Machida Shinichi 町田晋一

Researcher Number	50732195
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, テニュアトラック部長
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立国際医療研究センター, 研究所, テニュアトラック部長 2017: 早稲田大学, 理工学術院, 次席研究員(研究院助教) 2014 – 2017: 早稲田大学, 理工学術院, 助教
Review Section/Research Field	Principal Investigator Genome biology / Basic Section 49060:Virology-related
Keywords	Principal Investigator ヒストン / ヒストン修飾 / クロマチン / H3K9me3 / ヌクレオソーム / HP1 / ヘテロクロマチン / エピジェネティクス / ユビキチン / RAD54 / RAD51 / リンカーヒストン / 相同組換え

B型肝炎ウイルスの転写メカニズムに関する包括的解析Principal Investigator
- Principal Investigator
  
  町田晋一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Center for Global Health and Medicine
The structural study of heterochromatin by cryo-EMPrincipal Investigator
- Principal Investigator
  
  Machida Shinichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Waseda University
The homologous recombination reaction in chromatinPrincipal Investigator
- Principal Investigator
  
  Machida Shinichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Genome biology
- Research Institution
  Waseda University

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] HP1との結合により形成される構成的なヘテロクロマチンの基盤となる構造2018
- Author(s)
  町田晋一, 滝沢由政, Matthias Wolf, 胡桃坂仁志
- Journal Title
  
  First Author's
  
  Volume: . Pages: 014
- DOI
  10.7875/first.author.2018.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18473
[Journal Article] Structural Basis of Heterochromatin Formation by Human HP12018
- Author(s)
  Machida Shinichi、Takizawa Yoshimasa、Ishimaru Masakazu、Sugita Yukihiko、Sekine Satoshi、Nakayama Jun-ichi、Wolf Matthias、Kurumizaka Hitoshi
- Journal Title
  
  Molecular Cell
  
  Volume: 69 Issue: 3 Pages: 385-397
- DOI
  10.1016/j.molcel.2017.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15080, KAKENHI-PROJECT-17K15704, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-16K18473
[Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018
- Author(s)
  Takizawa Yoshimasa、Tanaka Hiroki、Machida Shinichi、Koyama Masako、Maehara Kazumitsu、Ohkawa Yasuyuki、Wade Paul A.、Wolf Matthias、Kurumizaka Hitoshi
- Journal Title
  
  Open Biology
  
  Volume: 8 Issue: 3 Pages: 170255-170255
- DOI
  10.1098/rsob.170255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15080, KAKENHI-PUBLICLY-16H01550, KAKENHI-PUBLICLY-16H01577, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-16K18473, KAKENHI-PROJECT-16K18479, KAKENHI-PUBLICLY-18H04802, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-17K19356
[Journal Article] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.2017
- Author(s)
  Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A.
- Journal Title
  
  Cell Rep
  
  Volume: 20(12) Issue: 12 Pages: 2756-2765
- DOI
  10.1016/j.celrep.2017.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112006, KAKENHI-PLANNED-25112009, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-16H04687, KAKENHI-PROJECT-17H03939, KAKENHI-PROJECT-17J00058, KAKENHI-PROJECT-16K18473
[Journal Article] SYCP3 regulates strand invasion activities of RAD51 and DMC12017
- Author(s)
  Kobayashi Wataru、Hosoya Noriko、Machida Shinichi、Miyagawa Kiyoshi、Kurumizaka Hitoshi
- Journal Title
  
  Genes to Cells
  
  Volume: 22 Issue: 9 Pages: 799-809
- DOI
  10.1111/gtc.12513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10471, KAKENHI-PUBLICLY-16H01298, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-16K18473
[Journal Article] Phosphorylation of CBX2 controls its nucleosome-binding specificity2017
- Author(s)
  Takayuki Kawaguchi, Shinichi Machida, Hitoshi Kurumizaka, Hideaki Tagami, Jun-ichi Nakayama
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 162 Issue: 5 Pages: 343-355
- DOI
  10.1093/jb/mvx040
- NAID
  40021394855
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01315, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-16K18473
[Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017
- Author(s)
  Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K.
- Journal Title
  
  Cell Reports
  
  Volume: 18(3) Issue: 3 Pages: 593-600
- DOI
  10.1016/j.celrep.2016.12.065
- NAID
  120006957416
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05976, KAKENHI-PUBLICLY-16H01219, KAKENHI-PUBLICLY-16H01550, KAKENHI-PUBLICLY-16H01577, KAKENHI-PLANNED-25112007, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-15J06922, KAKENHI-PROJECT-16J09361, KAKENHI-PROJECT-25712035, KAKENHI-PROJECT-15K18457, KAKENHI-PROJECT-16K08748, KAKENHI-PROJECT-16K18473, KAKENHI-PROJECT-16K18479, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K07099, KAKENHI-PUBLICLY-16H01319, KAKENHI-PROJECT-17J06605
[Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.2017
- Author(s)
  Kakumu E
- Journal Title
  
  Genes Cells.
  
  Volume: 3 Issue: 3 Pages: 310-327
- DOI
  10.1111/gtc.12479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01307, KAKENHI-PUBLICLY-16H01311, KAKENHI-WRAPUP-16H01688, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-26281020, KAKENHI-PROJECT-26281026, KAKENHI-PROJECT-15K12203, KAKENHI-PROJECT-15K18988, KAKENHI-PROJECT-16H06307, KAKENHI-PROJECT-16K18473
[Journal Article] Influence of polynucleosome preparation methods on sedimentation velocity analysis of chromatin.2017
- Author(s)
  Kujirai T, Machida S, Osakabe A, Kurumizaka H.
- Journal Title
  
  J. Biochem.
  
  Volume: 161 Issue: 4 Pages: 381-388
- DOI
  10.1093/jb/mvw081
- NAID
  40021219908
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-15J06807, KAKENHI-PROJECT-16K18473
[Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing2016
- Author(s)
  Kobayashi W., Takaku M., Machida S., Tachiwana H., Maehara K., Ohkawa Y. and Kurumizaka H
- Journal Title
  
  Scientific reports
  
  Volume: 6 Issue: 1 Pages: 24428-24428
- DOI
  10.1038/srep24228
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J03652, KAKENHI-PUBLICLY-16H01550, KAKENHI-PUBLICLY-16H01577, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-16H07295, KAKENHI-PROJECT-26290064, KAKENHI-PROJECT-16K18473, KAKENHI-PROJECT-16K18479
[Journal Article] Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.2016
- Author(s)
  Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler M, Machida S, Yan K, Kurumizaka H, Poirier MG, Cote J, Luger K, Kutateladze TG.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 44 Issue: 1 Pages: 472-484
- DOI
  10.1093/nar/gkv1321
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26890023
[Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing2016
- Author(s)
  Kobayashi, W., Takaku, M., Machida, S., Tachiwana, H., Maehara, K., Ohkawa, Y., and Kurumizaka, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26890023
[Journal Article] GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler.2016
- Author(s)
  Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade P.
- Journal Title
  
  Genome Biol.
  
  Volume: 17 Issue: 1 Pages: 36-36
- DOI
  10.1186/s13059-016-0897-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26890023
[Journal Article] Structure and function of human histone H3.Y nucleosome.2016
- Author(s)
  Kujirai, T., Horikoshi, N., Sato, K., Maehara, K., Machida, S., Osakabe, A., Kimura, H., Ohkawa, Y. and Kurumizaka, H.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 1 Issue: 13 Pages: 1-15
- DOI
  10.1093/nar/gkw202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26890023, KAKENHI-PROJECT-15J06807, KAKENHI-PROJECT-26840025, KAKENHI-PLANNED-25116002, KAKENHI-PLANNED-25116005
[Journal Article] Structural and biochemical analyses of monoubiquitinated human histones H2B and H42016
- Author(s)
  Machida S, Sekine S, Nishiyama Y, Horikoshi N, Kurumizaka H.
- Journal Title
  
  Open Biol.
  
  Volume: 6 Issue: 6 Pages: 160090-160090
- DOI
  10.1098/rsob.160090
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-16K18473
[Journal Article] Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T.2016
- Author(s)
  Machida S, Hayashida R, Takaku M, Fukuto A, Sun J, Kinomura A, Tashiro S, Kurumizaka H.
- Journal Title
  
  Biochemistry.
  
  Volume: 55 Issue: 4 Pages: 637-646
- DOI
  10.1021/acs.biochem.5b01126
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-25116002, KAKENHI-PUBLICLY-26116514, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-15H02821, KAKENHI-PROJECT-26890023
[Journal Article] Green fluorescent protein fused to the C terminus of RAD51 specifically interferes with secondary DNA binding by the RAD51-ssDNA complex2014
- Author(s)
  Kobayashi, W., Sekine, S., Machida, S., and Kurumizaka, H.
- Journal Title
  
  Genes Genet. Syst.
  
  Volume: 89 Issue: 4 Pages: 169-179
- DOI
  10.1266/ggs.89.169
- NAID
  130004750050
- ISSN
  1341-7568, 1880-5779
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J03652, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-26890023
[Journal Article] N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.2014
- Author(s)
  Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama JI.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 42 Issue: 20 Pages: 12498-12511
- DOI
  10.1093/nar/gku995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-23114001, KAKENHI-PLANNED-23114005, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-26840025, KAKENHI-PROJECT-26890023
[Presentation] ヘテロクロマチンの立体構造解析2017
- Author(s)
  町田晋一、滝沢由政、石丸雅一、関根慧、中山潤一、Matthias Wolf、胡桃坂仁志
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-16K18473
[Presentation] The biochemical analyses of the chromatin containing mono-ubiquitinated nucleosomes2015
- Author(s)
  Shinichi Machida, Yuki Nishiyama and Hitoshi Kurumizaka
- Organizer
  International Symposium on Chromatin Structure, Dynamics,and Function
- Place of Presentation
  淡路島
- Year and Date
  2015-08-23
- Data Source
  KAKENHI-PROJECT-26890023
[Presentation] Nap1は高次クロマチンでの相同組換えを促進する
- Author(s)
  町田晋一、高久誉大、井倉正枝、孫継英、鈴木秀和、小林航、木野村愛子、越阪部晃永、立和名博昭、堀越保則、福戸敦彦、松田諒、浦聖恵、田代聡、井倉毅、胡桃坂仁志
- Organizer
  第32回染色体ワークショップ・第13回核ダイナミクス研究会合
- Place of Presentation
  安芸グランドホテル(広島県)
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-26890023
[Presentation] Nap1 is required for the homologous recombination reaction in higher-order chromatin containing histone H1.
- Author(s)
  Machida S., Takaku M., Ikura M., Sun J., Suzuki H., Kobayashi W., Kinomura A., Osakabe A., Tachiwana H., Horikoshi Y., Fukuto A., Matsuda R., Ura K., Tashiro S., Ikura T., and Kurumizaka H.
- Organizer
  The 4D Nucleome
- Place of Presentation
  安芸グランドホテル(広島県)
- Year and Date
  2014-12-17 – 2014-12-20
- Data Source
  KAKENHI-PROJECT-26890023
[Presentation] リンカーヒストンバリアントH1Tの相同組換えにおける機能
- Author(s)
  町田晋一、林田亮太、加藤大貴、越阪部晃永、小林航、胡桃坂仁志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26890023
[Presentation] Biochemical analyses of the RAD51-mediated homologous pairing in chromatin containing the linker histone variant, H1T.
- Author(s)
  Shinichi Machida, Ryota Hayashida, and Hitoshi Kurumizaka
- Organizer
  3R Symposium
- Place of Presentation
  御殿場高原ホテル(静岡県)
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26890023

1. NAKAMURA Toshinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. OKADA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. Wolf Matthias

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. KURUMIZAKA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. HORI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小倉淳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 細谷紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中山潤一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 滝沢由政

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Machida Shinichi 町田 晋一

Research Projects

Research Products

Co-Researchers

B型肝炎ウイルスの転写メカニズムに関する包括的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The structural study of heterochromatin by cryo-EMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The homologous recombination reaction in chromatinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] HP1との結合により形成される構成的なヘテロクロマチンの基盤となる構造2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Basis of Heterochromatin Formation by Human HP12018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SYCP3 regulates strand invasion activities of RAD51 and DMC12017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of CBX2 controls its nucleosome-binding specificity2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of polynucleosome preparation methods on sedimentation velocity analysis of chromatin.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.2016

Author(s)

Journal Title

DOI

Data Source

Machida Shinichi 町田晋一