koto kazutaka 小藤和孝

… Alternative Names

KOTO Kazutaka 小藤和孝

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Researcher Number	50649340
Affiliation (Current)	2025: 明治国際医療大学, 臨床医学講座, 教授
Affiliation (based on the past Project Information) *help	2016 – 2017: 明治国際医療大学, 医学教育研究センター, 准教授 2015: 明治国際医療大学, 医学教育研究センター, 講師 2013 – 2014: 明治国際医療大学, 公私立大学の部局等, 講師 2012: 明治国際医療大学, 講師
Review Section/Research Field	Except Principal Investigator Orthopaedic surgery
Keywords	Except Principal Investigator 骨肉腫 / ビスホスホネート / 軟部肉腫 / アポトーシス / 放射線治療 / 超音波 / parathyroid Hormone / 徐放 / ハイドロキシアパタイト / 骨セメント … More / 転移性骨腫瘍 / ビスホスフォネート / P53遺伝子 / p53遺伝子 / 悪性軟部腫瘍 / 悪性骨腫瘍 / p53 遺伝子 / 化学療法 / スルフォラファン / 線維肉腫 Less

Development of non-operative treatment for local control and new bone formation against metastatic bone tumors
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Development of new treatments against malignant bone and soft tissue tumors by using bisphosphonate and ionizing radiation
- Principal Investigator
  
  MURATA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular-targeting chemotherapy related to p53-RB for malignant bone and soft tissue tumors
- Principal Investigator
  
  TSUJI Yoshiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine

All 2017 2016 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Cytotoxic effects of zoledronic acid-loaded hydroxyapatite and bone cement in malignant tumors2017
- Author(s)
  Koto Kazutaka、Murata Hiroaki、Sawai Yasushi、Ashihara Eishi、Horii Motoyuki、Kubo Toshikazu
- Journal Title
  
  Oncology Letters
  
  Volume: 14 Issue: 2 Pages: 1648-1656
- DOI
  10.3892/ol.2017.6355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462274
[Journal Article] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells2013
- Author(s)
  Y. Sawai, H. Murata, M. Horii, K. Koto,T. Matsui, N. Horie, Y. Tsuji, E. Ashihara, T. Maekawa, T. Kubo, S. Fushiki
- Journal Title
  
  Oncol Rep
  
  Volume: 29 Issue: 3 Pages: 941-945
- DOI
  10.3892/or.2012.2195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591668, KAKENHI-PROJECT-23591404, KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PUBLICLY-23112507
[Journal Article] Zoledronic acid significantly enhances radiation induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.2013
- Author(s)
  8. Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S.
- Journal Title
  
  Int J Oncol
  
  Volume: 42 Issue: 2 Pages: 525-534
- DOI
  10.3892/ijo.2012.1735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591404, KAKENHI-PROJECT-23592196, KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PUBLICLY-23112507
[Journal Article] A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells2010
- Author(s)
  T.A. Matsui, H. Murata, Y. Sowa, T. Sakabe, K. Koto, N. Horie, Y. Tsuji, T. Sakai, T. Kubo
- Journal Title
  
  Oncol Rep
  
  Volume: 24 Issue: 2 Pages: 329-333
- DOI
  10.3892/or_00000863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591668
[Presentation] Cytotoxic Effects of Zoledronic Acid-Loaded Hydroxyapatite/Bone Cement on Several Cancer Cell Lines2016
- Author(s)
  Koto K, Murata H, Sawai Y, Horii M, Kubo K
- Organizer
  11th Asia Pacific Musculoskeletal Tumour Society
- Place of Presentation
  Singapore
- Year and Date
  2016-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462274
[Presentation] Zoledronic Acid Significantly Enhances Radiation-Induced Cement on Several Cancer Cell Lines2016
- Author(s)
  Murata H, Koto K, Sawai Y, Horii M, Kubo K
- Organizer
  11th Asia Pacific Musculoskeletal Tumour Society
- Place of Presentation
  Singapore
- Year and Date
  2016-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462274
[Presentation] Zoledronic acid significantly enhances radiation-induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling2013
- Author(s)
  Koto K, Murata H, Matsui TA, Horie N, Sawai Y, Ashihara E, Kimura S, Maekawa T, Fushiki S, Horii M, Kubo T
- Organizer
  International Society of Limb Salvage 17th General Meeting
- Place of Presentation
  Bologna, Italy
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] The third-generation bisphosphonate shows combined effects with anti-tumor drugs in human fibrosarcoma cells2013
- Author(s)
  Murata H, Koto K, Sawai Y, Matsui TA, Horie N, Fushiki S, Kimura S, Maekawa T, Horii M, Kubo T
- Organizer
  International Society of Limb Salvage 17th General Meeting
- Place of Presentation
  Bologna, Italy
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells2013
- Author(s)
  Y. Sawai, H. Murata, M. Horii, K. Koto,T. Matsui, N. Horie, Y. Tsuji, E. Ashihara, T. Maekawa, T. Kubo, S. Fushiki
- Organizer
  2013 Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Antonio, USA
- Data Source
  KAKENHI-PROJECT-22591668
[Presentation] Combined effects of the Third-Generation Bisphosphonate and Radiation on Fibrosarcoma Cells2012
- Author(s)
  Koto K, Murata H, Sakabe T, Matsui TA, Horie N, Sawai Y, Ashihara E, Kimura S, Maekawa T, Fushiki S, Kubo T
- Organizer
  13th EFORT Congress
- Place of Presentation
  Berlin, Germany
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] 線維肉腫細胞株に対するゾレドロン酸と放射線の併用による細胞内シグナル伝達経路への影響の検討2012
- Author(s)
  小藤和孝,堀井基行,村田博昭,松井隆明,堀江直行,澤井泰志,久保俊一
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] マウス骨肉腫細胞株に対するsulforaphane の放射線増感作用の検討2012
- Author(s)
  澤井泰志、村田博昭、小藤和孝、松井隆明、堀江直行、堀井基行、久保俊一
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591668
[Presentation] 線維肉腫細胞株に対する第3世代ビスフォスフォネートと放射線の併用による抗腫瘍効果の検討2011
- Author(s)
  小藤和孝，村田博昭，坂部智哉，松井隆明，堀江直行，澤井泰志，久保俊一
- Organizer
  第44回日本整形外科学会骨・軟部腫瘍学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] 線維肉細胞株に対するゾレドロン酸と放射線の併用によるアポトーシス誘導効果および細胞内シグナル伝達経路への影響の検討2011
- Author(s)
  小藤和孝,村田博昭,坂部智哉,大島康史,松井隆明,堀江直行,澤井泰志,久保俊一
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] 線維肉細胞株に対する第3世代ビスフォスフォネートと放射線の併用による抗腫瘍効果の検討2011
- Author(s)
  小藤和孝,村田博昭,坂部智哉,松井隆明,堀江直行,澤井泰志,久保俊一
- Organizer
  第44回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] Effect of a specific MEK inhibitor against human fibrosarcoma cells2010
- Author(s)
  T. Matsui, H. Murata, T. Sakabe, K. Koto, N. Horie, Y. Sowa, T. Sakai, T. Kubo
- Organizer
  8th Asis Pacific Musculoskeletal Tumor Society Meeting
- Place of Presentation
  Cebu, Philippines
- Data Source
  KAKENHI-PROJECT-22591668
[Presentation] 線維肉腫細胞株に対するゾレドロン酸と放射線の併用による細胞内シグナル伝達経路への影響の検討
- Author(s)
  小藤和孝，堀井基行，村田博昭，松井隆明，堀江直行, 澤井泰志，久保俊一
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] Combined effects of the Third-Generation Bisphosphonate and Radiation on Fibrosarcoma Cells
- Author(s)
  Koto K, Murata H, Sakabe T, Matsui TA, Horie N, Sawai Y, Ashihara E, Kimura S, Maekawa T, Fushiki S, Kubo T.
- Organizer
  13th EFORT Congress 2012
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23592196
[Presentation] マウス骨肉腫細胞株に対するsulforaphaneの放射線増感作用の検討
- Author(s)
  澤井泰志，村田博昭，小藤和孝，松井隆明，堀江直行，堀井基行，久保俊一(澤井泰志)
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591668

1. MURATA Hiroaki (90360031)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. ASHIHARA Eishi (70275197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TSUJI Yoshiro (70453123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. MAEKAWA Taira (80229286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. KIMURA Shinya (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

koto kazutaka 小藤 和孝

KOTO Kazutaka 小藤 和孝

Research Projects

Research Products

Co-Researchers

Development of non-operative treatment for local control and new bone formation against metastatic bone tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new treatments against malignant bone and soft tissue tumors by using bisphosphonate and ionizing radiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular-targeting chemotherapy related to p53-RB for malignant bone and soft tissue tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cytotoxic effects of zoledronic acid-loaded hydroxyapatite and bone cement in malignant tumors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zoledronic acid significantly enhances radiation induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] Cytotoxic Effects of Zoledronic Acid-Loaded Hydroxyapatite/Bone Cement on Several Cancer Cell Lines2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Zoledronic Acid Significantly Enhances Radiation-Induced Cement on Several Cancer Cell Lines2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Zoledronic acid significantly enhances radiation-induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] The third-generation bisphosphonate shows combined effects with anti-tumor drugs in human fibrosarcoma cells2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Combined effects of the Third-Generation Bisphosphonate and Radiation on Fibrosarcoma Cells2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 線維肉腫細胞株に対するゾレドロン酸と放射線の併用による細胞内シグナル伝達経路への影響の検討2012

Author(s)

Organizer

Place of Presentation

koto kazutaka 小藤和孝

KOTO Kazutaka 小藤和孝