NAKAGAWA TSUTOMU 中川勉

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NAKAGAWA Tsutomu 中川勉

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Researcher Number	50722063
Other IDs
Affiliation (Current)	2025: 北海道医療大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 北海道医療大学, 薬学部, 准教授 2018: 北海道医療大学, 薬学部, 准教授 2016 – 2017: 神戸大学, 医学研究科, 特命講師 2014 – 2015: 神戸大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Eating habits
Keywords	Principal Investigator ChREBP / メトホルミン / 糖尿病 / GLUT2 / SUMO / n-3系脂肪酸

GLP-1/GIP共受容体作動薬チルゼパチドによるインスリン抵抗性改善の分子メカニズムPrincipal Investigator
- Principal Investigator
  
  中川勉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Health Sciences University of Hokkaido
Metformin lowers blood glucose levels via inhibition of ChREBP activityPrincipal Investigator
- Principal Investigator
  
  NAKAGAWA Tsutomu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Health Sciences University of Hokkaido
ChREBP regulates blood glucose level via the expression of GLUT2Principal Investigator
- Principal Investigator
  
  Nakagawa Tsutomu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Health Sciences University of Hokkaido
  Kobe University
Elucidation of the mechanisms underlying n-3 polyunsaturated fatty acids mediated degradation of ChREBPPrincipal Investigator
- Principal Investigator
  
  NAKAGAWA TSUTOMU
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  Kobe University

All 2024 2023 2021 2020 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Glycosignals in Cancer2023
- Author(s)
  Eiji Miyoshi, Kazutoshi Fujita, Koichi Morishita, Tsunenori Ouchida, Tsutomu Nakagawa, Shinji Takamatsu, Jumpei Kondo
- Total Pages
  238
- Publisher
  Springer
- ISBN
  9789811977329
- Data Source
  KAKENHI-PROJECT-20K11628
[Journal Article] Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.2023
- Author(s)
  1.Muranaka M., Takamatsu S., Ouchida T., Kanazawa Y., Kondo J., Nakagawa T., Egashira Y., Fukagawa K., Gu J., Okamoto T., Kamada Y., and Miyoshi E.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 24 Issue: 8 Pages: 7037-7037
- DOI
  10.3390/ijms24087037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10895, KAKENHI-PROJECT-22H04961, KAKENHI-PROJECT-23K24228
[Journal Article] A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue2021
- Author(s)
  Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 476 Issue: 10 Pages: 3577-3590
- DOI
  10.1007/s11010-021-04178-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11570, KAKENHI-PROJECT-20K11628
[Journal Article] The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions.2020
- Author(s)
  Jung H, Takeshima T, Nakagawa T, MacMillan KS, Wynn RM, Wang H, Sakiyama H, Wei S, Li Y, Bruick RK, Posner BA, De Brabander JK, Uyeda K.
- Journal Title
  
  Biochemical Journal
  
  Volume: 477 Issue: 17 Pages: 3253-3269
- DOI
  10.1042/bcj20200520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11570, KAKENHI-PROJECT-20K11628
[Journal Article] Association of Expression Levels or Activation Status of STAT3 with Treatment Outcomes of Sunitinib in Patients with Renal Cell Carcinoma.2018
- Author(s)
  Yamamoto K., Hara T., Nakagawa T., Hirai M., Miyake H., Fujisawa M., Yano I.
- Journal Title
  
  Targeted Oncology
  
  Volume: 13 Issue: 3 Pages: 371-378
- DOI
  10.1007/s11523-018-0563-4
- NAID
  120006649622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01820, KAKENHI-PROJECT-16K08401
[Journal Article] Association of Single Nucleotide Polymorphisms in STAT3, ABCB1, and ABCG2 with Stomatitis in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Analysis in Japanese Patients2017
- Author(s)
 Watanabe A., Yamamoto K., Ioroi T., Hirata S., Harada K., Miyake H., Fujisawa M., Nakagawa T., Yano I., Hirai M.
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 40 Issue: 4 Pages: 458-464
- DOI
 10.1248/bpb.b16-00875
- NAID
 130005530145
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-16K01820, KAKENHI-PROJECT-16K08401
[Journal Article] Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib2017
- Author(s)
  Yamamoto K., Shichiri H., Ishida T., Kaku K., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Bito T., Nishigori C., Yano I., Hirai M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 9 Pages: 1530-1536
- DOI
  10.1248/bpb.b17-00386
- NAID
  130006038784
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01820, KAKENHI-PROJECT-16K08401
[Journal Article] Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.2017
- Author(s)
  Shichiri H., Yamamoto K., Tokura M., Ishida T., Uda A., Bito T., Nishigori C., Nakagawa T., Hirano T., Yano I., Hirai M.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 485 Issue: 2 Pages: 227-233
- DOI
  10.1016/j.bbrc.2017.02.107
- NAID
  120006733140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01820, KAKENHI-PROJECT-16K08401
[Journal Article] 転写因子ChREBPを標的とした生活習慣病の予防法及び治療薬の開発2017
- Author(s)
  崎山晴彦，中川勉，江口裕伸，吉原大作，藤原範子，鈴木敬一郎
- Journal Title
  
  細胞
  
  Volume: 49 Pages: 81-84
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K01820
[Journal Article] Compatibility and Stability of Nab-Paclitaxel in Combination with Other Drugs.2017
- Author(s)
  Mizuta N., Nakagawa T., Yamamoto K., Nishioka T., Kume M., Makimoto H., YANO I., Minami H., Hirai M.
- Journal Title
  
  Kobe Journal of Medical Sciences
  
  Volume: 63 Pages: 9-16
- NAID
  120006329054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01820
[Journal Article] シグナル伝達因子に起因する間質性肺炎発症メカニズム2017
- Author(s)
  山本和宏，中川勉，矢野育子，平井みどり
- Journal Title
  
  BIO Clinica
  
  Volume: 6 Pages: 121-125
- Data Source
  KAKENHI-PROJECT-16K01820
[Journal Article] Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR2016
- Author(s)
  Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 20 Pages: 10515-10527
- DOI
  10.1074/jbc.m115.708982
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01820
[Journal Article] STAT3 polymorphism rs4796793 may be a predictive factor of tumor response to multiple tyrosine kinase inhibitors in metastatic renal cell carcinoma in Japanese population.2016
- Author(s)
  Yamamoto K., Ioroi T., Kanaya K., Shinomiya K., Komoto S., Hirata S., Harada K., Watanabe A., Suno M., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Miyake H., Fujisawa M., Hirtai M.
- Journal Title
  
  Medical Oncology
  
  Volume: 33 Issue: 3 Pages: 24-24
- DOI
  10.1007/s12032-016-0733-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26750041, KAKENHI-PROJECT-26860104
[Journal Article] Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor.2016
- Author(s)
  Sato S., Jung H., Nakagawa T., Pawlosky R., Takeshima T., Lee W. R., Sakiyama H., Laxman S., Wynn R. M., Tu B., MacMillan J. B., De Brabander J. K., Veech R. L., Uyeda K.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26750041
[Journal Article] Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients.2016
- Author(s)
  Yamamoto K., Shinomiya K., Ioroi T., Hirata S., Harada K., Suno M., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Bito T., Nishigori C., Miyake H., Fujisawa M., Hirai M.
- Journal Title
  
  Targeted Oncology
  
  Volume: 11 Issue: 1 Pages: 93-99
- DOI
  10.1007/s11523-015-0382-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750041, KAKENHI-PROJECT-26860104
[Journal Article] Induction of epithelial-mesenchymal transition via activation of epidermal growth factor receptor contributes to sunitinib resistance in human renal cell carcinoma cell lines.2015
- Author(s)
  Mizumoto A., Yamamoto K., Nakayama Y., Takara K., Nakagawa T., Hirano T., Hirai M.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 355 Issue: 2 Pages: 152-158
- DOI
  10.1124/jpet.115.226639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750041, KAKENHI-PROJECT-26860104
[Journal Article] Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line.2015
- Author(s)
  Yamamoto K., Shichiri H., Uda A., Yamashita K., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Hirai M.
- Journal Title
  
  Phytotherapy Research
  
  Volume: 25 Issue: 5 Pages: 707-713
- DOI
  10.1002/ptr.5305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750041, KAKENHI-PROJECT-26860104
[Journal Article] Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3).2014
- Author(s)
  2.Yamamoto K., Mizumoto A., Nishimura K., Uda A., Mukai A., Yamashita K., Kume M., Makimoto H., Bito T., Nishigori C., Nakagawa T., Hirano T., Hirai M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 7 Pages: e102110-e102110
- DOI
  10.1371/journal.pone.0102110
- NAID
  120005465541
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26750041, KAKENHI-PROJECT-26860104
[Presentation] エゼチミブ‐アトルバスタチン配合錠の高湿度保存条件における安定性への影響2024
- Author(s)
  久保儀忠、栗栖幹典、大屋敷岳男、田村美桜、中川勉、柴山良彦
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10895
[Presentation] ChREBPの脂肪組織における新たな役割2020
- Author(s)
  崎山晴彦, Li Lan, 中川勉, 江口裕伸, 吉原大作, 藤原範子, 鈴木敬一郎
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K11628
[Presentation] ChREBP欠損マウスが有する抗肥満作用の検討2018
- Author(s)
  崎山晴彦, 中川勉, 井上美奈子, 江口裕伸, 吉原大作, 藤原範子, 鈴木敬一郎
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] ChREBPのグルコース濃度依存的なDNA結合はO-GlcNAc修飾により制御される2017
- Author(s)
  中川勉、吉村友希、崎山晴彦、中川孝俊、山本和宏、矢野育子、藤原範子、朝日通雄、鈴木敬一郎、平井みどり
- Organizer
  第64回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] 転写因子ChREBP欠損マウスにおける抗肥満効果2017
- Author(s)
  崎山晴彦、井上美奈子、中川勉、江口裕伸、吉原大作、藤原範子、鈴木敬一郎
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] Association of Single Nucleotide Polymorphisms in STAT3, ABCB1, and ABCG2 with Stomatitis in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Analysis in Japanese Patients2017
- Author(s)
  Watanabe A, Yamamoto K, Ioroi T, Hirata S, Harada K, Miyake H, Fujisawa M, Nakagawa T, Yano I, Hirai M
- Organizer
  The 5th International Symposium of Training Plan for Oncology Professionals
- Place of Presentation
  シェラトン都ホテル大阪（大阪府大阪市）
- Year and Date
  2017-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] Carbohydrate response element-binding protein (ChREBP)の活性制御に及ぼすO-GlcNAc修飾の影響2017
- Author(s)
  中川勉，崎山晴彦，山本和宏，藤原範子，鈴木敬一郎，平井みどり
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-09-25
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] 不飽和脂肪酸が血清中性脂肪を低下させる分子メカニズムの解明：ChREBPの抑制機構の解明2017
- Author(s)
  中川勉
- Organizer
  第16回油脂優秀論文賞受賞講演会
- Place of Presentation
  奈良女子大学（奈良県奈良市）
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] エイコサペンタエン酸（EPA）が血清中性脂肪を低下させる分子メカニズムの解明2017
- Author(s)
  中川勉，崎山晴彦，山本和宏，藤原範子，鈴木敬一郎，平井みどり
- Organizer
  第63回日本生化学会近畿支部例会
- Place of Presentation
  神戸薬科大学（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-16K01820
[Presentation] Carbohydrate response element-binding protein (ChREBP)の活性制御に及ぼす核移行/核外搬出シグナルの影響2015
- Author(s)
  中川勉、吉村友希、崎山晴彦、山本和宏、藤原範子、鈴木敬一郎、平井みどり
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26750041
[Presentation] ChREBPと14-3-3の結合に影響を与える代謝物の同定
- Author(s)
  中川勉、吉村友希、Qiang Ge、Robert pawlosky、R. Max Wynn、山本和宏、平野剛、Richard L. Veech、Kosaku Uyeda、平井みどり
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26750041
[Presentation] 新規mTORC1結合因子P110の栄養感知システムとしての生理機能解析
- Author(s)
  七里博章、山本和宏、中川勉、平野剛、平井みどり
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26750041
[Presentation] ChREBP-βの活性化機構の解明
- Author(s)
  吉村友希、中川勉、崎山晴彦、山本和宏、江口裕伸、藤原範子、平野剛、鈴木敬一郎、平井みどり
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26750041

1. UYEDA kosaku

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. SAKIYAMA haruhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. FUJIWARA Noriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. EGUCHI Hironobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. YOSHIHARA Daisaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. IHARA Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 鈴木敬一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAGAWA TSUTOMU 中川 勉

NAKAGAWA Tsutomu 中川 勉

Research Projects

Research Products

Co-Researchers

GLP-1/GIP共受容体作動薬チルゼパチドによるインスリン抵抗性改善の分子メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metformin lowers blood glucose levels via inhibition of ChREBP activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ChREBP regulates blood glucose level via the expression of GLUT2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanisms underlying n-3 polyunsaturated fatty acids mediated degradation of ChREBPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Glycosignals in Cancer2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Expression Levels or Activation Status of STAT3 with Treatment Outcomes of Sunitinib in Patients with Renal Cell Carcinoma.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Association of Single Nucleotide Polymorphisms in <i>STAT3</i>, <i>ABCB1</i>, and <i>ABCG2</i> with Stomatitis in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Analysis in Japanese Patients2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 転写因子ChREBPを標的とした生活習慣病の予防法及び治療薬の開発2017

Author(s)

NAKAGAWA TSUTOMU 中川勉

NAKAGAWA Tsutomu 中川勉