Simizu Dai 清水大

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Shimizu Dai 清水大

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Researcher Number	50723037
Affiliation (Current)	2025: 名古屋大学, 医学部附属病院, 病院講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 名古屋大学, 医学部附属病院, 病院講師 2020 – 2022: 名古屋大学, 医学部附属病院, 助教 2019 – 2020: 名古屋大学, 医学部附属病院, 病院助教 2017 – 2018: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / General surgery Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 診断 / ctDNA / DNAメチル化 / cfDNA / メチル化 / 大腸癌 / 次世代シーケンサー / 個別化治療 / Transcriptome解析 / FRAS1 / 肝転移 / 胃癌 … More Except Principal Investigator … More コンパニオン診断 / Transcriptome解析 / アンチセンス核酸医薬 / 血行性転移 / 食道癌 / 胃癌 / 細胞接着因子 / PCDHA11 / オフターゲット探索 / リンパ節転移 / 分子標的治療 / KLRG2 / 肝転移 / CHRNB2 / がん抗体医薬 / 分子標的治療薬 / アンチセンス核酸 / 高機能性人工核酸 / 癌治療核酸医薬 / 消化器癌 Less

食道癌転移の分子病態解明にもとづいたデュアル修飾型アンチセンス核酸医薬創出研究
- Principal Investigator
  
  神田光郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagoya University
DNAメチル化パネルによる多癌種鑑別診断技術の確立Principal Investigator
- Principal Investigator
  
  清水大
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya University
Drug discovery based on elucidation of molecular mechanisms of esophageal cancer metastasis
- Principal Investigator
  
  KODERA Yasuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University
細胞接着因子を標的とするデュアル修飾型アンチセンス核酸を用いた革新的癌治療薬創出
- Principal Investigator
  
  小寺泰弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagoya University
Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies
- Principal Investigator
  
  KANDA Mitsuro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University
Development of monoclonal antibody targeting CHRNB2 to treat gastric cancer
- Principal Investigator
  
  KANDA Mitsuro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Diagnosis of colorectal cancer using cfDNA by specific methylation markerPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Dai
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya University
Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancerPrincipal Investigator
- Principal Investigator
  
  Shimizu Dai
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer2021
- Author(s)
  Masahiro Sasahara, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 2 Pages: 609-617
- DOI
  10.21873/anticanres.14812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21629
[Journal Article] Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin.2021
- Author(s)
  Shimizu D, Taniue K, Matsui Y, Haeno H, Araki H, Miura F, Fukunaga M, Shiraishi K, Miyamoto Y, Tsukamoto S, Komine A, Kobayashi Y, Kitagawa A, Yoshikawa Y, Sato K, Saito T, Ito S, Masuda T, Niida A, Suzuki M, Baba H, Ito T, Akimitsu N, Kodera Y, Mimori K.
- Journal Title
  
  Cancer Gene Ther.
  
  Volume: Epub Issue: 5 Pages: 1-1
- DOI
  10.1038/s41417-021-00401-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09176, KAKENHI-PROJECT-18K18151, KAKENHI-PROJECT-19K16868, KAKENHI-PUBLICLY-20H05039, KAKENHI-PROJECT-18H03207, KAKENHI-PROJECT-19H03715, KAKENHI-PROJECT-20K20657, KAKENHI-PROJECT-21K19402, KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K20389, KAKENHI-PROJECT-23K24164, KAKENHI-PROJECT-21H02758
[Journal Article] Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells2021
- Author(s)
  Kanda Mitsuro、Shimizu Dai、Nakamura Shunsuke、Sawaki Koichi、Umeda Shinichi、Miwa Takashi、Tanaka Haruyoshi、Inokawa Yoshikuni、Hattori Norifumi、Hayashi Masamichi、Tanaka Chie、Nakayama Goro、Iguchi Yohei、Katsuno Masahisa、Kodera Yasuhiro
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 36 Pages: 5495-5504
- DOI
  10.1038/s41388-021-01945-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-20H03750
[Presentation] 胃癌転移形式特異的バイオマーカーの同定と創薬への展開2024
- Author(s)
  神田光郎，田中千恵，清水　大，中西香企，梅田晋一，高見秀樹，猪川祥邦，服部憲史，林　真路，中山吾郎，藤原道隆，小寺泰弘
- Organizer
  第96回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-20H03750
[Presentation] 食道癌におけるNECAB2遺伝子の機能および組織中発現の検討2023
- Author(s)
  笹原正寛，神田光郎，佐藤雄亮，清水　大，猪川祥邦，高見秀樹，服部憲史，林　真路，田中千恵，中山吾郎，藤原道隆，小寺泰弘
- Organizer
  第61回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19525
[Presentation] CHRNB2を標的としたモノクローナル抗体による新規胃癌分子標的治療の開発2022
- Author(s)
  神田光郎，清水　大，田中千恵，林　真路，服部憲史，猪川祥邦，高見秀樹，中山吾郎，小池聖彦，藤原道隆，小寺泰弘
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20H03750
[Presentation] 胃癌化学療法耐性遺伝子CSRNP3の機能解析と臨床的意義の検討2022
- Author(s)
  中村俊介，神田光郎，田中千恵，清水　大，猪川祥邦，高見秀樹，服部憲史，林　真路，中山吾郎，小池聖彦，藤原道隆，小寺泰弘
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K21629
[Presentation] Blockade of CHRNB2 signaling attenuates the aggressiveness of gastric cancer cells2022
- Author(s)
  Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Masamichi Hayashi, Norifumi Hattori, Yoshikuni Inokawa, Hideki Takami, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
- Organizer
  第94回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-20H03750
[Presentation] 転移臓器嗜好性に焦点をあてた食道癌バイオマーカー開発2022
- Author(s)
  神田光郎，清水　大，田中千恵，高見秀樹，猪川祥邦，服部憲史，林　真路，中山吾郎，藤原道隆，小寺泰弘
- Organizer
  第76回日本食道学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19525
[Presentation] トランスクリプトーム解析を切り口とした新規癌治療抗体医薬の開発研究2022
- Author(s)
  神田光郎，清水　大，中西香企，田中千恵，服部憲史，林　真路，高見秀樹，中山吾郎，小池聖彦，藤原道隆，小寺泰弘
- Organizer
  第54回制癌剤適応研究会
- Data Source
  KAKENHI-PROJECT-20H03750
[Presentation] 外科臨床検体を用いたトランスクリプトーム解析からの癌治療抗体医薬開発研究2022
- Author(s)
  神田光郎，清水　大，中西香企，田中千恵，猪川祥邦，高見秀樹，服部憲史，林真路，中山吾郎，藤原道隆，小寺泰弘
- Organizer
  第47回日本外科系連合学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03750
[Presentation] 胃癌化学療法抵抗性遺伝子CSRNP3の機能解析と治療効果予測バイオマーカーとしての意義2021
- Author(s)
  中村俊介，神田光郎，清水　大，服部憲史，林　真路，田中千恵，中山吾郎，小池聖彦，藤原道隆，小寺泰弘
- Organizer
  第19回消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-20K21629
[Presentation] 胃癌化学療法抵抗性遺伝子CSRNP3の機能解析と治療効果予測バイオマーカーとしての意義の検討2021
- Author(s)
  中村俊介，神田光郎，清水　大，林　真路，田中千恵，中山吾郎，小池聖彦，藤原道隆，小寺泰弘
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K21629

1. KANDA Mitsuro (00644668)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
2. 田中千恵 (50589786)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. KODERA Yasuhiro (10345879)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. 小比賀聡 (80243252)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 笠原勇矢 (10740673)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 横島聡 (10376593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山口繭美 (80822345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中西香企 (10836183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KATSUNO Masahisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 三森功士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 増田隆明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井口洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Simizu Dai 清水 大

Shimizu Dai 清水 大

Research Projects

Research Products

Co-Researchers

食道癌転移の分子病態解明にもとづいたデュアル修飾型アンチセンス核酸医薬創出研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNAメチル化パネルによる多癌種鑑別診断技術の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery based on elucidation of molecular mechanisms of esophageal cancer metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞接着因子を標的とするデュアル修飾型アンチセンス核酸を用いた革新的癌治療薬創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of monoclonal antibody targeting CHRNB2 to treat gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Diagnosis of colorectal cancer using cfDNA by specific methylation markerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 胃癌転移形式特異的バイオマーカーの同定と創薬への展開2024

Author(s)

Organizer

Data Source

[Presentation] 食道癌におけるNECAB2遺伝子の機能および組織中発現の検討2023

Author(s)

Organizer

Data Source

[Presentation] CHRNB2を標的としたモノクローナル抗体による新規胃癌分子標的治療の開発2022

Author(s)

Organizer

Data Source

Simizu Dai 清水大

Shimizu Dai 清水大