Takemura Naoki 武村直紀

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Takemura NaokiNaoki 武村直紀

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Researcher Number	50648699
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院薬学研究科, 准教授 2022: 大阪大学, 大学院薬学研究科, 准教授 2021: 大阪大学, 薬学研究科, 講師 2018 – 2019: 大阪大学, 薬学研究科, 講師 2016 – 2017: 千葉大学, 大学院医学研究院, 講師 2013 – 2015: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Medium-sized Section 38:Agricultural chemistry and related fields / Immunology / Pathological medical chemistry
Keywords	Principal Investigator 細胞死 / 自然免疫 / TLR3 / 呼吸器疾患 / 炎症 / 吸入性微粒子 / 微粒子 / バリア / 粒子 / アレルギー … More / プラスチック / 口腔内粘膜炎 / 小腸線維症 / 放射線 / 筋繊維芽細胞 / 放射線誘導性小腸線維症 / 放射線誘導性口腔内粘膜炎 / 好酸球 / 放射線誘導性腸線維症 / 放射線性消化管症候群 / p53 / 小腸陰窩 / 急性放射線性消化管症候群 Less

Elucidation of new molecular mechanisms linking airborne particulate mater-induced cell death and respiratory diseasesPrincipal Investigator
- Principal Investigator
  
  武村直紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Osaka University
Evaluation of micro- and nano-sized plastics as a risk factor for food allergyPrincipal Investigator
- Principal Investigator
  
  Takemura NaokiNaoki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Osaka University
Development of prophylactic strategies for acute and chronic radiation-induced gastrointestinal syndrome by targeting the innate immune systemPrincipal Investigator
- Principal Investigator
  
  Takemura Naoki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
  Chiba University
Study on the role of TLR3 in radiation-induced gastrointestinal syndromePrincipal Investigator
- Principal Investigator
  
  Takemura Naoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] 標準生理学　第９版2019
- Author(s)
  武村　直紀, 植松　智
- Total Pages
  1172
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16K19148
[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017
- Author(s)
  武村　直紀、植松　智
- Total Pages
  355
- Publisher
  シーエムシー
- Data Source
  KAKENHI-PROJECT-16K19148
[Journal Article] パイロトーシスによる自然炎症とその制御―オルガネラを標的とする新たな抗炎症薬の開発2022
- Author(s)
  武村直紀，齊藤達哉
- Journal Title
  
  医学のあゆみ
  
  Volume: 283 Pages: 455-462
- Data Source
  KAKENHI-PROJECT-21K19083
[Journal Article] Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia2022
- Author(s)
  Sugisawa Erika、Kondo Takeshi、Kumagai Yutaro、Kato Hiroki、Takayama Yasunori、Isohashi Kayako、Shimosegawa Eku、Takemura Naoki、Hayashi Yoshinori、Sasaki Takuya、Martino Mika?l M.、Tominaga Makoto、Maruyama Kenta
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 10 Pages: 110462-110462
- DOI
  10.1016/j.celrep.2022.110462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03114, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-18K07296, KAKENHI-PROJECT-20K09896, KAKENHI-ORGANIZER-21H05238
[Journal Article] Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.2022
- Author(s)
  Ikoma K, Takahama M, Kimishima A, Pan Y, Taura M, Nakayama A, Arai M, Takemura N, Saitoh T.
- Journal Title
  
  Int Immunol.
  
  Volume: 34 Issue: 10 Pages: 493-504
- DOI
  10.1093/intimm/dxac018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19643, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K21156, KAKENHI-PROJECT-23K24029
[Journal Article] Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction2022
- Author(s)
  Matsui Yudai、Takemura Naoki、Shirasaki Yoshitaka、Takahama Michihiro、Noguchi Yoshihiko、Ikoma Kenta、Pan Yixi、Nishida Shuhei、Taura Manabu、Nakayama Akiyoshi、Funatsu Takashi、Misawa Takuma、Harada Yoshie、Sunazuka Toshiaki、Saitoh Tatsuya
- Journal Title
  
  International Immunology
  
  Volume: 34 Issue: 10 Pages: 505-518
- DOI
  10.1093/intimm/dxac028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05785, KAKENHI-PROJECT-21H03388, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19643, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K23847, KAKENHI-PROJECT-23K24029
[Journal Article] Macrophage Response Driven by Extracellular ATP2021
- Author(s)
  Wang J, Takemura N, Saitoh T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 5 Pages: 599-604
- DOI
  10.1248/bpb.b20-00831
- NAID
  130008033237
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-05-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06415, KAKENHI-PROJECT-19H03371, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19643
[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021
- Author(s)
  Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
- Journal Title
  
  Mucosal Immunol
  
  Volume: 14 Issue: 3 Pages: 640-651
- DOI
  10.1038/s41385-020-00358-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-19H03450, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-19K22634, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19495, KAKENHI-PROJECT-18KK0432
[Journal Article] PRRを介した炎症反応における細胞骨格の役割2021
- Author(s)
  田浦学, 武村直紀, 齊藤達哉
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 76 Pages: 614-621
- Data Source
  KAKENHI-PROJECT-21K19083
[Journal Article] NLRP3 インフラマソームを標的とした痛風性関節炎の治療戦略2019
- Author(s)
  武村直紀, 齊藤達哉
- Journal Title
  
  循環器内科
  
  Volume: 87 Pages: 112-117
- NAID
  40022147234
- Data Source
  KAKENHI-PROJECT-16K19148
[Journal Article] 放射線誘導性腸線維症に対する好酸球除去を介した新規予防戦略2018
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 70 Pages: 168-174
- NAID
  40021650995
- Data Source
  KAKENHI-PROJECT-16K19148
[Journal Article] Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice2018
- Author(s)
  Usui Yuki、Kimura Yasumasa、Satoh Takeshi、Takemura Naoki、Ouchi Yasuo、Ohmiya Hiroko、Kobayashi Kyosuke、Suzuki Hiromi、Koyama Satomi、Hagiwara Satoko、Tanaka Hirotoshi、Imoto Seiya、Eberl G?rard、Asami Yukio、Fujimoto Kosuke、Uematsu Satoshi
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 7 Pages: 319-331
- DOI
  10.1093/intimm/dxy035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0017, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-16H05330, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-17KK0189
[Journal Article] Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.2018
- Author(s)
  Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.
- Journal Title
  
  Sci Transl Med.
  
  Volume: -- Issue: 429 Pages: 264-273
- DOI
  10.1126/scitranslmed.aan0333
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-16K08581, KAKENHI-PROJECT-17K15725, KAKENHI-PROJECT-17K19550, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-16H06243
[Journal Article] Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing2018
- Author(s)
  Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 4 Pages: 141-154
- DOI
  10.1093/intimm/dxy006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K07212, KAKENHI-PROJECT-16K16144
[Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018
- Author(s)
  Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
- Journal Title
  
  iScience
  
  Volume: 6 Pages: 306-318
- DOI
  10.1016/j.isci.2018.08.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09885, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-17K15793, KAKENHI-PLANNED-15H05928, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-16H01849, KAKENHI-PROJECT-18H01841, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-18H02970, KAKENHI-PROJECT-17K15725
[Journal Article] A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.2017
- Author(s)
  Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: -- Issue: 1 Pages: 314-328
- DOI
  10.1016/j.stemcr.2017.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08836, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-16H06243
[Journal Article] Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis2017
- Author(s)
  Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 13 Pages: 2730-2742
- DOI
  10.1016/j.celrep.2017.06.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15725, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H02501, KAKENHI-PROJECT-15H05686, KAKENHI-PROJECT-16K15665, KAKENHI-PROJECT-16K19148
[Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017
- Author(s)
  Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
- Journal Title
  
  J Clin Invest.
  
  Volume: 127 Issue: 10 Pages: 3784-3795
- DOI
  10.1172/jci92931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-16K15280, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K19549, KAKENHI-PROJECT-26293102, KAKENHI-PROJECT-26713017, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-26460548, KAKENHI-PROJECT-15K15138, KAKENHI-PROJECT-16K19148, KAKENHI-PROJECT-17H05069
[Journal Article] Netrins as Prophylactic Targets of Skeletal diseases: A Double-Edged Sword?2017
- Author(s)
  *Kenta Maruyama, Naoki Takemura, Mikael M. Martino, Takeshi Kondo, and Shizuo Akira.
- Journal Title
  
  Pharmacological Research
  
  Volume: 122 Pages: 46-52
- DOI
  10.1016/j.phrs.2017.05.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05686, KAKENHI-PROJECT-16K15665, KAKENHI-PROJECT-16K19148
[Journal Article] Toll様受容体を標的とした急性放射線性消化管症候群の新たな予防戦略2016
- Author(s)
  武村　直紀, 植松　智.
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 66 Pages: 267-273
- NAID
  40020953204
- Data Source
  KAKENHI-PROJECT-16K19148
[Journal Article] Isolation and Fuctional Analysis of Lamina PropriaDendritic Cells from the Mouse Small Intestine.2016
- Author(s)
  Takemura N, Uematsu S.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1422 Pages: 181-188
- DOI
  10.1007/978-1-4939-3603-8_17
- ISBN
  9781493936014, 9781493936038
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01367, KAKENHI-PROJECT-15K14404, KAKENHI-PROJECT-16K19148
[Journal Article] p53 is a Host Cell Regulator during Herpes Simplex Encephalitis.2016
- Author(s)
  Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.
- Journal Title
  
  J Virol.
  
  Volume: 90(15) Issue: 15 Pages: 6738-6745
- DOI
  10.1128/jvi.00846-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01367, KAKENHI-PUBLICLY-15H01530, KAKENHI-PROJECT-15J09601, KAKENHI-PROJECT-26713017, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-15K14404, KAKENHI-PROJECT-26670220, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-26460548, KAKENHI-PROJECT-15K15138, KAKENHI-PROJECT-16K19148
[Journal Article] Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.2016
- Author(s)
  Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.
- Journal Title
  
  Immunity.
  
  Volume: 45(6) Issue: 6 Pages: 1299-1310
- DOI
  10.1016/j.immuni.2016.11.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01367, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-16H05256, KAKENHI-PROJECT-15K14404, KAKENHI-PROJECT-15K19142, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-15H05790, KAKENHI-PROJECT-16K19148
[Journal Article] Isolation methods of lamina propria dendritic cells from the mouse small intestine2016
- Author(s)
  Naoki Takemura, Satoshi Uematsu
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1422
- Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] Bone-protective Functions of Netrin 1 Protein2016
- Author(s)
  Kenta Maruyama, Takahiko Kawasaki, Masahide Hamaguchi, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Naoki Takemura, Thangaraj Karuppuchamy, Takeshi Kondo, Takumi Kawasaki, Masahiro Fukusaka, Takuma Misawa, Tatsuya Saitoh, Yutaka Suzuki, Mikael M Martino, Yutaro Kumagai, and Shizuo Akira
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 46 Pages: 23854-23868
- DOI
  10.1074/jbc.m116.738518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05686, KAKENHI-PROJECT-14J05334, KAKENHI-PROJECT-26713005, KAKENHI-PROJECT-16K15665, KAKENHI-PROJECT-16K19148
[Journal Article] 放射線誘導性細胞死が引き起こす臓器障害に対する自然免疫学的治療戦略2016
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  実験医学増刊号
  
  Volume: 34 Pages: 110-115
- Data Source
  KAKENHI-PROJECT-16K19148
[Journal Article] 放射線誘導性腸管上皮傷害におけるTLR3の役割2016
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  炎症と免疫
  
  Volume: 24 Pages: 10-16
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 放射線誘導性細胞死が引き起こす臓器障害に対する自然免疫学的治療戦略2016
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  実験医学増刊号
  
  Volume: 34
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 急性放射線性消化管症候群におけるToll様受容体の役割2015
- Author(s)
  武村　直紀,　植松　智
- Journal Title
  
  放射線生物研究
  
  Volume: 50 Pages: 84-97
- NAID
  40020417037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 放射線誘導性小腸上皮傷害におけるTLR3の役割2015
- Author(s)
  武村　直紀,　植松　智
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 64
- NAID
  40020540511
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] Toll様受容体と急性放射線性消化管症候群2015
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  医学のあゆみ
  
  Volume: 235 Pages: 403-409
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] Toll様受容体と急性放射線性消化管症候群2015
- Author(s)
  武村　直紀,　植松　智
- Journal Title
  
  医学のあゆみ
  
  Volume: 253
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 小腸粘膜固有層の自然免疫細胞が担う腸管免疫応答2015
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 64 Pages: 318-325
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 放射線誘導性小腸上皮傷害におけるTLR3の役割2015
- Author(s)
  武村　直紀, 植松　智
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 64 Pages: 70-77
- NAID
  40020540511
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.2014
- Author(s)
  Takemura, N., et al.
- Journal Title
  
  Nature Commun.
  
  Volume: 5 Issue: 1 Pages: 3492-3492
- DOI
  10.1038/ncomms4492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23689030, KAKENHI-PROJECT-24590582, KAKENHI-PROJECT-25860353, KAKENHI-PROJECT-25870165
[Journal Article] Gastric emptying is involved in Lactobacillus colonisation in mouse stomach2014
- Author(s)
  Sahasakul Y, Takemura N, Sonoyama K.
- Journal Title
  
  Br J Nutr
  
  Volume: 112 Issue: 3 Pages: 408-415
- DOI
  10.1017/s0007114514000968
- NAID
  120005661428
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] TLR3を介した放射線誘導性腸上皮傷害機構2014
- Author(s)
  武村　直紀,　植松　智
- Journal Title
  
  Isotope News
  
  Volume: 727 Pages: 2-8
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] 放射線誘導性腸上皮傷害における増悪因子としてのTLR3の役割2014
- Author(s)
  武村　直紀,　植松　智
- Journal Title
  
  日本インターフェロン・サイトカイン学会ニュースレター
  
  Volume: 38 Pages: 19-30
- Data Source
  KAKENHI-PROJECT-25870165
[Journal Article] The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling2013
- Author(s)
  Kawasaki T, Takemura N, Standley DM, Akira S, Kawai T
- Journal Title
  
  Cell Host Microbe
  
  Volume: 14;14(2) Issue: 2 Pages: 148-58
- DOI
  10.1016/j.chom.2013.07.011
- NAID
  120005716837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689030, KAKENHI-PROJECT-25870165
[Journal Article] KK/Ta Mice Administered <i>Lactobacillus plantarum</i> Strain No. 14 Have Lower Adiposity and Higher Insulin Sensitivity2013
- Author(s)
  Okubo T, Takemura N, Yoshida A, Sonoyama K
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 32 Issue: 3 Pages: 93-100
- DOI
  10.12938/bmfh.32.93
- NAID
  10031193314
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380069, KAKENHI-PROJECT-25870165
[Patent] 放射線障害の治療又は予防剤ならびに治療又は治療方法2018
- Inventor(s)
  植松智、武村直紀、森聖寿、岡田和樹
- Industrial Property Rights Holder
  植松智、武村直紀、森聖寿、岡田和樹
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19148
[Patent] 放射線障害の治療方法2017
- Inventor(s)
  発明者植松智、武村直紀、岡田和樹、森聖寿
- Industrial Property Rights Holder
  発明者植松智、武村直紀、岡田和樹、森聖寿
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-010542
- Filing Date
  2017-01-24
- Data Source
  KAKENHI-PROJECT-16K19148
[Patent] ワクチン用アジュバント、ワクチン組成物、及び免疫誘導方法2016
- Inventor(s)
  植松智、武村直紀
- Industrial Property Rights Holder
  植松智、武村直紀
- Industrial Property Rights Type
  特許
- Filing Date
  2016-06-10
- Overseas
- Data Source
  KAKENHI-PROJECT-16K19148
[Patent] PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RADIATION-INDUCED GASTROINTESTINAL SYNDROME2013
- Inventor(s)
  植松　智、武村　直紀、審良　静男
- Industrial Property Rights Holder
  植松　智、武村　直紀、審良　静男
- Industrial Property Rights Type
  特許
- Filing Date
  2013-07-30
- Overseas
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] インフラマソーム非依存的パイロトーシスに起因する微粒子疾患とその制御2023
- Author(s)
  武村直紀
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 環境中微粒子がもたらす炎症性疾患とその制御2022
- Author(s)
  武村直紀
- Organizer
  第29回日本免疫毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] インフラマソームの活性化を阻害するプロスタグランジン類の解析2022
- Author(s)
  武村直紀，西田周平，田浦学，齊藤達哉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 刺激性微粒子による炎症応答を阻害する生薬由来化合物の解析2022
- Author(s)
  生駒健太，武村直紀，齊藤達哉
- Organizer
  第21回・次世代を担う若手のためのファーマ・バイオフォーラム2022
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction2022
- Author(s)
  Naoki Takemura, Tatsuya Saitoh
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] パイロトーシスを標的とする新たな機序で働く抗炎症薬の開発2022
- Author(s)
  武村直紀，生駒健太，松井裕大，齊藤達哉
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 刺激性微粒子による炎症応答を阻害する生薬由来化合物の解析2022
- Author(s)
  生駒健太，武村直紀，田浦学，君嶋敦，荒井雅吉，齊藤達哉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] Nanaomycin類化合物はイミキモド誘導性乾癬を抑制する2022
- Author(s)
  松井裕大，武村直紀，田浦学，齊藤達哉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 極小微粒子により誘導される炎症応答を阻害する化合物の探索2021
- Author(s)
  潘逸羲，武村直紀，齊藤達哉
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] Oridonin as a potential therapeutic agent for microparticle-induced inflammatory diseases2021
- Author(s)
  Naoki Takemura, Manabu Taura, Tatsuya Saitoh
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 刺激性微粒子により誘導される細胞死の解析2021
- Author(s)
  生駒健太，武村直紀，田浦学，小迫英尊，齊藤達哉
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 微粒子による現代病を防ぐ延命草茶成分Oridoninの解析2021
- Author(s)
  生駒健太, 武村直紀
- Organizer
  日本食品免疫学会第17回学術大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 抗炎症作用を有する新規化合物の腸炎制御剤としての活性評価2021
- Author(s)
  東優一，森田明典，西山祐一，村田貴嗣，酒井杏樹，金井昭教，谷本大河，坂井卓磨，中田健也，武村直紀，齊藤達哉，稲葉俊哉，椎名勇
- Organizer
  日本Cell Death学会第29回学術集会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] Nanaomycin類化合物はイミキモド誘導性乾癬を抑制する2021
- Author(s)
  武村直紀，松井裕大，田浦学，齊藤達哉
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 免疫調節作用を有する新規化合物は亜全身照射による腸死を防ぐ2021
- Author(s)
  谷本大河，森田明典，西山祐一，村田貴嗣，酒井杏樹，金井昭教，東優一，國井大誓，坂井卓磨，貞富凌，王冰，下川卓志，中田健也，武村直紀，齊藤達哉，稲葉俊哉，椎名勇
- Organizer
  日本放射線影響学会第 64 回大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] インフラマソームの活性化を阻害するプロスタグランジン類の解析2021
- Author(s)
  西田周平，武村直紀，田浦学，齊藤達哉
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-21K19083
[Presentation] 刺激性微粒子による炎症応答を抑制する生薬由来化合物の解析2020
- Author(s)
  生駒健太, 武村直紀, 齊藤達哉
- Organizer
  日本薬学会第 140 年会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Nanaomycin AはATP誘導性の炎症を抑える2020
- Author(s)
  武村直紀, 松井裕大, 齊藤達哉
- Organizer
  日本薬学会第 140 年会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] 15d-Prostaglandin J2はインフラマソームが誘導する炎症を抑制する2019
- Author(s)
  佐々木稜介, 武村直紀, 齊藤達哉
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Eosinophil Depletion Suppresses Radiation-Induced Small Intestinal Fibrosis2019
- Author(s)
  武村直紀
- Organizer
  11th Biennial Symposium of the International Eosinophil Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Nanaomycin AはATP誘導性の炎症を抑える2019
- Author(s)
  松井裕大, 武村直紀, 齊藤達哉
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] 刺激性微粒子による炎症応答を抑制する生薬由来化合物の解析2019
- Author(s)
  生駒健太, 武村直紀
- Organizer
  日本食品免疫学会設立15周年記念学術大会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Nanaomycin AはNLRP3インフラマソームの活性化を阻害する2019
- Author(s)
  武村直紀, 松井裕大, 齊藤達哉
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] 刺激性微粒子によるIL-1αおよびIL-1βの放出を阻害する化合物の探索2019
- Author(s)
  生駒健太, 武村直紀, 齊藤達哉
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] インフラマソームを制御するオルガネラ・ゾーンの解析2019
- Author(s)
  武村直紀, 佐々木稜介, 齊藤達哉
- Organizer
  第３回オルガネラゾーン研究会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] 生体防御応答を制御するオルガネラ・ゾーンの解析2019
- Author(s)
  武村直紀, 齊藤達哉
- Organizer
  第2回新学術領域「オルガネラ・ゾーン」全体班会議
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Prime-boost vaccination with CpG ODN and curdlan strongly induces both systemic and mucosal immunity2018
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  第11回次世代アジュバント研究会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Intestinal dendritic cell and mucosal vaccine development.2018
- Author(s)
  Naoki Takemura.
- Organizer
  第11回次世代アジュバント研究会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Combination adjuvant containing TLR and Dectin-1 agonists strongly induces mucosal and systemic immunity.2017
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  第10回次世代アジュバント研究会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府　豊中市）
- Year and Date
  2017-01-23
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] A new prime-boost vaccine method to strongly induce both systemic and mucosal immunity.2017
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  Korea-Japan joint meeting on mucosal immunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.2017
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  5th Annual Meeting of the International Cytokine & Interferon Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Prime-boost vaccination with CpG ODN and curdlan strongly induces both systemic and mucosal immunity.2017
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Immunization with GM-CSF-induced RALDH2-expressing dendritic cells induce antigen-specific IgA and Th responses in intestine.2016
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県　宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] 放射線性小腸繊維症は上皮細胞死を起因とする好酸球性炎症によって誘導される2016
- Author(s)
  武村　直紀、植松　智
- Organizer
  第25回日本Cell Death学会学術集会
- Place of Presentation
  きゅりあん（東京都　品川区）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Development of a new vaccine strategy to induce antigen-specific immune responses in intestine.2016
- Author(s)
  Naoki Takemura, Satoshi Uematsu.
- Organizer
  マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  ソラシティ・カンファレンスセンター（東京都　千代田区））
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19148
[Presentation] Innate Immune Responses in Radiation-induced Intestinal Injury2015
- Author(s)
  Naoki Takemura
- Organizer
  The 15th International Congress of Radiation Research Symposium
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] TLR3 EXACERBATES RADIATION-INDUCED GASTROINTESTINAL SYNDROME BY INDUCING EXTENSIVE CRYPT CELL DEATH2015
- Author(s)
  Naoki Takemura, Satoshi Uematsu
- Organizer
  Japan Australia Meeting ON CELL DEATH
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Resident myofibroblasts and eosinophils create a mutual activation loop for submucosal fibrosis in small intestine after abdominal irradiation2015
- Author(s)
  Satoshi Uematsu,Naoki Takemura
- Organizer
  TOLL2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Interaction of eosinophils with alpha-SMA+ stromal cells create a positive feedback loop for fibrosis of small intestine after abdominal irradiation2015
- Author(s)
  Naoki Takemura, Satoshi Uematsu
- Organizer
  The 44th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] TLR3 As an Exacerbating Factor for Radiation-Induced Gastrointestinal Syndrome2013
- Author(s)
  Naoki Takemura, Shizuo Akira, Hiroshi Kiyono, Satoshi Uematsu
- Organizer
  題４２回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ（千葉県千葉市美浜区）
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Innate immune responses in radiation-induced intestinal injury
- Author(s)
  Naoki Takemura
- Organizer
  The 15th International Congress of Radiation Research
- Place of Presentation
  京都府、京都市
- Year and Date
  2015-05-25 – 2015-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Resident myofibroblasts and eosinophils mediate radiation-induced intestinal fibrosis
- Author(s)
  Naoki Takemura, Kouta Matsunaga, Satoshi Uematsu
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  京都府、京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
- Author(s)
  Naoki Takemura, Satoshi Uematsu
- Organizer
  The 13th Awaji International Forum on Infection and Immunity
- Place of Presentation
  奈良県、奈良市
- Year and Date
  2014-09-23 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-25870165
[Presentation] Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
- Author(s)
  Naoki Takemura, Satoshi Uematsu
- Organizer
  2015 Keystone Symposia Conference C1
- Place of Presentation
  Keystone, USA
- Year and Date
  2015-03-01 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-25870165

1. KAWAI Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. KUMAGAI Yutaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 田中廣壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 植松智

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 伊沢久未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 丸山健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 有井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 野村政壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 原田慶恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takemura Naoki 武村 直紀

Takemura NaokiNaoki 武村 直紀

Research Projects

Research Products

Co-Researchers

Elucidation of new molecular mechanisms linking airborne particulate mater-induced cell death and respiratory diseasesPrincipal Investigator

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Evaluation of micro- and nano-sized plastics as a risk factor for food allergyPrincipal Investigator

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Development of prophylactic strategies for acute and chronic radiation-induced gastrointestinal syndrome by targeting the innate immune systemPrincipal Investigator

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Study on the role of TLR3 in radiation-induced gastrointestinal syndromePrincipal Investigator

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[Book] 標準生理学 第９版2019

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[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

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[Journal Article] パイロトーシスによる自然炎症とその制御―オルガネラを標的とする新たな抗炎症薬の開発2022

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[Journal Article] Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia2022

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[Journal Article] Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.2022

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[Journal Article] Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction2022

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[Journal Article] Macrophage Response Driven by Extracellular ATP2021

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[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021

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[Journal Article] PRRを介した炎症反応における細胞骨格の役割2021

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Journal Title

Data Source

[Journal Article] NLRP3 インフラマソームを標的とした痛風性関節炎の治療戦略2019

Author(s)

Journal Title

NAID

Takemura Naoki 武村直紀

Takemura NaokiNaoki 武村直紀

[Book] 標準生理学　第９版2019