YOKOI Norihiko 横井紀彦

… Alternative Names

NORIHIKO Yokoi 横井紀彦

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Researcher Number	50710969
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 名古屋大学, 医学系研究科, 講師 2023: 生理学研究所, 分子細胞生理研究領域, 助教(兼任) 2016 – 2022: 生理学研究所, 分子細胞生理研究領域, 助教 2013 – 2014: 生理学研究所, 細胞器官研究系, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Neurophysiology / General neuroscience / Neurochemistry/Neuropharmacology / Cell biology
Keywords	Principal Investigator 蛋白質複合体 / てんかん / リン酸化 / シナプス / PSD-95 / シナプス伝達 / ADAM22 / LGI1 / 蛋白質合成 / AMPA受容体 … More / タンパク質複合体 / タンパク質翻訳後修飾 / 蛋白質分解 / 神経回路 / 結晶構造 / トランスシナプス / ナノドメイン/ナノカラム / 変異体 / 分泌蛋白質 / 構造病 / 辺縁系脳炎 / 治療薬 / モデルマウス / タンパク質構造病 / ケミカルシャペロン … More Except Principal Investigator 生理学 / 蛋白質 / シナプス / パルミトイル化 / 酵素 / 脳・神経 / ABHD17 / PSD-95 / 脂質 / 脱パルミトイル化 / 脱パルミトイル化酵素 / Zdk1-iLID / LOVTRAP / LOV2 / 光科学 / タンパク質 / NMDA受容体 / 超解像顕微鏡 / 遺伝学 / 脳神経疾患 / 神経科学 / LGI1 / ナノドメイン / てんかん / パルミトイル化脂質修飾 / グルタミン酸受容体 / AMPA受容体 / 脂質修飾 / 翻訳後修飾 / 膜ドメイン / パルミトイル化酵素 / シナプス伝達 / パルミトイル化修飾 Less

パルミトイル化酵素群の多重欠損による酵素-基質蛋白質ペアの同定と機能解明Principal Investigator
- Principal Investigator
  
  横井紀彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagoya University
抗てんかん作用の発揮を目指したLGI1-ADAM22複合体の形成制御機構の解明Principal Investigator
- Principal Investigator
  
  横井紀彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  National Institute for Physiological Sciences
Regulatory mechanisms of the antiepileptic ligand-receptor level to control excitation-inhibition balance in the brainPrincipal Investigator
- Principal Investigator
  
  Yokoi Norihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  National Institute for Physiological Sciences
Regulatory mechanisms of synaptic transmission by an epilepsy-causative ligand-receptor complexPrincipal Investigator
- Principal Investigator
  
  Norihiko Yokoi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Institute for Physiological Sciences
Optogenetic manipulation of protein palmitoylation for synapse organization
- Principal Investigator
  
  Masaki Fukata
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  National Institute for Physiological Sciences
Mechanisms for AMPA-type glutamate receptor anchoring at the synapse
- Principal Investigator
  
  FUKATA Yuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Institute for Physiological Sciences
Identification of depalmitoylating enzymes
- Principal Investigator
  
  FUKATA Masaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute for Physiological Sciences
Studies on excitatory synaptic transmission regulated by neuronal ligand/receptor interactionsPrincipal Investigator
- Principal Investigator
  
  NORIHIKO Yokoi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Institute for Physiological Sciences

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 膜タンパク質工学ハンドブック zDHHC パルミトイル化酵素と ABHD17 脱パルミトイル化酵素2020
- Author(s)
  深田正紀、横井紀彦、平田哲也、深田優子
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860435370
- Data Source
  KAKENHI-PROJECT-19K06893
[Book] メンブレントラフィック2016
- Author(s)
  深田優子、横井紀彦、宮崎裕理、深田正紀
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-26291045
[Book] メンブレントラフィック2016
- Author(s)
  深田優子、横井紀彦、宮崎裕理、深田正紀
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16K14560
[Book] メンブレントラフィック2016
- Author(s)
  深田優子、横井紀彦、宮崎裕理、深田正紀
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-15H04279
[Book] 細胞工学2015
- Author(s)
  横井紀彦、深田正紀、深田優子
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-26291045
[Book] 細胞工学2015
- Author(s)
  横井紀彦、深田優子、深田正紀
- Total Pages
  85
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-26291045
[Book] 細胞工学2015
- Author(s)
  横井紀彦、深田正紀、深田優子
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-15H04279
[Journal Article] Regulatory mechanisms of the LGI1–ADAM22 protein levels to prevent epilepsy2023
- Author(s)
  横井紀彦、深田優子、深田正紀
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 3 Pages: 384-388
- DOI
  10.14952/SEIKAGAKU.2023.950384
- ISSN
  0037-1017
- Year and Date
  2023-06-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06451
[Journal Article] Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription2022
- Author(s)
  Wirth Alexander、Labus Josephine、Abdel Galil Dalia、Schill Yvonne、Schmidt Silke、Bunke Tania、Gorinski Nataliya、Yokoi Norihiko、Fukata Masaki、Ponimaskin Evgeni
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 6 Pages: 102048-102048
- DOI
  10.1016/j.jbc.2022.102048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06451, KAKENHI-PROJECT-20H00459
[Journal Article] Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum2022
- Author(s)
  Kawai T、Narita H、Konno K、Akter S、Andriani RT、Iwasaki H、Nishikawa S、Yokoi N、Fukata Y、Fukata M、Wiriyasermkul P、Kongpracha P、Nagamori S、Takao K、Miyakawa T、Abe M、Sakimura K、Watanabe M、Nakagawa A、Okamura Y
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 11 Pages: 1127-1145
- DOI
  10.1042/bcj20220033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06451, KAKENHI-PROJECT-22K06805, KAKENHI-PROJECT-21K19350, KAKENHI-PROJECT-20KK0376, KAKENHI-PROJECT-18H05213, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03538, KAKENHI-PROJECT-21H03365, KAKENHI-PROJECT-22KF0249, KAKENHI-PROJECT-23K23986, KAKENHI-PROJECT-20K07274, KAKENHI-PLANNED-20H05791, KAKENHI-PROJECT-21H02444, KAKENHI-PROJECT-23K24066
[Journal Article] APEGS法によるタンパク質パルミトイル化修飾の定量2021
- Author(s)
  深田正紀、横井紀彦、深田優子
- Journal Title
  
  電気泳動
  
  Volume: 65
- NAID
  130008072916
- Data Source
  KAKENHI-PROJECT-19K06893
[Journal Article] Trans-synaptic LGI1-ADAM22?MAGUK in AMPA and NMDA receptor regulation2021
- Author(s)
  Fukata Yuko、Hirano Yoko、Miyazaki Yuri、Yokoi Norihiko、Fukata Masaki
- Journal Title
  
  Neuropharmacology
  
  Volume: 194 Pages: 108628-108628
- DOI
  10.1016/j.neuropharm.2021.108628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06893, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PROJECT-19K16269, KAKENHI-PUBLICLY-20H04915, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-21K19390
[Journal Article] 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice2021
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Kei Okatsu, Atsushi Yamagata, Yan Liu , Makoto Sanbo, Yuri Miyazaki, Teppei Goto, Manabu Abe , Hidetoshi Kassai, Kenji Sakimura, Dies Meijer, Masumi Hirabayashi, Shuya Fukai, Masaki Fukata
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 11 Pages: 110107-110107
- DOI
  10.1016/j.celrep.2021.110107
- NAID
  120007177780
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06478, KAKENHI-PROJECT-19K06893, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PROJECT-19K16269, KAKENHI-PUBLICLY-20H04915, KAKENHI-PROJECT-18H03983, KAKENHI-PROJECT-20H00459, KAKENHI-PROJECT-19H03162, KAKENHI-PROJECT-19H03331, KAKENHI-PROJECT-21K19390
[Journal Article] APEGS法によるタンパク質パルミトイル化修飾化の定量2021
- Author(s)
  深田正紀、横井紀彦、深田優子
- Journal Title
  
  電気泳動
  
  Volume: 6 Pages: 41-45
- Data Source
  KAKENHI-PROJECT-19K06893
[Journal Article] Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay2019
- Author(s)
  Kanadome T, Yokoi N, Fukata Y, Fukata M.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 印刷中 Pages: 83-98
- DOI
  10.1007/978-1-4939-9532-5_7
- ISBN
  9781493995318, 9781493995325
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05709, KAKENHI-PROJECT-19K06893, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PUBLICLY-18H04873, KAKENHI-PUBLICLY-19H04974, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-19H03331
[Journal Article] Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis2019
- Author(s)
  Daisuke Hasegawa、Yumi Ohnishi、Eiji Koyama、Satoru Matsunaga、Shouhei Ohtani、Akio Nakanishi、Takanori Shiga、James K. Chambers、Kazuyuki Uchida、Norihiko Yokoi、Yuko Fukata、Masaki Fukata
- Journal Title
  
  Journal of Veterinary Internal Medicine
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14969
[Journal Article] Limbic Encephalitis in a Cat with Hippocampal Necrosis, putatively associated with DCC (deleted in colorectal cancer; Netrin-1 Receptor) Antibodies2019
- Author(s)
  Hasegawa D, Ohnishi Y, Koyama E, Matsunaga S, Ohtani S, Nakanishi A, Shiga T, Chambers JK, Uchida K, Yokoi N, Fukata Y, Fukata M.
- Journal Title
  
  J Vet Intern Med
  
  Volume: 印刷中 Issue: 3 Pages: 1440-1445
- DOI
  10.1111/jvim.15492
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05709, KAKENHI-PUBLICLY-18H04873, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-19K06893, KAKENHI-PROJECT-19K22439, KAKENHI-PROJECT-19K22548, KAKENHI-PUBLICLY-19H04974, KAKENHI-PROJECT-19H03331
[Journal Article] Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay2019
- Author(s)
  Takashi Kanadome、Norihiko Yokoi、Yuko Fukata、Masaki Fukata
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14969
[Journal Article] Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM222018
- Author(s)
  Yamagata A, Miyazaki Y, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M, Fukai S
- Journal Title
  
  Nat Commun
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04279
[Journal Article] Neurobiology of autoimmune encephalitis.2018
- Author(s)
  Fukata M, Yokoi N, Fukata Y.
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 48 Pages: 1-8
- DOI
  10.1016/j.conb.2017.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K14969, KAKENHI-PUBLICLY-16H01371, KAKENHI-PUBLICLY-17H05709, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-16K14560
[Journal Article] Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies2018
- Author(s)
  Yoshikura Nobuaki、Kimura Akio、Fukata Masaki、Fukata Yuko、Yokoi Norihiko、Harada Naoko、Hayashi Yuichi、Inuzuka Takashi、Shimohata Takayoshi
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 319 Pages: 63-67
- DOI
  10.1016/j.jneuroim.2018.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15445, KAKENHI-PUBLICLY-17H05709, KAKENHI-PUBLICLY-18H04873, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-17K14969
[Journal Article] Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM222018
- Author(s)
  Yamagata Atsushi、Miyazaki Yuri、Yokoi Norihiko、Shigematsu Hideki、Sato Yusuke、Goto-Ito Sakurako、Maeda Asami、Goto Teppei、Sanbo Makoto、Hirabayashi Masumi、Shirouzu Mikako、Fukata Yuko、Fukata Masaki、Fukai Shuya
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1546-1546
- DOI
  10.1038/s41467-018-03947-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J07958, KAKENHI-PROJECT-18K06172, KAKENHI-PUBLICLY-17H05709, KAKENHI-PUBLICLY-17H05897, KAKENHI-PUBLICLY-18H04873, KAKENHI-PROJECT-18H03983, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-17H03678, KAKENHI-PROJECT-17K14969
[Journal Article] Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM222018
- Author(s)
  Yamagata A, Miyazaki Y, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M, Fukai S
- Journal Title
  
  Nat Commun
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14560
[Journal Article] The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders2017
- Author(s)
  Fukata Y, Yokoi N, Miyazaki Y, Fukata M
- Journal Title
  
  Neurosci Res
  
  Volume: 116 Pages: 39-45
- DOI
  10.1016/j.neures.2016.09.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01299, KAKENHI-PUBLICLY-15H01570, KAKENHI-PUBLICLY-16H01371, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-16K14560, KAKENHI-PROJECT-17K14969
[Journal Article] Local palmitoylation cycles and specialized membrane domain organization2016
- Author(s)
  Fukata Y, Murakami T, Yokoi N, Fukata M
- Journal Title
  
  Curr Top Membr
  
  Volume: 77 Pages: 97-141
- DOI
  10.1016/bs.ctm.2015.10.003
- ISBN
  9780128054048
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01299, KAKENHI-PUBLICLY-15H01570, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-14J02851, KAKENHI-PROJECT-26291045
[Journal Article] Identification of PSD-95 depalmitoylating enzymes2016
- Author(s)
  Yokoi N*, Fukata Y*, Sekiya A, Murakami T, Kobayashi K, Fukata M
- Journal Title
  
  J Neurosci
  
  Volume: 36 Issue: 24 Pages: 6431-6444
- DOI
  10.1523/jneurosci.0419-16.2016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01299, KAKENHI-PUBLICLY-15H01570, KAKENHI-PUBLICLY-16H01371, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-16K14560
[Journal Article] Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial temporal lobe epilepsy.2015
- Author(s)
  Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
- Journal Title
  
  Nat Med
  
  Volume: 21 Issue: 1 Pages: 19-26
- DOI
  10.1038/nm.3759
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-24108007, KAKENHI-PUBLICLY-25110733, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-25890021, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-26460250, KAKENHI-PROJECT-24220007
[Journal Article] Synaptic nanodomains generated by local palmitoylation cycles2015
- Author(s)
  Masaki Fukata, Atsushi Sekiya, Tatsuro Murakami, Norihiko Yokoi, Yuko Fukata
- Journal Title
  
  Biochemical Society Transactions
  
  Volume: 43(2) Issue: 2 Pages: 199-204
- DOI
  10.1042/bst20140238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J02851, KAKENHI-PROJECT-25890021, KAKENHI-PUBLICLY-15H01299, KAKENHI-PUBLICLY-15H01570, KAKENHI-PROJECT-15H04279, KAKENHI-PROJECT-26291045
[Journal Article] Identification and characterization of GABAA receptor autoantibodies in autoimmune encephalitis2014
- Author(s)
  Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, *Fukata Y, *Fukata M (*corresponding author).
- Journal Title
  
  J Neurosci
  
  Volume: 34 Issue: 24 Pages: 8151-8163
- DOI
  10.1523/jneurosci.4415-13.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25110733, KAKENHI-PROJECT-25461286, KAKENHI-PROJECT-25890021, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-26291045, KAKENHI-PROJECT-26430079
[Journal Article] Antibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.2013
- Author(s)
  Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, Watanabe M, Watanabe O, Fukata M
- Journal Title
  
  J Neurosci,
  
  Volume: 33 Issue: 46 Pages: 18161-18174
- DOI
  10.1523/jneurosci.3506-13.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-24790185, KAKENHI-PROJECT-24790187, KAKENHI-PUBLICLY-25110733, KAKENHI-PROJECT-25461286, KAKENHI-PROJECT-25890021
[Presentation] Regulatory mechanisms of the LGI1-ADAM22 level to prevent epilepsy in mice2022
- Author(s)
  Yokoi N, Fukata Y, Sanbo M, Goto T, Hirabayashi M, Fukata M.
- Organizer
  The 11th NIPS-PRI-BRINU Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] 14-3-3 proteins stabilize LGI1-ADAM22 levels to prevent epilepsy in mice2022
- Author(s)
  Yokoi N, Fukata Y, Okatsu K, Yamagata A, Liu Y, Sanbo M, Miyazaki Y, Goto T, Hirabayashi M, Fukai S, Fukata M
- Organizer
  The 45th annual meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06451
[Presentation] LGI1-ADAM22 levels to regulate seizure threshold in mice2022
- Author(s)
  Yokoi N, Fukata Y, Sanbo M, Goto T, Hirabayashi M, Fukata M.
- Organizer
  The 3th Nagoya CIBoG Retreat
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] LGI1-ADAM22抗てんかん蛋白質複合体の量的制御機構の解明2022
- Author(s)
  横井紀彦, 深田正紀, 深田優子
- Organizer
  生理研研究会「機能的神経回路の構築と動作を支える分子細胞基盤」
- Invited
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Effective expression level of the anti-epileptic complex, LGI1-ADAM22, is maintained by ADAM22 phosphorylation2021
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Makoto Sanbo, Teppei Goto, Masumi Hirabayashi, Masaki Fukata
- Organizer
  第10回生理研-霊長研-新潟脳研合同シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] 脳内蛋白質複合体の研究を通して、生物無機化学の未来について考えること2021
- Author(s)
  横井紀彦
- Organizer
  分子研研究会「錯体化学から始まる学術展開の可能性」
- Invited
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] シナプス蛋白質複合体LGI1-ADAM22のリン酸化による抗てんかん機構の解明2021
- Author(s)
  横井紀彦
- Organizer
  自然科学研究機構「ネットワーク型研究加速事業（国際ネットワーク）」生理研プロジェクト年度末成果報告会
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] ADAM22 biosynthetic analysis reveals the seizure threshold in a mouse model2021
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Makoto Sanbo, Teppei Goto, Masumi Hirabayashi, Masaki Fukata
- Organizer
  第2回CIBoGリトリート（第13回NAGOYAグローバルリトリート）
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] 抗てんかん作用を発揮するLGI1-ADAM22複合体の量とその制御機構の解明2021
- Author(s)
  横井紀彦, 深田優子, 三宝誠, 後藤哲平, 平林真澄, 深田正紀
- Organizer
  第11回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Acyl-PEGyl exchange gel-shift (APEGS) assay for palmitoylation quantification2020
- Author(s)
  Fukata Masaki、Yokoi Norihiko、Fukata Yuko
- Organizer
  第71回日本電気泳動学会総会
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Synaptic function regulated by palmitate cycling on PSD-95 and trans-synaptic LGI1 and ADAM222020
- Author(s)
  Fukata Masaki、Yuri Miyazaki、Yokoi Norihiko、Fukata Yuko
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] ADAM22 phosphorylation stabilizes the antiepileptic LGI1-ADAM22 complex in the brain2020
- Author(s)
  横井紀彦, 深田優子, 三宝誠, 後藤哲平, 平林真澄, 深田正紀
- Organizer
  第1回 CIBoG リトリート（第12回 NAGOYAグローバルリトリート）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] S-アシル化修飾ゾーンと神経シナプス機能：S-アシル化修飾の化学量論的解析2019
- Author(s)
  横井紀彦, 関谷敦志, 平田哲也，深田優子, 深田正紀
- Organizer
  第2回オルガネラゾーン若手の会
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Phosphorylation of ADAM22 regulates the amount of the anti-epileptic LGI1-ADAM22 complex in the brain2019
- Author(s)
  Yokoi N, Fukata Y, Sanbo M, Goto T, Hirabayashi M, Fukata M
- Organizer
  The 40th annual meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Phosphorylation of ADAM22 stabilizes the anti-epileptic LGI1-ADAM22 complex in the brain2019
- Author(s)
  横井紀彦, 深田優子, 三宝誠, 後藤哲平, 平林真澄, 深田正紀
- Organizer
  第9回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06893
[Presentation] Assessment of palmitoylation status and cycles on PSD-95 in neurons and in vivo2017
- Author(s)
  Fukata Y, Yokoi N, Kobayashi K, and Fukata M
- Organizer
  13th International congress of Polish Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Identification of PSD-95 depalmitoylating enzymes and profiling of the palmitoylation stoichiometry of synaptic proteins2017
- Author(s)
  Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M.
- Organizer
  The 40th annual meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14969
[Presentation] PSD-95脱パルミトイル化酵素の同定、及び蛋白質パルミトイル化の定量的解析法の開発2017
- Author(s)
  横井紀彦
- Organizer
  第6回　生理研-霊長研-脳研　合同シンポジウム
- Data Source
  KAKENHI-PROJECT-17K14969
[Presentation] Assessment of palmitoylation status and cycles on PSD-95 in neurons and in vivo2017
- Author(s)
  Fukata Y, Yokoi N, Kobayashi K, and Fukata M
- Organizer
  5th Annual iGluR Retreat
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Role of local palmitoylation machinery in the postsynaptic nanodomain organization2017
- Author(s)
  Masaki Fukata, Norihiko Yokoi, Yuko Fukata
- Organizer
  13th International congress of the Polish Neuroscience Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14560
[Presentation] Molecular Mechanisms of a Familial Epilepsy Caused by Mutations of a Neuronal Secreted Protein, LGI12017
- Author(s)
  Yokoi N, Fukata Y, Fukata M.
- Organizer
  Yonsei-Korea-NIPS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14969
[Presentation] Postsynaptic nanodomains regulated by local palmitoylation machinery2016
- Author(s)
  Masaki Fukata, Norihiko Yokoi, Atsushi Sekiya, Tatsuro Murakami, Kenta Kobayashi, Yuko Fukata
- Organizer
  10th Forum of Neuroscience (FENS)
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2016-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] PSD organization regulated by PSD-95 palmitoylation machinery2016
- Author(s)
  Yuko Fukata, Norihiko Yokoi, Atsushi Sekiya, Tatsuro Murakami, Kenta Kobayashi, Masaki Fukata
- Organizer
  10th Forum of Neuroscience (FENS)
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2016-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Postsynaptic nanodomains regulated by local palmitoylation machinery2016
- Author(s)
  Masaki Fukata, Norihiko Yokoi, Atsushi Sekiya, Tatsuro Murakami, Kenta Kobayashi, Yuko Fukata
- Organizer
  10th Forum of Neuroscience (FENS)
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2016-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14560
[Presentation] Postsynaptic nanodomains organized by local palmitoylation machinery2015
- Author(s)
  Yuko Fukata, Atsushi Sekiya, Tatsuro Murakami, Norihiko Yokoi, Kenta Kobayashi, Masaki Fukata
- Organizer
  FASEB Science Research Conference “Protein lipidation, Signaling, and Membrane Domains”
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Postsynaptic nanodomains organized by local palmitoylation machinery2015
- Author(s)
  Yuko Fukata, Atsushi Sekiya, Tatsuro Murakami, Norihiko Yokoi, Kenta Kobayashi, Masaki Fukata
- Organizer
  FASEB Science Research Conference “Protein lipidation, Signaling, and Membrane Domains”
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Stoichiometric analysis of palmitoylation cycles on PSD-952015
- Author(s)
  Norihiko Yokoi, Atsushi Sekiya, Tatsuro Murakami, Yuko Fukata, Masaki Fukata
- Organizer
  FASEB Science Research Conference “Protein lipidation, Signaling, and Membrane Domains”
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Molecular pathogenic mechanisms of epilepsy caused by LGI1 mutations2015
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martin Jaegle, Keiji Imoto, Deis Meijer, Masahiko Watanabe, Masaki Fukata
- Organizer
  45th annual meeting of the Society for Neuroscience
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Molecular pathogenic mechanisms of epilepsy caused by LGI1 mutations2015
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martin Jaegle, Keiji Imoto, Deis Meijer, Masahiko Watanabe, Masaki Fukata
- Organizer
  45th annual meeting of the Society for Neuroscience
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Stoichiometric analysis of palmitoylation cycles on PSD-952015
- Author(s)
  Norihiko Yokoi, Atsushi Sekiya, Tatsuro Murakami, Yuko Fukata, Masaki Fukata
- Organizer
  FASEB Science Research Conference “Protein Lipidation, Signaling, and Membrane Domains”
- Place of Presentation
  Saxtons River, Vermont, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04279
[Presentation] Chemical Correction of Missense LGI1 Functions Ameliorates Seizure Phenotype in a Mouse Model of Human Epilepsy2014
- Author(s)
  横井紀彦、深田優子、加勢大輔、宮崎太輔、Martine Jaegle、井本敬二、Dies Meijer、渡辺雅彦、深田正紀
- Organizer
  第4回生理研・名大合同シンポジウム
- Place of Presentation
  名古屋大学、愛知県
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-25890021
[Presentation] Pathogenic mechanism of epilepsy-related LGI1 mutations in vivo2013
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Toshika Ohkawa, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata
- Organizer
  The 3rd NIPS-CIN Joint Symposium
- Place of Presentation
  愛知県岡崎市生理学研究所
- Data Source
  KAKENHI-PROJECT-25890021
[Presentation] Molecular pathogenic mechanisms of epilepsy caused by LGI1 mutations2013
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata
- Organizer
  43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  Convention center, San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25890021
[Presentation] Chemical Correction of Missense LGI1 Functions Ameliorates Seizure Phenotype in a Mouse Model of Human Epilepsy
- Author(s)
  横井紀彦、深田優子、加勢大輔、宮崎太輔、Martine Jaegle、井本敬二、Dies Meijer、渡辺雅彦、深田正紀
- Organizer
  第3回 NINS colloquium
- Place of Presentation
  ザ・プリンス箱根、神奈川県
- Year and Date
  2014-12-01 – 2014-12-03
- Data Source
  KAKENHI-PROJECT-25890021
[Presentation] A chemical chaperone corrects an LGI1 mutant protein and ameliorates seizure phenotypes in a mouse model of human epilepsy
- Author(s)
  横井紀彦、深田優子、加勢大輔、宮崎太輔、Martine Jaegle、井本敬二、Dies Meijer、渡辺雅彦、深田正紀
- Organizer
  第7回NAGOYA グローバルリトリート
- Place of Presentation
  あいち健康プラザ、愛知県
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25890021
[Presentation] LGI1分子の役割と自己抗体の作用機序
- Author(s)
  深田正紀、大川都史香、横井紀彦、深田優子
- Organizer
  第48回てんかん学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-10-02 – 2014-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] てんかん原因遺伝子LGI1の先天的および後天的分子異常による脳機能障害
- Author(s)
  深田優子､横井紀彦、深田正紀
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市西区）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Pathological roles of autoantibodies to synaptic proteins in encephalitic
- Author(s)
  Fukata Y., Ohkawa T., Satake S., Yokoi N., Watanabe M., Fukata M.
- Organizer
  44th annual meeting of the Society for Neuroscience
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Molecular mechanisms of LGI1 mutation-related epilepsy and new strategy for human epilepsy
- Author(s)
  Yokoi N., Fukata Y., Kase D., Miyazaki T., Jaegle M., Imoto K., Meijer D., Watanabe M., Fukata M.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市西区）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26291045
[Presentation] Molecular mechanisms for LGI1 mutation-related epilepsy and new strategy for human epilepsy
- Author(s)
  Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、神奈川県
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25890021

1. FUKATA Yuko (40416186)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
2. SUZUKI Yumi

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. FUKATA Masaki (00335027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. HIRATA Tetsuya (90780651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SEKIYA Atsushi

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. MURAKAMI Tatsuro

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. TAKAHASHI Naoki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. WATANABE Mie

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. INAHASHI Hiroki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FURUKAWA Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KANADOME Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAZAKI Taisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. YAMASAKI Miwako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 久保義弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高橋淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 木村暁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 葛西秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOKOI Norihiko 横井 紀彦

NORIHIKO Yokoi 横井 紀彦

Research Projects

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Co-Researchers

パルミトイル化酵素群の多重欠損による酵素-基質蛋白質ペアの同定と機能解明Principal Investigator

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抗てんかん作用の発揮を目指したLGI1-ADAM22複合体の形成制御機構の解明Principal Investigator

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Regulatory mechanisms of the antiepileptic ligand-receptor level to control excitation-inhibition balance in the brainPrincipal Investigator

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Regulatory mechanisms of synaptic transmission by an epilepsy-causative ligand-receptor complexPrincipal Investigator

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Optogenetic manipulation of protein palmitoylation for synapse organization

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Mechanisms for AMPA-type glutamate receptor anchoring at the synapse

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Identification of depalmitoylating enzymes

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Studies on excitatory synaptic transmission regulated by neuronal ligand/receptor interactionsPrincipal Investigator

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[Book] 膜タンパク質工学ハンドブック zDHHC パルミトイル化酵素と ABHD17 脱パルミトイル化酵素2020

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[Book] メンブレントラフィック2016

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[Book] メンブレントラフィック2016

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[Book] メンブレントラフィック2016

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[Book] 細胞工学2015

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[Book] 細胞工学2015

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[Book] 細胞工学2015

YOKOI Norihiko 横井紀彦

NORIHIKO Yokoi 横井紀彦