SEHARA YOSHIHIDE 瀬原吉英

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Sehara Yoshihide 瀬原吉英

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Researcher Number	50721156
Other IDs	https://orcid.org/0000-0003-0705-5736
Affiliation (Current)	2025: 自治医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2017 – 2024: 自治医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related / Neurosurgery Except Principal Investigator Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator 海馬 / ニューロン新生 / ポリコーム群タンパク質 / スナネズミ / 前脳虚血 / 心肺蘇生後 / 脳虚血 / てんかん / 一過性全脳虚血 / 神経新生 / 一過性脳虚血 / 全脳虚血 / 神経細胞新生 … More Except Principal Investigator … More 廃用性筋萎縮 / アデノ随伴ウイルス / ゲノムワイドスクリーニング / 筋萎縮 / マウス / 遺伝子治療 / 骨格筋 / ミトコンドリア / マイトファジー Less

Relationship between epilepsy and neurogenesis in hippocampus after cardiopulmonary resuscitationPrincipal Investigator
- Principal Investigator
  
  瀬原吉英
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Jichi Medical University
Mitophagy-mediated gene therapy for muscle atrophy
- Principal Investigator
  
  Inoue Keiichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Kyushu University
  Niigata University
Molecular Mechanisms of Neurogenesis and Roles of Newborn Cells in Gerbil Hippocampus after Transient Global IschemiaPrincipal Investigator
- Principal Investigator
  
  Sehara Yoshihide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2019 2018

All Journal Article Presentation Patent

[Journal Article] Therapeutic Strategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model2024
- Author(s)
  Hayashi Yuka、Sehara Yoshihide、Watano Ryota、Ohba Kenji、Takayanagi Yuki、Sakiyama Yoshio、Muramatsu Kazuhiro、Mizukami Hiroaki
- Journal Title
  
  Human Gene Therapy
  
  Volume: 35 Issue: 5-6 Pages: 192-201
- DOI
  10.1089/hum.2023.106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24699
[Journal Article] Therapeutic strategy for Fabry disease by intravenous administration of adeno‐associated virus 2 or 9 in α‐galactosidase A‐deficient mice2023
- Author(s)
  Hayashi Yuka、Sehara Yoshihide、Watano Ryota、Ohba Kenji、Takayanagi Yuki、Muramatsu Kazuhiro、Sakiyama Yoshio、Mizukami Hiroaki
- Journal Title
  
  The Journal of Gene Medicine
  
  Volume: 25 Issue: 12
- DOI
  10.1002/jgm.3560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24699
[Journal Article] Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy2022
- Author(s)
  Sehara Yoshihide、Tsuchiya Kyoichiro、Nishino Ichizo、Sato Hirotake、Ando Yoshihito
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 16 Pages: 2509-2515
- DOI
  10.2169/internalmedicine.9055-21
- NAID
  130008150464
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-08-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24699
[Journal Article] Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats2018
- Author(s)
  Sehara Yoshihide、Inaba Toshiki、Urabe Takao、Kurosaki Fumio、Urabe Masashi、Kaneko Naoki、Shimazaki Kuniko、Kawai Kensuke、Mizukami Hiroaki
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 48 Issue: 12 Pages: 3466-3476
- DOI
  10.1111/ejn.14169
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10846, KAKENHI-PROJECT-18K15932, KAKENHI-PROJECT-17H04305
[Journal Article] Efficient transduction of adeno-associated virus vectors into gerbil hippocampus with an appropriate combination of viral capsids and promoters2018
- Author(s)
  Sehara Yoshihide、Shimazaki Kuniko、Kurosaki Fumio、Kaneko Naoki、Uchibori Ryosuke、Urabe Masashi、Kawai Kensuke、Mizukami Hiroaki
- Journal Title
  
  Neuroscience Letters
  
  Volume: 682 Pages: 27-31
- DOI
  10.1016/j.neulet.2018.06.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10846, KAKENHI-PROJECT-18K15932, KAKENHI-PROJECT-17H04305
[Patent] 血管平滑筋細胞指向カプシド、アデノ随伴ウイルスベクター、医薬組成物、治療方法、核酸導入方法、及びカプシド製造方法2023
- Inventor(s)
  瀬原吉英、今野歩
- Industrial Property Rights Holder
  瀬原吉英、今野歩
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-117434
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] スナネズミ前脳虚血モデルにおけるポリコーム群タンパク質の急性期経時的変化2024
- Author(s)
  瀬原吉英、綿野亮太、大庭賢二、島崎久仁子、川合謙介
- Organizer
  第49回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] AAV9ベクター全身投与によるFabry病マウスへの遺伝子治療効果2024
- Author(s)
  林夢夏、瀬原吉英、崎山快夫
- Organizer
  第49回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] キャプシドの発現タイミングを調整した効率良いアデノ随伴ウイルスベクター産生システム2023
- Author(s)
  大庭賢二、瀬原吉英、榎竜嗣、峰野純一、小澤敬也、水上浩明
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] New viral production system for gene therapy using adeno-associated virus (AAV) vector.2023
- Author(s)
  大庭賢二、瀬原吉英、榎竜嗣、峰野純一、小澤敬也、水上浩明
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Improvement of a neutralizing antibody assay for AAV capsids.2023
- Author(s)
  Watano Ryota, Ohba Kenji, Sehara Yoshihide, Saga Yasushi, Urabe Masashi, Mizukami Hiroaki.
- Organizer
  European Society of Gene and Cell Therapy the 30th Annual Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Effect of Ezh2 knockdown on postischemic neurogenesis in gerbil hippocampus.2023
- Author(s)
  Sehara Yoshihide, Watano Ryota, Ohba Kenji, Shimazaki Kuniko, Kawai Kensuke, Mizukami Hiroaki
- Organizer
  Annual Meeting of Society for Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Intravenous administration of adeno-associated virus 9 in a symptomatic mouse model of Fabry disease.2023
- Author(s)
  林夢夏、瀬原吉英、綿野亮太、大庭賢二、崎山快夫、水上浩明
- Organizer
  第64回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] AAVベクターを用いたFabry病の遺伝子治療研究2023
- Author(s)
  林夢夏、瀬原吉英、崎山快夫
- Organizer
  第48回日本脳卒中学会総会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Fabry病モデルマウスにおけるAAV9ベクター全身投与による遺伝子治療2023
- Author(s)
  林夢夏、瀬原吉英、綿野亮太、大庭賢二、崎山快夫、水上浩明
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Polycomb group complex regulates neurogenesis after transient ischemia in gerbil hippocampus.2023
- Author(s)
  瀬原吉英、林夢夏、綿野亮太、大庭賢二、島崎久仁子、川合謙介、水上浩明
- Organizer
  第64回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] HEK293 細胞を使用した多様なAAV血清型に対する中和抗体測定法の開発2023
- Author(s)
  綿野亮太、大庭賢二、瀬原吉英、嵯峨泰、卜部匡司、水上浩明
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] スナネズミ海馬における野生型AAVの細胞指向性の比較2023
- Author(s)
  瀬原吉英、林夢夏、綿野亮太、大庭賢二、島崎久仁子、川合謙介、水上浩明
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Ezh2 knockdown reversed the post-ischemic promotion of neurogenesis in gerbil dentate gyrus.2023
- Author(s)
  Sehara Yoshihide, Ohba Kenji, Shimazaki Kuniko, Kawai Kensuke, Urabe Masashi, Mizukami Hiroaki
- Organizer
  The 31st International Symposium on Cerebral Blood Flow and Metabolism.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Systemic therapy for Fabry disease using AAV vector.2022
- Author(s)
  林夢夏、瀬原吉英、崎山快夫、綿野亮太、大庭賢二、卜部匡司、水上浩明
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Systemic therapy for Fabry disease using AAV vector.2022
- Author(s)
  林夢夏、瀬原吉英、綿野亮太、大庭賢二、卜部匡司、水上浩明
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Transduction Efficiency of Adeno-Associated Virus 2, 5, and rh10 to Neural Stem Cells in Gerbil Dentate Gyrus.2022
- Author(s)
  Sehara Yoshihide, Hayashi Yuka, Watano Ryota, Ohba Kenji, Shimazaki Kuniko, Kawai Kensuke, Mizukami Hiroaki
- Organizer
  The 20th Annual Meeting of American Society of Gene and Cell Therapy (ASGCT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Regulatory System of Neurogenesis in Gerbil Dentate Gyrus after Transient Forebrain Ischemia.2022
- Author(s)
  瀬原吉英、林夢夏、綿野亮太、大庭賢二、島崎久仁子、川合謙介、水上浩明
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] Tropism of Adeno-Associated Virus toward Neural Stem Cells in Gerbil Hippocampus.2022
- Author(s)
  瀬原吉英、林夢夏、綿野亮太、大庭賢二、島崎久仁子、川合謙介、水上浩明
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24699
[Presentation] 虚血周辺部のsurvivin過剰発現は抗アポトーシス効果により梗塞体積を減少させる．2019
- Author(s)
  瀬原吉英、稲葉俊東、卜部貴夫、島崎久仁子、卜部匡司、川合謙介、水上浩明
- Organizer
  第44回脳卒中学会総会
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] Efficient Gene Transduction in Gerbil Hippocampus Using Adeno-Associated Virus.2019
- Author(s)
  Yoshihide Sehara, Kuniko Shimazaki, Masashi Urabe, Kensuke Kawai, Hiroaki Mizukami.
- Organizer
  Brain and Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] Overexpression of Survivin in Ischemic Boundary Zone in Middle Cerebral Artery Occlusion Model.2019
- Author(s)
  Yoshihide Sehara, Toshiki Inaba, Takao Urabe, Kuniko Shimazaki, Masashi Urabe, Kensuke, Kawai, Hiroaki Mizukami.
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] Pre-Stroke Delivery of Anti-Apoptotic Factor Survivin Using Adeno-Associated Virus Rescued the Prognosis after Transient Middle Cerebral Artery Occlusion in Rats.2019
- Author(s)
  Yoshihide Sehara, Toshiki Inaba, Takao Urabe, Kuniko Shimazaki, Kensuke Kawai, Masashi Urabe, Hiroaki Mizukami.
- Organizer
  第25回日本遺伝子細胞治療学会学術大会
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] Combinations of Promoters and Virus Capsids May Affect Gene Transduction Efficiency in Adeno-associated Virus.2019
- Author(s)
  Yoshihide Sehara, Kuniko Shimazaki, Masashi Urabe, Kensuke Kawai, Hiroaki Mizukami.
- Organizer
  Australian Gene and Cell Thearpy, ASSCR-AGCTS-ISCT 2019 Joint Scientific Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] Adeno-Associated Virus-Mediated Overexpression of Survivin Prior to Transient Middle Cerebral Artery Occlusion Reduced Infarction Volume.2019
- Author(s)
  Yoshihide Sehara, Toshiki Inaba, Takao Urabe, Kuniko Shimazaki, Masashi Urabe, Kensuke, Kawai, Hiroaki Mizukami.
- Organizer
  Brain and Brain PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] The comparison of gene transduction of AAV-rh10 to AAV5 in gerbil hippocampus using different promoters.2018
- Author(s)
  Yoshihide Sehara, Kuniko Shimazaki, Masashi Urabe, Hiroaki Mizukami
- Organizer
  The 24th Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] The relationship between promoters and capsid proteins in induction of adeno-associated virus vector.2018
- Author(s)
  瀬原吉英、島崎久仁子、卜部匡司、内堀亮介、川合謙介、水上浩明
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K10846
[Presentation] ラット一過性中大脳動脳動脈閉塞モデルにおけるsurvivinの神経保護効果2018
- Author(s)
  瀬原吉英、稲葉俊東、卜部匡司、内堀亮介、島崎久仁子、卜部貴夫、水上浩明
- Organizer
  第43回日本脳卒中学会総会
- Data Source
  KAKENHI-PROJECT-17K10846

1. Inoue Keiichi (30396981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 橋本谷祐輝 (50401906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SEHARA YOSHIHIDE 瀬原 吉英

Sehara Yoshihide 瀬原 吉英

Research Projects

Research Products

Co-Researchers

Relationship between epilepsy and neurogenesis in hippocampus after cardiopulmonary resuscitationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mitophagy-mediated gene therapy for muscle atrophy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Mechanisms of Neurogenesis and Roles of Newborn Cells in Gerbil Hippocampus after Transient Global IschemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Therapeutic Strategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic strategy for Fabry disease by intravenous administration of adeno‐associated virus 2 or 9 in α‐galactosidase A‐deficient mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient transduction of adeno-associated virus vectors into gerbil hippocampus with an appropriate combination of viral capsids and promoters2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 血管平滑筋細胞指向カプシド、アデノ随伴ウイルスベクター、医薬組成物、治療方法、核酸導入方法、及びカプシド製造方法2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] スナネズミ前脳虚血モデルにおけるポリコーム群タンパク質の急性期経時的変化2024

Author(s)

Organizer

Data Source

[Presentation] AAV9ベクター全身投与によるFabry病マウスへの遺伝子治療効果2024

Author(s)

Organizer

Data Source

[Presentation] キャプシドの発現タイミングを調整した効率良いアデノ随伴ウイルスベクター産生システム2023

Author(s)

Organizer

Data Source

[Presentation] New viral production system for gene therapy using adeno-associated virus (AAV) vector.2023

Author(s)

Organizer

Data Source

[Presentation] Improvement of a neutralizing antibody assay for AAV capsids.2023

Author(s)

Organizer

Data Source

[Presentation] Effect of Ezh2 knockdown on postischemic neurogenesis in gerbil hippocampus.2023

SEHARA YOSHIHIDE 瀬原吉英

Sehara Yoshihide 瀬原吉英