic Acid Reagents2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid nickel(II)-promoted cysteine S-arylation with arylboronic acids2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Vinylogous Photocleavage Strategy Allows Direct Photocaging of Backbone Amide Structure2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] アルドール反応を用いたN末端アミノ酸の化学修飾2024

Author(s)

Organizer

Data Source

[Presentation] 超原子価ヨウ素試薬を用いた、水中での酸化的カップリング反応によるトリプトファン含有ペプチドの化学修飾2024

Author(s)

Organizer

Data Source

[Presentation] 酸化的カップリング反応によるトリプトファン含有ペプチドの化学修飾2023

Author(s)

Organizer

Data Source

[Presentation] タンパク質N末端アミノ酸に複数の人工分子を導入する手法の開発2023

Author(s)

Organizer

Data Source

Hanaya Kengo 花屋賢悟

HANAYA Kengo 花屋賢悟