IMAI MISA 今井美沙

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IMAI Misa 今井美沙

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Researcher Number	50709003
Other IDs	https://orcid.org/0000-0002-5192-5957
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 非常勤助教 2020: 順天堂大学, 医学(系)研究科(研究院), 非常勤助教 2014 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology / Obstetrics and gynecology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology / Developmental mechanisms and the body works
Keywords	Principal Investigator 骨髄増殖性腫瘍 / CALR / calreticulin / 骨髄繊維化 / 血液腫瘍学 / MPN / サイトカイン非依存性増殖 / ドライバー遺伝子変異 / 全エクソン配列解析 / 造血器腫瘍 … More / triple-negative MPN / 境界悪性腫瘍 / 婦人科腫瘍 / 卵巣がん / 稀少がん / がんの浸潤・転移 / 婦人科系がん / 顆粒膜細胞腫 / GPRC5B … More Except Principal Investigator 骨髄増殖性腫瘍 / calreticulin / 本態性血小板血症 / CALR / CD44 / 原発性骨髄線維症 / JAK2V617F / カルレティキュリン / 抗体 / 分子シャペロン / トロンボポエチン / トロンボポエチン受容体 / 造血幹細胞 / triple-negative / 診断マーカー / 転写因子 / 小胞体ストレス / 巨核球 / 血小板 / 小胞体ストレス応答因子 / 変異型CALR / 低分子化合物 / mutant CALR / 薬剤反応性 / 遺伝子変異 / スタチン / JAK2遺伝子変異 / ヒドロキシウレア / 個別化治療 / non-responder / アナグレリド / 緩和ケア / 対話学 / 生死観の教育 / がん哲学外来 / がん教育 / 死生観の教育 Less

骨髄増殖性腫瘍幹細胞におけるCD44を中心とする接着因子発現・機能の調節機構解明
- Principal Investigator
  
  後藤明彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
変異型CALRを標的とした骨髄増殖性腫瘍治療法の開発
- Principal Investigator
  
  荒木真理人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Elucidation of the mechanism of bone marrow fibrosis by focusing on the differences in tumorigenicity between mutant CALR typesPrincipal Investigator
- Principal Investigator
  
  今井美沙
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Elucidate the autonomous activation mechanism of thrombopoietin receptor without genetic mutation
- Principal Investigator
  
  Yang Yinjie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Understanding the mechanism of cell tumorigenesis promoted by essential thrombocythemia specific transcriptional network
- Principal Investigator
  
  Komatsu Norio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Development of novel therapeutic strategies for myeloproliferative neoplasms caused by mutant CALR
- Principal Investigator
  
  Yang Yinjie
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Individualized pharmacotherapy for essential thrombocythemia using pharmacogenomic information
- Principal Investigator
  
  Takahashi Harumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Meiji Pharmaceutical University
Development of a novel therapeutic method for myeloproliferative neoplasia by identifying a novel driver mutation and analyzing its function.Principal Investigator
- Principal Investigator
  
  Imai Misa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Establishment of "cancer education and dialogue" based on "cancer philosophy"
- Principal Investigator
  
  Hino Okio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Developmental mechanisms and the body works
- Research Institution
  Juntendo University
IDENTIFICATION OF CANDIDATE GENES FOR GRANULOSA CELL TUMOR PROGRESSIONPrincipal Investigator
- Principal Investigator
  
  IMAI Misa
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Juntendo University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms2023
- Author(s)
  Liu Chang、Imai Misa、Edahiro Yoko、Mano Shuichi、Takei Hiraku、Nudejima Mai、Kurose Akira、Morishita Soji、Ando Miki、Tsuneda Satoshi、Araki Marito、Komatsu Norio
- Journal Title
  
  Experimental Hematology
  
  Volume: 118 Pages: 12-20
- DOI
  10.1016/j.exphem.2022.11.005
- Data Source
  KAKENHI-PROJECT-21K08376
[Journal Article] Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors2022
- Author(s)
  Tanaka Yosuke....Goyama Susumu、Komatsu Norio、Takaku Tomoiku、Kitamura Toshio
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 271-271
- DOI
  10.1038/s41467-021-27928-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms2022
- Author(s)
  De Marchi Federico、Okuda Maho、Morishita Soji、Imai Misa、Baba Terumi、Horino Mei、Mori Yosuke、Furuya Chiho、Ogata Satoko、Yang Yinjie、Ando Jun、Ando Miki、Araki Marito、Komatsu Norio
- Journal Title
  
  Leukemia Research
  
  Volume: 119 Pages: 106883-106883
- DOI
  10.1016/j.leukres.2022.106883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-21K16275, KAKENHI-PROJECT-20H03715
[Journal Article] Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non‐neoplastic erythrocytosis patients2022
- Author(s)
  Mori Yosuke、Araki Marito、Morishita Soji、Imai Misa、Edahiro Yoko、Ito Masafumi、Ochiai Tomonori、Shirane Shuichi、Hashimoto Yoshinori、Yasuda Hajime、Ando Jun、Ando Miki、Komatsu Norio
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 2 Pages: 1079-1089
- DOI
  10.1002/cam4.4958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-20H03715
[Journal Article] In silico-labeled ghost cytometry2021
- Author(s)
  Ugawa M、Kawamura Y、Toda K、Teranishi K、Morita H、Adachi Hiroaki、Tamoto Ryo、Nomaru Hiroko、Nakagawa Keiji、Sugimoto Keiki、Borisova Evgeniia、An Y、Konishi Y、Tabata S、Morishita S、Imai M、Takaku T、Araki M、Komatsu N、Hayashi Y、Sato I、Horisaki R、Noji H、Ota S
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.67660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08376
[Journal Article] Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia2021
- Author(s)
  Inano Tadaaki、Araki Marito、Morishita Soji、Imai Misa、Kihara Yoshihiko、Okuda Maho、Yang Yinjie、Ito Masafumi、Osaga Satoshi、Mano Hiroyuki、Edahiro Yoko、Ochiai Tomonori、Misawa Kyohei、Fukuda Yasutaka、Ando Jun、Komatsu Norio
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17702-17702
- DOI
  10.1038/s41598-021-97106-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-21K16250, KAKENHI-PROJECT-21K16275
[Journal Article] CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome?negative myeloproliferative neoplasms2020
- Author(s)
  Morishita Soji、Yasuda Hajime、Yamawaki Saya、Kawaji Hideya、Itoh Masayoshi、Edahiro Yoko、Imai Misa、Kogo Yasushi、Tsuneda Satoshi、Ohsaka Akimichi、Hayashizaki Yoshihide、Ito Masafumi、Araki Marito、Komatsu Norio
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 2 Pages: 884-892
- DOI
  10.1111/cas.14763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-20H03715, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848
[Journal Article] Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy2019
- Author(s)
  Fukuda Yasutaka、Araki Marito、Yamamoto Kouji、Morishita Soji、Inano Tadaaki、Misawa Kyohei、Ochiai Tomonori、Edahiro Yoko、Imai Misa、Yasuda Hajime、Gotoh Akihiko、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Haematologica
  
  Volume: 印刷中 Issue: 11 Pages: e506-e509
- DOI
  10.3324/haematol.2018.208876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17K16195
[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019
- Author(s)
  Masubuchi Nami、Araki Marito、Yang Yinjie、Hayashi Erina、Imai Misa、Edahiro Yoko、Hironaka Yumi、Mizukami Yoshihisa、Kihara Yoshihiko、Takei Hiraku、Nudejima Mai、Koike Masato、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 2 Pages: 499-509
- DOI
  10.1038/s41375-019-0564-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126
[Journal Article] JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive mutation to polycythaemia vera2019
- Author(s)
  Inano, T. Araki, M. Morishita, S. Imai, M. Yasuda, H. Nitta, H. Ito, M. Edahiro, Y. Ochiai, T. Misawa, K. Fukuda, Y. Ohsaka, A. Komatsu, N.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 187 Issue: 1
- DOI
  10.1111/bjh.16146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17K16195
[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihsa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中 Issue: 6 Pages: 791-802
- DOI
  10.1111/bjh.15266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11017, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-18H04164
[Journal Article] Somatic mutations of calreticulin in myeloproliferative neoplasms2017
- Author(s)
  Imai Misa、Araki Marito、Komatsu Norio
- Journal Title
  
  Int J Hematol
  
  Volume: 105 Issue: 6 Pages: 743-747
- DOI
  10.1007/s12185-017-2246-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-17H04211
[Journal Article] Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells2017
- Author(s)
  Sunami Yoshitaka、Araki Marito、Kan Shin、Ito Akihiro、Hironaka Yumi、Imai Misa、Morishita Soji、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 7 Pages: 2815-2829
- DOI
  10.1074/jbc.m116.745398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16195
[Journal Article] Environmental carcinognensis-100th anniversary of creating cancer.2015
- Author(s)
  Misa Imai, Okio Hino
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 11 Pages: 1483-1485
- DOI
  10.1111/cas.12798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861341, KAKENHI-PROJECT-221S0001
[Journal Article] Asbestos-related mesothelioma: Prevention, early detection, treatment.2014
- Author(s)
  Misa Imai and Okio Hino
- Journal Title
  
  JSM Clinical Oncology and Research
  
  Volume: 2 Pages: 1018-1019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861341
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin2022
- Author(s)
  Yoshikawa S, Araki M, Lihara Y, Masubuchi M, Yang Y, Morishita S, Imai M, Ydahiro Y, Ando M, Komatsu N
- Organizer
  第84回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Clinical relevance of CREB3L1 expression in Ph-negative MPN2022
- Author(s)
  Soji Morishita, Federico De Marchi, Maho Okuda, Misa Imai, Terumi Baba, Yosuke Mori, Chiho Furuya, Satoko Ogata, Yinjie Yang, Jun Ando, Miki Ando, Marito Araki, Norio Komatsu
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin.2022
- Author(s)
  Shumpei Yoshikawa, Marito Araki, Yoshihiko Kihara, Nami Masubuchi, Yinjie Yang, Soji Morishita, Misa Imai, Yoko Edahiro, Miki Ando, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08424
[Presentation] Specific expression of CREB3L1 in megakaryocyte in myeloproliferative neoplasms2021
- Author(s)
  Okuda M，Araki M，Federico D，Morishita S，Imai M，Mori Y，Horino M，Ochiai T，Shirame S，Edahiro Y，Ando J，Komatsu N
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] JAK2 mutation discriminates neoplastic and non-neoplastic polycythemia.2021
- Author(s)
  Mori Y, Araki M, Morishita S, Imai M, Edahiro Y, Ito M, Ochiai T, Shirane S, Hashimoto Y, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients.2021
- Author(s)
  Satoko Ogata，Marito Araki，Yoshihiko Kihara，Maho Okuda， Soji Morishita，Misa Imai，Nami Masubuchi，Yosuke Mori，Yang Yinjie，Syunpei Yoshikawa，Tomonori Ochiai，Shuichi Shirane， Yoko Edahiro，Jun Ando，Norio Komatsu.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08424
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients2021
- Author(s)
  Ogata S, Araki M, Kihara Y, Okuda M, Morishita S, Imai M, Masubuchi N, Mori Y, Yang Y, Yoshikawa S, Ochiai T, Shirane S, Edahiro Y, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Specific expression of CREB3L1 in megakaryocyte in myeloproliferative neoplasms2021
- Author(s)
  Okuda M, Araki M, Federico M, Morishita S, Imai M, Mori Y, Horino M, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin.2020
- Author(s)
  Kihara Y, Araki M, Imai M, Fukuda Y, Mori Y, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Mizukami Y, Morishita S, Akazawa C, Ohsaka A, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] CREB3L1 overexpression as a novel diagnostic marker of Philadelphia-negative myeloproliferative neoplasms2020
- Author(s)
  Soji Morishita, Hajime Yasuda, Saya Yamawaki, Hideya Kawaji, Masayoshi Itoh, Yoko Edahiro, Misa Imai, Yasushi Kogo, Satoshi Tsuneda, Akimichi Ohsaka, Yoshihide Hayashizaki, Marito Araki, and Norio Komatsu
- Organizer
  The 82nd Annual Meeting of Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] Analysis of behavior of erythropoietin receptor on the cell surface in JAK2 mutant cells.2020
- Author(s)
  Shioiri K, Araki M, Kitazawa S, Masubuchi N, Morishita S, Imai M, Ohsaka A, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] CREB3L1 Overexpresion Can Reliably Discriminate Ph-MPNs From Reactive Cases2020
- Author(s)
  Soji Morishita, Hajime Yasuda, Saya Yamawaki, Hideya Kawaji, Masayoshi Itoh, Yoko Edahiro, Misa Imai, Yasushi Kogo, Satoshi Tsuneda, Akimichi Ohsaka, Yoshihide Hayashizaki, Marito Araki, and Norio Komatsu
- Organizer
  The 63rd American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] CREB3L1 overexpression as a novel diagnostic marker of myeloproliferative neoplasms.2020
- Author(s)
  Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Araki M, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] JAK2 V617Fのコピー数はサイトカイン受容体の活性化に重要である.2019
- Author(s)
  北澤爽汰, 荒木真理人, 塩入香穂, 森下総司, 増渕菜弥, 馬場照美, 山本誠司, 堀内祥行, 今井美沙, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム.2019
- Author(s)
  荒木真理人, 楊印杰, 増渕菜弥, 林英里奈, 水上喜久, 木原慶彦, 今井美沙, 弘中由美, 橳島麻衣, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定.2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林絵里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] 真性多血症患者由来iPS細胞におけるJAK2 V617F変異の修正.2019
- Author(s)
  枝廣陽子, 劉暢, 荒木真理人, 橳島麻衣, 森下総司, 今井美沙, 増渕菜弥, 水上喜久, 眞野修一, 竹井拓, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす.2019
- Author(s)
  増渕菜弥, 荒木真理人, 楊印杰, 林英里奈, 今井美沙, 枝廣陽子, 弘中由美, 水上喜久, 木原慶彦, 小池正人, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 分泌経路における変異型分子シャぺロンとサイトカイン受容体の会合による細胞の腫瘍化.2019
- Author(s)
  増渕菜弥, 荒木真理人, 木原慶彦, 楊印杰, 今井美沙, 水上喜久, 林英里奈, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] CALR遺伝子変異による骨髄増殖性腫瘍モデルマウスの作出.2019
- Author(s)
  今井美沙, 福田泰隆, 田口鉄平, 三澤恭平, 童紅連, 荒木喜美, 大里元美, 荒木真理人, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型calreticulin特異的配列によるゴルジ体への局在.2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林英里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型calreticulin特異的配列によるゴルジ体への局在.2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林英里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] JAK2 exon 12変異およびSF3B1 変異を有する MDS/MPN-RS-T における腫瘍クローンの様相の解明.2019
- Author(s)
  稲野資明, 荒木真理人, 森下総司, 今井美沙, 新田英昭, 伊藤雅文, 福田泰隆, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型CALRはMPLと分泌経路で相互作用し細胞表面で活性化を引き起こす.2019
- Author(s)
  増渕菜弥, 荒木真理人, 楊印杰, 林英里奈, 今井美沙, 枝廣陽子, 弘中由美, 水上喜久, 木原慶彦, 小池正人, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] 全トランス型レチノイン酸による白血病細胞分化制御因子の同定.2019
- Author(s)
  角南義孝, 荒木真理人, 山本誠司, 白根脩一, 堀内祥行, 辻岡一也, 茂櫛薫, 山口茂夫, 今井美沙, 森下総司, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定.2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林絵里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 分泌経路における変異型分子シャぺロンとサイトカイン受容体の会合による細胞の腫瘍化.2019
- Author(s)
  増渕菜弥, 荒木真理人, 木原慶彦, 楊印杰, 今井美沙, 水上喜久, 林英里奈, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] 真正トリプルネガティブ本態性血小板血症における臨床的・分子生物学的特異性.2019
- Author(s)
  稲野資明, 荒木真理人, 森下総司, 落合友則, 三澤恭平, 福田泰隆, 緑川直子, 橳島麻衣, 伊藤雅文, 大佐賀智, 枝廣陽子, 今井美沙, 田口鉄平, 奥田真帆, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 受容体活性化のにおいて野生型JAK2は変異型JAK2を抑制しているようである.2018
- Author(s)
  北澤爽汰, 荒木真理人, 森下総司, 楊印杰, 今井美沙, 大坂顕通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型 CALRの多量体化は MPLとの結合と活性化に必須である.2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] 細胞減少療法はPMF患者における腎機能の悪化を防止する.2018
- Author(s)
  福田泰隆, 荒木真理人, 山本紘司, 森下総司, 稲野資明, 三澤恭平, 落合友則, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin.2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Lihua Li, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Akimichi Ohsaka, Marito Araki and Norio Komatsu
- Organizer
  60th Annual Meeting of Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin.2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型 CALRの多量体化は MPLとの結合と活性化に必須である.2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] APL細胞の分化誘導におけるATRA標的遺伝子の同定.2018
- Author(s)
  角南義孝, 荒木真理人, 山本誠司, 堀内祥行, 辻岡一也, 茂櫛薫, 今井美沙, 森下総司, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型CALRタンパク質の発現を制御するメカニズム2017
- Author(s)
  木原慶彦, 荒木真理人, 楊印杰, 今井美沙, 増渕菜弥, 水上喜久, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] ATRAにより好中球細胞へ分化誘導されたAPL細胞の遺伝子発現プロファイル2017
- Author(s)
  角南義孝, 荒木真理人, 山本誠司, 堀内祥行, 茂櫛薫, 弘中由美, 今井美沙, 森下総司, 顯通大, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] カルレチキュリン変異を有する血球前駆細胞は巨核球への分化偏向性を有する2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 常田聡, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 変異型CALRによる巨核球分化偏向性はGATA2の発現亢進と相関している2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] 骨髄増殖性腫瘍に見出される変異型 CALR 蛋白質の細胞内局在2017
- Author(s)
  林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙, 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Mizukami Y, Hironaka Y, Takei H, Morishita S, Kihara Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Takei H, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  59th Annual Meeting of the American Society of Hematology and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16195
[Presentation] IDENTIFICATION OF CANDIDATE GENES FOR GRANULOSA CELL TUMOR PROGRESSION2016
- Author(s)
  Misa Imai
- Organizer
  GAP conference
- Place of Presentation
  ブラジル
- Year and Date
  2016-04-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861341

1. Komatsu Norio (50186798)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
2. 荒木真理人 (80613843)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
3. Yang Yinjie (90808643)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
4. 森下総司 (10635866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. Hino Okio (90127910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Takahashi Harumi (20211344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 後藤明彦 (00297293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 高野直治 (80445410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITO akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 合山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAI MISA 今井 美沙

IMAI Misa 今井 美沙

Research Projects

Research Products

Co-Researchers

骨髄増殖性腫瘍幹細胞におけるCD44を中心とする接着因子発現・機能の調節機構解明

Principal Investigator

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変異型CALRを標的とした骨髄増殖性腫瘍治療法の開発

Principal Investigator

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Research Institution

Elucidation of the mechanism of bone marrow fibrosis by focusing on the differences in tumorigenicity between mutant CALR typesPrincipal Investigator

Principal Investigator

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Research Institution

Elucidate the autonomous activation mechanism of thrombopoietin receptor without genetic mutation

Principal Investigator

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Research Institution

Understanding the mechanism of cell tumorigenesis promoted by essential thrombocythemia specific transcriptional network

Principal Investigator

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Research Institution

Development of novel therapeutic strategies for myeloproliferative neoplasms caused by mutant CALR

Principal Investigator

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Review Section

Research Institution

Individualized pharmacotherapy for essential thrombocythemia using pharmacogenomic information

Principal Investigator

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Research Institution

Development of a novel therapeutic method for myeloproliferative neoplasia by identifying a novel driver mutation and analyzing its function.Principal Investigator

Principal Investigator

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Research Institution

Establishment of "cancer education and dialogue" based on "cancer philosophy"

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

IDENTIFICATION OF CANDIDATE GENES FOR GRANULOSA CELL TUMOR PROGRESSIONPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms2023

Author(s)

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Data Source

[Journal Article] Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors2022

Author(s)

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DOI

Data Source

[Journal Article] Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms2022

Author(s)

Journal Title

DOI

Data Source

IMAI MISA 今井美沙

IMAI Misa 今井美沙