Oshima-Takago Tomoko 大島知子

… Alternative Names

OSHIMA Tomoko 大島知子

TAKAGO Tomoko

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Researcher Number	50731783
Other IDs	https://orcid.org/0000-0003-2698-2631
Affiliation (Current)	2025: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Affiliation (based on the past Project Information) *help	2019 – 2022: 東京大学, 大学院医学系研究科(医学部), 特任研究員 2018: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 分子細胞生物学研究部, 研究員 2016 – 2017: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 流動研究員 2015: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 流動研究員 2015: 国立障害者リハビリテーションセンター, 研究所感覚機能系障害研究部, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 46030:Function of nervous system-related / Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience Except Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator グルタミン酸イメージング / シナプス伝達 / カルシウムイメージング / 神経伝達物質放出 / リボンシナプス / シナプス / 感覚器 / 網膜 / パッチクランプ法 / STORM … More / 神経伝達 / アクティブゾーン / 開口放出 / 蝸牛 … More Except Principal Investigator 有毛細胞 / 蝸牛 / グルタミン酸イメージング / リボンシナプス / シナプス / 内耳 / パッチクランプ / 蝸牛神経 / STORM顕微鏡 / パッチクランプ法 / 超解像顕微鏡 / Otoferlin / 聴覚 / 加齢性難聴 / イメージング / グルタミン酸 / リボン / 国際情報交換（ドイツ） / 人工内耳 / オプトジェネティクス / 光遺伝学 Less

Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.Principal Investigator
- Principal Investigator
  
  大島知子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  The University of Tokyo
STORM顕微鏡を用いた有毛細胞シナプスにおけるOtoferlinの構造機能解析
- Principal Investigator
  
  鷹合秀輝
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
STORM顕微鏡を用いた網膜リボンシナプスにおける神経伝達機構の解明Principal Investigator
- Principal Investigator
  
  大島知子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
Pathophysiological study of age-related hearing loss by glutamate imaging
- Principal Investigator
  
  Takago Hideki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Real-time visualization of excitatory neurotransmitter release at sensory ribbon-type synapsesPrincipal Investigator
- Principal Investigator
  
  Oshima-Takago Tomoko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  The University of Tokyo
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
  National Rehabilitation Center for Persons with Disabilities
New method for auditory nerve stimulation using optogenetics
- Principal Investigator
  
  Takago Hideki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse2019
- Author(s)
  Hideki Takago, Tomoko Oshima-Takago, Tobias Moser
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 11 Pages: 492-492
- DOI
  10.3389/fnmol.2018.00492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals2018
- Author(s)
  Takago Hideki、Oshima-Takago Tomoko
- Journal Title
  
  Hearing Research
  
  Volume: 362 Pages: 1-13
- DOI
  10.1016/j.heares.2018.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups2017
- Author(s)
  Oshima-Takago Tomoko、Takago Hideki
- Journal Title
  
  Open Biology
  
  Volume: 7 Issue: 7 Pages: 170032-170032
- DOI
  10.1098/rsob.170032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015
- Author(s)
  Yoshimoto R, Iwasaki S*, Takago H, Nakajima T, Sahara Y, Kitamura K.
- Journal Title
  
  Neuroscience
  
  Volume: 284 Pages: 632-642
- DOI
  10.1016/j.neuroscience.2014.10.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293347, KAKENHI-PROJECT-25670722
[Journal Article] Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis2014
- Author(s)
  Chapochnikov NM*, Takago H*, Huang CH, Pangrsic T, Khimich D, Neef J, Auge E, Goettfert F, Hell S, Wichmann C, Wolf F, Moser T (* Co-1st authors)
- Journal Title
  
  Neuron
  
  Volume: 83 Issue: 6 Pages: 1389-1403
- DOI
  10.1016/j.neuron.2014.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] キンギョ網膜双極細胞終末端におけるシナプスリボン近位および遠位からのグルタミン酸放出の可視化2023
- Author(s)
  大島知子、坂本寛和、中村行宏、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Spatiotemporal dynamics of glutamate release from individual ribbon and non-ribbon regions in the goldfish retinal bipolar cell terminal.2023
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Probing glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2022
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 99th Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] キンギョ網膜双極細胞リボンシナプスにおけるグルタミン酸イメージング2021
- Author(s)
  大島知子, 坂本寛和, 中村行宏, 並木繁行, 廣瀬謙造, 立花政夫, 鷹合秀輝
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Glutamate imaging at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2021
- Author(s)
  Tomoko Oshima, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 98th Annual Meeting of The Physiological Society of Japan/ The 126th Annual Meeting of The Japanese Association of Anatomists
- Data Source
  KAKENHI-PROJECT-19K16276
[Presentation] Unveiling glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2021
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 44rd Annual Meeting of the Japan Neuroscience Society/ The CJK International Meeting
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] 網膜双極細胞リボンシナプスにおけるグルタミン酸放出の可視化2020
- Author(s)
  大島知子、坂本寛和、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 網膜双極細胞リボンシナプスにおけるグルタミン酸放出の可視化2020
- Author(s)
  大島知子, 坂本寛和, 並木繁行, 廣瀬謙造, 立花政夫, 鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] Novel imaging of glutamate release from the ribbon type synapses of goldfish retinal bipolar cell terminal2020
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 43rd Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19K16276
[Presentation] Novel imaging of glutamate release from the ribbon type synapses of goldfish retinal bipolar cell terminal2020
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 43rd Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] 網膜双極細胞リボンシナプスにおけるグルタミン酸放出の可視化2020
- Author(s)
  大島知子、坂本寛和、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Optical measurement of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Oshima-Takago, T., Sakamoto, H., Namiki, S., Hirose, K., Tachibana, M., Takago, H.
- Organizer
  Understanding Synapses-From Molecules to Function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] Optical measurements of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Optical measurement of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Oshima-Takago, T., Sakamoto, H., Namiki, S., Hirose, K., Tachibana, M., Takago, H.
- Organizer
  Understanding Synapses-From Molecules to Function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16276
[Presentation] Optical measurement of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Oshima-Takago, T., Sakamoto, H., Namiki, S., Hirose, K., Tachibana, M., Takago, H.
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] Optical measurement of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Oshima-Takago, T., Sakamoto, H., Namiki, S., Hirose, K., Tachibana, M., Takago, H.
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16276
[Presentation] Optical measurements of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] Presynaptic N-methyl-D-aspartate receptor inhibits Ca2+ currents at a rat central glutamatergic synapse2017
- Author(s)
  Oshima-Takago T, Takago H
- Organizer
  6th Mediterranean Neuroscience Society Conference 2017 MALTA MNS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 中枢神経系のグルタミン酸作動性シナプスにおいてシナプス前NMDA受容体は電位依存性カルシウムチャネルを抑制する2017
- Author(s)
  鷹合秀輝, 大島知子
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 聴覚中枢におけるNMDA受容体によるシナプス前抑制2017
- Author(s)
  鷹合秀輝, 大島知子
- Organizer
  第62回日本聴覚医学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 若齢ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2017
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] 若齢ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2017
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 聴覚中枢におけるNMDA受容体によるシナプス前抑制.2017
- Author(s)
  鷹合秀輝, 大島知子.
- Organizer
  第62回日本聴覚医学会総会・学術講演会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] 中枢神経系のグルタミン酸作動性シナプスにおいてシナプス前NMDA受容体は電位依存性カルシウムチャネルを抑制する2017
- Author(s)
  鷹合秀輝, 大島知子
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] N-methyl-D-aspartate receptor inhibits Ca2+ currents at a rat central glutamatergic synapse.2017
- Author(s)
  Oshima-Takago, T., Takago, H.
- Organizer
  6th Mediterranean Neuroscience Society Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] 幼若ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2016
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  生理学研究所シナプス研究会
- Place of Presentation
  岡崎市
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-16K18374
[Presentation] 幼若ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2016
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  生理学研究所シナプス研究会
- Place of Presentation
  岡崎市
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] Evaluation of synaptic function of otoferlin at the mouse inner hair cell ribbon synapse by postsynaptic recording
- Author(s)
  Hideki Takago, Tobias Moser
- Organizer
  Inner Ear Biology 2014 in Kyoto
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2014-11-01 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Otoferlin alters mode of exocytosis at the inner hair cell ribbon synapse
- Author(s)
  Hideki Takago, Tobias Moser
- Organizer
  The 1st annual meeting of the society for bioacoustics
- Place of Presentation
  Doshisha Biwako Retreat Center
- Year and Date
  2014-12-13 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Otoferlinはマウス内有毛細胞リボンシナプスにおいてエキソサイトーシスのモードを変える
- Author(s)
  鷹合　秀輝, 大島－鷹合　知子, トビアス　モーザー
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25670722

1. Takago Hideki (70401354)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. 中村行宏 (40460696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 岩崎真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中島敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima-Takago Tomoko 大島 知子

OSHIMA Tomoko 大島 知子

TAKAGO Tomoko

Research Projects

Research Products

Co-Researchers

Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

STORM顕微鏡を用いた有毛細胞シナプスにおけるOtoferlinの構造機能解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

STORM顕微鏡を用いた網膜リボンシナプスにおける神経伝達機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological study of age-related hearing loss by glutamate imaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Real-time visualization of excitatory neurotransmitter release at sensory ribbon-type synapsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New method for auditory nerve stimulation using optogenetics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] キンギョ網膜双極細胞終末端におけるシナプスリボン近位および遠位からのグルタミン酸放出の可視化2023

Author(s)

Organizer

Data Source

[Presentation] Spatiotemporal dynamics of glutamate release from individual ribbon and non-ribbon regions in the goldfish retinal bipolar cell terminal.2023

Author(s)

Organizer

Data Source

[Presentation] Probing glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2022

Author(s)

Organizer

Data Source

[Presentation] キンギョ網膜双極細胞リボンシナプスにおけるグルタミン酸イメージング2021

Oshima-Takago Tomoko 大島知子

OSHIMA Tomoko 大島知子