SAKABE Tomohiko 坂部友彦

… Alternative Names

Sakabe Tomohiko 坂部友彦

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Researcher Number	50639747
Other IDs
Affiliation (Current)	2025: 鳥取大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 鳥取大学, 医学部, 講師 2022 – 2023: 鳥取大学, 医学部, 講師 2014 – 2021: 鳥取大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 49020:Human pathology-related / Human pathology / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 49020:Human pathology-related / Basic Section 55040:Respiratory surgery-related / General surgery
Keywords	Principal Investigator IASLC/ATS/ERS分類 / 転写因子 / 充実型増殖部 / 浸潤性肺腺癌 / 組織亜型 / 膜タンパク質 / 腺房型増殖 / 免疫染色 / 充実型増殖 / オルガノイド培養法 … More / 腺房型亜型 / 組織亜型分類 / 膜タンパク / 充実型亜型 / RNA-Seq / ヘテロジェナイティ / 非小細胞肺癌 / micropapillary component / solid component / オルガノイド / 翻訳後修飾 / 三次元培養 / CD44 / DKK1 / miR-137 / 予後予測因子 / miRNA / 癌幹細胞 … More Except Principal Investigator 浸潤 / 細胞内局在 / Maspin / 肝細胞癌 / 長鎖非コードRNA / NEAT1 / lncRNA / 細胞浸潤 / EMT / 腫瘍免疫 / CD24 / 腫瘍内マクロファージ / 脳腫瘍 / 口腔扁平上皮癌 / 膵管癌 / 不良予後 / 扁平上皮癌 / 肺癌 / 細胞間接着 / 肺扁平上皮癌 / ネクロトーシス / 癌幹細胞 / 治療抵抗性 / 肝細胞がん / SOD2 / GABARAP / 放射線抵抗性 / マイトファジー / オートファジー / ミトコンドリア / maspin / アンプリコンシークエンス / 細胞増殖 / 上皮間葉転換 / 予後 / 乳癌 Less

肺腺癌における充実型成分関連タンパク質を標的とした新規治療薬開発Principal Investigator
- Principal Investigator
  
  坂部友彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tottori University
Maspinが癌患者の不良予後に関与する分子機構の解明
- Principal Investigator
  
  梅北善久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tottori University
肝細胞がんにおける新たな免疫回避メカニズムの解明
- Principal Investigator
  
  土谷博之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tottori University
浸潤性肺腺癌における充実型亜型の形成・維持機構の解明と治療薬開発への応用Principal Investigator
- Principal Investigator
  
  坂部友彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tottori University
Establishment of for evaluation model of pathological subtypes in lung adenocarcinoma using organoid culture and investigation of formation mechanismPrincipal Investigator
- Principal Investigator
  
  SAKABE Tomohiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tottori University
Regulation of liver cancer stem cells by a lncRNA
- Principal Investigator
  
  TSUCHIYA Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tottori University
Elucidation of molecular mechanism of maspin associated with poor prognosis of patients with lung squamous cell carcinoma
- Principal Investigator
  
  UMEKITA Yoshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tottori University
The elucidation of molecular mechanism of maspin related with unfavorable prognosis of human breast cancer patients
- Principal Investigator
  
  UMEKITA Yoshihisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tottori University
Investigation of epigenetic changes related to histological subtype in invasive lung adenocarcinoma and development of precision medicine.Principal Investigator
- Principal Investigator
  
  SAKABE Tomohiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Tottori University
Development of novel therapeutic strategies for targeting liver cancer stem cells based on the multi-omics data.Principal Investigator
- Principal Investigator
  
  Sakabe Tomohiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tottori University

All 2023 2022 2020 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line2022
- Author(s)
  Matsushige T, Sakabe T, Umekita Y.
- Journal Title
  
  Yonago Acta Medica
  
  Volume: 65 Issue: 1 Pages: 44-52
- DOI
  10.33160/yam.2022.02.006
- NAID
  130008162670
- ISSN
  0513-5710, 1346-8049
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09304
[Journal Article] Gene expression profiling by targeted RNA sequencing in pathological stage I lung adenocarcinoma with a solid component2020
- Author(s)
  Kidokoro Yoshiteru、Sakabe Tomohiko、Haruki Tomohiro、Kadonaga Taichi、Nosaka Kanae、Nakamura Hiroshige、Umekita Yoshihisa
- Journal Title
  
  Lung Cancer
  
  Volume: 147 Pages: 56-63
- DOI
  10.1016/j.lungcan.2020.06.035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07414, KAKENHI-PROJECT-19K18214
[Journal Article] CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line.2019
- Author(s)
  Ryoma Asai, Hiroyuki Tsuchiya, Masataka Amisaki, Kazuki Makimoto, Ai Takenaga, Tomohiko Sakabe, Shotaro Hoi, Shigemi Koyama, Goshi Shiota.
- Journal Title
  
  Cancer Med
  
  Volume: 8 Issue: 2 Pages: 773-782
- DOI
  10.1002/cam4.1968
- NAID
  120007144884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09359, KAKENHI-PROJECT-17K16556, KAKENHI-PROJECT-19K08469
[Journal Article] Identification of genes involved in the regulation of TERT in hepatocellular carcinoma.2019
- Author(s)
  Amisaki M, Tsuchiya H, Sakabe T, Fujiwara Y, Shiota G.
- Journal Title
  
  Cancer Sci.
  
  Volume: 110 Issue: 2 Pages: 550-560
- DOI
  10.1111/cas.13884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10588, KAKENHI-PROJECT-16K09359, KAKENHI-PROJECT-17K16556, KAKENHI-PROJECT-19K08469
[Journal Article] Prognostic relevance of miR-137 in patients with hepatocellular carcinoma.2017
- Author(s)
  Tomohiko Sakabe, Junya Azumi, Yoshihisa Umekita, Kan Toriguchi, Etsuro Hatano, Yasuaki Hirooka, Goshi Shiota
- Journal Title
  
  Liver International
  
  Volume: 37 Issue: 2 Pages: 271-279
- DOI
  10.1111/liv.13213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860505
[Journal Article] Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer.2017
- Author(s)
  Wakahara M, Sakabe T, Kubouchi Y, Hosoya K, Hirooka Y, Yurugi Y, Nosaka K, Shiomi T, Nakamura H, Umekita Y.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 5071-5077
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10458
[Presentation] 膵癌細胞株におけるmaspinの機能解析2023
- Author(s)
  持田洋利, 坂部友彦, 新宮崇之, 池田衡平, 牧嶋かれん, 尾崎加苗, 梅北善久
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06462
[Presentation] 肺扁平上皮癌におけるmaspinの細胞内局在依存的な機能の検討2023
- Author(s)
  坂部友彦, 松重貴大, 尾崎加苗, 梅北善久
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06462
[Presentation] 細胞質局在maspinは、EMT関連遺伝子の発現を増加させ、乳癌における細胞浸潤を亢進させる2018
- Author(s)
  坂部友彦, 野坂加苗, 梅北善久
- Organizer
  第77日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10458
[Presentation] 乳癌細胞株におけるmaspin細胞内局在および機能解析2018
- Author(s)
  坂部友彦, 野坂加苗, 梅北善久
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16K10458
[Presentation] 細胞質に発現するmaspinは乳癌細胞株の浸潤能亢進によって癌の進展や悪性化に寄与する2017
- Author(s)
  坂部友彦、若原誠、野坂加苗、塩見達志、梅北善久
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16K10458
[Presentation] 乳癌におけるMaspinの細胞内局在とHDAC1発現との関連性の検討2017
- Author(s)
  若原誠、窪内康晃、坂部友彦、野坂加苗、塩見達志、梅北善久
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16K10458
[Presentation] CD44陽性肝癌幹細胞関連miRNAを用いた肝細胞癌患者予後予測因子の探索2015
- Author(s)
  坂部友彦、安積遵哉、汐田剛史
- Organizer
  第26回日本消化器癌発生学会総会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26860505
[Presentation] CD44陽性肝癌幹細胞のmRNA/miRNA発現解析と臨床的意義2015
- Author(s)
  坂部友彦、安積遵哉、汐田剛史
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860505

1. UMEKITA Yoshihisa (80244226)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. TSUCHIYA Hiroyuki (00403402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 花木武彦 (30788592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WAKAHARA makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 藤原義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKABE Tomohiko 坂部 友彦

Sakabe Tomohiko 坂部 友彦

Research Projects

Research Products

Co-Researchers

肺腺癌における充実型成分関連タンパク質を標的とした新規治療薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Maspinが癌患者の不良予後に関与する分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝細胞がんにおける新たな免疫回避メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

浸潤性肺腺癌における充実型亜型の形成・維持機構の解明と治療薬開発への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of for evaluation model of pathological subtypes in lung adenocarcinoma using organoid culture and investigation of formation mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of liver cancer stem cells by a lncRNA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism of maspin associated with poor prognosis of patients with lung squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of molecular mechanism of maspin related with unfavorable prognosis of human breast cancer patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of epigenetic changes related to histological subtype in invasive lung adenocarcinoma and development of precision medicine.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategies for targeting liver cancer stem cells based on the multi-omics data.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Gene expression profiling by targeted RNA sequencing in pathological stage I lung adenocarcinoma with a solid component2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line.2019

Author(s)

SAKABE Tomohiko 坂部友彦

Sakabe Tomohiko 坂部友彦