TAKANO Ai 高野愛

Researcher Number	50647584
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 慶應義塾大学, 医学部(信濃町), 研究員 2013 – 2015: 慶應義塾大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator オルガノイド / 幹細胞 / HTS / 消化器がん / がん幹細胞 / 大腸癌 / 創薬 / 薬剤反応性 / 医療・福祉 / 膵癌 … More / cancer / High Contents Analyzer / High Throughput / organoid / 化合物ライブラリー / 創薬スクリーニング / スクリーニング / PKI / テーラーメイド治療 / ハイスループット / 下部消化管学 … More Except Principal Investigator LGR5 / WNT / 腸管上皮幹細胞 / 幹細胞 / 大腸がん Less

Drug discovery screening targeting gastrointestinal cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  TAKANO AI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
High- throughput screening for personalized medicine targeting gastrointestinal cancer stem cell.Principal Investigator
- Principal Investigator
  
  TAKANO AI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
High-throughput screening for drug discovery targeting gastrointestinal cancer stem cell.Principal Investigator
- Principal Investigator
  
  TAKANO Ai
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Identification of human colorectal cancer stem cells.
- Principal Investigator
  
  SATO Toshiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 細胞工学別冊 2015年上半期バイオ論文総集編2015
- Author(s)
  高野愛, 佐藤俊朗
- Total Pages
  2
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-15K19349
[Journal Article] Somatic inflammatory gene mutations in human ulcerative colitis epithelium.2020
- Author(s)
  Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K, Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T.
- Journal Title
  
  Nature
  
  Volume: 7789 Issue: 7789 Pages: 254-259
- DOI
  10.1038/s41586-019-1844-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0246, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-17J04827, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-17K09395, KAKENHI-PROJECT-19H03455, KAKENHI-PROJECT-19K22544
[Journal Article] Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis2018
- Author(s)
  Nanki Kosaku、Toshimitsu Kohta、Takano Ai、Fujii Masayuki、Takahashi Sirirat、Sukawa Yasutaka、Ishida Hiroki、Sugimoto Shinya、Kawakubo Hirofumi、Kim Jihoon、Kitagawa Yuko、Sekine Shigeki、Koo Bon-Kyoung、Kanai Takanori、Sato Toshiro
- Journal Title
  
  Cell
  
  Volume: 174 Issue: 4 Pages: 856-869
- DOI
  10.1016/j.cell.2018.07.027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09395, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-16J06433, KAKENHI-PROJECT-17J04827, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-16K09325, KAKENHI-PROJECT-17K15967, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition2018
- Author(s)
  Fujii Masayuki、Matano Mami、Toshimitsu Kohta、Takano Ai、Mikami Yohei、Nishikori Shingo、Sugimoto Shinya、Sato Toshiro
- Journal Title
  
  Cell Stem Cell
  
  Volume: 23 Issue: 6 Pages: 787-793
- DOI
  10.1016/j.stem.2018.11.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09395, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-17J04827, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-16K09325
[Journal Article] Visualization and Targeting of LGR5+ Human Colon Cancer Stem Cells2017
- Author(s)
  Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T
- Journal Title
  
  Nature
  
  Volume: 印刷中 Issue: 7653 Pages: 13-14
- DOI
  10.1038/nature22081
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J06065, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15K19349, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K09325, KAKENHI-PROJECT-17K09395, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-16J06433, KAKENHI-PROJECT-17J04827
[Journal Article] A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements2016
- Author(s)
  Masayuki Fujii,Mariko Shimokawa,Shoichi Date,Ai Takano, Mam iMatano,Kosaku Nanki,Yuki Ohta,Kohta Toshimitsu,YoshihiroNakazato,Kenta Kawasaki,Toshio Uraoka,Toshiaki Watanabe,Takanori Kanai,Toshiro Sato
- Journal Title
  
  Cell Stem Cell
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19349
[Journal Article] A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements.2016
- Author(s)
  Fujii M, Shimokawa M, Date S, Takano A, Matano M, Ohta Y, Nanki K, Kawasaki K, Nakazato Y, Uraoka T, Watanabe T, Kanai T, Sato T.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 18 Issue: 6 Pages: 827-838
- DOI
  10.1016/j.stem.2016.04.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-16H02672, KAKENHI-PROJECT-15J06065, KAKENHI-PROJECT-16J04984, KAKENHI-PROJECT-16J06433, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K15298, KAKENHI-PROJECT-15K19349, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K09325
[Journal Article] Modelling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.2015
- Author(s)
  Matano M,Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, Watanabe T, Kanai T, Sato T.
- Journal Title
  
  Nature Medicine
  
  Volume: 21(3) Issue: 3 Pages: 256-262
- DOI
  10.1038/nm.3802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390190, KAKENHI-PROJECT-25670372, KAKENHI-PROJECT-25670570, KAKENHI-PROJECT-25860560, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-26860528, KAKENHI-PROJECT-15K19349, KAKENHI-PROJECT-25253080
[Presentation] The Self-renewing Mechanism of Intestinal Stem Cell: Niche and Cancer2014
- Author(s)
  Toshiro Sato, Yuki Ohta, Ai Takano, Shoichi Date, Mamiko Matano, Mariko Shimokawa
- Organizer
  47th Annual Meeting of the Japanese Society of Developmental Biologists and Asia Pacific Developmental Biology Network
- Place of Presentation
  名古屋（WINC愛知）
- Year and Date
  2014-05-28
- Data Source
  KAKENHI-PROJECT-25860560
[Presentation] Molecular mechanism of intestinal stem cell self-renewal : Stem cells and their niche signals2013
- Author(s)
  Toshiro Sato, Mami Matano, Shoichi Date, Ai Takano, Mariko Shimokawa
- Organizer
  International Symposium 3. Molecular mechanisms for the growth and differentiation of tissue-specific stem cells in mammals, 第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24689036
[Presentation] Molecular mechanism of intestinal carcinogenesis; Stem cells and their niche signals2013
- Author(s)
  Toshiro Sato, Ai Takano, Shoichi Date, Mami Matano, Mariko Shimokawa, Takanori Kanai
- Organizer
  Symposia 12, Aberrant signal transduction and therapeutic strategy for molecular target, 第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-24689036
[Presentation] Molecular mechanism of intestinal carcinogenesis; Stem cells and their niche signals.
- Author(s)
  Toshiro Sato, Ai Takano, Shoichi Date, Mami, Matano, Mariko Shimokawa, Takanori Kanai.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24689036
[Presentation] Molecular mechanism of intestinal stem cell self-renewal:Stem cells and their niche signals.
- Author(s)
  Toshiro Sato, Mami Matano, Shoichi Date, Ai Takano, Mariko Shimokawa.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24689036

1. SATO Toshiro (70365245)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. MATANO Mami (20439889)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 杉本真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKANO Ai 高野 愛

Research Projects

Research Products

Co-Researchers

Drug discovery screening targeting gastrointestinal cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

High- throughput screening for personalized medicine targeting gastrointestinal cancer stem cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

High-throughput screening for drug discovery targeting gastrointestinal cancer stem cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of human colorectal cancer stem cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 細胞工学別冊 2015年上半期バイオ論文総集編2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Somatic inflammatory gene mutations in human ulcerative colitis epithelium.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Visualization and Targeting of LGR5+ Human Colon Cancer Stem Cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements2016

Author(s)

Journal Title

Data Source

[Journal Article] A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modelling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Self-renewing Mechanism of Intestinal Stem Cell: Niche and Cancer2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Molecular mechanism of intestinal stem cell self-renewal : Stem cells and their niche signals2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Molecular mechanism of intestinal carcinogenesis; Stem cells and their niche signals2013

TAKANO Ai 高野愛