SHIRAI Toshiaki 白井俊光

… Alternative Names

Shirai Toshiaki 白井俊光

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Researcher Number	50710381
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 山梨大学, 大学院総合研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator CLEC-2 / 血小板 / 子宮内膜症 / 癌関連血栓症 Except Principal Investigator 血小板 / CLEC-2 / SARS-CoV-2 / 血栓症 / SARS ~CoV-2 / COVID-19 … More / 発生 / リンパ節 / リンパ管 / 異所性リンパ組織 / リンパ節発生 / ポドプラニン / 抗体医薬 Less

子宮内膜症におけるCLEC-2/Podoplaninの関与の解明と治療戦略Principal Investigator
- Principal Investigator
  
  白井俊光
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  University of Yamanashi
SARS-CoV-2による血小板血栓の形成メカニズムの解析
- Principal Investigator
  
  佐々木知幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
iPS細胞由来巨核球が産生する血小板を活用したヒトCLEC-2の機能解析
- Principal Investigator
  
  大石沙織
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actions
- Principal Investigator
  
  Sasaki Tomoyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Contribution of platelet-activating receptor CLEC-2 in the pathogenesis of cancer-associated thrombosis.Principal Investigator
- Principal Investigator
  
  Shirai Toshiaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances
- Principal Investigator
  
  Suzuki-INoue Katsue
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model2023
- Author(s)
  Shirai Toshiaki、Tsukiji Nagaharu、Sasaki Tomoyuki、Oishi Saori、Yokomori Ryohei、Takano Katsuhiro、Suzuki-Inoue Katsue
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 21 Issue: 11 Pages: 3153-3165
- DOI
  10.1016/j.jtha.2023.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice2023
- Author(s)
  Yokomori Ryohei、Shirai Toshiaki、Tsukiji Nagaharu、Oishi Saori、Sasaki Tomoyuki、Takano Katsuhiro、Suzuki-Inoue Katsue
- Journal Title
  
  Platelets
  
  Volume: 34 Issue: 1 Pages: 1-11
- DOI
  10.1080/09537104.2023.2281941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-192023
- Author(s)
  Oishi Saori、Ueda Makyo、Yamazaki Hirokazu、Tsukiji Nagaharu、Shirai Toshiaki、Naito Yuna、Endo Masumi、Yokomori Ryohei、Sasaki Tomoyuki、Suzuki-Inoue Katsue
- Journal Title
  
  Platelets
  
  Volume: 34 Issue: 1 Pages: 1-6
- DOI
  10.1080/09537104.2023.2244594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08500, KAKENHI-PROJECT-23K07831
[Journal Article] Platelets and COVID-192023
- Author(s)
  SUZUKI-INOUE Katsue、SHIRAI Toshiaki、SASAKI Tomoyuki
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 34 Issue: 1 Pages: 53-57
- DOI
  10.2491/jjsth.34.53
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Detection of SARS-CoV-2 RNA Using RT-qPCR in Saliva Samples and Nasopharyngeal, Lingual, and Buccal Mucosal Swabs2022
- Author(s)
  Sasaki Tomoyuki、Inoue Osamu、Ogihara Shinji、Kubokawa Kayo、Oishi Saori、Shirai Toshiaki、Iwabuchi Keisuke、Suzuki-Inoue Katsue
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 75 Issue: 1 Pages: 102-104
- DOI
  10.7883/yoken.JJID.2021.091
- NAID
  130008143955
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2022-01-31
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08729
[Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue
- Journal Title
  
  blood advances
  
  Volume: 5 Issue: 7 Pages: 2017-2026
- DOI
  10.1182/bloodadvances.2020001698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04724, KAKENHI-PROJECT-19K16554, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-21K04674, KAKENHI-PROJECT-21K06883
[Journal Article] CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice2021
- Author(s)
  Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shogo Tamura, Katsuhiro Takano, Yukio Ozaki, Katsue Suzuki-Inoue
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: - Issue: 6 Pages: 1572-1584
- DOI
  10.1111/jth.15317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-18K16080, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729
[Journal Article] Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma2020
- Author(s)
  Jiro Ichikawa, Takashi Ando, Tomonori Kawasaki, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Yujiro Kimura, Kaoru Aoki, Keiko Hayakawa, Katsue Suzuki-Inoue, Masao Saitoh, Hirotaka Haro
- Journal Title
  
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  
  Volume: in press Issue: 9 Pages: 1738-1750
- DOI
  10.1002/jbmr.4045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-18K06912, KAKENHI-PROJECT-18K09060, KAKENHI-PROJECT-16H06276
[Presentation] 硫酸化多糖カラギナンによるヒト血小板活性化機構2023
- Author(s)
  横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、髙野勝弘、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] The molecular basis of carrageenan-induced thrombosis involves platelet activation via C-type lectin like receptor 2 (CLEC-2)2023
- Author(s)
  Ryohei Yokomori, Toshiaki Shirai, Saori Oishi, Tomoyuki Sasaki, Nagaharu Tsukiji, Katsuhiro Takano, Katsue Suzuki-Inoue
- Organizer
  ISTH 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 新型コロナウイルスによる血小板血栓形成メカニズムの解明2023
- Author(s)
  佐々木知幸、白井俊光、築地長治、大石沙織、横森良平、髙野勝弘、森石恆司、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 可溶型CLEC-2はCOVID-19患者の酸素療法の必要性を予測する2023
- Author(s)
  大石沙織、上田眞叶、山﨑浩和、築地長治、白井俊光、内藤悠菜、遠藤真澄、佐々木知幸、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] 鉄によるCLEC-2依存性血小板活性化機構とその生理的意義2023
- Author(s)
  築地長治、横森良平、田草川一穂、大石沙織、白井俊光、佐々木知幸、髙野勝弘、井上克枝
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07831
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  白井俊光
- Organizer
  国際血栓止血学会学術集会2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17374
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光, 佐々木知幸, 築地長治, 大石沙織, 横森良平, 高野勝弘, 井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光、佐々木知幸、築地長治、大石沙織、横森良平、高野勝弘、井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光, 佐々木知幸, 築地長治, 大石沙織, 横森良平, 髙野勝弘, 井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17374
[Presentation] 硫酸化多糖カラギーナンはCLEC-2依存症に血小板を活性化する2022
- Author(s)
  横森良平, 白井俊光, 佐々木知幸, 築地長治, 大石沙織, 高野勝弘, 井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 硫酸化多糖カラギーナンはCLEC-2依存性に血小板を活性化する2022
- Author(s)
  横森良平、白井俊光、佐々木知幸、築地長治、大石沙織、高野勝弘、井上克枝
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] 血小板活性化受容体CLEC-2と癌関連血栓症の病態2022
- Author(s)
  白井俊光, 井上克枝
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17374
[Presentation] 癌関連線維芽細胞はCLEC-2/PDPNを介して癌関連血栓症を増悪させる2022
- Author(s)
  白井俊光
- Organizer
  日本血栓止血学会学術集会2022
- Data Source
  KAKENHI-PROJECT-20K17374
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  T. Shirai, T. Sasaki, N. Tsukiji, S. Ohishi, R. Yokomori, K. Takano, K. Suzuki-Inoue
- Organizer
  International Society on Thrombosis and Haemostasis 2022 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08499
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  Toshiaki Shirai, Tomoyuki Sasaki, Nagaharu Tsukiji, Saori Oishi, Ryohei Yokomori, Katsuhiro Takano, Katsue Suzuki-Inoue
- Organizer
  ISTH2022 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17374
[Presentation] Cancer-associated fibroblasts promote venous thrombosis through C-type lectin-like receptor 2/podoplanin in 3LL lung cancer mouse model2022
- Author(s)
  Shirai T, Sasaki T, Tsukiji N, Ohishi S, Yokomori R, Takano K, Suzuki-Inoue K.
- Organizer
  ISTH 2022 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] CLEC-2はPDPN発現間質細胞からのIGF-1分泌を促進し、赤血球造血を正に制御する2021
- Author(s)
  大竹志門, 佐々木知幸, 白井俊光, 築地長治, 高野勝弘, 田村彰吾, 尾崎由基男, 井上克枝
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割2021
- Author(s)
  大石沙織，築地長治、大竹志門、大石直輝、佐々木知幸、白井俊光、吉河佑莉、髙野勝弘、新森英之、犬飼岳史、近藤哲夫、井上克枝
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020
- Author(s)
  大竹志門, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 高野勝弘, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ2020
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, T. Kondo, K. Suzuki-Inoue
- Organizer
  ISTH 2020 Congress(2020.07.12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2およびGPVIの役割2020
- Author(s)
  大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉河佑莉, 高野勝弘, 近藤哲夫, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 血小板受容体CLEC-2による関節リウマチの病態形成への関与2020
- Author(s)
  佐々木知幸, 白井俊光, 築地長治, 小山賢介, 田村彰吾, 大竹志門, 高野勝弘, 長田誠, 佐藤金夫, 波呂浩孝, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729

1. Sasaki Tomoyuki (40739124)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. Suzuki-INoue Katsue (10324211)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
3. 築地長治 (20710362)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
4. 大石沙織 (50894094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. 大竹志門 (50813060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 平島正則 (40383757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWASAKI Tomonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 新森英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 田村彰吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRAI Toshiaki 白井 俊光

Shirai Toshiaki 白井 俊光

Research Projects

Research Products

Co-Researchers

子宮内膜症におけるCLEC-2/Podoplaninの関与の解明と治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SARS-CoV-2による血小板血栓の形成メカニズムの解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPS細胞由来巨核球が産生する血小板を活用したヒトCLEC-2の機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Contribution of platelet-activating receptor CLEC-2 in the pathogenesis of cancer-associated thrombosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of platelets in lymphoid tissue development: platelets as a cargo of bioactive substances

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cancer-associated fibroblasts promote venous thrombosis through podoplanin/CLEC-2 interaction in podoplanin-negative lung cancer mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelets and COVID-192023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Detection of SARS-CoV-2 RNA Using RT-qPCR in Saliva Samples and Nasopharyngeal, Lingual, and Buccal Mucosal Swabs2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice2021

Author(s)

Journal Title

SHIRAI Toshiaki 白井俊光

Shirai Toshiaki 白井俊光