Sakai Yoko 堺陽子

Researcher Number	50723079
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 和歌山県立医科大学, 薬学部, 助教 2020 – 2021: 名古屋市立大学, 大学院薬学研究科, 助教 2018: 名古屋市立大学, 大学院薬学研究科, 助教 2017: 愛知学院大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy
Keywords	Principal Investigator トランスポーター / 毛細胆管 / 肝細胞 / 胆汁うっ滞肝毒性 / MPS / 胆汁鬱滞肝障害 / 胆汁酸 / 胆汁うっ滞肝障害 / 小腸細胞 / 灌流 … More / 胆汁うっ滞肝毒性評価系 / BSEP / HepG2細胞 / マイクロ流体デバイス / 生体模倣システム / 毛細胆管形成 / カスパーゼ / 薬剤性胆汁うっ滞肝障害 / 凍結ヒト肝細胞 / bile salt export pump / 細胞・組織 / in vitro肝障害評価系 / サンドイッチ培養 / MRP2/3/4 / ヒトiPS細胞 Less

灌流型小腸-肝臓2臓器連結デバイスを用いた胆汁鬱滞肝毒性評価系の展開Principal Investigator
- Principal Investigator
  
  堺陽子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Wakayama Medical University
Establishment of in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-hBSEP-C4 cells.Principal Investigator
- Principal Investigator
  
  Sakai Yoko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytesPrincipal Investigator
- Principal Investigator
  
  Sakai Yoko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
  Aichi Gakuin University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 小腸-肝臓連結MPSの開発と薬物動態・毒性評価への利用.2021
- Author(s)
  岩尾岳洋, 堺陽子, 深谷壮弥, 小川勇, 松永民秀
- Total Pages
  3
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-20K16051
[Journal Article] Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time2023
- Author(s)
  Yoko Sakai, Masanari Matsumura, Takahiro Iwao, Tamihide Matsunaga
- Journal Title
  
  In Vitro Cellular & Developmental Biology - Animal
  
  Volume: 59 Issue: 8 Pages: 606-614
- DOI
  10.1007/s11626-023-00805-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06773, KAKENHI-PROJECT-21H04865
[Journal Article] Development of a Perfusing Small Intestine－Liver Microphysiological System Device2023
- Author(s)
  Yoko Sakai, Masanari Matsumura, Hideki Yamada, Atsushi Doi, Isao Saito, Takahiro Iwao, Tamihide Matsunaga
- Journal Title
  
  Applied Sciences
  
  Volume: 13 Issue: 18 Pages: 10510-10510
- DOI
  10.3390/app131810510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06773, KAKENHI-PROJECT-23K24050
[Journal Article] A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes2022
- Author(s)
  Yamamoto C, Takemura A, Ishii S, Doi A, Saito I, Yamada H, Sakai Y, Matsunaga T, Ito K
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 1 Pages: 13-18
- DOI
  10.2131/jts.47.13
- NAID
  130008139750
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16051, KAKENHI-PROJECT-21H04865
[Journal Article] In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome2019
- Author(s)
  Sakai Yoko, Iwao Takahiro, Susukida Takeshi, Nukaga Takumi, Takemura Akinori, Sekine Shuichi, Ito Kousei, Matsunaga Tamihide
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 印刷中 Issue: 4 Pages: 264-271
- DOI
  10.1016/j.dmpk.2019.04.004
- NAID
  50014558514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15527, KAKENHI-PROJECT-16H01811
[Patent] 細胞培養基材および細胞培養方法2022
- Inventor(s)
  松永民秀、岩尾岳洋、堺陽子、小川勇、山田秀樹、土井淳史
- Industrial Property Rights Holder
  松永民秀、岩尾岳洋、堺陽子、小川勇、山田秀樹、土井淳史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-082939
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K06773
[Patent] 培養容器用アダプター2022
- Inventor(s)
  松永民秀、岩尾岳洋、堺　陽子、山田秀樹、西東　勲
- Industrial Property Rights Holder
  松永民秀、岩尾岳洋、堺　陽子、山田秀樹、西東　勲
- Industrial Property Rights Type
  意匠
- Filing Date
  2022
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] ヒト凍結肝細胞を用いた短期間で毛細胆管を形成する培養法の確立2023
- Author(s)
  堺陽子, 岩尾岳洋, 松永民秀, 長田茂宏
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] Characterization of new human induced pluripotent stem cell-derived intestinal epithelial cells and their application to an integrated small intestine liver device2023
- Author(s)
  Kotaro Shirai, Masami Fukaya, Yoko Sakai, Takahiro Iwao, Tamihide Matsunaga
- Organizer
  日本薬物動態学会第38年会第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] 灌流型小腸－肝臓2臓器連結デバイスを用いたヒト凍結肝細胞の長期培養法の検討2022
- Author(s)
  堺陽子, 深谷壮弥, 長田茂宏, 岩尾岳洋, 松永民秀
- Organizer
  第16回次世代を担う若手のための医療薬科学シンポジウム、口頭（O-15）
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] 短期間で毛細胆管を形成するヒト凍結肝細胞の培養法の確立2022
- Author(s)
  堺陽子, 深谷壮弥, 長田茂宏, 岩尾岳洋, 松永民秀
- Organizer
  第45回日本分子生物学会年会、口頭（1SP-26-13）
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] 短期間で毛細胆管を形成するヒト凍結肝細胞の培養法の確立2022
- Author(s)
  堺陽子, 深谷壮弥, 長田茂宏, 岩尾岳洋, 松永民秀
- Organizer
  第45回日本分子生物学会年会、ポスター（IP-540）
- Data Source
  KAKENHI-PROJECT-22K06773
[Presentation] ヒトiPS細胞由来肝細胞のNTCPに対する因子X添加の影響2022
- Author(s)
  金子昌平, 坡下真大, 堺陽子, 松永民秀
- Organizer
  細胞アッセイ研究会シンポジウム2022
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] 小腸－肝臓2臓器連結デバイスでのヒト凍結肝細胞長期培養2021
- Author(s)
  深谷壮弥, 堺陽子, 岩尾岳洋, 松永民秀
- Organizer
  日本薬物動態学会第36年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] 初回通過効果の評価を行うための小腸肝臓2臓器連結デバイスの有用性2021
- Author(s)
  深谷壮弥, 堺陽子, 松村将成, 徳島優樹, 岩尾岳洋, 松永民秀
- Organizer
  細胞アッセイ研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] 肝臓の生体模倣システムにおける細胞障害性の長期非侵襲的評価2021
- Author(s)
  Hiroyuki Moriguchi, Tae Dobashi, Miki Inou, Reiko Nagasaki, Takaya Kimura, Noriyuki Nakatani, Kaori Takama, Yoko Sakai, Hitoshi Naraoka, Tamihide Matsunaga, Kazuhiro Tetsuk
- Organizer
  日本薬物動態学会第36年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] 小腸-肝臓2臓器連結デバイスにおけるヒト凍結肝細胞長期培養法の検討2021
- Author(s)
  深谷壮弥, 堺陽子, 岩尾岳洋, 松永民秀
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] 初回通過効果の評価を行うための小腸ー肝臓2臓器連結デバイスの有用性2021
- Author(s)
  深谷壮弥, 堺陽子, 松村将成, 徳島優樹, 岩尾岳洋, 松永民秀
- Organizer
  細胞アッセイ研究会シンポジウム2021
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] ヒト凍結肝細胞の毛細胆管形成に着目した培養法の最適化2021
- Author(s)
  松村将成, 堺陽子, 岩尾岳洋, 松永民秀
- Organizer
  日本薬物動態学会第36年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] サンドイッチ培養したHepG2-hNTCP-C4細胞による胆汁鬱滞肝毒性評価2020
- Author(s)
  堺陽子, 奥村啓樹, 岩尾岳洋, 渡士幸一, 伊藤晃成, 松永民秀
- Organizer
  第27回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-20K16051
[Presentation] In Vitro Cholestatic Drug-Induced Liver Injury Evaluation System Using Human iPS Cell-Derived Hepatocytes2018
- Author(s)
  Sakai Yoko, Iwao Takahiro, Susukida Takeshi, Nukaga Takumi, Takemura Akinori, Sekine Shuichi, Ito Kousei, Matsunaga Tamihide
- Organizer
  International Meeting on 22nd MDO and 33rd JSSX, Kanazawa
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15527
[Presentation] Establishment of Cholestatic Drug-Induced liver Injury Evaluation System In Vitro Using Sandwich Cultured Human iPS Cell-Derived Hepatocytes2017
- Author(s)
  Yoko Sakai
- Organizer
  1st North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15527
[Presentation] Construction of Cholestatic Drug-Induced liver Injury Evaluation System In Vitro Using Sandwich Cultured Human iPS Cell-Derived Hepatocytes.2017
- Author(s)
  Yoko Sakai
- Organizer
  Nagoya City University Visit Of University of Michigan
- Invited
- Data Source
  KAKENHI-PROJECT-17K15527

1. 松永民秀 (40209581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 長田茂宏 (40263305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 岩尾岳洋 (50581740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

Sakai Yoko 堺 陽子

Research Projects

Research Products

Co-Researchers

灌流型小腸-肝臓2臓器連結デバイスを用いた胆汁鬱滞肝毒性評価系の展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-hBSEP-C4 cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 小腸-肝臓連結MPSの開発と薬物動態・毒性評価への利用.2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a Perfusing Small Intestine－Liver Microphysiological System Device2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Patent] 細胞培養基材および細胞培養方法2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 培養容器用アダプター2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] ヒト凍結肝細胞を用いた短期間で毛細胆管を形成する培養法の確立2023

Author(s)

Organizer

Data Source

[Presentation] Characterization of new human induced pluripotent stem cell-derived intestinal epithelial cells and their application to an integrated small intestine liver device2023

Author(s)

Organizer

Data Source

[Presentation] 灌流型小腸－肝臓2臓器連結デバイスを用いたヒト凍結肝細胞の長期培養法の検討2022

Author(s)

Organizer

Data Source

[Presentation] 短期間で毛細胆管を形成するヒト凍結肝細胞の培養法の確立2022

Author(s)

Organizer

Sakai Yoko 堺陽子