Yamaguchi Hirofumi 山口啓史

Researcher Number	50644241
Other IDs
Affiliation (Current)	2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 難治疾患研究所, 非常勤講師 2022: 東京医科歯科大学, 難治疾患研究所, 講師 2018 – 2021: 東京医科歯科大学, 難治疾患研究所, 助教 2017: 東京医科歯科大学, 難治疾患研究所, 特任助教 2016: 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 2015: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Biological pharmacy
Keywords	Principal Investigator ゴルジ体 / オートファジー / タンパク分解 / 神経変性 / Wipi3 / ゴルジ / 遺伝学

タンパク質分解機構GOMEDの分子機構および神経変性疾患の病態メカニズムの解明Principal Investigator
- Principal Investigator
  
  山口啓史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Physiological function analysis of GOMED, a novel proteolytic degradation mechanismPrincipal Investigator
- Principal Investigator
  
  Yamaguchi HIrofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of Aag4 in alternative autophagyPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Hirofumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical and Dental University
Identification and analysis of genes regulatiing Atg5-independent autophagyPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Hirofumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods2023
- Author(s)
  Sakurai Hajime Tajima、Arakawa Satoko、Yamaguchi Hirofumi、Torii Satoru、Honda Shinya、Shimizu Shigeomi
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 24 Pages: 2817-2817
- DOI
  10.3390/cells12242817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06909, KAKENHI-PROJECT-22K07345, KAKENHI-PROJECT-23K05748
[Journal Article] Inhibition of Insulin Secretion Induces Golgi Morphological Changes2023
- Author(s)
  IWAMOTO TATSUYA、SHIMIZU SHIGEOMI、TAJIMA-SAKURAI HAJIME、YAMAGUCHI HIROFUMI、NISHIDA YUYA、ARAKAWA SATOKO、WATADA HIROTAKA
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 69 Issue: 1 Pages: 42-49
- DOI
  10.14789/jmj.JMJ22-0040-OA
- ISSN
  2187-9737, 2188-2126
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07353, KAKENHI-PROJECT-21K15082, KAKENHI-PROJECT-22K06909
[Journal Article] Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases.2020
- Author(s)
  Honda S, Arakawa S, Yamaguchi H, Torii S, Tajima Sakurai H, Tsujioka M, Murohashi M, Shimizu S.
- Journal Title
  
  Journal of molecular biology
  
  Volume: 432 Issue: 8 Pages: 2622-2632
- DOI
  10.1016/j.jmb.2020.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-19K08859, KAKENHI-PROJECT-19K16119, KAKENHI-PROJECT-19K07382, KAKENHI-PROJECT-20K07353, KAKENHI-PUBLICLY-20H05314
[Journal Article] Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy2020
- Author(s)
  Torii Satoru、Yamaguchi Hirofumi、Nakanishi Akira、Arakawa Satoko、Honda Shinya、Moriwaki Kenta、Nakano Hiroyasu、Shimizu Shigeomi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 1754-1754
- DOI
  10.1038/s41467-020-15577-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01533, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-19K07382, KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-20K07353, KAKENHI-PUBLICLY-20H05314, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-18K06210, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06414
[Journal Article] Autophagy involvement in oncogenesis2020
- Author(s)
  Torii Satoru、Honda Shinya、Murohashi Michiko、Yamaguchi Hirofumi、Shimizu Shigeomi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 11 Pages: 3993-3999
- DOI
  10.1111/cas.14646
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07382, KAKENHI-PROJECT-19K08859, KAKENHI-PROJECT-18K06210
[Journal Article] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2020
- Author(s)
  Yamaguchi Hirofumi、Honda Shinya、Torii Satoru、Shimizu Kimiko、Katoh Kaoru、Miyake Koichi、Miyake Noriko、Fujikake Nobuhiro、Sakurai Hajime Tajima、Arakawa Satoko、Shimizu Shigeomi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5311-5311
- DOI
  10.1038/s41467-020-18892-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07382, KAKENHI-PROJECT-19K08859, KAKENHI-PROJECT-20K07353, KAKENHI-PUBLICLY-20H05314, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-19K16119, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Dram1 regulates DNA damage-induced alternative autophagy2018
- Author(s)
  Nagata M, Arakawa S, Yamaguchi H, Torii S, Endo H, Tsujioka M, Honda S, Nishida Y, Konishi A, Shimizu S
- Journal Title
  
  Cell Stress
  
  Volume: 2 Issue: 3 Pages: 55-65
- DOI
  10.15698/cst2018.03.127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08649, KAKENHI-PLANNED-17H06414, KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-15K08420, KAKENHI-PROJECT-16K15230, KAKENHI-PROJECT-17K15448, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H01533
[Journal Article] Golgi membrane-associated degradation pathway in yeast and mammals2016
- Author(s)
  H. Yamaguchi, S. Arakawa, T. Kanaseki, T. Miyatsuka, Y. Fujitani, H. Watada, Y. Tsujimoto, S. Shimizu
- Journal Title
  
  EMBO J.
  
  Volume: 35 Issue: 18 Pages: 1991-2007
- DOI
  10.15252/embj.201593191
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01554, KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-15K14519, KAKENHI-PROJECT-15K18860, KAKENHI-PROJECT-15K08420, KAKENHI-PROJECT-16K15230
[Presentation] 新規オートファジーGOMEDの発見とその生理機能解析2022
- Author(s)
  荒川聡子、山口啓史、清水重臣
- Organizer
  第78回日本顕微鏡学会年会
- Data Source
  KAKENHI-PROJECT-22K06909
[Presentation] GOMED制御分子の機能解析2021
- Author(s)
  山口啓史
- Organizer
  2021年度　新学術領域「オルガネラゾーン」zoom班会議
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2021
- Author(s)
  山口啓史
- Organizer
  2019年度・2020年度難治疾患研究所研究発表会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2021
- Author(s)
  山口啓史
- Organizer
  2019年度・2020年度難治疾患研究所発表会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] Wipi3分子による新規オートファジー機構(GOMED)の制御とインスリン分泌への影響2021
- Author(s)
  山口啓史
- Organizer
  2021年度難治疾患研究所発表会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] The membrane origin of mitophagy after enucleation in red blood cell.2020
- Author(s)
  Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi and Shigeomi Shimizu
- Organizer
  International Symposium for Female Researchers in Chromatin Biology (ISFRCB) 2020 (Satellite Symposium of the 43rd MBSJ), Session 2 “Scientific talks by young female researchers in epigenetics”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] オルタナティブ・オートファジーの生理機能解析と通常型との機能分担についての解明2020
- Author(s)
  荒川聡子・山口啓史・清水重臣
- Organizer
  マルチモードオートファジー第2回班会議
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] 新規オートファジー制御分子の機能解析2020
- Author(s)
  山口啓史、荒川聡子、清水重臣
- Organizer
  第12回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] 新規オートファジー遺伝子欠損マウス(Aag3KO)と従来型オートファジー欠損マウス(Atg7KO)及び両オートファジー欠損マウス（Atg７／Aag３DKO）を比較した形態機能解析2019
- Author(s)
  荒川　聡子、山口　啓史、清水　重臣
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] 新規オートファジーを制御するAAG3の機能解析2019
- Author(s)
  山口　啓史
- Organizer
  第２回　オルガネラゾーン若手の会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] 新規オートファジーを制御するAAG3の機能解析2019
- Author(s)
  山口啓史、荒川　聡子、清水　重臣
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07382
[Presentation] ゴルジ体ストレスに関わる応答ゾーンの解析2018
- Author(s)
  荒川聡子、山口啓史、清水重臣
- Organizer
  第1回新学術領域「オルガネラ・ゾーン」全体班会議
- Data Source
  KAKENHI-PROJECT-17K15448
[Presentation] Alternative autophagy pathways conserved from yeast to mammals2018
- Author(s)
  Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu
- Organizer
  第13回生命医科学研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15448
[Presentation] ゴルジ体を介したタンパク質分解システムの発見2018
- Author(s)
  荒川聡子、山口啓史、清水重臣
- Organizer
  第９１回日本生化学会、京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-17K15448
[Presentation] 新規オートファジーを制御するAAG3の機能解析2017
- Author(s)
  山口　啓史
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15448
[Presentation] Induction of Atg5-independet alternative macroautophagy by a disturbance of anterograde trafficking from the Golgi2017
- Author(s)
  山口　啓史
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15448
[Presentation] ゴルジ膜を用いたタンパク質分解機構の解析2017
- Author(s)
  山口啓史、荒川聡子、金関悳、清水重臣
- Organizer
  細胞競合・ダイイングコード合同若手ワークショップ
- Place of Presentation
  ホテルコスモスクエア国際交流センター (大阪)
- Year and Date
  2017-01-17
- Data Source
  KAKENHI-PROJECT-15K18860
[Presentation] Induction of Golgi membrane-associated degradation pathway in yeast and mammals.2016
- Author(s)
  山口啓史、荒川聡子、金関悳、清水重臣
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (横浜)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18860
[Presentation] ゴルジ膜を用いたタンパク質分解機構の解析2016
- Author(s)
  山口　啓史
- Organizer
  第10回オートファジー研究会
- Place of Presentation
  NASPAニューオータニ (越後湯沢)
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-15K18860
[Presentation] 出芽酵母における新規マクロオートファジー機構の発見と遺伝学的解析2015
- Author(s)
  山口啓史、荒川聡子、金関悳、清水重臣
- Organizer
  オートファジー研究会
- Place of Presentation
  淡路夢舞台国際会議場、兵庫県淡路市
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K18860
[Presentation] Induction of Atg5-independent alternative macroautophagy by a disturbance of anterograde trafficking from the Golgi2015
- Author(s)
  Hirofumi Yamaguchi, Satoko Arakawa, Toku Kanaseki, Shigeomi Shimizu
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド、兵庫県神戸市
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K18860

1. TORII Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 清水重臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 小西昭充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Hirofumi 山口 啓史

Research Projects

Research Products

Co-Researchers

タンパク質分解機構GOMEDの分子機構および神経変性疾患の病態メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological function analysis of GOMED, a novel proteolytic degradation mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of Aag4 in alternative autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and analysis of genes regulatiing Atg5-independent autophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Insulin Secretion Induces Golgi Morphological Changes2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autophagy involvement in oncogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dram1 regulates DNA damage-induced alternative autophagy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Golgi membrane-associated degradation pathway in yeast and mammals2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規オートファジーGOMEDの発見とその生理機能解析2022

Author(s)

Organizer

Data Source

[Presentation] GOMED制御分子の機能解析2021

Author(s)

Organizer

Data Source

[Presentation] Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration2021

Author(s)

Yamaguchi Hirofumi 山口啓史