SAKAI MANABU 酒井学

Researcher Number	50643376
Other IDs
Affiliation (Current)	2025: 天理大学, 医療学部, 講師
Affiliation (based on the past Project Information) *help	2023: 天理大学, 医療学部, 講師 2022: 天理医療大学, 医療学部, 講師 2021: 大阪大学, 医学系研究科, 招へい教員 2017 – 2020: 大阪大学, 歯学部附属病院, 技術職員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 唾液腺 / 老化 / 免疫学 / 口腔科学 / 老年医学 / 唾液分泌障害 / Rapamycin / Salivary glands / 唾液腺発達 / mTORシグナル経路 … More / 唾液腺障害 / 加齢 / 口腔乾燥症 / ラパマイシン / 歯学 / シェーグレンモデルマウス / 唾液腺疾患 / miRNA / シェーグレン症候群 Less

Establishment of new treatments for Age-Related Salivary Secretion DisordersPrincipal Investigator
- Principal Investigator
  
  酒井学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tenri University
Establishment of new treatments using Rapamycin for Age-Related Oral DisordersPrincipal Investigator
- Principal Investigator
  
  Sakai Manabu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tenri University
  Tenri Health Care University
  Osaka University
Investigation of the role of miRNAs in the pathogenesis of Sjögren's syndrome for miRNA deliveryPrincipal Investigator
- Principal Investigator
  
  SAKAI MANABU
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Establishment of a Mouse Submandibular Salivary Gland Organ Culture2022
- Author(s)
  Sakai M, Sakai T
- Journal Title
  
  Current Protocols in Toxicology
  
  Volume: 9 Issue: 9
- DOI
  10.1002/cpz1.543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19155, KAKENHI-PROJECT-19KK0230, KAKENHI-PROJECT-19H03852
[Journal Article] The HIF‐1α pathway plays a critical role in salivary gland development in <i>ex vivo</i> organ cultures2021
- Author(s)
  Kimura Tomomasa、Sakai Manabu、Gojo Nao、Watanabe Mikio、Uzawa Narikazu、Sakai Takayoshi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 2 Pages: 460-469
- DOI
  10.1002/2211-5463.13351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04048, KAKENHI-PROJECT-19K19155, KAKENHI-PROJECT-19KK0230, KAKENHI-PROJECT-19H03852
[Journal Article] Effect of xanthan gum‐thickened liquid aspiration on the lungs in a mouse model2020
- Author(s)
  Araie Takafumi、Ono Minagi Hitomi、Usami Yu、Ikai Kazuki、Sakai Manabu、Gojo Nao、Nohara Kanji、Sakai Takayoshi
- Journal Title
  
  Oral Science International
  
  Volume: 17 Issue: 2 Pages: 78-85
- DOI
  10.1002/osi2.1047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19155
[Journal Article] ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice2020
- Author(s)
  Ikai Kazuki、Sakai Manabu、Minagi Hitomi Ono、Gojo Nao、Sakai Takayoshi
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 19 Pages: 3216-3226
- DOI
  10.1002/1873-3468.13896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17223, KAKENHI-PROJECT-19K19155, KAKENHI-PROJECT-19KK0230, KAKENHI-PROJECT-19K24070, KAKENHI-PROJECT-19H03852
[Journal Article] Investigation of putative role of mi RNA 146a‐5p and mi RNA 146b‐5p in pathogenesis of Sj?gren's syndrome2019
- Author(s)
  Sakai Manabu、Ikai Kazuki、Minagi Hitomi Ono、Araie Takafumi、Sakai Takayoshi
- Journal Title
  
  Oral Science International
  
  Volume: 16 Issue: 3 Pages: 181-184
- DOI
  10.1002/osi2.1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19155
[Journal Article] Accuracy of liquid‐based cytology (LBC) in the oral mucosa according to novel diagnostic guidelines in Japan: Classification of cytology for oral mucosal disease (JSCC, 2015)2019
- Author(s)
  Kondo Yuko、Oya Kaori、Sakai Manabu、Fujiwara Chisato、Tojo Fumiaki、Usami Yu、Fukuda Yasuo、Kogo Mikihiko、Kishino Mitsunobu
- Journal Title
  
  Oral Science International
  
  Volume: 17 Issue: 1 Pages: 22-28
- DOI
  10.1002/osi2.1035
- Data Source
  KAKENHI-PROJECT-19K19155
[Journal Article] Role of the mTOR signalling pathway in salivary gland development2019
- Author(s)
  Sakai Manabu、Fukumoto Moe、Ikai Kazuki、Ono Minagi Hitomi、Inagaki Shinobu、Kogo Mikihiko、Sakai Takayoshi
- Journal Title
  
  The FEBS Journal
  
  Volume: 286 Issue: 18 Pages: 3701-3717
- DOI
  10.1111/febs.14937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K17223, KAKENHI-PROJECT-19K19155, KAKENHI-PROJECT-19KK0230
[Journal Article] Analysis of the mechanism in salivary gland development using gene database2018
- Author(s)
  Sakai Takayoshi、Minagi Hitomi Ono、Obana-Koshino Aya、Sakai Manabu
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 60 Issue: 4 Pages: 83-86
- DOI
  10.1016/j.job.2018.09.001
- Data Source
  KAKENHI-PROJECT-17K17244
[Journal Article] Grhl2 regulation of SPINT1 expression controls salivary gland development.2018
- Author(s)
  Matsushita T, Sakai M, Yoshida H, Morita S, Hieda Y, Sakai T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 504 Issue: 1 Pages: 263-269
- DOI
  10.1016/j.bbrc.2018.08.166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15737, KAKENHI-PROJECT-17K17244, KAKENHI-PROJECT-15H02575
[Journal Article] Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.2018
- Author(s)
  Minagi HO, Ikai K, Araie T, Sakai M, Sakai T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 503 Issue: 2 Pages: 1098-1102
- DOI
  10.1016/j.bbrc.2018.06.125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15737, KAKENHI-PROJECT-16K20573, KAKENHI-PROJECT-17K17244, KAKENHI-PROJECT-15H02575, KAKENHI-PROJECT-18K17223
[Journal Article] Identification of the protective mechanisms of Lactoferrin in the irradiated salivary gland.2017
- Author(s)
  Sakai M, Matsushita T, Hoshino R, Ono H, Ikai K, Sakai T.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 9753-9753
- DOI
  10.1038/s41598-017-10351-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15737, KAKENHI-PROJECT-17K17244
[Presentation] 低酸素誘導因子HIF1αの顎下腺形成機構の解析2022
- Author(s)
  木村友昌, 酒井学, 阪井丘芳
- Organizer
  日本口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] 唾液腺の発達におけるHypoxia inducible factor 1αの役割2021
- Author(s)
  木村友昌, 酒井学, 阪井丘芳
- Organizer
  第65回日本唾液腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] 顎下腺の発育における低酸素誘導因子HIFの役割2021
- Author(s)
  木村友昌, 酒井学、鵜澤成一, 阪井丘芳
- Organizer
  第66回(公社)日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] 胎児期において低酸素誘導因子HIF（Hypoxia inducible factor）が顎下腺の発育に及ぼす影響2021
- Author(s)
  木村友昌, 酒井学, 五條菜央, 鵜澤成一, 阪井丘芳
- Organizer
  第75回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] CDK4/CyclinD1 control submandibular branching morphogenesis2020
- Author(s)
  五條菜央、井階一樹、皆木瞳、酒井学、阪井丘芳
- Organizer
  歯科基礎学会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] 唾液腺の分枝形態形成におけるCDK4/CyckinD1の働き2020
- Author(s)
  五條菜央、井階一樹、皆木瞳、酒井学、阪井丘芳
- Organizer
  日本口腔化学会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] 唾液腺発達におけるmTORシグナル経路の役割2019
- Author(s)
  酒井学、井階一樹、皆木瞳、阪井丘芳
- Organizer
  第64回日本唾液腺学会学術集会
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] Analysis of transcriptional factor p63 expression in salivary glands regeneration2019
- Author(s)
  Kazuki Ikai, Hitomi Minagi, Manabu Sakai, Takafumi Araie, Takayoshi Sakai
- Organizer
  GordonResearch Conference -Salivary glands & Exocrine Biology
- Data Source
  KAKENHI-PROJECT-19K19155
[Presentation] Lactoferrin promotes salivary gland development2018
- Author(s)
  酒井　学
- Organizer
  第72回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K17244

1. SAKAI Takayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 小野瞳

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 渡邉幹夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI MANABU 酒井 学

Research Projects

Research Products

Co-Researchers

Establishment of new treatments for Age-Related Salivary Secretion DisordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of new treatments using Rapamycin for Age-Related Oral DisordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of miRNAs in the pathogenesis of Sj&ouml;gren's syndrome for miRNA deliveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of a Mouse Submandibular Salivary Gland Organ Culture2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The HIF‐1α pathway plays a critical role in salivary gland development in <i>ex vivo</i> organ cultures2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of xanthan gum‐thickened liquid aspiration on the lungs in a mouse model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigation of putative role of mi RNA 146a‐5p and mi RNA 146b‐5p in pathogenesis of Sj?gren's syndrome2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accuracy of liquid‐based cytology (LBC) in the oral mucosa according to novel diagnostic guidelines in Japan: Classification of cytology for oral mucosal disease (JSCC, 2015)2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of the mTOR signalling pathway in salivary gland development2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the mechanism in salivary gland development using gene database2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Grhl2 regulation of SPINT1 expression controls salivary gland development.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the protective mechanisms of Lactoferrin in the irradiated salivary gland.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 低酸素誘導因子HIF1αの顎下腺形成機構の解析2022

Author(s)

Organizer

SAKAI MANABU 酒井学

Investigation of the role of miRNAs in the pathogenesis of Sjögren's syndrome for miRNA deliveryPrincipal Investigator